Gene 18735 (Tetrahymena)

18735

Species: Tetrahymena
Alias: 18735, TTHERM_00469330, PreTt18735, 55.m00290, 3710.m00138, 419
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-D1

Sequence

Name Sequence Type Origin Length Description Download
18735.AA Protein None 773 None Fasta, JSON
18735.kin_dom Protein Kinase Domain None 102 None Fasta, JSON
18735.NA RNA None 2322 None Fasta, JSON

Protein domain

Protein domains of 18735.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 18735.AA Ciliate-A5 34-172 22 4.3e-14 45.31 In-house 1-140 (275) Show / Hide 
Range on Protein: 34-172
Range on HMM: 1-140/275
Sequence Identity: 22% (32 aa)

AQGEIIIAEDKAQKHLYAVQSFIFSDQLEMEQFIQKTKIFKKLKHTNLVRLKKIQRAEHNSMCTEQLLVNLFFEHYERDLLSEYIFRSLTK-QHLFTLEE
. |.. |    .|   |.. .  . |    ..|.|..   ..|.| |.| | ..     .. |.  . ||...| .  .| .| . |.  .    ... |
FYGCMKIWKNQHQQEYYICKQKQIQDEDRQKHFQQYFEQRMQLQHPNIVKLIDFHTHKKEEFCSQFYKVNCYYEYHDNNLEQEMQMRKQCQKDIFYNEQE

ITFILKSLVSALAYLQIHKIAYQNLNLKSILITNEGNIKL
. .|...|.|...|||  .|   ..  ..|..| .| .||
LWYIMDCLISVCMYLQQNNICHGDIRPQNICLTQDGQVKL
Kinase 18735.AA Ciliate-A5 231-309 30 1e-12 40.49 In-house 195-275 (275) Show / Hide 
Range on Protein: 231-309
Range on HMM: 195-275/275
Sequence Identity: 30% (25 aa)

NIYKENVFSLGCLMLNLCVNQNI-GISFHQNS-DSASQQFINQQLSLVEKMYSYDFAQILCKMLVKNDEKRPDFIELAEKL
|.||  ||.|| ..| .|  . . ..     .      | | | . ..||.||  |  .. .||. ...|||||..... |
NWYKSDVFCLGMICLEMCTMRDCTQFYYDYETFQIQNNQLIKQLIQMKEKKYSEQFINFIKQMLQFEENKRPDFHQIYQYL
Kinase 18735.AA Ciliate-E4 36-174 23 1.3e-11 35.37 In-house 13-150 (150) Show / Hide 
Range on Protein: 36-174
Range on HMM: 13-150/150
Sequence Identity: 23% (32 aa)

GEIIIAEDKAQKHLYAVQSFIFSDQLEMEQFIQKTKIFKKLKHTNLVRLKKIQRAEHNSMCTEQLLVNLFFEHYERDLLSEYIFRSLTKQHLFTLEEITF
| | | | | ||   .     |.   ...|  |     ..|.| |....  .        |.    . .|.|   .||  .   . .. || |.  ||  
GDIQIMEHKIQKQIIVMKIRKFQNETKARQQQQQFRRRQDLNHENIIMVYEYFHKKEDQFCSSIYRLYWFMEYLQKDLQQHIKQHKQQGQH-FDESEIWQ

ILKSLVSALAYLQIHKIAYQNLNLKSILITNEGNIKLNE
|. ....|..|||   |....|    |....   .|.  
IAFCCINAMYYLQQVNITHGDLKPSNIFFDQYFMVKIAD
Kinase 18735.AA S_TKc 24-317 15 2.8e-08 -55.54 SMART 1-231 (231) Show / Hide 
Range on Protein: 24-317
Range on HMM: 1-231/231
Sequence Identity: 15% (48 aa)

FDVHIKNNQGAQGEIIIAEDKAQKHLYAVQSFIFSDQLEMEQFIQKTKIFKKLKHTNLVRLKKIQRAEHNSMCTEQLLVNLFFEHYER---DLLSEYIFR
.... |  .|| |.   . .|  ....|.           |....  .| || .| |.|.|. . .            . ...|. .    ||..    |
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD---------DHLYMVMEYCDGDLGDLFDYIKKR

SL-TKQHLFTLEEITFILKSLVSALAYLQIHKIAYQNLNLKSILITNEGNIKLNEHFFTQQYLKEKFKNPSQLKIDQHTILPIQNKNKTSQLNNKTQIQP
    ... |.  .. |... ...||.|.  |.| .  |    ||...  .||.    .  |.                                .|..  
GRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------------------------------TTFCGT

KS------LKQLSINPTNIYKE---NVFSLGCLMLNLCVNQNIGISFHQNSDSASQQFINQQLSLVEKMYSYDFAQILCKMLVKNDEKRPDFIELAE-KL
        |          |      . |.||..  ... .              .| . ...       | .. ....|.|.|. ||||   |. .  .
PWYMAPEVL---------GYGKCKCDWWSCGCILYEMLCGYPPFP---------QMQMMFKKIG------SPEAKDFIRKCLQKDPEKRPTA-EALQDEW

GVINKPIK
 . . |  
DIKCHPWF
Kinase 18735.AA Ciliate-E1 31-238 14 3.3e-05 13.44 In-house 2-202 (202) Show / Hide 
Range on Protein: 31-238
Range on HMM: 2-202/202
Sequence Identity: 14% (33 aa)

NQGAQGEIIIA---EDK-AQKHLYAVQSFIFSDQLEMEQFIQKTK-IFKKLK-HTNLVRLKKIQRAEHNSMCTEQLLVNLFFEHYERD---LLSEYIFRS
 .| .. ...|   ...  |.... ..  ....| . .. |.. . |.| .| . ... . .... . | .|.. .       . . .    | ||..  
GNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRL-EYWQQC

