Gene 18036 (Tetrahymena)
18036
Group:
Other
Family:
Ciliate-D1
Sequence
Protein domains of 18036.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| PH_Akt_basal | 18036.AA | PH_Akt_basal | 81-166 | 50 | 5e-47 | 162.55 | In-house | 1-90 (90) | Show / Hide |
Range on Protein: 81-166 Range on HMM: 1-90/90 Sequence Identity: 50% (45 aa) IEKFNRKNKKQKRSLMITNYFVYNLK---GLSLKRKIDIQKIKKIIQN-RQNCEFILNIPDEYDYRYCAHSESQKQCIIDILCSFSQGLQ ..|.||.||.|.|.||||...|||.| ..|.|..|..|||..|.|. ...|||....|||||||||.|||.|.||||..||. .... VIKYNRYNKRQERNLMITSKHVYNCKPNKKHSIKWCIPLQKIYGIHQSTTEGCEFVIHVPDEYDYRYCMHSEDQRQCIIMVLCRAYCCYC |
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| Myosin_TH1 | 18036.AA | Myosin_TH1 | 70-122 | 23 | 1.1e-07 | 27.4 | Pfam | 55-126 (234) | Show / Hide |
Range on Protein: 70-122 Range on HMM: 55-126/234 Sequence Identity: 23% (17 aa) DPFEQIAYSDH----IEKFNR--KNKKQKRSLMITNYFVYNL-------------KGLSLKRKIDIQKIKKI .|| .. ..|| . |.|| ..| ..| | |. ..| . | .||.|....|... HPFMKVLFADHCECLVNKYNRFWFGKPSPRDLLLTDKHIYLVGREKKKKGPEKDQKTYQVKRRIPLNEITSV |
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| Kinase | 18036.AA | AGC | 521-612 | 29 | 1e-48 | 122.94 | In-house | 273-395 (395) | Show / Hide |
Range on Protein: 521-612 Range on HMM: 273-395/395 Sequence Identity: 29% (38 aa) YAAPEIINEQPNTYSSDWWS--FGVLLFEMLLGYTPFYDQNPS----------QIQQKIL-----TSKEIIFPKM--------ANISPAAKNLIQRCLDK | ||||. ... |||| .|.|..||| ||.|||..|| .. |||. .... || ..|| ||.||...| | YMAPEIL----YGKACDWWSFGLGCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCK NQKNRIK----------SNEVLSHEFF . ..|. .|. .|..| DPEKRLGCGGNDFGDKGAEEIKNHPWF |
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| Kinase | 18036.AA | AktR | 521-612 | 37 | 3.1e-33 | 116.74 | In-house | 170-268 (268) | Show / Hide |
Range on Protein: 521-612 Range on HMM: 170-268/268 Sequence Identity: 37% (37 aa) YAAPEIINE-QPNTYSSDWWSFGVLLFEMLLGYTPFYDQNPSQIQQKILTSKEIIFPKMANISPAAKNLIQ-RCLDKNQKNRIK-----SNEVLSHEFF | |||.|.. .. ..|.|||.||....||. |..|||..| |. |||... . ||. ...|...|.||| ..|.||...|.. |. || .| YMAPEMITKKKGHNKSVDWWAFGIFIYEMVTGCPPFYHKNQNQMFQKIKIKQQNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF |
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| Kinase | 18036.AA | Ciliate-E2-Unclassified | 391-612 | 22 | 1.2e-32 | 110.52 | In-house | 100-352 (352) | Show / Hide |
Range on Protein: 391-612 Range on HMM: 100-352/352 Sequence Identity: 22% (65 aa) LDAIKYIDLAQLIDEQSF-----------------LSENVAK-----LIAAQIAYSLHILHQKK-IIYNQVNSKDIKIDLAG---NTILNRFEFSQFLFT .. ... || | | .... ..|. || ..||| | ||.|. ||. | .| | . . | .| .. . MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQ PFQVSPKNGGKLFVKSENVKSSNDTFSQVAQNKSAQNYRNSTCNIKERNSDDI--NYCYA----APEIINEQPNT----YSSDWWSFGVLLFEMLLGYTP . . .|. | . . ..|. ..... ...| |||.. .| . |..|.||.||.|.||| || | NNNCD-TNQ--------------------------Q---QKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYP FYDQNPSQ---------------IQQKILTSKEIIFPKMAN------ISPAAKNLIQ----RCLDKNQKNRIKSNEVLSHEFF |||.| | ..... |.| |||. . .|| ||..|. ..|.||...|| ...| | .| FYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF |
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| Kinase | 18036.AA | RSK | 521-612 | 30 | 3e-32 | 113.44 | In-house | 174-278 (278) | Show / Hide |
