Gene 23775 (Tetrahymena)
23775
Group:
Other
Family:
Ciliate-D1
Sequence
Protein domains of 23775.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 23775.AA | Ciliate-B2 | 217-308 | 34 | 3.9e-18 | 39.16 | In-house | 108-197 (197) | Show / Hide |
Range on Protein: 217-308 Range on HMM: 108-197/197 Sequence Identity: 34% (34 aa) KIISNVLECLFIMHIQGIAHLDVKPQNILFVDELNRYTLADFGCSLELNSIDFENYQLATEEIVGFTPQYTDPNILEKE------FFNPFKADIWSVG ..| . .. | ... | |||.||||||| . . | . ||| | || .| | .| ||| .| | .|. |..||.| | QMIFQLIDGLIQFRMYNILHLDIKPQNILFMQN-GNYVYCDFGIS----SIKKDNQQI---KIKGFTKKYASPEQMECDHNQTFVTNIDFQSDIYSMG |
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| Kinase | 23775.AA | CAMK | 229-311 | 21 | 1.7e-15 | 45.73 | In-house | 195-324 (425) | Show / Hide |
Range on Protein: 229-311 Range on HMM: 195-324/425 Sequence Identity: 21% (28 aa) MHIQGIAHLDVKPQNILFVDEL----------------NRYTLADFGCSLELNSIDFEN------------------YQLATEEIVGFTPQYTD-PNILE .| ..|.|.| || |||..| | ..||| . .... . .. . .. .| || | | .|. CHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCG-TPEYMAAPEVLN K-------------EFFNPFKADIWSVGVIL . . ..|.|.||.|||| GKGHCNMQNATDEEKPYYGPKCDMWSCGVIL |
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| Kinase | 23775.AA | Ciliate-E1 | 204-305 | 25 | 2.3e-13 | 40.27 | In-house | 100-202 (202) | Show / Hide |
Range on Protein: 204-305 Range on HMM: 100-202/202 Sequence Identity: 25% (27 aa) KKNKKPYFIYEINKIISNVLECLFIMHIQGIAHLDVKPQNILFVDELNRYTLADFGCSLELNSIDFENY-QLATEEIVGFTPQYTDPNILEKEFFNPF-- ..|.. . . .. .|| . .. | ..|...| |.| ||||||. .. ..| ..|||.|. |.. . ... . . . ..||..|. | . .. QQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQ-GNYVYCDFGISKFLKNNQNQQCQYKGYTHYYYPPEQYNCPEQ-EHNKNQKINY KADIW | || KSDIY |
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| Kinase | 23775.AA | Ciliate-E2 | 204-316 | 24 | 1.8e-12 | 39.14 | In-house | 126-291 (365) | Show / Hide |
Range on Protein: 204-316 Range on HMM: 126-291/365 Sequence Identity: 24% (42 aa) KKNKKPYF----------IYEINKIISNVLE---------------CLFIMHIQG-IAHLDVKPQNILFVDELNRYTLADFGCSLELN-----------S |.||| . ..|| .|. .|. .| .| .. | | | ||.|||| ..||| | ... . KNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------IKIIDFGLSKKYDDDNQNRTHKQQC IDFENYQLATEEIVG---------------FTPQYTDPNILEKEFF--------NPFKADIWSVGVILLELLS . . . |. | || | | ||... .|.||||.|||| |.|. KWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLF |
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| Kinase | 23775.AA | S_TKc | 62-395 | 15 | 2e-12 | 5.36 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 62-395
Range on HMM: 1-231/231
Sequence Identity: 15% (54 aa)
YANFEFIAAGGFGLVFKAKKKVNNNKPNKIYEERELAKYIAFKFMLNDLNAKREIAIMKKLFQMSTKLLMARNIQVFRRYEIVTKENGTNQNACRIINSD
| . | |.|| |.|...| .. | | . . .. .| .
