Gene 18517 (Tetrahymena)
18517
Group:
Other
Family:
Ciliate-D1
Sequence
Protein domains of 18517.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 18517.AA | Ciliate-E2-Unclassified | 248-337 | 19 | 1.3e-10 | 33.02 | In-house | 100-218 (352) | Show / Hide |
Range on Protein: 248-337 Range on HMM: 100-218/352 Sequence Identity: 19% (23 aa) TEFLSGGSLQDLLESFGT-----------------LPESIIK-----QIVIQTISAL-DIIHNLPNSYYGGLTPSQILFKQDG---NVKLSL-GISYRSQ .|.. ||.|.. ...... ..| .| .. | ...| ..|.. | . ..|. |||...| ..|.. |||...| MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKN-NIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQ QQQQNFFNS----VNMSKQNE |.... .. .. ||.. QNNNCD-TNQQQKMQIWKQQM |
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| Kinase | 18517.AA | S_TKc | 166-494 | 14 | 3.7e-10 | -27.99 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 166-494
Range on HMM: 1-231/231
Sequence Identity: 14% (51 aa)
LEEMITLGVIKCQRDSGVVKKIFHAPTLRLYSVKEVPLSSKQARQSLRDWVITWQNKLHNTGKHVKLYGHFWNVPEGCVSILTEFLSG--GSLQDLLESF
| . ..| |.|.| | | |.. .|... .. .| | . . ||||..| . ... . .|...| |.| |....
YEILRKIGKGA----FGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK----HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKR
GT------LPESIIKQIVIQTISALDIIHNLPNSYYGGLTPSQILFKQDGNVKLS-LGISYRSQQQQQNFFNSVNMSKQNERMSLFDPSGVNTPNLFKVP
|. .|| .. .. |...||. .|.. . . | |. ||. . ..|.. |.. . . | .
GRHGLRFPFPE-HARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE--HIKICDFGLARQL-------------------------------TTFCGT
P-------LDNNNNNNQQNQKAQIQK-QDDVFRLGMLALSCAIGSF--DIIENVSLLYECIHKLLDDQNKQDPQYRVCCILHAEDILQQMMDEKLKINSK
| | . | |. .| . .. | . .. .... |
PWYMAPEVL-------------GYGKCKCDWWSCGCILYEMLCGYPPFP---QMQMMFKKIG--------------------------------------
KQRINLSINNLLTTNRFTKEFLDFLCQTLRFNYQSRSTLANLKQ-------HPFL
..|..||... |... . | | . | ||..
-----------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
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| Kinase | 18517.AA | STE | 230-288 | 25 | 1.7e-08 | 26.25 | In-house | 93-171 (359) | Show / Hide |
Range on Protein: 230-288 Range on HMM: 93-171/359 Sequence Identity: 25% (20 aa) VKLYGHFWNVP-----EGCVSILTEFLSGGSLQDLLE-SFGT-------------LPESIIKQIVIQTISA-LDIIHNL || ||.. . .. . | |...|||| |... .|. .|||.|. |. |.. . |. .|.. VKYYGCYFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSH |
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| Kinase | 18517.AA | STE | 460-494 | 29 | 9.6e-08 | 23.56 | In-house | 323-359 (359) | Show / Hide |
Range on Protein: 460-494 Range on HMM: 323-359/359 Sequence Identity: 29% (11 aa) TNRFTKEFLDFLCQTLRFNYQSRSTLANLKQ--HPFL . ....|| ||. . |. ... | | | . |||. PHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI |
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| Kinase | 18517.AA | Ciliate-C1 | 461-494 | 44 | 2.1e-07 | 14.68 | In-house | 295-328 (328) | Show / Hide |
Range on Protein: 461-494 Range on HMM: 295-328/328 Sequence Identity: 44% (15 aa) NRFTKEFLDFLCQTLRFNYQSRSTLANLKQHPFL | | || |.. | | .| | | ||. .|.|| . NFFSNEFMDLINQMLAYNPQKRITLQEIKCHPWY |
