Gene 27370 (Tetrahymena)

27370

Species: Tetrahymena
Alias: 27370, 84.m00131, 27, TTHERM_00607140, PreTt27370
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-D1

Sequence

Name Sequence Type Origin Length Description Download
27370.AA Protein None 591 None Fasta, JSON
27370.kin_dom Protein Kinase Domain None 151 None Fasta, JSON
27370.NA RNA None 1776 None Fasta, JSON

Protein domain

Protein domains of 27370.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 27370.AA TKL 424-578 20 9.7e-23 78.71 In-house 143-364 (364) Show / Hide 
Range on Protein: 424-578
Range on HMM: 143-364/364
Sequence Identity: 20% (45 aa)

SGCEYMSKMG--------ILHRDLQINNILIKLKGDDQDKENFEVEEIEHLKISDFGVSA-IEEDK---------------------QNIVKGSTRHYSP
.|..|.  |.        |.||||  .|||.. .. ... . . . .. ..||.||| |  .....                      . . |..|. .|
RGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAP

ESIEDKAN---------------YTEKADVFSFGALLYEIFYKHWVFSDCTVS--------ESCIKTKS--GELSRFD------------DTIPSQIKEI
| .... |               |.||.||.||| .|.||.   ....|   .        |  ..  .  |.    .            ...| ..|..
EVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKL

IQLTWKFDPKERITFSSLTQIL
.|  |. ||..| .|. ....|
MQDCWDHDPEKRPSFQEILKRL
Kinase 27370.AA Ciliate-E2 424-579 18 7.7e-20 64.78 In-house 171-361 (365) Show / Hide 
Range on Protein: 424-579
Range on HMM: 171-361/365
Sequence Identity: 18% (41 aa)

SGCEYMSKMG-ILHRDLQINNILIKLKGDDQDKENFEVEEIEHLKISDFGVSAIEEDKQN------IVK----------------------------GST
.. ||. . . |.|||.  .|||.                   .||.||| | .  |...      . |                            |. 
LALEYLHSKNNIIHRDIKPENILF-------------------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTP

RHYSPESIEDKAN--------YTEKADVFSFGALLYEIFYKHWVFSDCTVSESCIKTKSGELSRFD------------------DTIPSQIKEIIQL---
   .|| .. | .        |..|.|..|.| .|||  .. . |         .. .     .|.                  . .. . | .|.    
GYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF---------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGK

-TWKFDPKERITFSSLTQILQ
   . ||..|||  .  |||.
RMLQKDPEKRIT--GWEQILN
Kinase 27370.AA Pkinase 427-580 24 3.3e-16 58.39 Pfam 122-290 (293) Show / Hide 
Range on Protein: 427-580
Range on HMM: 122-290/293
Sequence Identity: 24% (44 aa)

EYMSKMGILHRDLQINNILIKLKGDDQDKENFEVEEIEHLKISDFGVSA---IEEDKQNIVKGSTRHYSPESIEDKANYTEKADVFSFGALLYEIFYKHW
||. .|||.||||   ||||. .|.  .          ..||.|||...   .  .  . . |. .  .|| | .   |. |.|..|.| .||| . .. 
EYCHSMGIIHRDLKPENILIDNNGHIDA----------CVKICDFGLAKQFDY-NNSMTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRP

VFSDC------TVSESCIKTKSGELSRFDDTI--------------------PSQIKEIIQLTWKFDPKERITFSSLTQILQQ
 |...      .  .   ......|..  ..                     ..  |..|   ...|||.|.|    .|||| 
PFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT---AEQILQH
Kinase 27370.AA TK 424-519 19 1.9e-14 44.1 In-house 245-388 (486) Show / Hide 
Range on Protein: 424-519
Range on HMM: 245-388/486
Sequence Identity: 19% (29 aa)

SGCEYMSKM------GILHRDLQINNILIKLKGDDQDKENFEVEEIEH----LKISDFG--------VSAIEEDKQNIVKGSTRH---------------
.|.||....      .. ||||   |.|.  .. .  . .      ..     ||.|||         .   ..... .. |..                
CGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWH-F------DGCGPVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQD

--------------YSPESIED--------KANYTEKADVFSFGALLYEIF
              ..||...|        .  .|.| ||.||| |..|||
YYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIF
Kinase 27370.AA CAMK 424-516 24 9.1e-14 40.04 In-house 190-325 (425) Show / Hide 
Range on Protein: 424-516
Range on HMM: 190-325/425
Sequence Identity: 24% (33 aa)

