Gene 26670 (Tetrahymena)
26670
Group:
Other
Family:
Ciliate-D1
Sequence
Protein domains of 26670.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 26670.AA | TKL | 650-953 | 14 | 2.5e-23 | 80.89 | In-house | 1-364 (364) | Show / Hide |
Range on Protein: 650-953
Range on HMM: 1-364/364
Sequence Identity: 14% (60 aa)
MRKGQFGSVHTIMYKD----------ELYAAKQIQFVPRN---------------------------FYDKLLEELKNNLEVVHPTLFPILAVTKWYSNK
.| || |. .. . | |.. . | ... ||.. . || . ..... . .
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCC---CP
EHR-TSKDPI----NILLIMDLK-KSNLEQVLQENLVLSQSIAFRIASQVCSGICALHDHD--------IIHTNIKLKNILIDSNFN-------------
... . .|. .. ..|.. . .|. .|. . .|.| ....|.. || .. ||| ..| ||||.|.|..
PCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADW
-AFITDWGISHLFSNEIDRNLDE------------------FTTSLAFAAPELIQ---------GISLERGSISGKSQFQENISSNFNQNITAYFSSNGE
. |.| |.| .|.. . | . .... |||... ||
CCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGI----------------------------------
NSNPNKENMFEENAVRTSRISNFSKESDVWSFGVVLLCLFF---EFY-PNEKSIK------DINLYNGVTILN---------------CNPKLQQIYSLI
.. . . .|. .||.|||.|| .. .| ... ... .. .... | |.. .... .|.
-------------DE-FCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLM
QDMLKIQPSQRISISQVQQRL
|| . |..| | ... .||
QDCWDHDPEKRPSFQEILKRL
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| S_TKc | 26670.AA | S_TKc | 644-959 | 14 | 2.2e-22 | 81.58 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 644-959
Range on HMM: 1-231/231
Sequence Identity: 14% (49 aa)
IRIKSMMRKGQFGSVHTIMYKD--ELYAAKQIQFVPRNFYDKLLEELKNNLEVVHPTLFPILAVTKWYSNKEHRTSKDPINILLIMDLKKS---NLEQVL
.| || ||.|. |. ...| |.| .... |.. . || . .. | .. ..|.. .| ...
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD------------DHLYMVMEYCDGDLGDLFDYI
QENLV------LSQSIAFRIASQVCSGICALHDHDIIHTNIKLKNILIDSNFNAFITDWGISHLFSNEIDRNLDEFTTSLAFAAPELIQGISLERGSISG
... .. | ... |.|... .|.| ||| .| |||.|. . |.| |.. .. . | .. . |||..
KKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL------------
KSQFQENISSNFNQNITAYFSSNGENSNPNKENMFEENAVRTSRISNFSK-ESDVWSFGVVLLCLFFEFYPNEKSIKDINLYNGVTILNCNPKLQQIYSL
..| ..|.||.|..| .. | . . ... . .. ..
----------------------------------------------GYGKCKCDWWSCGCILYEMLCGYPPFP---QMQMMFKKIG-------SPEAKDF
IQDMLKIQPSQRISISQVQQ---RLQQMQIF
|. .|. |..|... .. | ... |
IRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
|
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| Kinase | 26670.AA | Pkinase | 722-953 | 14 | 1.1e-18 | 67.21 | Pfam | 74-293 (293) | Show / Hide |
Range on Protein: 722-953
Range on HMM: 74-293/293
Sequence Identity: 14% (39 aa)
NILLIMDLKKS-----NLEQVLQ--ENLVL--SQSIAFRIASQVCSGICALHDHDIIHTNIKLKNILIDSNFNA----FITDWGISHLFSNEIDRNLDEF
.| ..|.. | ... .. .. | . ... |...|. .|.. ||| .|. |||||.| . |.|.|.. .|.. .. .. |
HIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTF
TTSLAFAAPELIQGISLERGSISGKSQFQENISSNFNQNITAYFSSNGENSNPNKENMFEENAVRTSRISNFSKESDVWSFGVVLLCLFFEFYPNEKS--
. .. ..|||.|. . ....|.||.|..| .... | .