Range on Protein: 521-612 Range on HMM: 174-278/278 Sequence Identity: 30% (32 aa) YAAPEIIN---EQP-NTYSSDWWSFGVLLFEMLLGYTPFYD---QNPSQIQQKILTSKEIIFPKM--ANISPAAKNLIQRCLDKNQKNRIK-----SNEV |.|||... | . . ||||.|||..||| |..||. .|...| ..|.. | . .. . ...|..||.||...| .. ..|.. .|. YMAPEMLKRANQQGGHDKACDWWSLGVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGK-FSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEI LSHEFF ..|..| KQHPWF |
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| Kinase | 18036.AA | NDR | 521-612 | 34 | 9.9e-32 | 94.64 | In-house | 247-350 (350) | Show / Hide |
Range on Protein: 521-612 Range on HMM: 247-350/350 Sequence Identity: 34% (36 aa) YAAPEIINE-QPNTYSSDWWSFGVLLFEMLLGYTPFYDQNPSQIQQKILTSKEII------FPKMANISPAAKNLIQRCLDKNQKNRIKSNE-----VLS | |||... . .. . |||| |. ..||| ||.||.. .| ...||. |.. ||. ||.|| |..||.|.. ....|. |.. . | YMAPEVFQQKTGYNQTCDWWSLGCIMYEMLVGYPPFCSDTPQETCMKIMNWKQTWDWPMTHFPPEANLSPEAWDLIRRLCCPDPDHRLGSHGKGVDEIKS HEFF | || HPFF |
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| Kinase | 18036.AA | Ciliate-E2 | 521-612 | 27 | 1.6e-31 | 105.43 | In-house | 253-365 (365) | Show / Hide |
Range on Protein: 521-612 Range on HMM: 253-365/365 Sequence Identity: 27% (34 aa) YAAPEIINEQP---------NTYSSDWWSFGVLLFEMLLGYTPFYDQNPSQIQQKILTSKEIIFPKM----------------ANISPAAKNLIQR---- | ||||.| .. .|..|.||.||.|.||| |..|| |.. ..| ||. ..|. .|.||.. YMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF---------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKR CLDKNQKNRIK-SNEVLSHEFF .|.|....|| ...| |..| MLQKDPEKRITGWEQILNHPWF |
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| Kinase | 18036.AA | SGK | 521-612 | 35 | 7.4e-30 | 89.01 | In-house | 191-283 (283) | Show / Hide |
Range on Protein: 521-612 Range on HMM: 191-283/283 Sequence Identity: 35% (34 aa) YAAPEIINEQPNTYSSDWWSFGVLLFEMLLGYTPFYDQNPSQIQQKILTSKEIIFPKMANISPAAKNLIQRCLDKNQKNRIKSN----EVLSHEFF | |||... || . |||. | .|.||. | |||..| .| ...|. .... .|. ..|..|. ||| | |..|.| .. |. .| || YLAPEVLRKQPHDRTVDWWCLGCVLYEMMYGLPPFYSRNKQQMYDNII-NQPLQIPP--QMSNDAWDLIQGLLQKDPKKRLGTKRDFMEIKNHPFF |
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| Kinase | 18036.AA | ULK | 521-612 | 30 | 9.2e-26 | 88.43 | In-house | 213-324 (324) | Show / Hide |
Range on Protein: 521-612 Range on HMM: 213-324/324 Sequence Identity: 30% (35 aa) YAAPEIINEQ-----PNTYSSDWWSFGVLLFEMLLGYTPFYDQNPSQIQ-------------QKILTSKEIIFPKMA---NISPAAKNLIQRCLDKNQKN | ||.|...| ...| .| ||.|....||| |..||. . ... . | . . | ||| .||| |.||.|.| ...| YMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKDLIRRMLQYDEKD RIKSNEVLSHEFF || |...|..| RISWEEIFNHPWF |
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| Kinase | 18036.AA | ULK | 521-612 | 29 | 2.1e-25 | 85.7 | In-house | 217-329 (329) | Show / Hide |
Range on Protein: 521-612 Range on HMM: 217-329/329 Sequence Identity: 29% (34 aa) YAAPEIINEQ-----PNTYSSDWWSFGVLLFEMLLGYTPFYDQNPSQIQQKILTS--------------KEIIFP---KMANISPAAKNLIQRCLDKNQK | ||.|...| ...| .| ||.|....||| |..||| . ... . .|... . . || . .||| |.||.|.| ...| YMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISPECKDLIRRMLQYDEK NRIKSNEVLSHEFF || |...|..| DRISWEELFNHPWF |
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| Kinase | 18036.AA | RSK | 521-612 | 31 | 2.4e-24 | 83.89 | In-house | 171-271 (271) | Show / Hide |