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| Kinase | 18517.AA | STE20 | 460-494 | 31 | 2.3e-07 | 23.3 | In-house | 254-288 (288) | Show / Hide |
Range on Protein: 460-494 Range on HMM: 254-288/288 Sequence Identity: 31% (11 aa) TNRFTKEFLDFLCQTLRFNYQSRSTLANLKQHPFL ......|| ||. . | ... | | | .|||. PHKWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI |
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| Kinase | 18517.AA | MEK1 | 166-311 | 29 | 4.9e-07 | 19.54 | In-house | 1-139 (297) | Show / Hide |
Range on Protein: 166-311 Range on HMM: 1-139/297 Sequence Identity: 29% (43 aa) LEEMITLGVIKCQRDSGVVKKIFHAPTLRLYSVKEVPLSSKQARQSLRDWVITWQNKLH--NTGKHVKLYGHFWNVPEGCVSILTEFLSGGSLQDLLESF .|.. || . ||| |. | .| . | . | | | .|. .| . || | | || |.. .| .|| |.. |||| .| . FEKIGELG----HGNGGVVMKCRHRHTGMIMARKLIHLEIKPA---IRNQIIRELQVLHECNSPYIVGFYGAFYS--DGEISICMEYMDGGSLDQVLKKA GTLPESIIKQIVIQTISALDIIHNLPNSYYGGLTPSQILFKQDGNVKL | .||.|. .. . . | ... . || || | .|| GRIPEKILGKVSVAVLRGLTYLRDKHKIMHRDVKPSNILVNSRGEIKL |
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| Kinase | 18517.AA | MAST | 249-287 | 28 | 6.2e-07 | 18.04 | In-house | 79-117 (334) | Show / Hide |
Range on Protein: 249-287 Range on HMM: 79-117/334 Sequence Identity: 28% (11 aa) EFLSGGSLQDLLESFGTLPESIIKQIVIQTISALDIIHN |...|| . ||...|...|.. |... .|. .|. .|. EYMEGGDCASLLHMYGYFDEWMAKMYIAETVLCLEYLHS |
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| Kinase | 18517.AA | MAST | 249-287 | 30 | 6.8e-07 | 16.4 | In-house | 81-120 (337) | Show / Hide |
Range on Protein: 249-287 Range on HMM: 81-120/337 Sequence Identity: 30% (12 aa) EFLSGGSLQDLLESFG-TLPESIIKQIVIQTISALDIIHN |...|| ||...| ..||.. |... .|. .|. .|. EYMEGGDCASLLRMYGNCMPEWMAKMYIAETVLCLEYLHS |
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| Kinase | 18517.AA | SLK | 457-494 | 39 | 2e-06 | 17.28 | In-house | 222-259 (259) | Show / Hide |
Range on Protein: 457-494 Range on HMM: 222-259/259 Sequence Identity: 39% (15 aa) LLTTNRFTKEFLDFLCQTLRFNYQSRSTLANLKQHPFL |.. ...||| ||| ..| . | | | |.| ||... LEQPSHWSKEFKDFLKKCLVKDPQNRWTTAQLMQHQWV |
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| Kinase | 18517.AA | PAKA | 249-287 | 22 | 6e-06 | 16.97 | In-house | 78-121 (260) | Show / Hide |
Range on Protein: 249-287 Range on HMM: 78-121/260 Sequence Identity: 22% (10 aa) EFLSGGSLQDLLESFG-----TLPESIIKQIVIQTISALDIIHN |...||.| |... . ...|..| .. .....|. ||. EYMEGGCLTDVITQCCNIQCNYMDEGQIAYVCRECLQGLEFIHS |
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| Kinase | 18517.AA | PAKA | 457-494 | 31 | 6e-06 | 17.1 | In-house | 223-260 (260) | Show / Hide |
Range on Protein: 457-494 Range on HMM: 223-260/260 Sequence Identity: 31% (12 aa) LLTTNRFTKEFLDFLCQTLRFNYQSRSTLANLKQHPFL .. ......|| ||| . | . ..| . | .|||| IKDPDKWSQEFCDFLDKCLCVDVDRRASAQELLHHPFL |
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| Kinase | 18517.AA | STE7 | 243-283 | 26 | 7e-06 | 17.9 | In-house | 75-124 (288) | Show / Hide |
