Gene 28991 (Tetrahymena)
28991
Group:
Other
Family:
Ciliate-D1
Sequence
Protein domains of 28991.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 28991.AA | TKL | 584-834 | 13 | 3.6e-18 | 62.02 | In-house | 1-364 (364) | Show / Hide |
Range on Protein: 584-834
Range on HMM: 1-364/364
Sequence Identity: 13% (49 aa)
IKKGDLGAIYGVRYNSEY----------YAAKVITFIS--------------------------QKQLKQFIDFQNKL---PNCLNLLSILGYSISQNK-
| .| | .| ... . | |.. . ......|. .. .. .. |.....||... ..
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG
-------DGAVNLYLISE-IRRSNLESSMQKNELTKLEQRFKIFEQLLDCVNMLHKNN--------IYHSNIKDTNILLDSQCN--------------VY
.. .|... | . . .|.. .. ..||... . .| || .| | | ..| |||.|. . .
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCK
LSDLAVSRVLKDYE---------------------FGENSFKEPYGAPEQMNQEEPNNG--------------KPSDIWAVGIVCLQLFTNIQQY-----
..|. ||... . . . ||| ........ . .|... ||| ..| . |
ICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPY
TPQKIKELNIYSNNDFKINSVSSSPIPEI----------NQLENQIILFIESLLRQDPKKRLSAKDAVKKF
|... . . .. |||.| .. ... .. .||.||.|... .|..
MPMIFQDP-FEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
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| Kinase | 28991.AA | Ciliate-E1 | 584-757 | 20 | 7.1e-17 | 51.81 | In-house | 1-202 (202) | Show / Hide |
Range on Protein: 584-757 Range on HMM: 1-202/202 Sequence Identity: 20% (41 aa) IKKGDLGAIYGV--RYNSEYYAAKVITFISQKQLKQFIDFQNKLPN-CLNLLSILGYSISQNKDGAVNLYLIS-EIRRS---NLESSMQ----------- |..|. . .. . |... |..| . ... .. .....| . .. . |.| . . ...|. .| .. .|. .| IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYWQQC --KNELTKLEQRFKIFEQLLDCVNMLHKNNIYHSNIKDTNILLDSQCNVYLSDLAVSRVLK---DYEFGENSFKEPYGAPEQMN------QEEPNNGKPS .. . .| .|. ||.| ...|| .||.|..|| .||| ..| | ..|...|..|| ... .. ... | |||.| ... . .. | QQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYCDFGISKFLKNNQNQQCQYKGYTHYYYPPEQYNCPEQEHNKNQKINYKS DIW || DIY |
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| Kinase | 28991.AA | S_TKc | 578-840 | 18 | 8.9e-15 | 39.79 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 578-840 Range on HMM: 1-231/231 Sequence Identity: 18% (52 aa) IKLKSMIKKGDLGAIYGVRYNS--EYYAAKVITFISQKQLKQFIDFQNKLPNCLNLLSILGYSISQNKDGAVNLYLISEIRRS---NLESSMQKNE---- .. | || | | .| .. ...| |.| ..... |. | .. |. .... . .||.. | .| . ..|. YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----EHIRREIQILKK--HHPNIVKLYDVFQD------DHLYMVMEYCDGDLGDLFDYIKKRGRHGL ---LTKLEQRFKIFEQLLDCVNMLHKNNIYHSNIKDTNILLDSQCNVYLSDLAVSRVLKDYEFGENSFK--EPYGAPEQMNQEEPNNGK-PSDIWAVGIV .. . || .. |... .. .|...| | .| |||||. .. ..| ..|.| ..| | ||| . || ..|.|..|.. RFPFPE-HARF-YMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL-----GYGKCKCDWWSCGCI CLQLFTNIQQYTPQKIKELNIYSNNDFKINSVSSSPIPEINQLENQIILFIESLLRQDPKKRLSAKDAVK---KFESIKLI ... . | . ... . . ||. .|. ||.||..| .| . . . . LYEMLCGYPPFP-QMQMMFKKIG--------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | 28991.AA | Pkinase | 673-834 | 15 | 1.8e-14 | 52.23 | Pfam | 108-293 (293) | Show / Hide |
Range on Protein: 673-834 Range on HMM: 108-293/293 Sequence Identity: 15% (32 aa) EQRFKIFEQLLDCVNMLHKNNIYHSNIKDTNILLDSQCNV----YLSDLAVSRVLKDYEFGENSFKEPYG-----APEQMNQEEPNNGKPSDIWAVGIVC .. ... |.| .. .|...| | .| |||.|..... ..| ...... | .. .. . | ||| . . . |...|.|..|... WECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS--MTTFCGTPWYMAPEVIR-GGQYYGPKVDMWSCGCIL LQLFTNIQQYTPQKIKELNIYSNN--------DFKINSVSSSPIPEINQLE---------------------NQIILFIESLLRQDPKKRLSAKDAVKK- .... .... ...|. . . |... . . . ||...|..|||||..|..... YEMLCGR-----------PPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHP -F | WF |
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| Kinase | 28991.AA | Ciliate-E2-Unclassified | 578-832 | 14 | 4.4e-14 | 45.28 | In-house | 1-348 (352) | Show / Hide |
Range on Protein: 578-832
Range on HMM: 1-348/352
Sequence Identity: 14% (50 aa)
IKLKSMIKKGDLGAIYGVRYNSEY------YAAKVITFISQKQLKQFIDFQNK--LPNCLN-------------LLS-------ILGYSISQNKDGAVNL
|. | .| | .| .. .... |. |.. . ....... .. |. |... .|. . . . |.|. |.
