Gene 20607 (Tetrahymena)
20607
Group:
Other
Family:
Ciliate-D1
Sequence
Protein domains of 20607.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 20607.AA | Ciliate-E2 | 587-829 | 18 | 5.9e-18 | 58.22 | In-house | 1-286 (365) | Show / Hide |
Range on Protein: 587-829
Range on HMM: 1-286/365
Sequence Identity: 18% (62 aa)
SNKIHLLGQGTFGKVYKAKLLPKEQRY--------------QHQSSSQHTKKRNNRDLLSLLKQQQDPIIEDEFYALKVI-KCKNMNELEKKSQEII-IE
..| ..|||.||.|||.| . ... | || | ..|. ..|. |.| |
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQ----------------------------------EKVKIKIYAMKIMKKNQIEQIKQE
YYLMQ-------------RQFRHSCNLILPVYYIQQ--NDQLDLLFLKQLADFNFTQLLNKRREKY-------LVYTEGELLQIFKMLLR----------
..|. ... ... |. |. | .|. | . . . ....... | . .|| | ..|.| .|.
IHIMREINCFYKKINEKNILEQLNHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYI
-----IIKDMHDRN-VAHRDIKPSNFVFFKKDRSWKLIDYGTAKIEMDL----------KQVKEYN---------------------FCGTRLYAIPKIS
.. .| .| . ||||||.| .| |.|| |..|. | | .. . .||| | | |
ACIILALEYLHSKNNIIHRDIKPENILF------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEIL
QMKNFGELSSKVRMSLKAYDIYSLGITF
..|. . .| .. ||.|||...
NGKKYDNQ-QKQKGYDYKCDIWSLGVIL
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| Kinase | 20607.AA | S_TKc | 587-967 | 13 | 7.2e-15 | 41.14 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 587-967
Range on HMM: 1-231/231
Sequence Identity: 13% (52 aa)
SNKIHLLGQGTFGKVYKAKLLPKEQRYQHQSSSQHTKKRNNRDLLSLLKQQQDPIIEDEFYALKVIKCKNMNELEKKSQEIIIEYYLMQRQFRHSCNLIL
.. ..|.|.||||||.. .. .|.|.|| . |. | .... . |
YEILRKIGKGAFGKVYKCRHKK----------------------------------TGRIVAIKIIK-----------EHIRREIQILKK----HHPNIV
PVYYIQQNDQLDLLFLKQLADF---NFTQLLNKRRE--KYLVYTEGELLQIFKMLLRIIKDMHDRNVAHRDIKPSNFVFFKKDRSWKLIDYGTAKIEMDL
|.. |. .| . ..| . ... ||. .. ...| . ... ... .. .|.... |||.||.| . . |..| | |..
KLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL---
KQVKEYNFCGTRLYAIPKISQMKNFGELSSKVRMSLKAYDIYSLGITFIKIKKLLINPFDQKALKQILTSGTLDDETLLSNKIINQLINPNEEFRINLDL
. ||||. | | . . .. |..|.|.... ||. .. .. .||
-----TTFCGTPWYMAPEVL------------GYGKCKCDWWSCGCILYEMLC-GYPPFP--------------QMQMMFKKIG----------------
NDLIQEIEDKQHSKEDNIPNDYGVMFDHHSDFDYSKQKLEDEDQFERALTLKKINKTDGALSILFSLLDKDIQ--SKLRNYLQ------SLKYL
.. |.... .|.|| . || . ..