CGTPWYMAPEVIR------------------------------------------------------GGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCW
--IKDINLYNGVTILNCNPKLQQIYS--------------------------LIQDMLKIQPSQRISISQVQQR--L
. .. . |. . .. . .. .| ..|. |..|... |. | .
HDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
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| Kinase | 26670.AA | Ciliate-E2-Unclassified | 712-822 | 21 | 3.1e-16 | 52.82 | In-house | 85-240 (352) | Show / Hide |
Range on Protein: 712-822 Range on HMM: 85-240/352 Sequence Identity: 21% (33 aa) KEHRTSKDPINILLIMDLKKS-NLEQVLQENLV-----------------LSQSIAF-----RIASQVCSGICALHDHD-IIHTNIKLKNILIDSN---F |.. . .| || ..|.. . .|.| .... .. | ... |...|.. || ||| .||. |||.|.| . KMFYCFQDKQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNY NAFITDWGISH--------------LFSNEIDRNLDEFTTSLAFA----APELIQG . |.|.||| ... .. ... |. .. . |||..|| YIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQG |
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| Kinase | 26670.AA | CAMK | 751-822 | 21 | 5.5e-15 | 44.03 | In-house | 183-294 (425) | Show / Hide |
Range on Protein: 751-822 Range on HMM: 183-294/425 Sequence Identity: 21% (24 aa) RIASQVCSGICALHDHDIIHTNIKLKNILIDSN-----------------FNAFITDWGISHLFSNEI----------------------DRNLDEFTTS |. |.||.. .|.|.|.| .|. |||.|.| .| |.|.| . | . . .| . RYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGT LAFAA-PELIQG ....| ||...| PEYMAAPEVLNG |
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| Kinase | 26670.AA | CAMKL | 751-822 | 35 | 6.7e-15 | 43.85 | In-house | 131-207 (297) | Show / Hide |
Range on Protein: 751-822 Range on HMM: 131-207/297 Sequence Identity: 35% (27 aa) RIASQVCSGICALHDHDIIHTNIKLKNILIDSNF--NAFITDWGISHLFS---NEIDRNLDEFTTSLAFAAPELIQG |. |..|.. .|.|.|.| ||. |||.|.| |. |.| | | .. . .. |..| |....|||..|| RYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYMAPEIFQG |
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| Kinase | 26670.AA | Ciliate-E1 | 721-821 | 22 | 7.5e-14 | 41.86 | In-house | 70-183 (202) | Show / Hide |
Range on Protein: 721-821 Range on HMM: 70-183/202 Sequence Identity: 22% (26 aa) INILLIMDLKKSNLEQVLQ-------------ENLVLSQSIAFRIASQVCSGICALHDHDIIHTNIKLKNILIDSNFNAFITDWGISHLFSNEIDRNLDE .....|... . .|.. || .. ... .|. | |...||.. ||| .|| .||||... | ..| |||... |. . . .. YICIIIFECCCCSLKDYLQNHNRLEYWQQCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYCDFGISKFLKNNQNQQCQY FTTSLAFAAPELIQ . .. || .. KGYTHYYYPPEQYN |
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| Kinase | 26670.AA | Ciliate-E2 | 718-822 | 17 | 1.8e-13 | 42.55 | In-house | 104-261 (365) | Show / Hide |
Range on Protein: 718-822 Range on HMM: 104-261/365 Sequence Identity: 17% (29 aa) KDPINILLIMDLKKS-NLEQVLQEN---------------LVLSQSIAFRIAS-----------QVCSGICALHDHD-IIHTNIKLKNILIDSNFNAFIT || || |.|.. . .|.. ...| . . | |.. ...... || ||| .||. |||. .|. KDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----IKII DWGISHLFSNEID-------RNLDEFTT------------------------SLAFAAPELIQG |.|.| .... . ... | .. . ||| ..| DFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNG |
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| Kinase | 26670.AA | NuaK | 743-822 | 35 | 5.6e-13 | 29.93 | In-house | 95-172 (252) | Show / Hide |