Range on Protein: 521-612 Range on HMM: 171-271/271 Sequence Identity: 31% (32 aa) YAAPEIINEQPNTYSSDWWSFGVLLFEMLLGYTPFYDQNPSQIQQKILTSKEII----FPKMANISPAAKNLIQRCLDKNQKNRIKS-----NEVLSHEF | |||... | . ..||||||||..||| |.|||. .. ..|. |. . . ..||. || |. . |. . || . .....| . YMAPEVLKRQGHDQACDWWSFGVLMYEMLTGCTPFQNKPRDTPMNIIQRIKLGMFSMTHGNWDFISDEAKDLLRMMLHRDPHNRLGAGPNGVEQIKQHPW F | F |
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| Kinase | 18036.AA | Pkinase | 521-612 | 27 | 1.5e-23 | 84.4 | Pfam | 177-293 (293) | Show / Hide |
Range on Protein: 521-612 Range on HMM: 177-293/293 Sequence Identity: 27% (32 aa) YAAPEIIN-EQPNTYSSDWWSFGVLLFEMLLGYTPFYDQ------NPSQIQQKILT-SKEIIFPKMANIS-----------------PAAKNLIQRCLDK |.|||.|. |. ....|.||.|..|.|||.|..||... .. |. ..|. . .|. .|| ...| .| .||.| YMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCK NQKNRIKSNEVLSHEFF . | |. ..| |..| DPKKRPTAEQILQHPWF |
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| S_TKc | 18036.AA | S_TKc | 306-612 | 16 | 8.5e-21 | 76.33 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 306-612
Range on HMM: 1-231/231
Sequence Identity: 16% (57 aa)
FELIEVLG---YNSIWRYFRVRECQNTKKIYQMRVINIHNLFKQESEDMQNQFVQEQIYLIKELDSNYFTQQFYYIHQGNYFAVLQEELDAIKYI---DL
.|.....| . . .. .. |..|. . .|. . .. | . |. . . . ..... ... . | .| ||
YEILRKIGKGAFGKVYKCRHKK----TGRIVAIKIIK--------------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCD----GDLGDL
AQLIDEQSF------LSENVAKLIAAQIAYSLHILHQKKIIY----------NQVNSKDIKI---DLAGNTILNRFEFSQFLFTPFQVSPKNGGKLFVKS
..|... ..| .|. ...||. | .|...||. .. ||| ||
FDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----HIKICDFGLARQL-----------------------------
ENVKSSNDTFSQVAQNKSAQNYRNSTCNIKERNSDDINYCYAAPEIINEQPNTY-SSDWWSFGVLLFEMLLGYTPFYDQNPSQIQQKILTSKEIIFPKMA
.. | |||.. . .. ..||||.|..|.||| ||.||. .. .. .||.
--------------------------------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG-----------
NISPAAKNLIQRCLDKNQKNRIKSNEVLS-------HEFF
|| ||..|..||.|. ..|. |.| |..|
--SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
|
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| Kinase | 18036.AA | AGC | 409-435 | 28 | 3e-05 | 7.96 | In-house | 143-177 (395) | Show / Hide |
Range on Protein: 409-435 Range on HMM: 143-177/395 Sequence Identity: 28% (10 aa) LSENVAKLIAAQ-------IAYSLHILHQ-KKIIY ..|..|. .||. |. |. ||. ..||. FDEERARFYAAEMQKICGCIVLALEYLHSHMGIIH |
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| TyrKc | 18036.AA | TyrKc | 306-612 | 13 | 3.9e-05 | -139.52 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 306-612
Range on HMM: 1-280/280
Sequence Identity: 13% (49 aa)
FELIEVLG-------YNSIWRYFRVRECQNTKKIYQMRV----INIHNLFKQESEDMQNQFVQEQIYLIKEL--DSNYFTQQFYYIHQG-------NYFA
.|...|| | .|. . | .. . . | .| . . ..| . . . .. |.
ITLGKKLGEGAFGEVYKGTWK---------------IQVAVKMLKEDA---------REDFMRE-ARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLM
VLQEELDAIKYIDLAQLI-DEQSFLSENVAKLIAAQIAYSLHILHQKKIIYNQVNSKDIKIDLAGNTILNRFEFSQFLFTPFQVSPKNGGKLFVKSENVK
.. | .. || . . . . |. .. ||| ||.|
IVME---YMPHGDLKDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSK-----------------------------------------------------
SSNDTFSQ------------VAQNK---------SAQNYRN-------STCNIKERNSDD--INYCYAAPEIINEQPNTYSSDWWSFGVLLFEML-LGYT
. |. |. | | .. ||. . . . . ||| ||. | || |||||...|.. .| .