LTKQHLFTLEEITFILKSLVSALAYLQIHKIAYQNLNLKSILITNEGNIKLNEHFFTQQYLKEKFKNPSQLKIDQHTILPIQNKNKTSQLNNKTQIQPKS
 ..|  || .... | . |. .|..|....| ..... . |||.|.|| ...                     |. . . ..|... ..  .  .   ..
QQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYC---------------------DFGISKFLKNNQNQQCQYKGYTHYYYP

LKQLS------INPTNI-YKENVF
  |.       ... .| || ...
PEQYNCPEQEHNKNQKINYKSDIY
Kinase 18735.AA Ciliate-E2-Unclassified 24-172 15 4e-05 13.73 In-house 1-188 (352) Show / Hide 
Range on Protein: 24-172
Range on HMM: 1-188/352
Sequence Identity: 15% (31 aa)

FDVHIKNNQGAQGEIIIAEDKAQKHLY-----AVQSFIFSDQLEME--QFIQKTKIFKKLKHTNLVRLKKIQRAEHNSMCTEQLLVN----------LFF
. .. . .||..|..  ...| || .|     . .. |..... |.  ..... |. ...|. . .| |            .... .          . .
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKK-YHQR-K---------Y--NKIMQQILLNHPHPFIVKM

EHYERDL--------------LSEYI-------------FRSLTKQHLFTLEEIT-----FILKSLVSALAYLQIHK-IAYQNLNLKSILITNEG---NI
.....|               |..||             |... ... || ...      |... ....| ||   . | . .. .  ||..|.|   .|
FYCFQDKQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYI

KL
|.
KI
Kinase 18735.AA Abl 24-84 29 0.000121 10.86 In-house 1-60 (252) Show / Hide 
Range on Protein: 24-84
Range on HMM: 1-60/252
Sequence Identity: 29% (18 aa)

FDVHIKNNQGAQGEIIIAEDKAQKHLYAVQSFIFSDQLEMEQFIQKTKIFKKLKHTNLVRL
  .. |   |  ||.  .  |  ..  ||.. .  |..|...|..   | |..|| |||.|
IMMKHKLGGGQYGEVYEGVWKRHDCTVAVKT-LKEDTMEVHEFLKEAAIMKEMKHPNLVQL
Kinase 18735.AA NEK-Unclassified 276-311 36 0.000344 9.43 In-house 223-258 (258) Show / Hide 
Range on Protein: 276-311
Range on HMM: 223-258/258
Sequence Identity: 36% (13 aa)

VEKMYSYDFAQILCKMLVKNDEKRPDFIELAEKLGV
| | || |  |..  || .| ..||  .|. |   .
VSKTYSTDLQQVIRFMLRRNFQQRPSATEIVEQDYI
Kinase 18735.AA MSK 119-172 28 0.000446 9.67 In-house 89-145 (277) Show / Hide 
Range on Protein: 119-172
Range on HMM: 89-145/277
Sequence Identity: 28% (16 aa)

FRSLTKQHLFTLEEITFILKSLVSALAYLQIHKIAYQNLNLKSILITNE---GNIKL
| .. |   |...|  .|. .||.|. ..   .| .  | .  || ..|   | .||
FTHIRKREHFDESECRMIMRELVMAVDHMHQKGIIHRDLKPENILFDDEEDNGHVKL
Kinase 18735.AA SAK 124-172 30 0.000554 9.15 In-house 93-141 (254) Show / Hide 
Range on Protein: 124-172
Range on HMM: 93-141/254
Sequence Identity: 30% (15 aa)

KQHLFTLEEITFILKSLVSALAYLQIHKIAYQNLNLKSILITNEGNIKL
. . || ||   ... .|  . ||  | |    | |  ||.| . ..|.
RMRPFTEEEARHFMHQIVIGMLYLHSHGIMHRDLTLSNILLTRDMHCKI
Kinase 18735.AA SLK 125-172 29 0.000605 9.06 In-house 91-138 (259) Show / Hide 
Range on Protein: 125-172
Range on HMM: 91-138/259
Sequence Identity: 29% (14 aa)

QHLFTLEEITFILKSLVSALAYLQIHKIAYQNLNLKSILITNEGNIKL
.|  | . | .. | .. || .|  .|. . .|    ||.| .|...|
EHPLTEDQIQYVCKHMCEALNWLHSNKVIHRDLKAGNILMTMDGDVRL
Kinase 18735.AA SLK 24-84 27 0.002691 6.84 In-house 1-61 (259) Show / Hide 
Range on Protein: 24-84
Range on HMM: 1-61/259
Sequence Identity: 27% (17 aa)

FDVHIKNNQGAQGEIIIAEDKAQKHLYAVQSFIFSDQLEMEQFIQKTKIFKKLKHTNLVRL
...      || | .  |..| || . | ..    |. |.| ..    |  ..|| |.|.|
WEIIGELGDGAFGKVYKAQHKEQKVFAAAKMIEIKDEEELEDYMVEIDILSECKHPNIVKL
Kinase 18735.AA SLK 280-311 31 0.081836 1.76 In-house 228-259 (259) Show / Hide 
Range on Protein: 280-311
Range on HMM: 228-259/259
Sequence Identity: 31% (10 aa)

YSYDFAQILCKMLVKNDEKRPDFIELAEKLGV
.| .|  .| | |||. ..|.   .| .   |
WSKEFKDFLKKCLVKDPQNRWTTAQLMQHQWV