Gene 25731 (Tetrahymena)
25731
Group:
Other
Family:
Ciliate-D1
Sequence
Protein domains of 25731.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 25731.AA | Ciliate-E2-Unclassified | 341-490 | 21 | 3.2e-20 | 66.88 | In-house | 135-352 (352) | Show / Hide |
Range on Protein: 341-490 Range on HMM: 135-352/352 Sequence Identity: 21% (46 aa) FNEKEAK-----IWMIKILQALQILHESH-LEHGNLKPNNILLGQG----QLKLTDINMFK--------------------NKKHLHNL----YS----A | |..|| .. |||.|. ||... | ..||.|||. .. ..|..| .| ... .. | | FTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTA PELLQRDQLT----EKSDIWSACLIFIEMRTGVMPYLEKDPDM-------------TVEKLKEKIERMELRLP---------FDIETQEFIR----MMNN ||.||. . .|.|||| |. || .| |. .. . . ....... . . | ..||. | . PEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLK IDPNKRKTAKELLNSRYL .|||| |....|| .. KNPNKRITFEQILNHPWF |
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| Kinase | 25731.AA | Ciliate-E2 | 341-490 | 20 | 5.2e-20 | 65.37 | In-house | 142-365 (365) | Show / Hide |
Range on Protein: 341-490
Range on HMM: 142-365/365
Sequence Identity: 20% (50 aa)
FNEKEAKIWMIKILQ---------------ALQILHESH-LEHGNLKPNNILLGQGQLKLTDINMFK----------------NKKHLHN----------
|.|||.| | .||| ||. ||. . | ..||.|||. .|..| . | ... .|
FTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMD
---------------LYSAPELLQRDQ---------LTEKSDIWSACLIFIEMRTGVMPYLEKDPDMTVEKLKEKIERMELRLP----------------
| ||| |.. . ..|.||||. |. || .| |. ..|. ....|
QIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF------------QQQIKQCKIDFPCPEWQKDTQCIQCKWK
----FDIETQEFIRM----MNNIDPNKRKT-AKELLNSRYL
. |.. .|. | . ||.|| | ....|| ..
SWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
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| Kinase | 25731.AA | CAMK | 341-490 | 19 | 1.1e-17 | 52.95 | In-house | 176-425 (425) | Show / Hide |
Range on Protein: 341-490
Range on HMM: 176-425/425
Sequence Identity: 19% (48 aa)
FNEKEAKIWMIKILQALQILHESHLEHGNLKPNNILL-GQ-----------------GQLKLTDINMFKNKKHLHN------------------------
|.|.||. .. |..|.. .|. . | ||| |||| ...|..| . . ... .|
FTEREARRYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQK
--------LYSA-PELLQR--------------DQLTEKSDIWSACLIFIEMRTGVMPYLEKDPD---------MTVEKLKEKIERMELRLPFDI-----
| | ||.|.. . ..|.|.||. | | .| .|. ... . |. ..|.||| . . . | .
MKTFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPIS
---------------------ETQEFIRMMNNIDPNKRKTAKELLNSRYL
| . .|| | . ||.|| |... || .
CNYGPEWWDDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
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| Kinase | 25731.AA | Pkinase | 400-490 | 22 | 5.3e-15 | 54.12 | Pfam | 177-293 (293) | Show / Hide |
Range on Protein: 400-490 Range on HMM: 177-293/293 Sequence Identity: 22% (26 aa) YSAPELLQ-RDQLTEKSDIWSACLIFIEMRTGVMPYLEK---DPDMTVEKLKEKIERMELRLPFD-----------------------IETQEFIRMMNN | |||... . . |.|.||. .|..|| .| |. .. |. .. .. ..| . .|. ... | ..||. . . YMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLC IDPNKRKTAKELLNSRYL ||.|| ||...|.. .. KDPKKRPTAEQILQHPWF |
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| Kinase | 25731.AA | RSKL | 347-419 | 31 | 3.2e-14 | 29.39 | In-house | 276-363 (436) | Show / Hide |
Range on Protein: 347-419 Range on HMM: 276-363/436 Sequence Identity: 31% (28 aa) KIWMIKILQALQILHESH-LEHGNLKPNNILLGQ-GQLKLTDINMFK-------------NKKHLHNLYSAPELLQRDQLTEKSDIWS ..| .. || ||. . . | |.||||.| |...|| . . | . . |.|.||| | ||| .|.|| RQWACEMVVALHALHAEGHVICRDLNPDNILLDQKGHIQLTYFGQWSGLTSDDNWVCQQCNREAVTNMYCAPEVGQIWELTEACDWWS |
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| Kinase | 25731.AA | MSK | 341-490 | 23 | 2.3e-13 | 41.54 | In-house | 98-277 (277) | Show / Hide |
Range on Protein: 341-490 Range on HMM: 98-277/277 Sequence Identity: 23% (43 aa) FNEKEAKIWMIKILQALQILHESHLEHGNLKPNNILLGQG----QLKLTD-----INMFKNKKHLHN-----LYSAPELLQR--DQLT---EKSDIWSAC | |.|. . | .. |.. .|. . |. ||| |||. ..||.| .. ... .. | |||.|.| | . | |.|| FDESECRMIMRELVMAVDHMHQKGIIHRDLKPENILFDDEEDNGHVKLIDFGFARLFPQDEEWRMKSPCFTLHYMAPEMLRRGYAQDGGYDEACDWWSLG LIFIEMRTGVMPYL--EKDPD---MTVEKLKEKIERMELRLP------FDIETQEFIRMMNNIDPNKRKTAKELLNSRYL | .| || |. |.| . . . .| . | .| .. . ...|. . ||.|| .. .|. . . VILYTMLTGQVPFQQNEDDRQHSCNSHHEIMKRICKGEFSFPGMAWQNMSPDAKDLIQWLLTKDPKKRLGMNDLRAHEWK |
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| S_TKc | 25731.AA | S_TKc | 217-490 | 20 | 5.5e-13 | 13.54 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 217-490
Range on HMM: 1-231/231
Sequence Identity: 20% (61 aa)
FDSGGVLERIM----RENRHKKNGLGIDSHSGQTYVLKQVFLTQYKKLSIINCVKIKYSPEDVQELIFDYDLAQRIKQIQMQNNCFCMIHAIRKQSDDNY
.. . .. . . |||| .|. . .|.. . ..| || .. .. .. . |
YEILRKIGKGAFGKVYKCRHKK--------TGRIVAIKIIK-----------------------------EHIRREIQILKK-HHPNIVKLYDVFQD---
WQKQNLEGLLIVQNHEKG--GSLSLFLDTA--------FNEKEAKIWMIKILQALQILHESHLEHGNLKPNNILLGQGQLKLTD----INMFKNKKHLHN
. | .| . | |.| ... |.| .|. .| |..||. .|. . | ||| |||| . ..|..| . .
------DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-HIKICDFGLARQL-------TT
L-----YSAPELLQRDQLTE-KSDIWSACLIFIEMRTGVMPYLEKDPDMTVEKLKEKIERMELRLPFDIETQEFIRMMNNIDPNKRKTAKELLN------
. | |||.| . . |.|.|| |..|| .| |. ...|. .|.. . | .||| . . ||.|| || |.|.
FCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIK
-SRYL
..
