Gene 24136 (Tetrahymena)
24136
Group:
Other
Family:
Ciliate-D1
Sequence
Protein domains of 24136.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 24136.AA | CAMK | 17-159 | 21 | 3.2e-33 | 103.87 | In-house | 201-425 (425) | Show / Hide |
Range on Protein: 17-159
Range on HMM: 201-425/425
Sequence Identity: 21% (49 aa)
IHCDLKLANIFCEKHESDD---------DGVQIRRVKIGDLGLIQKIDAEKKTA---------------------YLEETCGTFGFKA-PEAKKG-----
.|.|||. || . ....|. | . .|| | |. .|.| .. ... ||| .. | || .|
VHRDLKPENILLDDNNDDSDPVEHDEIFD-WNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN
---------AHITQQSDMWSLGIILYFMTVAYMPHH-----------------MKGY-KYGQGPVPFREFD------------WKKRSPE--------LR
.....||||.|.|||.| . |.| . . | .| | .. |.. | | .
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK
DFVQKMLSLDPSQRPTAREALQHPFL
|...||| ||..|.|. ..|.||..
DLIRKMLQVDPEKRMTIEQCLNHPWM
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| Kinase | 24136.AA | Ciliate-E2 | 17-159 | 24 | 3.2e-31 | 104.41 | In-house | 183-365 (365) | Show / Hide |
Range on Protein: 17-159
Range on HMM: 183-365/365
Sequence Identity: 24% (50 aa)
IHCDLKLANIFCEKHESDDDGVQIRRVKIGDLGLIQKIDAEKK--------TAYLEET----------------------CGTFGFKAPEAKKGAH----
|| |.|. ||. .|| |.|| .|.| . . |.. ||| |..||| .|
IHRDIKPENILF--------------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQ
-----ITQQSDMWSLGIILYFMTVAYMPHHMKGYK-YGQGPVPFREF--------------DWKKRSPELRDFVQK----MLSLDPSQRPT-AREALQHP
. ..|.||||.|||.| . | .. |... |... .||| |.| |. .| || ||..|.| . ..|.||
QKQKGYDYKCDIWSLGVILYEMLFGKPPF----QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHP
FL
..
WF
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| Pkinase | 24136.AA | Pkinase | 15-159 | 28 | 5.7e-31 | 110.6 | Pfam | 128-293 (293) | Show / Hide |
Range on Protein: 15-159
Range on HMM: 128-293/293
Sequence Identity: 28% (50 aa)
SFIHCDLKLANIFCEKHESDDDGVQIRRVKIGDLGLIQKIDAEKKTAYLEETCGTFGFKAPEAKK-GAHITQQSDMWSLGIILYFMTVAYMPHHMK----
..||.|||..||.. .. |. .|||.| || ..| . . . ||| .. ||| . | .... .||||.|.||| | . | .
GIIHRDLKPENILIDNNGHIDA-----CVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHD
-------GYKYGQGPVPFREFDWKKRS-----------------PELRDFVQKMLSLDPSQRPTAREALQHPFL
.. ...|..| .. | .| .|..||. ..| .||..||||...||||..
NHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
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| Kinase | 24136.AA | CAMKL | 17-159 | 25 | 1.4e-25 | 78.49 | In-house | 149-297 (297) | Show / Hide |
Range on Protein: 17-159
Range on HMM: 149-297/297
Sequence Identity: 25% (41 aa)
IHCDLKLANIFCEKHESDDDGVQIRRVKIGDLGLIQKIDA--EKKTAYLEETCGTFGFKAPEAKKG--A-HITQQSDMWSLGIILYFMTVAYMPHH----
.| |.|. || .. . .|| | |. ... .. |.. ||. . ||| .| .. .. |.||.|.|||.| . |.|
VHRDIKPENILLDENGNN-------NIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTY
------MKGYKYGQGPVPFREF-DWKKRSPELRDFVQKMLSLDPSQRPTAREALQHPFL
. |.| . . .. |.. | ..||. .||| .|..|||. . ..||..
NKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM
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| Kinase | 24136.AA | STE | 17-159 | 22 | 6.9e-19 | 63.42 | In-house | 174-359 (359) | Show / Hide |
Range on Protein: 17-159 Range on HMM: 174-359/359 Sequence Identity: 22% (46 aa) IHCDLKLANIFCEKHESDDDGVQIRRVKIGDLGLIQKIDAEKKTAYLEE----------------TCGTFGFKAPEAKKG------AHITQQSDMWSLGI || |.| |||. ||. | |. ... . . . .|| . ||| .. . . ..|.||||. IHRDIKPANILL--------------VKLCDFGVCGQLTDSMANI-Q-SNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGC ILYFMTVAYMPH---H------MKGYKYGQGP---------VPFREF-DW-----------------KKRSPELRDFVQKMLSLDPSQRPTAREALQ--H . | |. | |. .|. .. | . | .| |||..||..| | ||..|||| . |. | TIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEH PFL ||. PFI |
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| Kinase | 24136.AA | ULK | 17-159 | 21 | 1.5e-16 | 55.27 | In-house | 148-324 (324) | Show / Hide |
Range on Protein: 17-159 Range on HMM: 148-324/324 Sequence Identity: 21% (39 aa) IHCDLKLANIFCEKH----ESDDDGVQIR-----RVKIGDLGLIQKIDA-EKKTAYLEETC------GTFGFKAPEAKK----GAHIT-QQSDMWSLGII ||.|.|..|| .. .| . ..||.| |. ...| .. . ... || . ||. . . . . .|.||||.| IHRDIKPQNILIHNGQPKTDSK------KVHPNGVLKIADFGFAKHVDNNNMEQQMCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCI LYFMTVAYMP---HHMKGYK----------------YGQGPVPFREF-DWKKRSPELRDFVQKMLSLDPSQRPTAREALQHPFL .| | . | .. . |..|. . .|.|||..|. ..|| |...| . | ..||.. FYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKDLIRRMLQYDEKDRISWEEIFNHPWF |
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| Kinase | 24136.AA | ULK | 17-159 | 22 | 3.5e-16 | 53.05 | In-house | 152-329 (329) | Show / Hide |
Range on Protein: 17-159 Range on HMM: 152-329/329 Sequence Identity: 22% (42 aa) IHCDLKLANIFCEKH----ESDDDGVQIR-----RVKIGDLGLIQKIDAE-----KKTAYL-EET--CGTFGFKAPEAKK----GAHIT-QQSDMWSLGI ||.|.|..|| .. .| . ..||.| |. ...| . .... | . ||| . ||. . . . . .|.||||. IHRDIKPQNILIHNGQPKTDSK------KVHPNGVLKIADFGFAKHVDNDNMEQQMMMTCVNE-KRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGC ILYFMTVAYMP---HHMKGY-----KY-GQGPVP-----FREFDWKK------RSPELRDFVQKMLSLDPSQRPTAREALQHPFL |.| | . . | .. | | ..|.. . ....| .|||..|. ..|| |...| . | ..||.. IFYEMLYGKPPFYAWFNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISPECKDLIRRMLQYDEKDRISWEELFNHPWF |
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| Kinase | 24136.AA | Ciliate-E2a | 124-159 | 45 | 2.2e-14 | 38.76 | In-house | 239-275 (275) | Show / Hide |
Range on Protein: 124-159 Range on HMM: 239-275/275 Sequence Identity: 45% (17 aa) D-WKKRSPELRDFVQKMLSLDPSQRPTAREALQHPFL . |.| | | |...||| ||..|.|| .||.||. ECWEKCSKECKDLMKKMLEKDPKKRITAQQALNHPWF |
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| Kinase | 24136.AA | Ciliate-E2-Unclassified | 16-99 | 25 | 7.9e-14 | 44.37 | In-house | 165-263 (352) | Show / Hide |
Range on Protein: 16-99 Range on HMM: 165-263/352 Sequence Identity: 25% (27 aa) FIHCDLKLANIFCEKHESDDDGVQIRRVKIGDLGLIQKIDAEKK-------------TAYLEETCGTFGFK----APEAKKGAHITQQ----SDMWSLGI .|| |.|. ||. . . ..|| |.|.. |.. . . .||| ... ||| .| . .. .|.||||. IIHRDIKPENILFDNNGK------NYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGV ILYFM |||.| ILYEM |
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| Kinase | 24136.AA | Ciliate-E2-Unclassified | 115-159 | 35 | 1.4e-13 | 43.46 | In-house | 300-352 (352) | Show / Hide |