Range on Protein: 243-283 Range on HMM: 75-124/288 Sequence Identity: 26% (13 aa) CVSILTEFLSGGSLQ---DLLESF------GTLPESIIKQIVIQTISALD |..| |. .||.| ... . |..||.|. |....|..|. CIWICMEYMDGGCLDKFYKRVKKVYRGIKKGRIPEQILGKIAVAVIKGLH |
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| Kinase | 18517.AA | MEK1 | 458-494 | 35 | 8.5e-05 | 11.74 | In-house | 261-297 (297) | Show / Hide |
Range on Protein: 458-494 Range on HMM: 261-297/297 Sequence Identity: 35% (13 aa) LTTNRFTKEFLDFLCQTLRFNYQSRSTLANLKQHPFL | |..|| || . |. | . | .| .|..|.|. LPHRVFSEEFQDFVDKCLIKNPDERADLKQLMVHTFI |
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| Kinase | 18517.AA | Pkinase | 464-494 | 29 | 0.000193 | 16.78 | Pfam | 263-293 (293) | Show / Hide |
Range on Protein: 464-494 Range on HMM: 263-293/293 Sequence Identity: 29% (9 aa) TKEFLDFLCQTLRFNYQSRSTLANLKQHPFL ..|..||.. |... ..| | . ..|||.. SEECKDFIKWCLCKDPKKRPTAEQILQHPWF |
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| Kinase | 18517.AA | STE20 | 246-287 | 27 | 0.000237 | 12.15 | In-house | 85-135 (288) | Show / Hide |
Range on Protein: 246-287 Range on HMM: 85-135/288 Sequence Identity: 27% (14 aa) ILTEFLSGGSLQDLLE---SFG------TLPESIIKQIVIQTISALDIIHN |. |...||||.|... . | .. |. | | .. .|| .|. IVMEYCGGGSLTDIMKHCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHS |
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| Kinase | 18517.AA | STE7 | 458-494 | 31 | 0.001634 | 9.09 | In-house | 253-288 (288) | Show / Hide |
Range on Protein: 458-494 Range on HMM: 253-288/288 Sequence Identity: 31% (12 aa) LTTNRFTKEFLDFLCQTLRFNYQSRSTLANLKQ-HPFL | |..|| || . |. ... | .. .|.. |||. LP--KFSPEFQDFVNKCLQKDPNERPKYHQLMKEHPFI |
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| Kinase | 18517.AA | SLK | 230-324 | 25 | 0.003078 | 6.64 | In-house | 59-152 (259) | Show / Hide |
Range on Protein: 230-324 Range on HMM: 59-152/259 Sequence Identity: 25% (25 aa) VKLYGHFWNVPEGCVSILTEFLSGGSLQD-LLESFGTLPESIIKQIVIQTISALDIIHNLPNSYYGGLTPSQILFKQDGNVKLS-LGISYRSQQQQQ ||||. .. .. . .. || || . ..| .| |. |. . ... ||. .|. . . | ||. .||.|.| |.| . ... | VKLYEAYYY--DNKLWMMIEFCDGGAVDNIMVELEHPLTEDQIQYVCKHMCEALNWLHSN-KVIHRDLKAGNILMTMDGDVRLADFGVSAKNKHTMQ |
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| Kinase | 18517.AA | Ciliate-E2-Unclassified | 430-494 | 12 | 0.004027 | 6.7 | In-house | 292-352 (352) | Show / Hide |
Range on Protein: 430-494 Range on HMM: 292-352/352 Sequence Identity: 12% (9 aa) EDILQQMMDEKLKINSKKQ-----RINLSINNLLTTNRFTKEFLDFLCQTLRFNYQSRSTLANLKQHPFL . ..|. .. ...... .. ... . .... |.|.. | | .| |. ...||.. KQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFIN---------DLLQKMLKKNPNKRITFEQILNHPWF |
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| Kinase | 18517.AA | Pkinase | 244-287 | 21 | 0.056973 | 8.05 | Pfam | 75-126 (293) | Show / Hide |
Range on Protein: 244-287 Range on HMM: 75-126/293 Sequence Identity: 21% (11 aa) VSILTEFLSGG----SLQDLLE--SFGTL--PESIIKQIVIQTISALDIIHN . . .|.. || .| |... . |.. .| .| .. |....|. .|. IYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHS |
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