YEILRKIGKGAFGKVYKCRHKK-------------TGRIVAIKIIK-----------------------------------------EHIRREIQILKK-
SFFENSPKLVQSASEGTKDKIPYVMVEMSKATF---SVDAAISYRKKNKKP--YFIYEINKIISNVLECLFIMHIQGIAHLDVKPQNILFVDELNRYTLA
. | .|. .. . | . .. | |...... . .. ... ... | .| .|| | |.||.|||. . . ..
----HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKIC
DFGCSLELNSIDFENYQLATEEIVGFTPQYTDPNILEKEFFNPFKADIWSVGVILLELLS----VGQDFDLVQILKTCKSSQDVEEKIFKKYIFNSNGEM
||| . .| . || | | .| ....|.|.||.|.|| |.|. .. ...| ..
DFGLARQL-------------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP---QMQMMFKKIG---------------------
IYCPMLKNFVEIDNQLKMYLQWDENQRWNIIEILI---EIQNSILV
| . .. ||.| ..|. . |.| .| . .
--------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
|
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| Kinase | 23775.AA | Ciliate-C6 | 214-269 | 38 | 3e-12 | 39.74 | In-house | 136-192 (306) | Show / Hide |
Range on Protein: 214-269 Range on HMM: 136-192/306 Sequence Identity: 38% (22 aa) EINKIISNVLECLFIMHI-QGIAHLDVKPQNILFVDELNRYTLADFGCSLELNSIDF || .. . . . | .... ..||| | ||.|||. |. | | | ||||. .|. .| EIVQFCKQIGKTLADIYNECNIAHRDIKPSNILIMDDENNYYLSDFGCAQQLFQSEF |
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| Kinase | 23775.AA | Ciliate-E2-Unclassified | 213-315 | 28 | 7.6e-12 | 37.4 | In-house | 138-264 (352) | Show / Hide |
Range on Protein: 213-315 Range on HMM: 138-264/352 Sequence Identity: 28% (36 aa) YEIN-----KIISNVLECLFIMHIQG-IAHLDVKPQNILFVDELN--RYTLADFGCSL---ELNSIDFENY-----QLATEEIVGF--TPQYT----DPN ... ... .|..| .| .. | | | ||.|||| .. . . ..||| | . | .| .| .. ... | ||.| | QQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPE ILEKEFFNP---FKADIWSVGVILLELL .|... . .|.||||.|||| |.| VLQGQNYDHSKAYKCDIWSLGVILYEML |
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| Kinase | 23775.AA | ULK | 229-315 | 31 | 9.4e-12 | 38.04 | In-house | 142-246 (324) | Show / Hide |
Range on Protein: 229-315 Range on HMM: 142-246/324 Sequence Identity: 31% (33 aa) MHIQGIAHLDVKPQNILFVDEL-----------NRYTLADFGCSLELNSIDFENYQLATEE----IVGFTPQYTDPNILE----KEFFNPFKADIWSVGV .| ..| | | |||||| . ... .|||| . ... ..| .. | |.| || | | ||. .. .. .|.||||.|. LHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQTCVNEKRIKG-TPLYMAPQILQGQGEQKPYYDYKCDIWSLGC ILLELL |. |.| IFYEML |
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| Kinase | 23775.AA | ULK | 229-315 | 30 | 1.4e-11 | 36.79 | In-house | 146-250 (329) | Show / Hide |
Range on Protein: 229-315 Range on HMM: 146-250/329 Sequence Identity: 30% (32 aa) MHIQGIAHLDVKPQNILFVDEL-----------NRYTLADFGCSLELNSIDFENYQLATEE----IVGFTPQYTDPNILE----KEFFNPFKADIWSVGV .| ..| | | |||||| . ... .|||| . ... .|. .. | . | || | | ||. .. .. .|.||||.|. LHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQMMMTCVNEKRLCG-TPLYMAPQILQGQGEQKPYYDYKCDIWSLGC ILLELL |. |.| IFYEML |
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| Kinase | 23775.AA | Pkinase | 229-316 | 30 | 7.6e-11 | 39.42 | Pfam | 124-207 (293) | Show / Hide |
