Gene 2219 (Tetrahymena)
2219
Group:
Other
Family:
Ciliate-D1
Sequence
Protein domains of 2219.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 2219.AA | Ciliate-E2 | 179-454 | 21 | 4.2e-44 | 149.28 | In-house | 1-358 (365) | Show / Hide |
Range on Protein: 179-454 Range on HMM: 1-358/365 Sequence Identity: 21% (81 aa) LKTKKYIASGQYSRIYQV----VDENFLVSQGKVDT--------NNPNNYYALKEIQKAIIKENKLTNRIQSEIEIMYK---------QQNNEHIIKLYT | | | .|... .|.. |...| . . . . ...||.| ..| |.. | ..| ||.. || | |. .|||.| YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYE HFE--DSFTVYLVMEYVEGWNLKQLSYVQ------------TLDKNLKISIISQIGQ---------------GIKYLHEQN-IIHRDLKPDNILISNNNQ .|. | ..||||||..| .|... . . .. . . |. || | ...|||..| |||||.||.|||. CFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----- VKISDFGWSNYFPQNNRKRI---TRLQTPQNK------------------------FSPFVCPDITLMMG---------HSEKVDIWCYGMLIYFILSDG .||.||| | .. ..| .|. . .. | ....| | . . ...|.|||. |...|. |. | IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLF-G NYPYGIPENYISAEQSVINNAEANMRQNIFLFDPN-------------IELQFPKS-TELISA----MLNKEQNQRPT-IIE ..|. . .. ..| .. |. . .. ... ||. ||.|....|.| . . KPPF----------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQ |
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| Kinase | 2219.AA | Aur | 217-344 | 38 | 4.4e-44 | 113.85 | In-house | 27-157 (257) | Show / Hide |
Range on Protein: 217-344 Range on HMM: 27-157/257 Sequence Identity: 38% (51 aa) YALKEIQKAIIKENKLTNRIQSEIEIMYKQQNNEHIIKLYTHFEDSFTVYLVMEYVEGWNL-KQLSYV--QTLDKNLKISIISQIGQGIKYLHEQNIIHR .||| ..| ||.... .. ||.|... | ..|.|.|..|.|. .||..|| .| .| |.| . . .| .. ...|| ...|.|..||||| FALKVMFKEQIKKYCMEHQLRREIKIQSHL-NHPNILKMYGYFHDDQRIYLILEYAPGGELYKELQKQPNKRFDEQRAAKYMYQICNALDYCHSKNIIHR DLKPDNILISN-NNQVKISDFGWSNYFPQNNR |.|| |||.. |. .||.|||||...| ||| DIKPENILLDQCNGNIKICDFGWSVHCPNNNR |
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| Kinase | 2219.AA | S_TKc | 179-461 | 21 | 1e-42 | 149.15 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 179-461 Range on HMM: 1-231/231 Sequence Identity: 21% (65 aa) LKTKKYIASGQYSRIYQVVDENFLVSQGKVDTNNPNNYYALKEIQKAIIKENKLTNRIQSEIEIMYKQQNNEHIIKLYTHFEDSFTVYLVMEYVEG--WN . . | .| ... |.... . . ..|.|.| ..|..||.|. | . ..|.||| .|.| .|.||||..| . YEILRKIGKGAFGKVYKCRHKK------------TGRIVAIKIIK----------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGD LKQLSYVQT-------LDKNLKISIISQIGQGIKYLHEQNIIHRDLKPDNILISNNNQVKISDFGWSNYFPQNNRKRITRLQTPQNKFSPFVCPDITLMM |... . .. ... || ....|.|...||||||||.|||... ..||.||| . . | || .. | . LFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPW-----YMAPEVL--- GHSE-KVDIWCYGMLIYFILSDGNYPYGIPENYISAEQSVINNAEANMRQNIFLFDPNIELQFPKSTELISAMLNKEQNQRPTIIEKAL-------SELE |.. |.|.| | ..| |. | |. .. . . | ..|. .|.|. ..|||. | . GYGKCKCDWWSCGCILYEMLC-GYPPFP---QMQMMFKKIG---------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | 2219.AA | Ciliate-E2-Unclassified | 180-454 | 22 | 4.1e-41 | 140.37 | In-house | 2-345 (352) | Show / Hide |
Range on Protein: 180-454 Range on HMM: 2-345/352 Sequence Identity: 22% (82 aa) KTKKYIASGQYSRIYQVVDENFLVSQGKVDTNNPNNYYALKEIQKAIIKENKLTNR----IQSEIEIMYKQ-----------------QNNEHIIKLYTH | | | .|... .|...... . |||.|.. |..|. |. .. .....|.. |. ....|.|.. . KIIKQIGQGGFGKVYKCQHKK-----------QK-QYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYC FEDSFTVYLVMEYVEGWNLKQLSYV------------------QTLDKNLKI-----SIISQIGQGIKYLHEQN-IIHRDLKPDNILISNNN---QVKIS |.| ...|.||||.|| .|.| . .. . . .. || ||..|||..| |||||.||.|||..||. ..||. FQDKQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKII DFGWSNYFPQNNRKRITRL-----QTPQNKFSPFVCPDITL---------MM-GHS----EKVDIWCYGMLIYFILSDGNYPYG---IPENYISAEQSVI ||| | . ||| .. |. ...|.... |.. ... . ... .|.|||. |...|..| |.||.. ..... .| . DFGISKKYQQNNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLF-GYYPFYDNNCEQHQQLITQWI- NNAEAN-----MRQNIFLFDPNIEL--------QFPKST-----ELISAMLNKEQNQRPTIIE | | ..|||. .... . ... .|.. ||.| .|.|.|. . N----NAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQ |
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| Kinase | 2219.AA | CAMK | 208-343 | 23 | 3.7e-35 | 110.22 | In-house | 27-250 (425) | Show / Hide |
Range on Protein: 208-343
Range on HMM: 27-250/425
Sequence Identity: 23% (53 aa)
VDTNNPNNYYALKEIQKAIIKE-------------------------NKLTNRIQSEIEIMYKQQ------NNEHIIKLYTHFEDSFT------------
. ..| . .| | | | .|. | ....||||| | | . ..||||| ..||..
I-YTN-GQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNIIKLYEVYEDPHYFKNTNDYETSKQ
-------VYLVM---EYVEGWNL--KQLSYVQT------------------LDKNLKISIISQIGQGIKYLHEQNIIHRDLKPDNILISNN---------
.|.|| ||..| | ..|.. .. .. || ....|.|..||.||||||.|||...|
VFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEH
--------NQVKISDFGWSNYFPQNN
|..||.||| .|.|....
DEIFDWNNNNIKIIDFGFANKFDPGE
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| Kinase | 2219.AA | Ciliate-E2b | 179-396 | 26 | 5.9e-34 | 100.67 | In-house | 1-211 (272) | Show / Hide |
Range on Protein: 179-396 Range on HMM: 1-211/272 Sequence Identity: 26% (60 aa) LKTKKYIASGQYSRIYQVVDENFLVSQGKVDTNNPNNYYALKEIQKAIIKENKLTNRIQSEIEIMYKQQNNEHIIKLYTHFEDSFTVYLVMEYVEGWNLK . | .||. .|.| .| ..|||.| |.|. | .. .. ...|.... | | |.|.. | |. .|..||.. | | MIYIKKLGFGQFGSVYLVWNT-----------KNTKQYYAMKCISKNQIIQQNMEKHMLQEKNVLEK-CNHPFIMKFIRSFKDDQHMYFMMEFCNGMELF QLSYVQT---LDKNLKISIISQIGQGIKYLHEQNIIHRDLKPDNILISNNNQVKISDFGWSNYFPQNNR---KRITRLQTPQNKFSPFVCPDITL----- . . | .. .| .| ...|||.||||.||.|| ||.. .. ..|. |.| . .. ..| . | || . |.| DVIREIGRLLLSTYDSQFYIASICLCLEYLHNQNIIYRDIKPENIMVDHKGYMKLIDMGTAKHMYKKNEQMTRTFTIIGTPH-----YMAPEIIQSLQPG MMGHSEKVDIWCYGMLIYFILSDGNYPYG | . ||||| | |.... | |.. GKGYTYKVDIWSVGICLYEFMC-GYVPWA |
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| Kinase | 2219.AA | CAMKL | 208-339 | 28 | 1.7e-32 | 100.92 | In-house | 19-179 (297) | Show / Hide |
Range on Protein: 208-339 Range on HMM: 19-179/297 Sequence Identity: 28% (46 aa) VDTNNPNNYYALKEIQKAIIK-ENKLTNR-----------IQSEIEIMYKQQN---NEHIIKLYTHFEDSFT------VYLVMEYVEGWN------LKQL ... ... .| | | | |. . . ... |. ||.|| |. | ..||||| ..|.. . .||||||..| . ... THIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIM-KMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVMEYCSGGEMDLFDYIVKH SYVQ-TLDKNLKISIISQIGQGIKYLHEQNIIHRDLKPDNILISNNN--QVKISDFGWSNYF .. .. . . || ...|.|...|.|||.||.|||...|. ..||.||| ||.. GHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMY |
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| Kinase | 2219.AA | Ciliate-E2a | 239-349 | 35 | 1e-31 | 90.67 | In-house | 49-170 (275) | Show / Hide |
Range on Protein: 239-349 Range on HMM: 49-170/275 Sequence Identity: 35% (44 aa) EIEIMYKQQNNEHIIKLYTHFEDSFTVYLVMEYVEGWNLK-QLSYVQTLDKN--LKISIISQIG-QGIKYLHEQNIIHRDLKPDNILIS---NNN----Q || || .| .. .||||| .|| . ||||||.|| |. ... ...... .|. |. ||. |.| .||.||||||.|||. |. . EINIM-RQLDHPNIIKLYEVYEDENNYYLVMEYCEGGELYDKIKQCKRFFEEIQEICDIMQQLLWQGLHYMHQRNIMHRDLKPENILFKNCSKNSIQNSD VKISDFGWSNYFPQN-NRKRITR .||.||| . ..... .... .. IKIIDFGLATFIDKDEKKYMFQK |
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| Kinase | 2219.AA | Pkinase | 179-334 | 31 | 6.6e-29 | 103.28 | Pfam | 1-157 (293) | Show / Hide |