CHPWF
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| Kinase | 25731.AA | STE | 402-490 | 22 | 2.7e-11 | 36.25 | In-house | 230-359 (359) | Show / Hide |
Range on Protein: 402-490 Range on HMM: 230-359/359 Sequence Identity: 22% (29 aa) APELLQR------DQLTEKSDIWSACLIFIEMRTGVMPYLE-KDPDMTVEKLKEKIERM-----------ELRLPFD---------------------IE ||| .|. .. ..|.|||| . ||| || |. . ... . ....... . .|| . | APEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPE TQEFIRMMNNIDPNKRKTAKELLN--SRYL ..||. ..||||| ||..||. . FKDFINKCLQKDPNKRPTASQLLKSEHPFI |
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| Kinase | 25731.AA | STE | 330-386 | 29 | 3.4e-08 | 25.18 | In-house | 121-190 (359) | Show / Hide |
Range on Protein: 330-386 Range on HMM: 121-190/359 Sequence Identity: 29% (22 aa) GGSLSLFLD----------------TAFNEKEAKIWMIKILQA-LQILHESHLEHGNLKPNNILLGQGQLKLTD ||||. ... . |.|.. .. ||.. |. ||. | | .|| |||| ||.| GGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL----VKLCD |
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| Kinase | 25731.AA | AGC | 341-386 | 37 | 6.9e-08 | 14.94 | In-house | 143-198 (395) | Show / Hide |
Range on Protein: 341-386 Range on HMM: 143-198/395 Sequence Identity: 37% (21 aa) FNEKEAKIWMIK-------ILQALQILHE-SHLEHGN-LKPNNILLGQ-GQLKLTD |.|..|.... |. ||. ||. . | ||| |||| . | .|||| FDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTD |
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| Kinase | 25731.AA | RSK | 400-490 | 25 | 1e-07 | 24.64 | In-house | 174-278 (278) | Show / Hide |
Range on Protein: 400-490 Range on HMM: 174-278/278 Sequence Identity: 25% (27 aa) YSAPELLQ---RDQ-LTEKSDIWSACLIFIEMRTGVMPYLEKDPDMTVEKLKEKIERME--LRLP----FDIETQEFIRMMNNIDPNKRKT-----AKEL | |||.| .. .. |.|| . || || |. . | . ... ..|.. . |..| | ...||.| ||.|| . |.|. YMAPEMLKRANQQGGHDKACDWWSLGVLMYEMLTGCPPFQG-PNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEI LNSRYL ... .. KQHPWF |
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| Kinase | 25731.AA | ULK | 399-490 | 27 | 1.2e-07 | 22.8 | In-house | 216-329 (329) | Show / Hide |
Range on Protein: 399-490 Range on HMM: 216-329/329 Sequence Identity: 27% (32 aa) LYSAPELLQRD----QLT-EKSDIWSACLIFIEMRTGVMP---YLEKDPD-MTVEKLKEK-------IERMELRLP-------FDIETQEFIRMMNNIDP || ||..||. . . |.|||| || || .| | . | . . ..||... |. |. | . |....|| | .|. LYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISPECKDLIRRMLQYDE NKRKTAKELLNSRYL ..| . ||.| . KDRISWEELFNHPWF |
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| Kinase | 25731.AA | AGC | 400-490 | 22 | 3.5e-07 | 13.08 | In-house | 273-395 (395) | Show / Hide |
Range on Protein: 400-490 Range on HMM: 273-395/395 Sequence Identity: 22% (29 aa) YSAPELLQRDQLTEKSDIWS---ACLIFIEMRTGVMPYLEKDPD------MTVEKLKEKIE------RMELRLP------------FDIETQEFIRMMNN | ||| | . |.|| ||.. || || |. ..|. . ... .||. ....| |. | . .|... . YMAPEIL----YGKACDWWSFGLGCLMY-EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLC IDPNKRKT----------AKELLNSRYL ||.|| . |.|. | . KDPEKRLGCGGNDFGDKGAEEIKNHPWF |
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| Kinase | 25731.AA | Dicty3 | 341-377 | 31 | 4.8e-07 | 19.09 | In-house | 108-145 (351) | Show / Hide |