Range on Protein: 229-316 Range on HMM: 124-207/293 Sequence Identity: 30% (28 aa) MHIQGIAHLDVKPQNILFVDELNR---YTLADFGCSLELNSIDFENYQLATEEIVGFTPQYTDPNILEKEFFNPFKADIWSVGVILLELLS .| .|| | |.||.|||.... . ..|||.. .. |.. . ..| || | | .. . . |.|.||.|.|| |.|. CHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD---Y-NNS--MTTFCG-TPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLC |
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| Kinase | 23775.AA | MLCK | 229-248 | 55 | 2.2e-10 | 23.06 | In-house | 113-132 (257) | Show / Hide |
Range on Protein: 229-248 Range on HMM: 113-132/257 Sequence Identity: 55% (11 aa) MHIQGIAHLDVKPQNILFVD || |.|.|||.||.||.... MHWQNIVHLDLKPENIMCQT |
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| Kinase | 23775.AA | STE | 214-315 | 25 | 1.5e-09 | 30.02 | In-house | 152-262 (359) | Show / Hide |
Range on Protein: 214-315
Range on HMM: 152-262/359
Sequence Identity: 25% (31 aa)
EINKIISNVLEC-LFIMHIQGIAHLDVKPQNILFVDELNRYTLADFGCSLELNS-------------IDFENYQLATEEIVGFTPQYTDPNILEKEFFNP
.| .|. .|. | | ..| | |.||.|||. |.|||.. |.. | |. | . .|| . | ..... .
QIAYICRQILKGLLYYLHSHHIIHRDIKPANILL------VKLCDFGVCGQLTDSMANIQSNNIIDCI--ETMQQKRNTFVGTP--WMAPEVIQQNGQG-
F------KADIWSVGVILLELL
|.||||.| ..|..
RDKGYDTKCDIWSLGCTIIEMA
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| Kinase | 23775.AA | Ciliate-B2 | 62-128 | 27 | 6.1e-08 | 14.66 | In-house | 1-61 (197) | Show / Hide |
Range on Protein: 62-128 Range on HMM: 1-61/197 Sequence Identity: 27% (19 aa) YANFEFIAAGGFGLVFKAKKKVNNNKPNKIYEERELAKYIAFK-FMLNDLNAKREIAIMKKLFQMSTK | ..|. ||.|.... || . | | ..|| | |. . .. || || |.|... . YYLCKYINKGGCGFICEGYKK------HSIREYQDLAFKIYFNKQDCDKEEIQHEIKIM-KMFEYNIN |
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| Kinase | 23775.AA | Ciliate-E1 | 68-87 | 50 | 0.000773 | 8.92 | In-house | 1-20 (202) | Show / Hide |
Range on Protein: 68-87 Range on HMM: 1-20/202 Sequence Identity: 50% (10 aa) IAAGGFGLVFKAKKKVNNNK |..|.|..|||||.. ||.. IGNGSFSIVFKAKQQNNNYN |
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| Kinase | 23775.AA | MLCK | 300-310 | 72 | 0.004052 | 3.5 | In-house | 178-188 (257) | Show / Hide |
Range on Protein: 300-310 Range on HMM: 178-188/257 Sequence Identity: 72% (8 aa) FKADIWSVGVI |. |.|||||| FQTDMWSVGVI |
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| Kinase | 23775.AA | STE | 62-122 | 22 | 0.00572 | 6.47 | In-house | 1-85 (359) | Show / Hide |
Range on Protein: 62-122 Range on HMM: 1-85/359 Sequence Identity: 22% (19 aa) YANFEFIAAGGFGLVFKAKKKV---NNNKPNKIYEERELAKYIAFKFML----------------------NDLNAKREIAIMKKL . . |.| |.|| |.||... .. | ... . | ...| | | . . ..|| ||||. WEGIEKIGKGAFGTVYKAMNHKNCNIH-KTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKC |
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| Kinase | 23775.AA | Pkinase | 62-122 | 22 | 0.026942 | 9.2 | Pfam | 1-57 (293) | Show / Hide |
