Gene 5902 (Tetrahymena)
5902
Group:
Other
Family:
Ciliate-D1
Sequence
Protein domains of 5902.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Aa_trans | 5902.AA | Aa_trans | 50-262 | 15 | 9.1e-08 | 27.03 | Pfam | 1-237 (459) | Show / Hide |
Range on Protein: 50-262 Range on HMM: 1-237/459 Sequence Identity: 15% (39 aa) KKNRSIHVILSMANSTIGSVALVLPASVLQGGLILAIICMTIIGFINYVTCYFISVYQR--------EDEIDLASIV---------RRILGPKW-KVAFI .. . ... ..|. ||. | || .. |.|... .|.|....|| | . . .. .. . .. . .. .|..||.. . .. HTISWWQAWFHLINAMIGAGVLGLPYAFKQLGWWPGVIMMVFCWFICYYCMHLLIQCHKYVDKRYKGKRNYSYMDMGVCMQWCMFWYRCFGPWMKRYICN LSSAFQLFVACIIYFLLINSICYPIIQFIMHKCGTENYGSSKEIVFD--------KFSIQYQAMILFVPVFLLC-SLKELNFIVKLGRIGVTSIFAY--- .. ..|.| .|..|...| . . |.... .. .| | ||.......|| ..... . .. .. ..|.| FMQYVQQFGFCCVYMIFIGDNLQAIFDSFC---------------HHMNGHNHWCHISQCYWMMIFGIICIPLCIFIPNFHALWWWSFFAAVMMFCYCIG --GIFLLYCFIENISDGNVSEYWDEQM-----SLFSK--NIVGVAGPFSFAF .. ..| .. .. ... ..|.. | . |.| |. .| ..||. PCCCCIVYVYHWEMIHQTWQGWWHWTMCWCWPWYFFKIWNWFTAIGMIVFAY |
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| S_TKc | 5902.AA | S_TKc | 481-768 | 18 | 4e-19 | 70.76 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 481-768
Range on HMM: 1-231/231
Sequence Identity: 18% (58 aa)
VTLLSIFGRGRIANGGVYCYKYSN--KEYAVKIYTEKKSESFTHILREISILDRINNVIKSDSIIRFHGFYFEILGNSIQFYIIMDKADG---TLTEFIQ
..| . |.| | | ||. . . ...|.|| ||.|||.|| . . . |....... . .|..|. .|| .| ..|.
YEILRKIGKG--AFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-----HHPNIVKLYDVFQD-----DHLYMVMEYCDGDLGDLFDYIK
QKYR------FKMTELLEITNQFIITFAELEGNGIAHRDIKTDNILYIRNSENKIMIKITDFSEGKLVDNEQTHNTLVGNAEHLSPELYYMYRRGETDIK
.. | | . .. | . . . .|| |||.| .||| . |||.|| ... .|..| . ..||. .
KRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL------TTFCGTPWYMAPEVL----------G
YNPFKNDVYGIGVLLCQLASCEYRPSRKEEAKVDPYKNDKGPCDDLWNLRLQQTKQYYLENSDNVSKSIIEQYFIIIKEMISYNPKQRPRFYQIMY----
|...| |.. .|..| ... | | . .|. . .. .|. . ..|..|| ...
YGKCKCDWWSCGCILYEMLC-GYPPFP---QMQMMFKKIG-----------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWD
----QWM
.|.
IKCHPWF
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| Kinase | 5902.AA | Ciliate-E2 | 501-684 | 21 | 9.6e-19 | 60.96 | In-house | 44-286 (365) | Show / Hide |
Range on Protein: 501-684
Range on HMM: 44-286/365
Sequence Identity: 21% (54 aa)
KYSNKEYAVKIYTEKKSESFT---HILREISILD--RINN------VIKSDSIIRFHGFYFEILGNSIQFYIIMDKADG-TLTEFIQQK-----------
|. .|.||.||. ... |.. ||.||| . . .| | .... ||... .. |. . .|..|. ..| .| ..|...
