Gene 19053 (Tetrahymena)

19053

Species: Tetrahymena
Alias: 3673.m00016, 19053, PreTt19053, 1118, TTHERM_00715790, 113.m00092
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-D1

Sequence

Name Sequence Type Origin Length Description Download
19053.AA Protein None 2930 None Fasta, JSON
19053.kin_dom Protein Kinase Domain None 53 None Fasta, JSON
19053.NA RNA None 8793 None Fasta, JSON

Protein domain

Protein domains of 19053.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Nnf1 19053.AA Nnf1 193-214 22 5.423912 2.24 Pfam 90-111 (111) Show / Hide 
Range on Protein: 193-214
Range on HMM: 90-111/111
Sequence Identity: 22% (5 aa)

EIENLKIENSRLKQKIEALASV
... .. || .|.|.| ..   
RLQKICAENAQLAQEIQEQREE
Nnf1 19053.AA Nnf1 415-449 25 0.001015 14.76 Pfam 77-111 (111) Show / Hide 
Range on Protein: 415-449
Range on HMM: 77-111/111
Sequence Identity: 25% (9 aa)

VRNLKEMNDNLNEKLKFVEKQNLELTDELSKKRQE
. ..... | ||..|. ....| .| .|.. .|.|
MPHKEKQQDQLNMRLQKICAENAQLAQEIQEQREE
DUF3250 19053.AA DUF3250 620-775 21 2.6e-20 72.08 Pfam 1-169 (169) Show / Hide 
Range on Protein: 620-775
Range on HMM: 1-169/169
Sequence Identity: 21% (37 aa)

AEEELGPGENFFDIFI--------GSVDLD-ENICQ-RQSDTI--LNMQEIMTFFTVDFYNHDTQHTTIVDGKKNSYNFQATFKVKVDDFFITFLKEKYL
  ..|..|||.|....        . . .  | . . . ...   .   . .||.|.||| |.|..| .|.|.   |.|.. ..| .|. |.  | . ..
PMCHLHCGENLFELHLGQLQTCCCHKATFTPEGLELMGDFHPQGNDDGGDLLTFCTYDFYDHETHTTPVVRGQQPFYDFTSQYCVHMDALFLHYLQTNQI

KLELYHVQ-QQN--AILFGTANVPLGQLISENTSPSISAVIEQTVKVRATRGMSQDQ--FIACLNIKYRMRYP
.|||. ..  |   . . ...  .| .|. ||        .....  ... . . ..   .  |  . |||||
RLELHQAMNGQEEIYMTMAAGWIQLDPLLHEN----KNERVGERIFCSVHLHGVSGEIQMFGVLEYWMRMRYP
Efhand 19053.AA efhand 992-1010 26 11.145869 3.24 Pfam 11-29 (29) Show / Hide 
Range on Protein: 992-1010
Range on HMM: 11-29/29
Sequence Identity: 26% (5 aa)

RDQDEYISKDDFYSTVRET
.|.| ||....| . ....
KDGDGYIDFEEFCEMMKKL
Efhand 19053.AA efhand 1111-1139 27 0.003852 15.91 Pfam 1-29 (29) Show / Hide 
Range on Protein: 1111-1139
Range on HMM: 1-29/29
Sequence Identity: 27% (8 aa)

TVNQIFKEIDDDGNGQISLFNLSNYLTFQ
 ....|||.| ||.|.|..  . .... .
ELKEMFKEFDKDGDGYIDFEEFCEMMKKL
EFh 19053.AA EFh 1111-1139 20 0.008128 13.35 SMART 1-29 (29) Show / Hide 
Range on Protein: 1111-1139
Range on HMM: 1-29/29
Sequence Identity: 20% (6 aa)

TVNQIFKEIDDDGNGQISLFNLSNYLTFQ
 ....|...| ||.|.|..  .   ..  
EFKEMFRMFDKDGDGYIDFEEFKDMMKSL
Efhand 19053.AA efhand 1147-1175 31 3e-06 27.2 Pfam 1-29 (29) Show / Hide 
Range on Protein: 1147-1175
Range on HMM: 1-29/29
Sequence Identity: 31% (9 aa)

EIQTFLKVIDFNKDGQISLEEFKQFIYNS
|.. . |..| ..||.|..|||.... . 
ELKEMFKEFDKDGDGYIDFEEFCEMMKKL
EFh 19053.AA EFh 1147-1175 31 1.8e-05 25.41 SMART 1-29 (29) Show / Hide 
Range on Protein: 1147-1175
Range on HMM: 1-29/29
Sequence Identity: 31% (9 aa)