SGCEYMSKMGILHRDLQINNILIKLKGDDQDK----ENFEVEEIEHLKISDFGVSAI--------------------------EEDKQNIVKGSTRHYS-
|. .|. ...| ||||   |||.  ..||.|.    | |  ..   .||.||| ...                          | .| . . |.    . 
SAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFD-WNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAA

PESIED-------------KANYTEKADVFSFGALLY
|| ..              |  |..|.|. | | .||
PEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILY
S_TKc 27370.AA S_TKc 342-582 19 1.4e-13 22.29 SMART 1-231 (231) Show / Hide 
Range on Protein: 342-582
Range on HMM: 1-231/231
Sequence Identity: 19% (56 aa)

QKNKDFLGSGLQARVISMKYQIEELKEIEVAVKMVKFENQISRRQATFYRDLRGVWRCNGHPNIVQAYGAGNYKEIGYIVLE--SG-----CEYMSK---
 .  . .|.|  ..|   .         .||.|..|          ...| ..   .  .|||||. |..    .  |.|.|  .|      .|. |   
YEILRKIGKGAFGKVYKCRHKK---TGRIVAIKIIK---------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGR

---------------------------MGILHRDLQINNILIKLKGDDQDKENFEVEEIEHLKISDFGVSAIEEDKQNIVKGSTRHYSPESIEDKANYTE
                           .||.||||   |||.                  |.||.|||....     . . |.    .|| .     |. 
HGLRFPFPEHARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----------------HIKICDFGLARQL----TTFCGTPWYMAPEVL----GYGK

-KADVFSFGALLYEIFYKHWVFSDCTVSESCIKTKSGELSRFDDTIPSQIKEIIQLTWKFDPKERITFSSLTQ-----ILQQYT
 |.|. |.| .||| ..    |.     .  .  | |         ... |..|.  ...||..|.|   . |      . .. 
CKCDWWSCGCILYEMLCGYPPFP----QMQMMFKKIG---------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 27370.AA RAF 433-578 18 1.5e-13 42.74 In-house 120-275 (275) Show / Hide 
Range on Protein: 433-578
Range on HMM: 120-275/275
Sequence Identity: 18% (32 aa)

GILHRDLQINNILIKLKGDDQDKENFEVEEIEHLKISDFGVSAIE----E----DKQNIVKGSTRHYSPESIEDK-----------ANYTEKADVFSFGA
.|.||||  .||..              ..   ..| ||| . ..    .    ..... .|.. . .|| |                .....||..|| 
NIIHRDLKSKNIFL--------------HNGKVVVITDFGLFTVKRCRWCKRRKQQLCQPHGWICWMAPEVIRMMRPDWDEYQCDCNPFSFQSDVYAFGT

LLYEIFYKHWVFS-DCTVSESCIKTKSGELSRF----DDTIPSQIKEIIQLTWKFDPKERITFSSLTQIL
 .||.   .| .. .. .     .. .|.|. .      ..|. .||...  |...|.|| .|. .   .
VWYELMAGEWPYQHIQWHEQIIWMVCRGYLRMDRSKARVQCPKEMKELLMECWSYQPEERPSFQQIMKMI
Kinase 27370.AA Ciliate-E2-Unclassified 433-576 20 2e-13 42.97 In-house 164-348 (352) Show / Hide 
Range on Protein: 433-576
Range on HMM: 164-348/352
Sequence Identity: 20% (41 aa)

GILHRDLQINNILIKLKGDDQDKENFEVEEIEHLKISDFGVSAIEED---------------KQNIVKGS--TRHY-----SPESIEDKANYT---EKAD
.|.|||.. .|||.. .|              ..||.||| |   ..               ||.. .    |  |     .|| .. . ...   .|.|
NIIHRDIKPENILFDNNGK-----------NYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCD

VFSFGALLYEIFYKHWVFS--DCTV----------------SESCIKTKSGELSRFD-----DTIPSQIKEIIQ----LTWKFDPKERITFSSLTQ
..|.| .|||. .  . |.  .|.                  .. || |  . . |.     .... . |..|.       | .|..||||. . .
IWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILN
Kinase 27370.AA STE 427-517 22 7.3e-13 41.86 In-house 166-260 (359) Show / Hide 
Range on Protein: 427-517
Range on HMM: 166-260/359
Sequence Identity: 22% (26 aa)

