Gene 29059 (Tetrahymena)
29059
Group:
Other
Family:
Ciliate-D1
Sequence
Protein domains of 29059.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| S_TKc | 29059.AA | S_TKc | 60-342 | 14 | 7.5e-11 | -17.79 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 60-342
Range on HMM: 1-231/231
Sequence Identity: 14% (46 aa)
FEDFEVIAT--------VQEKSTEDMKKFTVKIFFNRLRNECLFDIFDHSPEATIQNEQDKRQLKLEAQNLQKCIHDNIVQIHSYYIQDGISYIFMEECK
.| ..| ...|. . ... .|| .... | | |.| |.|||... .. . |..|| |
YEILRKIGKGAFGKVYKCRHKK--TGRIVAIKIIK--------------------------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCD
Y---SLAQCIEYRHH------LSEIQIIEIISELVSGMSYLHQHNLLVGDFNFQNILYDSQNKLKIT----SLIFNKASLINGKFCLYKKSFYQQLNPIF
.| . |. | . ..| .. .. ...... |.|.|. . | .||| |. .||. . .. . | .
GDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----------------TTFCGTPWY
LPPHIKKIVVQFHEDHDESLFDDHSIIYDQ-SCDIWGLGILIYILMGQHIDFVKQYGIRRDTSTYKEIPSMSQELNKLAKQMLDCENSINLTIFDIKT--
..| . |. .||.| .|...|... | . ..| | |.|. . ...|. . . .|. .. .
MAPEVL--------------------GYGKCKCDWWSCGCILYEMLCGYPPFP------QMQMMFKKIG--SPEAKDFIRKCLQKDPEKRPTA-EALQDE
--MLNNSVI
. .
WDIKCHPWF
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| Kinase | 29059.AA | STE | 108-187 | 25 | 3.2e-10 | 32.43 | In-house | 68-172 (359) | Show / Hide |
Range on Protein: 108-187 Range on HMM: 68-172/359 Sequence Identity: 25% (27 aa) NEQDKRQLKLEAQNLQKCI--HDNIVQIHSYYIQDG-------ISYIFMEECK-YSLAQCIEYR--------------HHLSEIQIIEIISELVSG-MSY |.... |.. | . ..|| |.|||. . .|...| .|.|| . || . |. . |...| ||. |. ... | ..| NHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYY LHQHN ||.|. LHSHH |
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| Kinase | 29059.AA | Ciliate-E2 | 106-283 | 16 | 9.1e-10 | 29.69 | In-house | 61-290 (365) | Show / Hide |
Range on Protein: 106-283
Range on HMM: 61-290/365
Sequence Identity: 16% (42 aa)
IQNEQDKRQLK---------LEAQNLQKCIHDNIVQIHSYYI--QDGISYIFMEECKY-SLAQCIE------------YRHHLSEIQIIEIISELVS---
.| .| ..... | ..|.. |.||.... ... .| |. || |.. .| ..|. . . ..| .|..|. ....
EQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFK
------------GMSYLHQHN-LLVGDFNFQNILYDSQNKLKITSLIF-------NKASLINGKFCLYKKSFY---------------------QQLNPI
.. |||. | . | .|||. .||. . . |. .. .. | .. . .|
TKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----IKIIDFGLSKKYDDDNQNRTH-KQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPG
FLPPHIKKIVV---QFHEDHDESLFDDHSIIYDQSCDIWGLGILIYILM
...| | . | . || .|||| ||...|...