Range on Protein: 743-822 Range on HMM: 95-172/252 Sequence Identity: 35% (28 aa) VLSQSIAFRIASQVCSGICALHDHDIIHTNIKLKNILIDSNFNAFITDWGISHLFSNEIDRNLDEFTTSLAFAAPELIQG .|. | .. |. | . | | |.| || ||| | | || | | | | .... .. | | | .| || . | SLPEREARHFFRQIVSAVHYCHKHRICHRDLKLENILLDQNCNAKIADFGLSNYYHD--QKFLHTFCGSPLYASPEIVNG |
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| Kinase | 26670.AA | Ciliate-E3 | 722-826 | 28 | 7.4e-10 | 27.22 | In-house | 78-188 (202) | Show / Hide |
Range on Protein: 722-826 Range on HMM: 78-188/202 Sequence Identity: 28% (32 aa) NILLIMDLKKS-NLEQVLQENLVLSQSIAFRIASQVCSGICALHDHDIIHTNIKLKNILIDSNFN---AFITDWGISHLFSNEI--DRNLDEFTTSLAFA .| ..... .| .. ....| | |. |. |. |.| ||| || |||.|.| | . | | | | . ... .. .|.. .| MIFIVQEYCSNGDLYHYIK-QQNKTQNIIYDICIQIIQGMIAIHEKNIIHSDIKPDNILVDKNNNQLIIKICDFGESKQLRKNKGHTHTQYQGWTPF-YA APELIQ--GISLE |||. . ||.| APEQNDQQQISKE |
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| Kinase | 26670.AA | ULK | 733-794 | 30 | 5.6e-09 | 28.05 | In-house | 103-185 (324) | Show / Hide |
Range on Protein: 733-794 Range on HMM: 103-185/324 Sequence Identity: 30% (25 aa) NLEQVLQ---------ENLVLSQSIAFRIASQVCSGICALHDHDIIHTNIKLKNILIDSNFN------------AFITDWGIS .||| .. |. ||...| . | |.| .||.| ||| ||. |||| .. . |.| | . DLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFA |
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| Kinase | 26670.AA | ULK | 733-790 | 28 | 6.7e-09 | 27.29 | In-house | 106-185 (329) | Show / Hide |
Range on Protein: 733-790 Range on HMM: 106-185/329 Sequence Identity: 28% (23 aa) NLEQVLQ----------ENLVLSQSIAFRIASQVCSGICALHDHDIIHTNIKLKNILIDSNFN------------AFITD .||| .. |. ||...| . | ..| .||.| ||| ||. ||||. .. . |.| DLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIAD |
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| Kinase | 26670.AA | Ciliate-E2 | 881-951 | 18 | 8.1e-08 | 22.9 | In-house | 274-361 (365) | Show / Hide |
Range on Protein: 881-951 Range on HMM: 274-361/365 Sequence Identity: 18% (18 aa) SKESDVWSFGVVLLCLFFEFYPNEKSIKDINLYNGVTILNCNPKLQQI-----------------------YSLIQD----MLKIQPSQRIS-ISQVQQ ....|.||.||.| .. | .| |..|. .... ||. ||. .|..||. ..|. . DYKCDIWSLGVILYEMLFGKPPF-----------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILN |
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| TyrKc | 26670.AA | TyrKc | 644-953 | 15 | 1.4e-07 | -100.14 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 644-953
Range on HMM: 1-280/280
Sequence Identity: 15% (54 aa)
IRIKSMMRKGQFGSVHTIMYKDELYAAKQIQFVPRNFYDKLLEELKNNLEV--VHPTLFPILAVTKWYSNKEHRTSK-------DPINILLIMDLKKSNL
|. . . |.|| |. ..| . | | .. ...|.. .. || . ...| |.. .|. |.. .. .|
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVC---------TQQGRNFMYIEPLMIVMEY-MPHGDL
EQVLQENLV-LSQSIAFRIASQVCSGICALHDHDIIHTNIKLKNILIDSNFNAFITDWGISHLFSNE--------IDRN----LDEFTTSLAFAAPELIQ
. |... |. . .. |...| ||.. .|| . |.|...|. . |.| | | .. | . . ||| |
KDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-
GISLERGSISGKSQFQENISSNFNQNITAYFSSNGENSNPNKENMFEENAVRTSRISNFSKESDVWSFGVVLLCLF---FEFYPNEKS--IKDINLYNGV
.... |. .||||||||.. .| . ||.. .... ... |
---------------NYGK---------------------------------------FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYV
TILNCNPKLQQ------------IYSLIQDMLKIQPSQRISISQVQQRL
. |. . .|..... . .|..| . |.. ...
KQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
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| Kinase | 26670.AA | Ciliate-E2-Unclassified | 881-951 | 19 | 2.3e-07 | 21.65 | In-house | 246-348 (352) | Show / Hide |
Range on Protein: 881-951 Range on HMM: 246-348/352 Sequence Identity: 19% (20 aa) S--KESDVWSFGVVLLCLFFEFYPNE--------------------KSIKDINLYNGVTILNCNP-----KLQQIY-----SLIQDMLKIQPSQRISISQ | ...|.||.||.| .. | || . | .... . . . . . .. .... . |.| ||| .|..||...| SKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQ VQQ . . ILN |
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| Kinase | 26670.AA | ULK | 879-949 | 14 | 2e-06 | 18.24 | In-house | 231-323 (329) | Show / Hide |
Range on Protein: 879-949 Range on HMM: 231-323/329 Sequence Identity: 14% (14 aa) NFS-KESDVWSFGVVLLCLFFEFYP---NEKSIKD-----INLYNGVTI--------LNCN------PKLQQIYSLIQDMLKIQPSQRISISQV ... ...|.||.|... . . .| . .. . .. |. .. |... . ... .||. ||......|||. .. PYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISPECKDLIRRMLQYDEKDRISWEEL |
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| Kinase | 26670.AA | ULK | 879-949 | 16 | 3e-06 | 18.17 | In-house | 227-318 (324) | Show / Hide |
Range on Protein: 879-949 Range on HMM: 227-318/324 Sequence Identity: 16% (15 aa) NFS-KESDVWSFGVVLLCLFF-EFYPNEKSIKDIN----------------LYNGVTILN---CNPKL-QQIYSLIQDMLKIQPSQRISISQV ... ...|.||.|... . . . .... . | . .| . .||. ... .||. ||......|||. .. PYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKDLIRRMLQYDEKDRISWEEI |
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| Kinase | 26670.AA | Ciliate-E3 | 878-897 | 45 | 7e-06 | 14.64 | In-house | 183-202 (202) | Show / Hide |
Range on Protein: 878-897 Range on HMM: 183-202/202 Sequence Identity: 45% (9 aa) SNFSKESDVWSFGVVLLCLF ...||||| | |.|.. | QQISKESDYYSVGAVFCQLC |
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| Kinase | 26670.AA | CAMK | 881-951 | 16 | 7e-06 | 14.2 | In-house | 312-421 (425) | Show / Hide |
Range on Protein: 881-951 Range on HMM: 312-421/425 Sequence Identity: 16% (18 aa) SKESDVWSFGVVLLCLFFEFYPNEKS------------IKDINLYNGVTILNCN-PKLQ--------------------------QIYSLIQDMLKIQPS ....|.|| ||.| . ..| . . | .|. .. ... | . . .||. ||. |. GPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKDLIRKMLQVDPE QRISISQVQQ .|..|.|. . KRMTIEQCLN |
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| Kinase | 26670.AA | CAMKL | 882-951 | 23 | 8.5e-05 | 11.08 | In-house | 215-293 (297) | Show / Hide |
Range on Protein: 882-951 Range on HMM: 215-293/297 Sequence Identity: 23% (19 aa) KESDVWSFGVVLLCLFFEFYPNEKS-----IKDINLYNGVTILNCNPKLQ------QIYSLIQDMLKIQPSQRISISQVQQ .. |.|| ||.| . . .| . .|| . | | . . . .||. ||. |..|..| |. . PKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVSDCRDLIRKMLQVNPEKRPTIHQIMN |
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| Kinase | 26670.AA | NuaK | 931-949 | 36 | 0.051598 | 0.48 | In-house | 228-246 (252) | Show / Hide |
Range on Protein: 931-949 Range on HMM: 228-246/252 Sequence Identity: 36% (7 aa) LIQDMLKIQPSQRISISQV || .||...| .| .| .. LIRWMLMVNPRRRATIYDI |
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