KVKIKIYAMKIMKKNQIEQIKQEIHIMREINC-FYKKI-NEKNILEQLNHPNIIKMYECFQEK--DDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD
YRFKMTELLEITNQFI---------------ITFAELEGNG-IAHRDIKTDNILYIRNSENKIMIKITDFSEGKLVDNE---------------------
.|.. | ..|. | . . .| .. | ||||| .|||. |||.|| | .|..
KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF---------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSR
-----------QTHNTLVGNAEHLSPELYY-MYRRGETDIKYNPFKNDVYGIGVLL
...||..|... ..|| . .... |. .| |.. .||.|
TPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVIL
|
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| Kinase | 5902.AA | CAMK | 501-684 | 15 | 5.1e-16 | 47.41 | In-house | 16-324 (425) | Show / Hide |
Range on Protein: 501-684
Range on HMM: 16-324/425
Sequence Identity: 15% (48 aa)
KYSN------------KEYAVKIYTEK----------------------------KSESFTHILREISILDRINNV---IKSDSIIRFHGFYFE------
| .. ...|.||. | . .. ..|||.|. ..... .. ||... .|
KNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNIIKLYEVYEDPHYFKN
-----ILGN-----SIQFYIIM---DKADGT-----LTEFIQQK---------------YRFKMTELLEITNQFIITFAELEGNGIAHRDIKTDNILYIR
. ..|..| . ..| | ..|... ||. | . | . . . ..|.|||.| .|||.
TNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNIVHRDLKPENILLDD
NSENKI-------------MIKITDFSEGKLVDN------------------------EQTHNTLVGNAEHLS-PELYYMYRRGETD------IKYNPFK
|.... |||.|| . .| | .| .| | . ||. .... ..| ..|
NNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPK
NDVYGIGVLL
|. .||.|
CDMWSCGVIL
|
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| Kinase | 5902.AA | RAD53 | 602-631 | 38 | 2.7e-11 | 29.38 | In-house | 128-171 (305) | Show / Hide |
Range on Protein: 602-631 Range on HMM: 128-171/305 Sequence Identity: 38% (17 aa) NGIAHRDIKTDNILYIRNSENK--------------IMIKITDF |||.|||.| .|||. ..|.. . |||||| NGICHRDLKPENILCNHQDEECPQVQLGPWDEDEISFLIKITDF |
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| Kinase | 5902.AA | Pkinase | 501-689 | 23 | 6.2e-11 | 39.75 | Pfam | 21-207 (293) | Show / Hide |
Range on Protein: 501-689 Range on HMM: 21-207/293 Sequence Identity: 23% (47 aa) KYSNKEYAVKIYTEKKSESFTHIL----REISILDRINNVIKSDSIIRFHGFYFEILGNSIQFYIIMDKADG-----TLTEFIQ--QKYRF--KMTELLE | ..|..|||| .. .| .. .||.|. |.| .. |.|..... . . |..|. ..| | ..|. .. .| . |. KGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLN----HPNIVRLYDWFED----KDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKF ITNQFIITFAELEGNGIAHRDIKTDNILYIRNSENKIMIKITDFSEGKL--VDNEQTHNTLVGNAEHLSPELYYMYRRGETDIKYNPFKNDVYGIGVLLC . | . . . .|| |||.| .|||. .| ... ..||.|| |. | . .|..| . ..||. . .| . | |....|..| YMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIR-------GGQYYGPKVDMWSCGCILY QLAS .... EMLC |
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| Kinase | 5902.AA | Ciliate-C8 | 602-684 | 23 | 3.8e-10 | 32.88 | In-house | 138-238 (238) | Show / Hide |
Range on Protein: 602-684 Range on HMM: 138-238/238 Sequence Identity: 23% (24 aa) NGIAHRDIKTDNILYIRNSENKIMIKITD------FSEGKLVDNEQT---------HNTL-----VGNAEHLSPELYYMYRRGETDIKYNPFKNDVYGIG . | ||||| .|.|.. . .. ||. | | . .... . .|| ||... | . || . .| |.| | FNIMHRDIKPHNFLVCFDQQYQPTIKLCDFKKQCDFGFASQLPKNKSHYHSKKFKGTDQYIEMYFCGNWGYFAPEVEKKQSRIQSDI-FS-KKSDSYSVG VLL ..| LVL |