EYMSKMGILHRDLQINNILIKLKGDDQDKENFEVEEIEHLKISDFGVSAIEED-------------------KQNIVKGSTRHYSPESIED-----KANY
.|  ...| |||.   |||.                    |..||||... .|                   | | . |.  . .|| |.      .  |
YYLHSHHIIHRDIKPANILL-------------------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGY

TEKADVFSFGALLYE
..|.|. |.| .. |
DTKCDIWSLGCTIIE
Kinase 27370.AA TyrKc 342-578 23 5.2e-12 -28.49 SMART 1-280 (280) Show / Hide 
Range on Protein: 342-578
Range on HMM: 1-280/280
Sequence Identity: 23% (71 aa)

QKNKDFLGSGLQARVISMKYQIEELKEIEVAVKMVKFENQISRRQATFYRDLRGVWRCN--GHPNIVQAYGAGNYK-------EIGYIVLE---------
 . .. ||.|   .|   ..       |.|||||.| .      .. |.| .| . .     |||||. ||.   .       |  .||.|         
ITLGKKLGEGAFGEVYKGTWK------IQVAVKMLKEDA-----REDFMREAR-IMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

----------------------SGCEYMSKMGILHRDLQINNILIKLKGDDQDKENFEVEEIEHLKISDFGVSAIEEDK-------QNIVK----GST--
                      .|.|| ..... ||||   |.|.. ..              . |||||| |   .|.       . ..|    |.   
YLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH--------------TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTM

---RHYSPESIEDKANYTEKADVFSFGALLYEIF------YKHWVFSDCTVSESCIKTKSGELSRFDDT--------IPSQIKEIIQLTWKFDPKERITF
   | ..||.| ..  .|.| ||.||| ...|||      |   .. ... .|   . |.|.  .  .          |. . .|..  |..||..| ||
LPIRWMAPECI-NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTF

SSLTQIL
| . ...
SEIHECF
Kinase 27370.AA TK-Unique 427-519 28 2.5e-10 31.95 In-house 145-233 (294) Show / Hide 
Range on Protein: 427-519
Range on HMM: 145-233/294
Sequence Identity: 28% (29 aa)

EYMSK--MGILHRDLQINNILIKLKGDDQDKENFEVEEIEHLKISDFGVS------AIEEDKQNIVKGSTRHYSPESIE--DKANYTEKADVFSFGALLY
||...  ..| ||||   |.|.                   .||.||| .         . ..   . . |. .|||.   ..  .|.| || ||| |..
EYLASQRKKIVHRDLCARNVLLTE--------------DKVCKICDFGMARDVYTNGVYSMMCSQGRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMW

EIF
|||
EIF
Kinase 27370.AA HH498 434-519 31 4.1e-10 27.86 In-house 145-220 (284) Show / Hide 
Range on Protein: 434-519
Range on HMM: 145-220/284
Sequence Identity: 31% (29 aa)

ILHRDLQINNILIKLKGDDQDKENFEVEEIEHLKISDFGVS----AIEEDKQNIVK--GSTRHYSPESIEDKANYTEKADVFSFGALLYEIF
| ||||   ||||   |              | .. ||| |     ...|  |. |  |  |  .||       |..|.||||..  ..|..
IIHRDLNSHNILIHEDG--------------HAVVADFGESRFVCDMHDD--NMTKQPGNLRWMAPEVFSQCQKYSIKVDVFSYAMCIWEMH
Kinase 27370.AA MLK 434-519 32 1.6e-09 29.3 In-house 148-230 (291) Show / Hide 
Range on Protein: 434-519
Range on HMM: 148-230/291
Sequence Identity: 32% (30 aa)

ILHRDLQINNILIK-LKGDDQDKENFEVEEIEHLKISDFGVSA-IEEDKQNIVK--GSTRHYSPESIE--DKANYTEKADVFSFGALLYEIF
| ||||   ||||           . . .. ..|||.|||.|  . . ..|  .  |. .  .|| |.      |.||.||.|.| .|.|..
IIHRDLKSHNILIDEIC-------H-DMHH-GTLKICDFGTSRDWHQMCTNMMSNAGTYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEML
Kinase 27370.AA Pkinase_Tyr 424-519 30 2.9e-09 31.98 Pfam 122-208 (270) Show / Hide 
Range on Protein: 424-519
Range on HMM: 122-208/270
Sequence Identity: 30% (31 aa)