--------------------------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
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| Kinase | 20607.AA | Pkinase | 587-830 | 17 | 1.1e-13 | 49.53 | Pfam | 1-203 (293) | Show / Hide |
Range on Protein: 587-830 Range on HMM: 1-203/293 Sequence Identity: 17% (44 aa) SNKIHLLGQGTFGKVYKAKLLPKEQRYQHQSSSQHTKKRNNRDLLSLLKQQQDPIIEDEFYALKVIKCKNMNELEKKSQEIIIEYYLMQRQFRHSCNLIL .. .|.|.||.|||.. .. .|.|.|| .. .. .... . | ..|.| .| . |. YHIGRKIGSGSFGCVYKCHHKGTGK----------------------------------IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPN--IV PVYYIQQNDQLDLLFLKQLADF-----NFTQLLN-KRREKYLVYTEGELLQIFKMLLRIIKDMHDRNVAHRDIKPSNFVFFKKDRSW----KLIDYGTAK |.. .. .. . ... .. .|. ... .| |. ... .|| .. .|.... |||.||.|. . .. |..| | || RLYDWFED-KDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAK -IEMDLKQVKEYNFCGTRLYAIPKISQMKNFGELSSKVRMSLKAYDIYSLGITFI .. ... . ||||. |. | |. . .. .. |..|.|.... QFD-Y-NNS-MTTFCGTPWYMAP---------EVIRGGQYYGPKVDMWSCGCILY |
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| Kinase | 20607.AA | CAMK | 724-796 | 19 | 4.3e-11 | 31.25 | In-house | 176-286 (425) | Show / Hide |
Range on Protein: 724-796 Range on HMM: 176-286/425 Sequence Identity: 19% (22 aa) YTEGELLQIFKMLLRIIKDMHDRNVAHRDIKPSNFVFFKKD----------------RSWKLIDYGTAKIEMDLKQVKEYN------------------- .|| | ..|. .. .. .|..|..|||.|| | . ... |.|| | |.. .. .. . . FTEREARRYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQK ---FCGTRLYA |||| |. MKTFCGTPEYM |
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| Kinase | 20607.AA | CDC7 | 736-782 | 34 | 2.3e-09 | 22.58 | In-house | 117-163 (522) | Show / Hide |
Range on Protein: 736-782 Range on HMM: 117-163/522 Sequence Identity: 34% (16 aa) LLRIIKDMHDRNVAHRDIKPSNFVFFKKDRSWKLIDYGTAKIEMDLK |.. . | .. |||.||||| . . .. |.|.| | . || . LFYALRHVHQFGIIHRDVKPSNFLYNRRTKKFLLVDFGLAQHMMDYN |
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| Kinase | 20607.AA | AGC | 587-666 | 19 | 3.5e-09 | 18.35 | In-house | 1-53 (395) | Show / Hide |
Range on Protein: 587-666 Range on HMM: 1-53/395 Sequence Identity: 19% (16 aa) SNKIHLLGQGTFGKVYKAKLLPKEQRYQHQSSSQHTKKRNNRDLLSLLKQQQDPIIED--EFYALKVIKCKN-MNELEKKSQE . . ..|.|.||||| .. .. ..| ..||.||.| | . ...|. .| FEFLKVIGKGSFGKVYLVRKKDGCH------------------------------KKDTGKYYAMKVLKKKHKIVIKKKNMVE |
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| Kinase | 20607.AA | CK1 | 736-776 | 30 | 3.5e-09 | 28.26 | In-house | 141-196 (339) | Show / Hide |
Range on Protein: 736-776 Range on HMM: 141-196/339 Sequence Identity: 30% (17 aa) LLRIIKDMHDRNVAHRDIKPSNFVFFKKD---------------RSWKLIDYGTAK .| ...|||.. ||||||.||.. .. | . .||.| |. MLEALEYMHDCGFIHRDIKPDNFCMGRNESFKYGKHHHEWNNEHRQVYMIDFGMAR |
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| Kinase | 20607.AA | CDPK | 743-777 | 48 | 3.5e-09 | 24.52 | In-house | 119-159 (271) | Show / Hide |