Range on Protein: 341-377 Range on HMM: 108-145/351 Sequence Identity: 31% (12 aa) FNEKEAKIWMIKILQALQILHES-HLEHGNLKPNNILL |||.| .. ..... .| .|.. |. |...|..||.| FNEHEISKIICDLVKTLNYIHKNCHIIHRDIKCDNIML |
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| Kinase | 25731.AA | RSK | 341-386 | 42 | 6.3e-07 | 21.75 | In-house | 101-150 (278) | Show / Hide |
Range on Protein: 341-386 Range on HMM: 101-150/278 Sequence Identity: 42% (21 aa) FNEKEAKIWMIKILQALQILHESHLEHGNLKPNNILLGQ----GQLKLTD | |.||.. | .| |.. ||. . | ||| |||. . | .|||| FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTD |
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| TyrKc | 25731.AA | TyrKc | 247-490 | 17 | 1e-06 | -114.89 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 247-490 Range on HMM: 1-280/280 Sequence Identity: 17% (52 aa) YVLK---------QVFLTQYKKLSIINCVKIKYSPEDVQELIFDYDLAQRIKQIQMQ----NNCFCMIHAIRKQSDDNYWQKQNL---EGLLIVQNHEKG .|. .|.. ..| |.. .| || |. . .. . | ... ....|. | |.|| . .. ITLGKKLGEGAFGEVYKGTWK----IQVA-VKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN-------FMYIEPLMIVMEYMPH GSLSLFL-DTA--FNEKEAKIWMIKILQALQILHESHLEHGNLKPNNILLGQGQ-LKLTDINMFKNKKHL------HNLYS----------------APE |.| .| .. .. |. ... | . . ||. .. | | |.|.| .. | .| . .. .. . |. ||| GDLKDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPE LLQRDQLTEKSDIWS-ACLIFIEMRT-GVMPYLE----KDPDMTVEKLKEKIERMELRLP--------FDIETQEFIRMMNNIDPNKRKTAKELLNSRYL .. |.|||.|| ... |. | | .|| . . .. | .. .. .||. | . ... . ||..| | .|. ... CINYGKFTTKSDVWSFGVCMW-EIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF |
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| Kinase | 25731.AA | ULK | 330-386 | 25 | 1.2e-05 | 15.8 | In-house | 104-185 (329) | Show / Hide |
Range on Protein: 330-386 Range on HMM: 104-185/329 Sequence Identity: 25% (21 aa) GGSLSLFLDTA------------FNEKEAKIWMIKILQALQILHESHLEHGNLKPNNILLGQGQ-------------LKLTD || |. .. . ..|.||.. .. ||.... ||. | .|| |||. || ||..| GGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIAD |
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| Kinase | 25731.AA | Dicty3 | 402-441 | 37 | 3.3e-05 | 12.95 | In-house | 263-305 (351) | Show / Hide |
Range on Protein: 402-441 Range on HMM: 263-305/351 Sequence Identity: 37% (16 aa) APELLQRDQ--LTEKSDIWSACLIFIEMRTGVMPYLEKDPD-M ||| . ..| ...|||||| .. .|| | . .|.|.. | APEIKLNNQCCACRKSDIWSLGCTVWEMVGGNLCHCEQDINEM |
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| Kinase | 25731.AA | Pkinase | 333-386 | 31 | 0.006265 | 11.44 | Pfam | 89-155 (293) | Show / Hide |
Range on Protein: 333-386 Range on HMM: 89-155/293 Sequence Identity: 31% (21 aa) LSLF------LDTAF--NEKEAKIWMIKILQALQILHESHLEHGNLKPNNILLG-QGQL----KLTD ..|| ...| |.|.| .| ||..|. .|. | ||| |||. .|.. |..| MDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICD |
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| Kinase | 25731.AA | Dicty3 | 473-485 | 53 | 0.04568 | 2.39 | In-house | 339-351 (351) | Show / Hide |
Range on Protein: 473-485 Range on HMM: 339-351/351 Sequence Identity: 53% (7 aa) IDPNKRKTAKELL ||||.| . ||. IDPNHRWDMHELI |
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