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQ---NI
YLISEI-----RRSNLESSMQ----KNELTKLEQR---F-----------KIFEQLLDCVNMLHKNN-IYHSNIKDTNILLDSQC---NVYLSDLAVSR-
|.. | . ...... .|.| . .. | ..| |.|.. . ||..| | | .|| |||.|... .. ..|. |.
YIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKK
----------------VLKDYEFGENSFKEPYG----APEQMNQEEPNNG--KPSDIWAVGIVCLQLFTNIQQYTPQKIKELNIYSN---------NDFK
..|. .. .. | ||| . ...... . .|||..|... .. .. . .. .. ..... . ..
YQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQ
INSVSSSPIPEIN------QLENQIILFIE----SLLRQDPKKRLSAKDAVK
. .|. . .. .. . ||. ..| .|.||...... .
NIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILN
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| Kinase | 28991.AA | Ciliate-E6 | 665-760 | 25 | 6.6e-13 | 37.73 | In-house | 42-154 (154) | Show / Hide |
Range on Protein: 665-760 Range on HMM: 42-154/154 Sequence Identity: 25% (29 aa) QKNELTKLEQR---FKIFEQLLDCVNMLHKNNIYHSNIKDTNILLDSQCNVYLSDLA-----VSRVLK-DYEFGENSFKEPYGAPEQMN--------QEE |. ...|. ||. ||. |. ||..|....||. || || . |. ..| .. .. . . | |..| .||| . .. QHKNKKQINQNDQFFKFCCQLFHAVEYLHSKNYVLQNITLKNIFLDKNMNIKICDFGFQQCIIPNQQTKEFMAQKNQNKYHYCPPEQFDYSKDQQSKHYK PNNGKPSDIWAVG | . .||| |. VNWTQEGDIWSVC |
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| Kinase | 28991.AA | Ciliate-E2 | 648-832 | 15 | 2.1e-12 | 38.9 | In-house | 108-361 (365) | Show / Hide |
Range on Protein: 648-832 Range on HMM: 108-361/365 Sequence Identity: 15% (42 aa) NLYLISEIRRS-NLESSMQKN---ELTK--------LEQRFKIFEQLLD---------------CVNMLHKNN-IYHSNIKDTNILLDSQCNVYLSDLAV |.||. | .|.. ...| .. . .... .|..|.|. ... ||..| | | .|| |||. . ..|. NIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----IKIIDFGL SR---------------VLKDYEFGENSFKEP-------------------YGAPEQMNQEEPN-------NGKPSDIWAVGIVCLQLFTNIQQYTPQKI |. .. . ....| | ||| | .. . .. .|||..|.. .. .. . |.| SKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF-QQQI KELNIYSNNDFKINSVSSSPIPEIN-----QLENQIILFIES----LLRQDPKKRLS-AKDAVK |. .| .. .... . .| ... ..... . .| .| ||.||.. .... . KQCKIDFPCPEWQKD-TQ-CI-QCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILN |
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| Kinase | 28991.AA | C8 | 664-763 | 25 | 3e-12 | 38.93 | In-house | 113-226 (226) | Show / Hide |
Range on Protein: 664-763 Range on HMM: 113-226/226 Sequence Identity: 25% (29 aa) MQKNELT-KLEQRFKIFEQLLDCVNMLHKNNIYHSNIKDTNIL--LDSQCN--VYLSDLAVSRVLKDYEFGENSFK------EPYGAPEQMNQ---EEPN ...... . |....| |..|.||..| || | || |.| || . . . |.|.... ... . | | | |||.... . RRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSKKMNTCGTWAYFAPEIEKKQDNQYKQ NGKPSDIWAVGIVC . . ||.. ||.| YRIQSDLFSVGLVL |
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| Kinase | 28991.AA | CAMK | 677-763 | 18 | 2.3e-11 | 32.17 | In-house | 183-324 (425) | Show / Hide |
Range on Protein: 677-763 Range on HMM: 183-324/425 Sequence Identity: 18% (26 aa) KIFEQLLDCVNMLHKNNIYHSNIKDTNILLDSQ-----------------CNVYLSDLAVSRVLKDYE-------------------------FGENSFK ..| |... |. .|..|| | .| |||||. .|. ..| ...... | . . RYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGT EPYGA-PEQMNQE------------EPNNGKPSDIWAVGIVC .| | || |.. .| |...|.|..|... PEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVIL |
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| Kinase | 28991.AA | Ciliate-B2 | 676-760 | 28 | 6.5e-11 | 21.79 | In-house | 107-197 (197) | Show / Hide |
Range on Protein: 676-760 Range on HMM: 107-197/197 Sequence Identity: 28% (26 aa) FKIFEQLLDCVNMLHKNNIYHSNIKDTNILLDSQCNVYLSDLAVSRVLK-DYEFGENSFKEPYGAPEQMNQE-----EPNNGKPSDIWAVG .... ||.| .. .|| | || .|||. .. | ..| .| . | . | | ||||.. .| |||. | YQMIFQLIDGLIQFRMYNILHLDIKPQNILFMQNGNYVYCDFGISSIKKDNQQIKIKGFTKKYASPEQMECDHNQTFVTNIDFQSDIYSMG |
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| Kinase | 28991.AA | Ciliate-C8 | 673-763 | 25 | 1.5e-09 | 30.72 | In-house | 119-238 (238) | Show / Hide |
Range on Protein: 673-763 Range on HMM: 119-238/238 Sequence Identity: 25% (31 aa) EQRFKIFEQLLDCVNMLHKNNIYHSNIKDTNIL--LD--SQCNVYLSD------LAVSRVLKDYEF--------GENSFKEP-------YGAPEQMNQ-- .. ..| | .|.|| || .|| | || |.| .| .| . |.| .. .. |.. . |. | | |||.... QMKEIIAIQMIDSVNYLHCFNIMHRDIKPHNFLVCFDQQYQPTIKLCDFKKQCDFGFASQLPKNKSHYHSKKFKGTDQYIEMYFCGNWGYFAPEVEKKQS --EEPNNGKPSDIWAVGIVC . | ||.. ||.| RIQSDIFSKKSDSYSVGLVL |
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| Kinase | 28991.AA | GIN4 | 677-768 | 29 | 2.5e-08 | 22.26 | In-house | 138-230 (293) | Show / Hide |
Range on Protein: 677-768 Range on HMM: 138-230/293 Sequence Identity: 29% (27 aa) KIFEQLLDCVNMLHKNNIYHSNIKDTNILLDSQCN-VYLSDLAVSRVLKDYEFGENSFKEPYGAPEQMNQEEPNNGKPSDIWAVGIVCLQLFT ..| |.. | | || | .| |.|||.. | . . | . . | . | | | | . | .| .||.|. |.. | | HYFRQIIIGVSYCHAFNICHRDLKPENLLLDHKYNRIKIADFGMAALETDNKLLETSCGSPHYAAPEIVMGIPYHGFASDVWSCGVILFALLT |
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| Kinase | 28991.AA | TyrKc | 578-834 | 18 | 1.3e-05 | -131.85 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 578-834 Range on HMM: 1-280/280 Sequence Identity: 18% (54 aa) IKLKSMIKKGDLGAIYGVRYNSEYYAAKVITFISQKQLKQFIDFQNKL-PNCLNLLSILGYSISQ--NKDGA---VNLYLISEI-RRSNLESSMQKNEL- |.|. .. | | .| ... . | |.. ... . . . || .. |.. ..|. ..| | |... | .| . .|.. ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN---FMYIEPLMIVMEYMPHGDLKDYLRKHRPK TKLEQRFKIFEQLLDCVNMLHKNNIYHSNIKDTNILLDSQCNVYLSDLAVSRVLKDY--------EFGEN---SFK--EPY--GAPEQMNQEEPNNG--- .... .. | . . ||..|. | . |.|.... | || || ..|. . | |. ||| . | | LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-----NYGKFT KPSDIWAVGIVCLQLFTNIQQYTPQKIKELNIYSNNDFKINSVSSSPIPEINQ--------LENQIILFIESLLRQDPKKRLSAKDAVKKF ||.|. |... .||. || | |.. || . . . | . ... . ||..| . .. ...| TKSDVWSFGVCMWEIFTYGQQPYPGMIQQ--MMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF |
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| Kinase | 28991.AA | CAMK | 812-832 | 28 | 0.001804 | 6.25 | In-house | 401-421 (425) | Show / Hide |
Range on Protein: 812-832 Range on HMM: 401-421/425 Sequence Identity: 28% (6 aa) FIESLLRQDPKKRLSAKDAVK .| ..|. ||.||...... . LIRKMLQVDPEKRMTIEQCLN |
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