YMAPEILNGKKYDNQ-----------QKQKGYDYKCDIWSLGVILYEML
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| Kinase | 29059.AA | TKL-ciliate1 | 164-209 | 31 | 1.1e-09 | 29.38 | In-house | 100-147 (279) | Show / Hide |
Range on Protein: 164-209 Range on HMM: 100-147/279 Sequence Identity: 31% (15 aa) LSEIQIIEIISELVSGMSYLHQHN--LLVGDFNFQNILYDSQNKLKIT ....... .. .. ||.|||. . | | |||||| . ||. IKWQHRMRWCKDIAQGMQYLHMRQNPLIHRDLKMQNILYDEPYQYKIC |
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| Kinase | 29059.AA | Ciliate-A1 | 136-208 | 31 | 1.2e-09 | 29.0 | In-house | 67-142 (301) | Show / Hide |
Range on Protein: 136-208 Range on HMM: 67-142/301 Sequence Identity: 31% (24 aa) YYIQD--GISYIFMEECKYSLAQCIEYRHH-LSEIQIIEIISELVSGMSYLHQHNLLVGDFNFQNILYDSQNKLKI || . . .| || |.| . . | .....|.|| . ...|.. .| || | | |||| .| || YYNTNNKECMFIIMEYCQYGNLFNYCYQNDYMKKEEIYEICYQIIEGYADIHDHNILHRDLKPQNILIHFDDKWKI |
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| Kinase | 29059.AA | Ciliate-E6 | 119-208 | 27 | 3.1e-09 | 25.91 | In-house | 1-94 (154) | Show / Hide |
Range on Protein: 119-208 Range on HMM: 1-94/154 Sequence Identity: 27% (26 aa) AQNLQKCIHDNIVQ-IHSYYIQDGISYIFMEECKYSLAQCIE---YRHHLSEI-QIIEIISELVSGMSYLHQHNLLVGDFNFQNILYDSQNKLKI .|||. | | ||.. . | |.. . .| || |...| . |. .. . | . . .|.....|||. |.. . . .|| .| . ..|| IQNLKNCNHPNILKYMDSFQIENYY-FIVMERCEMNLQDWIHQHKNKKQINQNDQFFKFCCQLFHAVEYLHSKNYVLQNITLKNIFLDKNMNIKI |
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| Kinase | 29059.AA | Ciliate-E1 | 106-233 | 21 | 1.5e-08 | 24.4 | In-house | 32-179 (202) | Show / Hide |
Range on Protein: 106-233 Range on HMM: 32-179/202 Sequence Identity: 21% (32 aa) IQNEQDKRQLKLEAQNLQKCIH--DNIVQIHSYYI--QDGISYIFMEECKYSLAQCIE-------------YRHHLSEIQIIEIISELVSGMSYLHQHNL ..|.... ... | ....| . ..|.|| |.. | |..| .|.|..|| . .. ... |...|| |. | ..|||.|. NYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYWQQCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNI LVGDFNFQNILYDSQNKLKIT----SLIFNKASLINGKFCLYKKSFYQQ . .| . ||||...|...... |..... .. . .. |....|.. IHRDIKPQNILINNQGNYVYCDFGISKFLKNNQNQQCQYKGYTHYYYPP |
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| Kinase | 29059.AA | TAO | 118-208 | 25 | 5.4e-08 | 21.91 | In-house | 49-140 (254) | Show / Hide |
Range on Protein: 118-208 Range on HMM: 49-140/254 Sequence Identity: 25% (23 aa) EAQNLQKCIHDNIVQIHSYYIQDGISYIFMEECKYSLAQCIE-YRHHLSEIQIIEIISELVSGMSYLHQHNLLVGDFNFQNILYDSQNKLKI | . ||. | |... .. |... ... || | | . .. .. . |. | | .. ..|..|||.|... | ||| . |. EVRFLQQVKHPNCIEYKGCYLREHTCWLVMEYCLGSASDILDVHKKPMQEVEIAAICHGALQGLRYLHSHKMIHRDIKAGNILLTEHGQVKL |
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| Kinase | 29059.AA | Pkinase | 107-189 | 18 | 1.1e-07 | 28.3 | Pfam | 37-130 (293) | Show / Hide |
Range on Protein: 107-189 Range on HMM: 37-130/293 Sequence Identity: 18% (17 aa) QNEQDKRQLKL--EAQNLQKCIHDNIVQIHSYYIQDGISYIFMEECKY-----SLAQCIE--YRHHL--SEIQIIEIISELVSGMSYLHQHNLL .... .... . |.| .... |.|||... .. .. |. || | .|. |. .. . || ... .. ....|. |.|... . EKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGII |
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| Kinase | 29059.AA | AGC | 266-283 | 40 | 1e-06 | 11.85 | In-house | 280-299 (395) | Show / Hide |
Range on Protein: 266-283 Range on HMM: 280-299/395 Sequence Identity: 40% (8 aa) YDQSCDIWG--LGILIYILM |...||.|. ||.|.| .. YGKACDWWSFGLGCLMYEML |
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| Kinase | 29059.AA | Ciliate-E2-Unclassified | 106-209 | 19 | 2e-06 | 18.21 | In-house | 43-189 (352) | Show / Hide |
Range on Protein: 106-209
Range on HMM: 43-189/352
Sequence Identity: 19% (29 aa)
IQNEQDKRQLKLEAQNLQK---------------CIHDNIVQIHSYYI--QDGISYIFMEECKY-SLAQCIEYRHH-----------------LSEIQII
|.|.. ..... | .| |.... .. .|. .. || || |.. .| |.|. |.. ..| |..
IMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAK
-----EIISELVSGMSYLHQHN-LLVGDFNFQNILYDSQN---KLKIT
.. ....| .|||. | . | .|||.|... ..||.
YKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKII
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| Kinase | 29059.AA | MSK | 158-209 | 29 | 0.000122 | 11.6 | In-house | 92-146 (277) | Show / Hide |
Range on Protein: 158-209 Range on HMM: 92-146/277 Sequence Identity: 29% (16 aa) IEYRHHLSEIQIIEIISELVSGMSYLHQHNLLVGDFNFQNILYDSQ---NKLKIT | | | .| .|. |||. ...|| .| |||.|.. ..|.. IRKREHFDESECRMIMRELVMAVDHMHQKGIIHRDLKPENILFDDEEDNGHVKLI |
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| Kinase | 29059.AA | MSK | 266-282 | 47 | 0.000153 | 11.26 | In-house | 187-203 (277) | Show / Hide |
Range on Protein: 266-282 Range on HMM: 187-203/277 Sequence Identity: 47% (8 aa) YDQSCDIWGLGILIYIL ||..||.|.||.. | . YDEACDWWSLGVILYTM |
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| Kinase | 29059.AA | Ciliate-E2-Unclassified | 266-283 | 45 | 0.003533 | 6.9 | In-house | 243-264 (352) | Show / Hide |
Range on Protein: 266-283 Range on HMM: 243-264/352 Sequence Identity: 45% (10 aa) YDQS----CDIWGLGILIYILM ||.| ||||.||...| .. YDHSKAYKCDIWSLGVILYEML |
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| Kinase | 29059.AA | AGC | 161-209 | 22 | 0.005823 | 1.9 | In-house | 140-197 (395) | Show / Hide |
Range on Protein: 161-209 Range on HMM: 140-197/395 Sequence Identity: 22% (13 aa) RHHLSEIQIIEIISE-------LVSGMSYLHQ-HNLLVGD-FNFQNILYDSQNKLKIT . ...| .. ...| .|... |||. .. | ||| |.. .|.| EGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLT |
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| Kinase | 29059.AA | STE | 266-279 | 64 | 0.021819 | 4.39 | In-house | 245-258 (359) | Show / Hide |
Range on Protein: 266-279 Range on HMM: 245-258/359 Sequence Identity: 64% (9 aa) YDQSCDIWGLGILI || .|||| ||..| YDTKCDIWSLGCTI |
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| Kinase | 29059.AA | Pkinase | 266-283 | 27 | 0.05373 | 8.14 | Pfam | 189-206 (293) | Show / Hide |
Range on Protein: 266-283 Range on HMM: 189-206/293 Sequence Identity: 27% (5 aa) YDQSCDIWGLGILIYILM |....|.|..|...|... YGPKVDMWSCGCILYEML |
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| TPR_1 | 29059.AA | TPR_1 | 424-457 | 32 | 2e-06 | 26.09 | Pfam | 1-34 (34) | Show / Hide |
Range on Protein: 424-457 Range on HMM: 1-34/34 Sequence Identity: 32% (11 aa) KASCIKIGNTYQREQQFDTAEQYYRKALEFDPYY . .||.| . ...| |...|.|||| .| . AEAWYNLGNCYYKMGNYDEAIECYQKALELNPNN |
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| TPR_2 | 29059.AA | TPR_2 | 424-457 | 32 | 3.6e-05 | 22.36 | Pfam | 1-34 (34) | Show / Hide |
Range on Protein: 424-457 Range on HMM: 1-34/34 Sequence Identity: 32% (11 aa) KASCIKIGNTYQREQQFDTAEQYYRKALEFDPYY . . .|. | . ...| |..||.|||. || . AEAWYNLGQCYYKQGDYDEAIEYYEKALKLDPNN |
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| TPR | 29059.AA | TPR | 424-457 | 35 | 0.000201 | 21.94 | SMART | 1-34 (34) | Show / Hide |
Range on Protein: 424-457 Range on HMM: 1-34/34 Sequence Identity: 35% (12 aa) KASCIKIGNTYQREQQFDTAEQYYRKALEFDPYY . .|| | . ..| |...|.|||| || . AEAWYNLGNCYYKMGDYDEAIECYQKALELDPNN |
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| TPR | 29059.AA | TPR | 493-526 | 23 | 0.000214 | 21.85 | SMART | 1-34 (34) | Show / Hide |