EIQTFLKVIDFNKDGQISLEEFKQFIYNS
|..   ...| ..||.|..||||... . 
EFKEMFRMFDKDGDGYIDFEEFKDMMKSL
EFh 19053.AA EFh 1209-1237 24 0.000391 20.98 SMART 1-29 (29) Show / Hide 
Range on Protein: 1209-1237
Range on HMM: 1-29/29
Sequence Identity: 24% (7 aa)

SFQDLFKLIDNDRSGTISNIELMIFLSEK
 |...|...| |..|.|.  |.. .....
EFKEMFRMFDKDGDGYIDFEEFKDMMKSL
Efhand 19053.AA efhand 1209-1237 24 0.002658 16.5 Pfam 1-29 (29) Show / Hide 
Range on Protein: 1209-1237
Range on HMM: 1-29/29
Sequence Identity: 24% (7 aa)

SFQDLFKLIDNDRSGTISNIELMIFLSEK
 ....||..| |..|.|.  |.. .....
ELKEMFKEFDKDGDGYIDFEEFCEMMKKL
Efhand 19053.AA efhand 1246-1274 34 1.48941 6.44 Pfam 1-29 (29) Show / Hide 
Range on Protein: 1246-1274
Range on HMM: 1-29/29
Sequence Identity: 34% (10 aa)

EIQIITYNFDKNNDDQIDLFEFIDSLKVE
|.. .   |||..| .||. ||.. .|  
ELKEMFKEFDKDGDGYIDFEEFCEMMKKL
EFh 19053.AA EFh 1313-1341 24 0.037882 7.96 SMART 1-29 (29) Show / Hide 
Range on Protein: 1313-1341
Range on HMM: 1-29/29
Sequence Identity: 24% (7 aa)

TRGDLFDLFDSNNDKFISEMETKKAFAEM
   ..|..|| ..| .|.  | |......
EFKEMFRMFDKDGDGYIDFEEFKDMMKSL
Efhand 19053.AA efhand 1313-1341 20 0.104734 10.66 Pfam 1-29 (29) Show / Hide 
Range on Protein: 1313-1341
Range on HMM: 1-29/29
Sequence Identity: 20% (6 aa)

TRGDLFDLFDSNNDKFISEMETKKAFAEM
   ..|..|| ..| .|.  | .......
ELKEMFKEFDKDGDGYIDFEEFCEMMKKL
Efhand 19053.AA efhand 1349-1377 31 0.000454 19.31 Pfam 1-29 (29) Show / Hide 
Range on Protein: 1349-1377
Range on HMM: 1-29/29
Sequence Identity: 31% (9 aa)

ELKEFYEFLDTNNDKKVSIKEFISTLKNE
||||. . .|...| .....||.. .|. 
ELKEMFKEFDKDGDGYIDFEEFCEMMKKL
EFh 19053.AA EFh 1349-1377 27 0.008364 13.25 SMART 1-29 (29) Show / Hide 
Range on Protein: 1349-1377
Range on HMM: 1-29/29
Sequence Identity: 27% (8 aa)

ELKEFYEFLDTNNDKKVSIKEFISTLKNE
|.||  . .|...| ... .||.  .|. 
EFKEMFRMFDKDGDGYIDFEEFKDMMKSL
Kinase 19053.AA STE 1928-1963 34 5.7e-12 38.68 In-house 322-359 (359) Show / Hide 
Range on Protein: 1928-1963
Range on HMM: 322-359/359
Sequence Identity: 34% (13 aa)

VSNNFSHSFRDFISQCLYVNPELRPTPLELIN--HSVF
.. ..| .|.|||..||  .|. |||. .|..  |. .
YPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 19053.AA STE20 1929-1963 37 2.5e-11 37.97 In-house 254-288 (288) Show / Hide 
Range on Protein: 1929-1963
Range on HMM: 254-288/288
Sequence Identity: 37% (13 aa)

SNNFSHSFRDFISQCLYVNPELRPTPLELINHSVF
....|..|.||...|| ..|| |||. .| .|. .
PHKWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI
Kinase 19053.AA FRAY 1932-1963 43 3.2e-11 30.76 In-house 246-277 (277) Show / Hide 
Range on Protein: 1932-1963
Range on HMM: 246-277/277
Sequence Identity: 43% (14 aa)

FSHSFRDFISQCLYVNPELRPTPLELINHSVF
..|||.. |..||.  |. |||. ||  |..|
YGHSFKKMIEKCLQKDPSKRPTASELLKHKFF
Kinase 19053.AA MST 1932-1963 40 1.5e-10 29.67 In-house 223-254 (254) Show / Hide 
Range on Protein: 1932-1963
Range on HMM: 223-254/254
Sequence Identity: 40% (13 aa)