Range on Protein: 743-777 Range on HMM: 119-159/271 Sequence Identity: 48% (20 aa) MHDRNVAHRDIKPSNFVF-FKKDRSW-----KLIDYGTAKI .|..|. |||.|| |. | .|||.|| |.|| ||.|. CHSNNIVHRDLKPENILFDSKKDDSWVIYNIKVIDWGTSKK |
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| Kinase | 20607.AA | Ciliate-E2a | 725-776 | 36 | 5.6e-09 | 22.59 | In-house | 98-157 (275) | Show / Hide |
Range on Protein: 725-776 Range on HMM: 98-157/275 Sequence Identity: 36% (22 aa) TE-GELLQIFKMLL-RIIKDMHDRNVAHRDIKPSNFVFF--KKD----RSWKLIDYGTAK .| | .| ..|| . || ||. |||.|| |. | .|. |.|| |.|. EEIQEICDIMQQLLWQGLHYMHQRNIMHRDLKPENILFKNCSKNSIQNSDIKIIDFGLAT |
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| Kinase | 20607.AA | Ciliate-E2-Unclassified | 647-829 | 18 | 1.4e-08 | 25.87 | In-house | 31-260 (352) | Show / Hide |
Range on Protein: 647-829
Range on HMM: 31-260/352
Sequence Identity: 18% (44 aa)
YALKVIKCKNMNELEKKSQEIIIEYYLMQRQ---------------FRHSCNLILPVYYIQQNDQLDLLFLKQLADFNFTQLLN-------------KRR
|. |....| . ..|. ... .. ..... | . .|. .|. |..| . . .. . . | .. ...
YMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNM
EKYLVYTEGELL-----QIFKMLLRIIKDMHDRN-VAHRDIKPSNFVFFKKDR--SWKLIDYGTAKIEMDL--------------KQVKEYNFCGTRLYA
.. || . . ..|. .| .. .| | . ||||||.| .| .. . |.||.| .| . || . . |||| |
KQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYM
----IPKISQMKNFGELSSKVRMSLKAYDIYSLGITF
| . | .| .. .. .. ||.|||. .
PQYTAPEVLQGQNYDHSKA------YKCDIWSLGVIL
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| Kinase | 20607.AA | Ciliate-C6 | 724-776 | 35 | 8.3e-08 | 23.76 | In-house | 132-185 (306) | Show / Hide |
Range on Protein: 724-776 Range on HMM: 132-185/306 Sequence Identity: 35% (19 aa) YTEGELLQIFKMLLRIIKDMHD-RNVAHRDIKPSNFVFFKKDRSWKLIDYGTAK ..| | .|. | . .. |.. |.||||||||| . ... .| | | |. FDENEIVQFCKQIGKTLADIYNECNIAHRDIKPSNILIMDDENNYYLSDFGCAQ |
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| Kinase | 20607.AA | Ciliate-A9 | 712-755 | 36 | 1e-07 | 13.53 | In-house | 110-153 (392) | Show / Hide |
Range on Protein: 712-755 Range on HMM: 110-153/392 Sequence Identity: 36% (16 aa) QLLNKRREKYLVYTEGELLQIFKMLLRIIKDMHDRNVAHRDIKP ||. |. . .| | || | .. .. || .|. |||.|| QLMKERKKNNQWFNEQEISQIMKCIMSAVMYMHQKNICHRDLKP |
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| Kinase | 20607.AA | AGC | 743-795 | 17 | 1.4e-07 | 14.15 | In-house | 169-273 (395) | Show / Hide |
Range on Protein: 743-795 Range on HMM: 169-273/395 Sequence Identity: 17% (19 aa) MHD-RNVAHRD-IKPSNFVFFKKDRSWKLIDYGTAKIEMDL-------------------------------------------------KQVKEYNFCG .|. ... ||| .|| | .. .. || | | .|. |. |... . ||| LHSHMGIIHRDYLKPENILLDED-GHIKLTDFGLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCG --TRLY | | PCTPEY |