Range on Protein: 115-159 Range on HMM: 300-352/352 Sequence Identity: 35% (19 aa) QGPVPFREFDW----KKRSPELRDFVQ----KMLSLDPSQRPTAREALQHPFL |... |..|.| |. ||| ||.. ||| .|..|.|. ..|.||.. QKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF |
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| Kinase | 24136.AA | CAMK-Unique | 17-105 | 26 | 8.9e-12 | 34.95 | In-house | 179-292 (363) | Show / Hide |
Range on Protein: 17-105 Range on HMM: 179-292/363 Sequence Identity: 26% (30 aa) IHCDLKLANIFCEKHESD-------DDGVQIRRVKIGDLGLIQKIDAEKKTAYLEETCGTFGFKAP--------------EAKKGAHITQQS----DMWS .| |||| || . . | . ..|. | || ... |. . . ..||| ..|| | .. . ||. | || VHRDLKLENIMVCYSFKDNNHHRDFPYDWSNWHIKLCDFGLCCHYNHNKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTRDEVINMQCYDQQCSPASDIWS LGIILYFMTVAYMP || |.|.| . ..| LGVIMYYMLCGCPP |
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| Kinase | 24136.AA | PLK | 129-159 | 51 | 1.3e-11 | 34.18 | In-house | 228-258 (258) | Show / Hide |
Range on Protein: 129-159 Range on HMM: 228-258/258 Sequence Identity: 51% (16 aa) SPELRDFVQKMLSLDPSQRPTAREALQHPFL |.|..|..||||. .|..|||. . |||||. SDEAKDLIQKMLNWNPDERPTIDQILQHPFF |
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| Kinase | 24136.AA | Ciliate-E2a | 17-99 | 32 | 2.9e-11 | 29.43 | In-house | 124-209 (275) | Show / Hide |
Range on Protein: 17-99 Range on HMM: 124-209/275 Sequence Identity: 32% (30 aa) IHCDLKLANIFCE--KHESDDDGVQIRRVKIGDLGLIQKI--DAEKKTAYLEETCGTFGFKAPEAKKGAHI------TQQSDMWSLGIILYFM .| |||. ||. . . .|. | .|| | || ..| | . |. ||| |. ||| . .. ... ||||.|.|.|.. MHRDLKPENILFKNCSKNSI----QNSDIKIIDFGLATFIDKD---EKKYMFQKCGTPGYVAPEVLNNKEVLKHKQYDTKCDMWSCGVIFYIL |
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| Kinase | 24136.AA | CAMK-Unique | 129-159 | 38 | 9.4e-10 | 28.17 | In-house | 333-363 (363) | Show / Hide |
Range on Protein: 129-159 Range on HMM: 333-363/363 Sequence Identity: 38% (12 aa) SPELRDFVQKMLSLDPSQRPTAREALQHPFL |.|. |||.. . .||..| .| |.|.|... SQEAKDFVKCCMTVDPDHRWSAKELLEHQWI |
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| S_TKc | 24136.AA | S_TKc | 1-159 | 19 | 9.6e-10 | -33.99 | SMART | 19-231 (231) | Show / Hide |
Range on Protein: 1-159 Range on HMM: 19-231/231 Sequence Identity: 19% (49 aa) MDRQ----------------------------------------------IDS------QFVSQMDS-----------------------------FIHC .. .| .. .. . .||. RHKKTGRIVAIKIIKEHIRREIQILKKHHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPEHARFYMYQICCALEYCHSHGIIHR DLKLANIFCEKHESDDDGVQIRRVKIGDLGLIQKIDAEKKTAYLEETCGTFGFKAPEAKKGAHITQ-QSDMWSLGIILYFMTVAYMPHHMKGYKYGQGPV ||| .||.. . ..||.| || .. ||| . ||| . . .|.||.|.||| | . | | . DLKPENILLDE-----------HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP----------Q PFREFDWKKRSPELRDFVQKMLSLDPSQRPTAREALQ-------HPFL ... |. . |||..||..|.| ||..|||| |||| ||.. MQMMFKKIG-SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | 24136.AA | PLK | 17-97 | 37 | 7e-06 | 15.27 | In-house | 122-193 (258) | Show / Hide |
Range on Protein: 17-97 Range on HMM: 122-193/258 Sequence Identity: 37% (33 aa) IHCDLKLANIFC-EKHESDDDGVQIRRVKIGDLGLIQKIDAE---KKTAYLEETCGTFGFKAPEA---KKGAHITQQSDMWSLGIILY || ||||.|.| .... ||||| || ... . ||| ||| . ||| .| | ..|.||||.|.| IHRDLKLGNLFLNDNMH----------VKIGDFGLATRLEYDGERKKTM-----CGTPNYIAPEVLDGNKQGH-SYEVDCWSLGCIMY |
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