-------NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQ
PFYD-----QNPSQIQQKILTSKEIIFPKMAN------ISPAAKNLIQRCLDKNQKNRIKSNEVLSHEFF
| .. ..... ... . . |. . ... .....| . . ..| .|. ||.|
PYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
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| Kinase | 18036.AA | Pkinase_Tyr | 523-563 | 39 | 5e-05 | 17.65 | Pfam | 182-224 (270) | Show / Hide |
Range on Protein: 523-563 Range on HMM: 182-224/270 Sequence Identity: 39% (17 aa) APEIINEQPNTYSSDWWSFGVLLFEMLL-GYTP-FYDQNPSQI ||| ||. | || ||||||..|.. | .| ... .... APECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEV |
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| Kinase | 18036.AA | RSK | 398-435 | 31 | 9.3e-05 | 13.18 | In-house | 87-124 (271) | Show / Hide |
Range on Protein: 398-435 Range on HMM: 87-124/271 Sequence Identity: 31% (12 aa) DLAQLIDEQSFLSENVAKLIAAQIAYSLHILHQKKIIY || . | ..||. .| ..| || .. ||...|.. DLFDRLLKQKMFSEREVKFYMAEIALAMEYLHSQGIVH |
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| Kinase | 18036.AA | RSK | 405-435 | 36 | 0.000228 | 12.3 | In-house | 95-127 (278) | Show / Hide |
Range on Protein: 405-435 Range on HMM: 95-127/278 Sequence Identity: 36% (12 aa) EQSF--LSENVAKLIAAQIAYSLHILHQKKIIY |..| .||. |. ..|.|. . |||..||. EKHFGCFSEDEACFYMAEIVLAVEHLHQQGIIH |
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| Kinase | 18036.AA | ULK | 398-434 | 31 | 0.000396 | 10.41 | In-house | 106-152 (329) | Show / Hide |
Range on Protein: 398-434 Range on HMM: 106-152/329 Sequence Identity: 31% (15 aa) DLAQLID----------EQSFLSENVAKLIAAQIAYSLHILHQKKII || |.| |. .|||. |. . ||. . ||...|| DLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNII |
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| Kinase | 18036.AA | ULK | 398-434 | 32 | 0.000507 | 10.23 | In-house | 103-148 (324) | Show / Hide |
Range on Protein: 398-434 Range on HMM: 103-148/324 Sequence Identity: 32% (15 aa) DLAQLID---------EQSFLSENVAKLIAAQIAYSLHILHQKKII || |.| |. .|||. |. . ||. . ||...|| DLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNII |
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| Kinase | 18036.AA | SGK | 409-435 | 40 | 0.001556 | 6.26 | In-house | 122-148 (283) | Show / Hide |
Range on Protein: 409-435 Range on HMM: 122-148/283 Sequence Identity: 40% (11 aa) LSENVAKLIAAQIAYSLHILHQKKIIY ..| .|. ||.|. | || ..||| FPEDRARFYAAEIVCALEYLHSQDIIY |
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| Kinase | 18036.AA | AktR | 408-435 | 44 | 0.029715 | 5.01 | In-house | 97-125 (268) | Show / Hide |
Range on Protein: 408-435 Range on HMM: 97-125/268 Sequence Identity: 44% (13 aa) FLSENVAKLIAAQIAYSLHILHQK-KIIY ..||..|. ..||| | |||. .||| KFSEEQARFYFAQILLALEYLHQHMNIIY |
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| Kinase | 18036.AA | RSK | 309-339 | 33 | 0.358636 | 0.49 | In-house | 1-33 (278) | Show / Hide |
Range on Protein: 309-339 Range on HMM: 1-33/278 Sequence Identity: 33% (11 aa) IEVLGYNSIWRYFRVRECQ--NTKKIYQMRVIN ..||| . .| .|.|. .|..|| | |.. LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLK |
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| Kinase | 18036.AA | Pkinase | 397-435 | 27 | 1.176968 | 3.4 | Pfam | 89-131 (293) | Show / Hide |
Range on Protein: 397-435 Range on HMM: 89-131/293 Sequence Identity: 27% (12 aa) IDLAQLID--EQSFL--SENVAKLIAAQIAYSLHILHQKKIIY .||. .| .. . ||...| .. ||. | .|...||. MDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIH |
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