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| Kinase | 20607.AA | Ciliate-A9 | 588-613 | 28 | 1.5e-07 | 13.13 | In-house | 2-29 (392) | Show / Hide |
Range on Protein: 588-613 Range on HMM: 2-29/392 Sequence Identity: 28% (8 aa) NKIHLLGQGTFGKVYKAKLLP--KEQRY | .|.|.||.|.... . .|.| EPIKIIGEGAFGCVIQCRDIQQEDKQEY |
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| Kinase | 20607.AA | CK1 | 590-696 | 16 | 3e-06 | 17.86 | In-house | 4-101 (339) | Show / Hide |
Range on Protein: 590-696 Range on HMM: 4-101/339 Sequence Identity: 16% (21 aa) IHLLGQGTFG-KVYKA-----KLLPKEQRYQHQSSSQHTKKRNNRDLLSLLKQQQDPIIEDEFYALKVIKCKNMNELEKKSQEIIIEYYLMQR------- ....|.| || .||. | .. | ..|.||.|| . |.| . .. |... .| . VKKIGEGGFGYQIYKVQKEDHKDMKNNKPY-----------------------------KGEEYAMKVEPKKSMGQHPQLMEEYQMYKKLQGGKKWKASI -QFRHSCN------LILPVYYIQQNDQ . .|.|. . ...| . .|. LKHKHFCKKHCGCPHPCMYWYHGEEDD |
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| Kinase | 20607.AA | Ciliate-E2-Unclassified | 587-636 | 24 | 3.3e-05 | 14.02 | In-house | 1-55 (352) | Show / Hide |
Range on Protein: 587-636 Range on HMM: 1-55/352 Sequence Identity: 24% (14 aa) SNKIHLLGQGTFGKVYKAKLLPKEQRY-------QHQSSSQHTKKRNNRDLLSLLKQ ..|. .||| ||||||.. . | ..|. .|. ..... ... .|. YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKE |
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| Kinase | 20607.AA | CAMK | 592-605 | 50 | 0.000124 | 10.06 | In-house | 1-14 (425) | Show / Hide |
Range on Protein: 592-605 Range on HMM: 1-14/425 Sequence Identity: 50% (7 aa) LLGQGTFGKVYKAK ||.|.||||.... TLGRGSFGKVKLCI |
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| Kinase | 20607.AA | Ciliate-E2a | 588-607 | 40 | 0.000236 | 8.75 | In-house | 2-21 (275) | Show / Hide |
Range on Protein: 588-607 Range on HMM: 2-21/275 Sequence Identity: 40% (8 aa) NKIHLLGQGTFGKVYKAKLL .| ..|.|.||.||.|... KFIKKIGKGNFGSVYLAQHK |
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| Kinase | 20607.AA | Ciliate-C6 | 588-610 | 47 | 0.001613 | 8.34 | In-house | 2-24 (306) | Show / Hide |
Range on Protein: 588-610 Range on HMM: 2-24/306 Sequence Identity: 47% (11 aa) NKIHLLGQGTFGKVYKAKLLPKE | ||.|.|| |||.| .|. NYRDSLGSGSFGQVYKCKNKHKQ |
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| Kinase | 20607.AA | CDC7 | 589-606 | 52 | 0.002689 | 4.06 | In-house | 2-20 (522) | Show / Hide |
Range on Protein: 589-606 Range on HMM: 2-20/522 Sequence Identity: 52% (10 aa) KIHL-LGQGTFGKVYKAKL |.| .|.|||. ||||.. KVHDKIGEGTFSSVYKATC |
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| Kinase | 20607.AA | CDPK | 587-606 | 40 | 0.005619 | 5.21 | In-house | 1-20 (271) | Show / Hide |
Range on Protein: 587-606 Range on HMM: 1-20/271 Sequence Identity: 40% (8 aa) SNKIHLLGQGTFGKVYKAKL . ||.|.|| |.|.|. YKIKKVLGKGHFGQVRKVKH |
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