Range on Protein: 493-526 Range on HMM: 1-34/34 Sequence Identity: 23% (8 aa) TDVYLMLGKYYSQKKMWKQAYDSFSQVYSSDPNN .... || | ... ...| . .... . |||| AEAWYNLGNCYYKMGDYDEAIECYQKALELDPNN |
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| TPR_1 | 29059.AA | TPR_1 | 493-526 | 20 | 0.001315 | 16.58 | Pfam | 1-34 (34) | Show / Hide |
Range on Protein: 493-526 Range on HMM: 1-34/34 Sequence Identity: 20% (7 aa) TDVYLMLGKYYSQKKMWKQAYDSFSQVYSSDPNN ... || | ... ...| . . .. . .||| AEAWYNLGNCYYKMGNYDEAIECYQKALELNPNN |
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| TPR_2 | 29059.AA | TPR_2 | 493-526 | 23 | 0.00187 | 16.31 | Pfam | 1-34 (34) | Show / Hide |
Range on Protein: 493-526 Range on HMM: 1-34/34 Sequence Identity: 23% (8 aa) TDVYLMLGKYYSQKKMWKQAYDSFSQVYSSDPNN ... .||. | ... ...| . . .. . |||| AEAWYNLGQCYYKQGDYDEAIEYYEKALKLDPNN |
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| TPR | 29059.AA | TPR | 458-492 | 28 | 0.175378 | 7.23 | SMART | 1-34 (34) | Show / Hide |
Range on Protein: 458-492 Range on HMM: 1-34/34 Sequence Identity: 28% (10 aa) VPAMINLANLYLQNEAKSQQAEEILNNAAKIDSKN . | ||.|.|.... . ..|.| .. | ..| .| AEAWYNLGNCYYKMG-DYDEAIECYQKALELDPNN |
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| TPR_2 | 29059.AA | TPR_2 | 458-492 | 28 | 0.784158 | 7.03 | Pfam | 1-34 (34) | Show / Hide |
Range on Protein: 458-492 Range on HMM: 1-34/34 Sequence Identity: 28% (10 aa) VPAMINLANLYLQNEAKSQQAEEILNNAAKIDSKN . | ||...|.... ..|.| .. | |.| .| AEAWYNLGQCYYKQGDY-DEAIEYYEKALKLDPNN |
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| TPR_1 | 29059.AA | TPR_1 | 458-492 | 25 | 4.44966 | 4.26 | Pfam | 1-34 (34) | Show / Hide |
Range on Protein: 458-492 Range on HMM: 1-34/34 Sequence Identity: 25% (9 aa) VPAMINLANLYLQNEAKSQQAEEILNNAAKIDSKN . | ||.|.|.. . . ..|.| .. | ... .| AEAWYNLGNCYYKMG-NYDEAIECYQKALELNPNN |
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| TPR_2 | 29059.AA | TPR_2 | 527-558 | 18 | 5.380946 | 4.07 | Pfam | 1-32 (34) | Show / Hide |
Range on Protein: 527-558
Range on HMM: 1-32/34
Sequence Identity: 18% (6 aa)
YNNILTMGAILEENKNYKQALQIYQIATQTSP
.| .......|..|.. |. | . |
AEAWYNLGQCYYKQGDYDEAIEYYEKALKLDP
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| TPR_1 | 29059.AA | TPR_1 | 533-558 | 30 | 5.459098 | 3.95 | Pfam | 7-32 (34) | Show / Hide |
Range on Protein: 533-558 Range on HMM: 7-32/34 Sequence Identity: 30% (8 aa) MGAILEENKNYKQALQIYQIATQTSP .|..... .||..|.. || | . | LGNCYYKMGNYDEAIECYQKALELNP |
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| TPR_1 | 29059.AA | TPR_1 | 583-595 | 38 | 39.704188 | 0.94 | Pfam | 22-34 (34) | Show / Hide |
Range on Protein: 583-595 Range on HMM: 22-34/34 Sequence Identity: 38% (5 aa) ESLKKALQIDSAN | ..|||... | ECYQKALELNPNN |
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| TPR_2 | 29059.AA | TPR_2 | 582-595 | 42 | 60.028865 | 0.36 | Pfam | 21-34 (34) | Show / Hide |
Range on Protein: 582-595 Range on HMM: 21-34/34 Sequence Identity: 42% (6 aa) KESLKKALQIDSAN .| ..|||..| | IEYYEKALKLDPNN |
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| TPR_2 | 29059.AA | TPR_2 | 642-663 | 22 | 64.471295 | 0.25 | Pfam | 13-34 (34) | Show / Hide |
Range on Protein: 642-663 Range on HMM: 13-34/34 Sequence Identity: 22% (5 aa) YQRNYIAAQHCFEVCIELAELS .|..| | ...| ...|.. KQGDYDEAIEYYEKALKLDPNN |
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