SGCEYMSKMGILHRDLQINNILIKLKGDDQDKENFEVEEIEHLKISDFGVSAIE--EDKQNIVKGS-----TRHYSPESIEDKANYTEKADVFSFGALLY
.|.|| . ... ||||   |.|..             |.  . ||.||| .     .|   ..|..      . ..||.| ..  .|.| || ||| |..
KGMEYLESKNCIHRDLAARNCLVT-------------ENN-VVKICDFGLARDIYNDDYY-YRKRGGGKLPIKWMAPECINYGK-FTTKSDVWSFGVLMW

EIF
|||
EIF
Kinase 27370.AA Pkinase_Tyr 550-578 34 4e-06 21.34 Pfam 242-270 (270) Show / Hide 
Range on Protein: 550-578
Range on HMM: 242-270/270
Sequence Identity: 34% (10 aa)

PSQIKEIIQLTWKFDPKERITFSSLTQIL
|  | ..... |..||..| ||| . ..|
PDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase 27370.AA TK 550-578 37 4e-06 15.71 In-house 458-486 (486) Show / Hide 
Range on Protein: 550-578
Range on HMM: 458-486/486
Sequence Identity: 37% (11 aa)

PSQIKEIIQLTWKFDPKERITFSSLTQIL
|  . ...|  |..||..| ||| | . |
PEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase 27370.AA MLK 342-411 24 3.6e-05 14.04 In-house 1-77 (291) Show / Hide 
Range on Protein: 342-411
Range on HMM: 1-77/291
Sequence Identity: 24% (19 aa)

QKNKDFLGSGLQARVISMKYQIEELKEIEVAVKMVKF-------ENQISRRQATFYRDLRGVWRCNGHPNIVQAYGA
 ... ..||| .  | . ... ..    .||||.|..       .  ...   .. | || ... | ||.|.| ||.
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGV
Kinase 27370.AA MLK 548-578 32 0.000307 10.76 In-house 261-291 (291) Show / Hide 
Range on Protein: 548-578
Range on HMM: 261-291/291
Sequence Identity: 32% (10 aa)

TIPSQIKEIIQLTWKFDPKERITFSSLTQIL
|.|  .|. ..  |. ||..| .|..  |.|
TCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase 27370.AA TK-Unique 550-578 20 0.000538 9.81 In-house 266-294 (294) Show / Hide 
Range on Protein: 550-578
Range on HMM: 266-294/294
Sequence Identity: 20% (6 aa)

PSQIKEIIQLTWKFDPKERITFSSLTQIL
. .. .... .|. .|.|| .|......|
SHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase 27370.AA HH498 548-578 31 0.00054 8.11 In-house 250-284 (284) Show / Hide 
Range on Protein: 548-578
Range on HMM: 250-284/284
Sequence Identity: 31% (11 aa)

T----IPSQIKEIIQLTWKFDPKERITFSSLTQIL
|    || ..  .||  |   | .| .|.    ||
TPTAQIPHHWSNLIQMCWHPCPENRPDFDQIVTIL
Kinase 27370.AA TKL 348-423 19 0.003781 7.2 In-house 1-118 (364) Show / Hide 
Range on Protein: 348-423
Range on HMM: 1-118/364
Sequence Identity: 19% (23 aa)

LGSGLQARVISMKYQIEE-----LKEIEVAVKMVKFEN-Q--------------------ISRRQATFYRDLRGVWRCNG---HPNIVQAYGAGNYKEIG
.|||  . |   |.. .      ..  .||||. | .| .                    ... .  |   .. ....     |||||| .|. .. . |
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

-------------YIVLE
             .|| |
CVCMHPVGPWGQLCIVME
Kinase 27370.AA STE 342-423 17 0.008919 5.78 In-house 1-117 (359) Show / Hide 
Range on Protein: 342-423
Range on HMM: 1-117/359
Sequence Identity: 17% (20 aa)

QKNKDFLGSGLQARVISMKYQ----IEELKEI--------EVAVKMVKFENQ---------------ISRRQATFYRDLRGVWRCNG-HPNIVQAYGAGN
... ...|.|    |   ..     |.. .|.         .|.| ...||.                .  .  . ....   .||  |||||. ||.  
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

YK-------EIGYIVLE
..       .  .|..|
KEGHNHKNDDELWICME