FSHSFRDFISQCLYVNPELRPTPLELINHSVF
.|  | ||...||  |||.|.|  .| .|. .
WSQEFNDFVCKCLQKNPEQRWTAEQLLQHPFI
Kinase 19053.AA STE7-Unclassified 1931-1963 38 1.1e-08 26.77 In-house 268-301 (301) Show / Hide 
Range on Protein: 1931-1963
Range on HMM: 268-301/301
Sequence Identity: 38% (13 aa)

NFSHSFRDFISQCLYVNPELRPTPLELIN-HSVF
..| .|.||||.|.. .|. ||.. .|.| |   
IWSKEFMDFISKCCKKHPRERPDIHQLLNEHPWI
Kinase 19053.AA STE7 1931-1963 35 1.2e-08 28.0 In-house 255-288 (288) Show / Hide 
Range on Protein: 1931-1963
Range on HMM: 255-288/288
Sequence Identity: 35% (12 aa)

NFSHSFRDFISQCLYVNPELRPTPLELIN-HSVF
.|| .|.||...||. .|  ||.. .| . |. .
KFSPEFQDFVNKCLQKDPNERPKYHQLMKEHPFI
Kinase 19053.AA PAKA 1930-1963 32 2e-08 25.83 In-house 227-260 (260) Show / Hide 
Range on Protein: 1930-1963
Range on HMM: 227-260/260
Sequence Identity: 32% (11 aa)

NNFSHSFRDFISQCLYVNPELRPTPLELINHSVF
...| .|.|| ..|| |... |..  ||..|  .
DKWSQEFCDFLDKCLCVDVDRRASAQELLHHPFL
Kinase 19053.AA MEK3 1932-1963 43 8.8e-08 22.53 In-house 233-264 (264) Show / Hide 
Range on Protein: 1932-1963
Range on HMM: 233-264/264
Sequence Identity: 43% (14 aa)

FSHSFRDFISQCLYVNPELRPTPLELINHSVF
||  . |||.|||  |.. ||. .||. |. .
FSPDCQDFINQCLKKNYMERPSYPELMEHPFM
S_TKc 19053.AA S_TKc 1545-1963 9 1.2e-07 -64.56 SMART 1-231 (231) Show / Hide 
Range on Protein: 1545-1963
Range on HMM: 1-231/231
Sequence Identity: 9% (45 aa)

FERIDK-------------DRNNSISLSEFKSAFKQMSLNLTDEELEDMYAYVDRDGKNGITIEEFASIHILNNLDDTHDIAQSNSEKRKNVQLFEQIQD
.| ..|             ...     .  . | |...                                                      ..   || 
YEILRKIGKGAFGKVYKCRHKK-----TGRIVAIKIIK-----------------------------------------------------EHIRREIQI

LKIINHSNLCRYIEMRAQKQLQNRYLIFQEAYDCSVQDLAFRRSLNGIP-----FTEMELLQMAYCLLKGIIYLYE------------------------
||  .| |.......       ... .. |  | .. ||  .   .| .     |.| .   ..| ..... |. .                        
LKK-HHPNIVKLYDVFQD----DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDEHIKICDF

--SKEFKLNNFGQFYLDAFNKLPENLEDLI----FRPPEYYILGKDNVKHREFSCGKGEVWSLGLLLRYCMADCEN-FAKEDDLMAKYFIQKPSKLNLNL
  ....                      ..    ...||             ... |  .||.| .| | |.  .  |  ....| |             
GLARQL--------------------TTFCGTPWYMAPEVL----------GYGKCKCDWWSCGCIL-YEMLCGYPPFP-QMQMMFKKIG----------

EIQKKKNDNQNQNNQDLDSNQNKILANNKELEESLDNKSFKNESIDSKRKKDLLNNSNNLEENIILQTEEQYEQDEQPQQQQQYKIDRSKLIEDIFQIIV
                                                                                                    
----------------------------------------------------------------------------------------------------

DDRYTNQSIFLQTPYYLPYLNPFQEYLNGYKGVSNNFSHSFRDFISQCLYVNPELRPTPLELIN-------HSVF
                                     |....|||..|| ..|| |||  |. .       |  |
-------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 19053.AA Ciliate-E2 1930-1963 28 1.2e-07 22.34 In-house 327-365 (365) Show / Hide 
Range on Protein: 1930-1963
Range on HMM: 327-365/365
Sequence Identity: 28% (11 aa)