Range on Protein: 179-334 Range on HMM: 1-157/293 Sequence Identity: 31% (55 aa) LKTKKYIASGQYSRIYQVVDENFLVSQGKVDTNNPNNYYALKEIQKAIIKENKLTNRIQ-SEIEIMYKQQNNEHIIKLYTHFEDSFTVYLVMEYVEGW-- ..... | || ... |. .. . .|.|.| | .|..|. ... |||.|| . | ..|..|| |||. .|.||||.|| YHIGRKIGSGSFGCVYKCHHKGTGK------------IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLY --NLKQLSYVQ-----TL--DKNLKISIISQIGQGIKYLHEQNIIHRDLKPDNILISNNNQV----KISDFG |. .|.. .. . . .... || .|..|.|...||||||||.||||.||... ||.||| VMDLF--DYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFG |
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| Kinase | 2219.AA | ULK | 205-334 | 32 | 2.3e-28 | 97.75 | In-house | 18-183 (324) | Show / Hide |
Range on Protein: 205-334
Range on HMM: 18-183/324
Sequence Identity: 32% (55 aa)
QGKVDTNNP-NNYYALKEIQKA-IIKENKLTN------RIQSEIEIMYKQQ--NNEH--IIKLYTHFEDS--FTVYLVMEYVEGWNLKQLSYVQ------
.|. .| | |.| | |.| ..| ... . ...||.|| | .... |.||| ||.| .|..||| .| .|.| | .
KGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCNGGDLEQ--YIKKNKKLP
------TLDKNLKISIISQIGQGIKYLHEQNIIHRDLKPDNILISNNN------------QVKISDFG
.| . |... || .| |.||..||||||.||.||||.|.. ..||.|||
ETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFG
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| Kinase | 2219.AA | ULK | 209-334 | 30 | 7.1e-27 | 90.91 | In-house | 20-187 (329) | Show / Hide |
Range on Protein: 209-334
Range on HMM: 20-187/329
Sequence Identity: 30% (52 aa)
DTNNP---NNYYALKEIQKA-IIKENKLTN------RIQSEIEIMYKQ------QN-NEHIIKLYTHFEDS--FTVYLVMEYVEGWNLKQLSYVQ-----
. .. | ..| | |.| ....|.. . ...||.|| | .| ...|.||| ||.| .|..||| .| .|.|. .
NKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIMEYCNGGDLEQYIKKNKKLPE
------TLDKNLKISIISQIGQGIKYLHEQNIIHRDLKPDNILISNNN------------QVKISDFG
.| . |... || .| |.||..||||||.||.||||.|.. ..||.|||
DTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFG
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| Kinase | 2219.AA | MARK | 296-340 | 48 | 8.4e-22 | 68.19 | In-house | 111-157 (262) | Show / Hide |
Range on Protein: 296-340 Range on HMM: 111-157/262 Sequence Identity: 48% (23 aa) SQIGQGIKYLHEQNIIHRDLKPDNILISNNN--QVKISDFGWSNYFP .|| ...|.|..||.|||.||.|||| |. ..||.|||.|. .| RQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDFGFSICIP |
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| Kinase | 2219.AA | Pkinase_Tyr | 238-334 | 33 | 1.2e-12 | 43.44 | Pfam | 52-156 (270) | Show / Hide |
Range on Protein: 238-334 Range on HMM: 52-156/270 Sequence Identity: 33% (36 aa) SEIEIMYKQQNNEHIIKLYTHFE-DSFT--VYLVMEYVEGWNLKQLSYVQT-------LDKNLKISIISQIGQGIKYLHEQNIIHRDLKPDNILISNNNQ .|..|| . ....|..|| .. .|.||||... .| |.| .. |. .... || .| ||...|.||||| |.|...||. REAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDL--LDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNV VKISDFG |||.||| VKICDFG |
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| Kinase | 2219.AA | TyrKc | 179-457 | 22 | 5.6e-12 | -28.99 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 179-457
Range on HMM: 1-280/280
Sequence Identity: 22% (70 aa)
LKTKKYIASGQYSRIYQVVDENFLVSQGKVDTNNPNNYYALKEIQKAI--IKENKLTNRIQSEIEIMYKQ-QNNEHIIKLYTHFEDS-------FTVYLV
.. .| . .|.. ..|. . || |. .||.. . .|..|| | ....|..|| .. ...|
ITLGKKLGEGAFGEVYKGTWK----------------------IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIV
MEYVEGWNLKQ-LSYVQT-LDKNLKISIISQIGQGIKYLHEQNIIHRDLKPDNILISNNNQVKISDFGWSNYFPQN----NRKRITRLQT-PQNKF-SPF
|||... .||. | . . | ..|. || .| |||..|.||||| |.|...|..||||||| | . .| | .. . |. |
MEYMPHGDLKDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLP-
VCPDI------TLMMG-HSEKVDIWCYGMLIYFILSDGNYPYGIPEN-YISAEQSVINNAEANMRQNIFLFDPNIEL----QFPKSTELISAMLNKEQNQ
| ... | ..| |.| .| ... |...| || .. .|... ||.. .. .| . | .. .. .... . . ..
----IRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQE-VIEYVKQGYRMPQPPNDY--PMSFVCCPDEMYQIMKQCWHEDPED
RPT--IIEKAL
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RPTFSEIHECF
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| Kinase | 2219.AA | MARK | 217-277 | 32 | 1.9e-08 | 23.94 | In-house | 27-89 (262) | Show / Hide |
Range on Protein: 217-277 Range on HMM: 27-89/262 Sequence Identity: 32% (21 aa) YALKEIQKAIIKENKLTNRIQSEIEIMYKQQNNEHIIKLYTHFE--DSFT-VYLVMEYVEGWNL .|.| ..| . ... . ...||||| |. . ..||||. .| .. . .||.|||..| .| VAIKIYEKFKLNDPQWMKNVMREIEIM-KKLDHPNIIKLFHVIEQDTEQHQIYLIMEYASGGEL |
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| Kinase | 2219.AA | Aur | 370-385 | 62 | 0.001305 | 4.84 | In-house | 177-192 (257) | Show / Hide |
Range on Protein: 370-385 Range on HMM: 177-192/257 Sequence Identity: 62% (10 aa) GHSEKVDIWCYGMLIY .| .|||||| | |.| MHDHKVDIWCLGVLCY |
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| Kinase | 2219.AA | ULK | 374-449 | 22 | 0.02757 | 3.99 | In-house | 232-312 (324) | Show / Hide |
Range on Protein: 374-449 Range on HMM: 232-312/324 Sequence Identity: 22% (19 aa) KVDIWCYGMLIYFILSDGNYPYGIPENYISAEQSVINNAEA-------NMRQNIFLFDPNIELQF--PKSTELISAMLNKEQNQR |.||| |...| .| | ||. . .. .. ... . |.| .|. . . |.. .||. || .....| KCDIWSLGCIFYEMLY-GKYPFFSW-FNDQYLY-IQKLINNGKEQQIYIKNQPIQFPKPP-KDPKISPECKDLIRRMLQYDEKDR |
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| Kinase | 2219.AA | ULK | 374-449 | 20 | 0.187784 | 0.94 | In-house | 236-317 (329) | Show / Hide |
Range on Protein: 374-449 Range on HMM: 236-317/329 Sequence Identity: 20% (17 aa) KVDIWCYGMLIYFILSDGNYPYGIPENYISAEQSVINNAEA------NMRQNIFLFD---PNIELQFPKSTELISAMLNKEQNQR |.||| |...| .| | .|. . .. .| .... . ..... . |. ... . |.. .||. || .....| KCDIWSLGCIFYEMLY-GKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQIS-PECKDLIRRMLQYDEKDR |
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| Kinase | 2219.AA | Pkinase | 370-460 | 16 | 0.872314 | 3.86 | Pfam | 188-293 (293) | Show / Hide |
Range on Protein: 370-460 Range on HMM: 188-293/293 Sequence Identity: 16% (19 aa) GHSEKVDIWCYGMLIYFILSDGNYPYGI--PENYISAEQSVINNAEANMRQNIFLFDPN------------------IELQFPKSTELISAMLNKEQNQR ... |||.| .| ..| |. .| ..| .. | . .. .. . ... ... |.. ..|. .|.| ..| YYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECK-----DFIKWCLCKDPKKR PTIIEKALSE--L || .| .| . PT-AEQILQHPWF |
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