Range on Protein: 62-122 Range on HMM: 1-57/293 Sequence Identity: 22% (16 aa) YANFEFIAAGGFGLVFKAKKKVNNNKPNKIYEERELAKYIAFKFMLNDLNAK---------REIAIMKKL | . | .|.|| |.|...| .. | | . . . . .||.|||.| YHIGRKIGSGSFGCVYKCHHKGTGK-------------IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL |
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| Kinase | 23775.AA | CAMK | 67-122 | 20 | 0.066508 | 1.11 | In-house | 1-88 (425) | Show / Hide |
Range on Protein: 67-122 Range on HMM: 1-88/425 Sequence Identity: 20% (18 aa) FIAAGGFGLVFKAKKKVNNNKPN-------------KIYEERELA------------KYIAFKFM------LNDLN-AKREIAIMKKL . |.|| |.... | ...| . ||.. . | . . . . .|. .|||.||||| TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKL |
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| Kinase | 23775.AA | Ciliate-E2 | 71-122 | 23 | 0.259351 | 0.24 | In-house | 10-73 (365) | Show / Hide |
Range on Protein: 71-122 Range on HMM: 10-73/365 Sequence Identity: 23% (15 aa) GGFGLVFKAKKKVNNNKPNKIYEEREL-----------AKYIAFKFM-LNDLNAK-REIAIMKKL |.|| |.|.|.. .... ... .. . .|..| | | |..... .|| ||... GNFGSVYKCKVWKVQKQFAIKIID-QKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREI |
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| Kinase | 23775.AA | Ciliate-E2-Unclassified | 62-92 | 31 | 0.279785 | 0.22 | In-house | 1-38 (352) | Show / Hide |
Range on Protein: 62-92 Range on HMM: 1-38/352 Sequence Identity: 31% (12 aa) YANFEFIAAGGFGLVFKAKKKVNN-------NKPNKIY | . | |||| |.|...| .. .| ..|| YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIY |
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| LRR_CC | 23775.AA | LRR_CC | 875-899 | 26 | 0.245056 | 6.54 | SMART | 1-26 (26) | Show / Hide |
Range on Protein: 875-899 Range on HMM: 1-26/26 Sequence Identity: 26% (7 aa) LKNIETLKLCYCQ-INDESISELKQL .|...| |..|. | |... .| .. CPNLRHLNLSHCPNITDHGLQALAKN |
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| LRR_CC | 23775.AA | LRR_CC | 924-949 | 38 | 0.344899 | 5.38 | SMART | 1-26 (26) | Show / Hide |
Range on Protein: 924-949 Range on HMM: 1-26/26 Sequence Identity: 38% (10 aa) MPNVKNLKLNGSQNISFKGLYLLSSN .|| . | | . .||. ||. |..| CPNLRHLNLSHCPNITDHGLQALAKN |
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| LRR_CC | 23775.AA | LRR_CC | 1089-1114 | 38 | 0.000146 | 22.4 | SMART | 1-26 (26) | Show / Hide |
Range on Protein: 1089-1114 Range on HMM: 1-26/26 Sequence Identity: 38% (10 aa) FNQLQHLSLSNCYNLSSKTIQVLLQN .|.||.||.|.|.. ..| | .| CPNLRHLNLSHCPNITDHGLQALAKN |
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| LRR_CC | 23775.AA | LRR_CC | 1146-1171 | 34 | 0.000614 | 20.33 | SMART | 1-26 (26) | Show / Hide |
Range on Protein: 1146-1171 Range on HMM: 1-26/26 Sequence Identity: 34% (9 aa) FPKLEILSVKNCIDISEASLQKLQKK |.|. |....| |. .|| | |. CPNLRHLNLSHCPNITDHGLQALAKN |
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