NNFSHSFRDFISQ----CLYVNPELRPT-PLELINHSVF
.. | .  |.|..    .| ..|| |.| . ...||  |
KKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 19053.AA Ciliate-E2-Unclassified 1870-1963 20 3.3e-07 21.07 In-house 272-352 (352) Show / Hide 
Range on Protein: 1870-1963
Range on HMM: 272-352/352
Sequence Identity: 20% (21 aa)

DEQPQQQQQYKI------DRSKLIEDIF-QIIVDDRYTNQSIFLQTPYYLPYLNPFQEYLNGYKGVSNNFSHSFRDFIS----QCLYVNPELRPTPLELI
|..  |.||...      .|. |...|. ..|  . . .|.                        .. . | .  |||.    ..| .||. |.|. ...
DNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQ------------------------IPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQIL

NHSVF
||  |
NHPWF
Kinase 19053.AA Pkinase 1926-1963 34 2e-06 23.76 Pfam 257-293 (293) Show / Hide 
Range on Protein: 1926-1963
Range on HMM: 257-293/293
Sequence Identity: 34% (13 aa)

KGVSNNFSHSFRDFISQCLYVNPELRPTPLELINHSVF
. .  | | ...|||. || ..|. |||. .. .|  |
WTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Efhand 19053.AA efhand 1540-1568 27 7e-06 25.88 Pfam 1-29 (29) Show / Hide 
Range on Protein: 1540-1568
Range on HMM: 1-29/29
Sequence Identity: 27% (8 aa)

DYQHAFERIDKDRNNSISLSEFKSAFKQM
. . .|. .|||..  |.. ||....|..
ELKEMFKEFDKDGDGYIDFEEFCEMMKKL
EFh 19053.AA EFh 1540-1568 31 1.9e-05 25.34 SMART 1-29 (29) Show / Hide 
Range on Protein: 1540-1568
Range on HMM: 1-29/29
Sequence Identity: 31% (9 aa)

DYQHAFERIDKDRNNSISLSEFKSAFKQM
. . .|. .|||..  |.. ||| ..| .
EFKEMFRMFDKDGDGYIDFEEFKDMMKSL
EH 19053.AA EH 1530-1626 16 0.000108 1.05 SMART 1-98 (98) Show / Hide 
Range on Protein: 1530-1626
Range on HMM: 1-98/98
Sequence Identity: 16% (16 aa)

IGRILREKRIDYQHAFERIDKDRNNSISLSEFKSAFKQMSLNLTDEELEDMYAYVDRDGKNGITIE-EFASIHILNNLDDTH--DIAQSNSEKRKNVQLF
.  |  | . .|.. | . |..... .. .. .  | |   .|.. .|.  .. .| |..  .. | ||.  . |...   .  .| ..      . ...
PWWISPEDKAKYWQIFHSLDPQQDGFVTGDQARPIFMQ--SGLPQQQLAHIWNLCDIDNDGELDREPEFCVAMHLIYCCMNGNYPIPMVLPPWLIPPSKR
Efhand 19053.AA efhand 1576-1600 40 0.059832 11.55 Pfam 1-25 (29) Show / Hide 
Range on Protein: 1576-1600
Range on HMM: 1-25/29
Sequence Identity: 40% (10 aa)

ELEDMYAYVDRDGKNGITIEEFASI
||..| . .|.||   |..||| ..
ELKEMFKEFDKDGDGYIDFEEFCEM
Kinase 19053.AA Ciliate-E2-Unclassified 1597-1700 12 0.129266 1.4 In-house 12-159 (352) Show / Hide 
Range on Protein: 1597-1700
Range on HMM: 12-159/352
Sequence Identity: 12% (18 aa)

FASIHILNNLDDTHDI--------AQSNSEKRKNVQLFEQIQDLKIIN--------------------HSNLCRYIEMRAQKQLQNRYLIFQEA------
|.... . . ..   .        .|... | .. .  | .. .|..|                    | ..... .. . .. || |.. . .      
FGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVMEYCEGGDLW

---YDCSV----QDLAFRRSLNGIPFTEMELL-----QMAYCLLKGIIYL
    ...     ... |.. ...  ||| . .     ......|.|. ||
QYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYL
Kinase 19053.AA Pkinase 1636-1702 20 0.225123 5.94 Pfam 58-126 (293) Show / Hide 
Range on Protein: 1636-1702
Range on HMM: 58-126/293
Sequence Identity: 20% (15 aa)

NHSNLCRYIEMRAQKQLQNRYLIFQEAYDCS--VQDLAFRRSLN---GIPF--TEMELLQMAYCLLKGIIYLYE
|| | .|....       ... . .|  ..   |.||.  . .    . .|  .| |.  ..| .|.|. |...
NHPNIVRLYDWFED---KDHIYMVMEYCEGGLYVMDLF--DYISTWRHGCFYFSEWECKFYMYQILRGLEYCHS
EFh 19053.AA EFh 1576-1606 32 0.366659 0.01 SMART 1-29 (29) Show / Hide 
Range on Protein: 1576-1606
Range on HMM: 1-29/29
Sequence Identity: 32% (10 aa)

ELEDMYAYVDRDGKNGITIEEFASIHILNNL
|...| . .|.||   |. |||  .... .|
EFKEMFRMFDKDGDGYIDFEEF--KDMMKSL
TBC 19053.AA TBC 2627-2715 20 5.7e-15 54.46 Pfam 141-240 (240) Show / Hide 
Range on Protein: 2627-2715
Range on HMM: 141-240/240
Sequence Identity: 20% (21 aa)

QQSPEDYIMKEKIL--IYKWLLRLEDPQLSDYLEEKQFYPEI----YTISWFLNLFTMVFDINTVLKIWD-FII-----CDCNF-TLCFAVS-LM-IELK
... ..  .. ..   ..  ||.  ||.|  .... .. ..|    ....||. ||| .|.. |||.||| |..     . ..|  . |... .. . ..
THDMPG-HLQRDFYFQVFEELLKKHDPKLYKHFQK-DC-LNIDPSMFATQWFMCLFTHCFPFETVLRIWDCFFFYCEGWN-AKFFLFRFCLACILVKYHR

DHLM
....
QEIL
TBC 19053.AA TBC 2505-2589 24 6e-09 33.08 Pfam 1-99 (240) Show / Hide 
Range on Protein: 2505-2589
Range on HMM: 1-99/240
Sequence Identity: 24% (25 aa)

SFLRSELYKKVI------------VLPQKANKLYKFLVSVPLMYNEKNNDIKQIENDLPRCHQ-YS--DFCSSQKGQS-QIKEILCAFLNLNSNYYYIQG
. ||... .. .              .|...  |.   .  . |.|...|..||| |..|... ..  .| ....||  | . ||.|. |.| .  | ||
DQLRWQVWPYLLGYYPWMNGYYKRLYYQEKKQWYQMK-YQ-NNYHEPHPDYHQIEKDVHRTFPNHHHFFFFQNGQGQQVQLRNILKAYSNYNPDVGYCQG

M
|
M
TBC 19053.AA TBC 2499-2718 15 5.1e-08 28.77 SMART 1-310 (310) Show / Hide 
Range on Protein: 2499-2718
Range on HMM: 1-310/310
Sequence Identity: 15% (48 aa)

IQVELPSFLRSELYKKVIVLPQKA-------------------------NKLYKFLVSVPLMYNEKN---------------------------NDIKQI
.    |. .| .......  ...                          ...|  . .   .   ..                            . .||
WWQGIPHHYRGWVWWLLLNCQPMNTSNWERMQYMWDGENCYFPVNWDRCKDYYDRMLNQHCPCDHHHDNWQDIMMNNNDHECCWMSYWHFFQDCWHWHQI

ENDLPRCHQYSDFC---------------SSQKGQSQIKEILCAFLNLNSN--YYYIQGMDAMTFAALQIAPNNSPSQALLILQETVKKSLLMHQSSQQ-
|.||.|...  .|                . ...| .   .| |.. .|..    | |||   .   |   |. .. .|   .      . || .  .. 
EKDLRRTFPNHPFFQFRMRYNQHCIMLHDQNGPHQESLRRVLYAYSWHNPEHIVGYCQGMNFIAAPLLLHMPCYDEEDAFWCF------CKLMERYCPWF

---------SPEDYIMKEKILIYKWLLRLEDPQLSDYLEE------------KQFYPEIYTISWFLNLFTMVFDINTVLKIWDFIICD-----CNFTLCF
         .|.   | .  . .. ||.  ||.|. .|.|            . . |..|...||| .|.  |  ..|..|||.. ..       | .|.
YFCDDQNCYTPDMMGMHWQMYQFDHLLQEHDPDLYKHLQEQDHHSMKWHFDHLEIDPSMYAFRWFLTCFAREFPLEDVCRIWDCYFFEYGRHGHPFLFCI

AVSLMIELKDHLMMKD
|....  ....|.  |
ALAMLKMHRQKLLQHD