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| Kinase | 5902.AA | Ciliate-E2-Unclassified | 499-684 | 17 | 8.9e-10 | 30.12 | In-house | 18-260 (352) | Show / Hide |
Range on Protein: 499-684 Range on HMM: 18-260/352 Sequence Identity: 17% (43 aa) CYKYSNKEYA--------VKIYT-EKKSESFTHILREISILDRIN-------------NVIKSDSIIRFHGFYFEILGNSIQFYIIMDKA-DGTLTEFIQ |.. ..| .. ..|| .. .. |..|. .. ... . ...... . || . . .||.|... .|.| ..|. CQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFY--CFQDKQNIYIVMEYCEGGDLWQYIK QK-----------------YRFKMTELL-----EITNQFIITF-AELEGNGIAHRDIKTDNILYIRNSENKIMIKITDFSEGKLVDN------------- .. .| . . .. | . . . |.| ||||| .|||. | . . |||.||. | .. KRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGK-NYYIKIIDFGISKKYQQNNNCDTNQQQKMQ ---EQTHNTLVGNAEHL----SPELYYMYRRGETDIKYNPFKNDVYGIGVLL .| .| .|. . . .||.. ... .| |... ||.| IWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKA----YKCDIWSLGVIL |
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| Kinase | 5902.AA | STE | 503-631 | 21 | 2.2e-09 | 29.4 | In-house | 29-191 (359) | Show / Hide |
Range on Protein: 503-631 Range on HMM: 29-191/359 Sequence Identity: 21% (37 aa) SNKE---------YAVKIYTEKKS-----------------ESFTHILREISILDRINNVIKSDSIIRFHGFYFEI---LGNSIQFYIIMDKAD-GTLTE .... .|.|. ... | . ||.||.|. . |. . .. |....| || .| . .|.| | |.|.. TGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNH-M-HPNIVKYYGCYFKEGHNHKNDDELWICMEYMDGGSLDD FIQQKYRFKM--------------TELLEITNQFIIT-FAELEGNGIAHRDIKTDNILYIRNSENKIMIKITDF .|..|| .. ... |. | . . |. ..| ||||| .||| .|..|| IIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL---------VKLCDF |
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| Kinase | 5902.AA | MAPKAPK | 501-631 | 26 | 3.5e-09 | 24.1 | In-house | 21-150 (292) | Show / Hide |
Range on Protein: 501-631 Range on HMM: 21-150/292 Sequence Identity: 26% (36 aa) KYSNKEYAVKIYTEKKSESFTHILREISILDRINNVIKSDSIIRFHGFYFEILGNSIQFYIIMDKAD-GTLTEFIQQ--KYRFKMTELLEITNQFIITFA |....|||||| .. | . ..|| .. . . |.. . .. . . ||..| . . | | . ||| . .| | .|... . KRTGQEYAVKILEDQPGHSRQKARREVELHWHCQ---GHPNIVQIIDWFENMYQFDKCFYLVMECMEGGELFQHIQQRGHKHFTEREASQIMKDICSAVD ELEGNGIAHRDIKTDNILYIRNSENKIMIKITDF | .|||||.| |||. ...| .|..|| FLHSMNIAHRDLKPENILCTDTNHN-CPVKLCDF |
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| Kinase | 5902.AA | IKK | 602-658 | 38 | 6.3e-09 | 26.95 | In-house | 133-189 (297) | Show / Hide |
Range on Protein: 602-658 Range on HMM: 133-189/297 Sequence Identity: 38% (22 aa) NGIAHRDIKTDNILYIRNSENKIMIKITDFSEGKLVDNEQTHNTLVGNAEHLSPELY ||| ||||| .|| . . |. ||||| . .| .. ..| | | |..| NGIVHRDIKPGNIMCQKGEDGKTIYKITDFGYAREWDDDEMFMSFYGTEEYLHPDMY |
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| Kinase | 5902.AA | TKL | 603-767 | 14 | 6.8e-09 | 28.17 | In-house | 160-364 (364) | Show / Hide |
Range on Protein: 603-767
Range on HMM: 160-364/364
Sequence Identity: 14% (32 aa)
GIAHRDIKTDNILYIRNSE----------NKIMIKITDFSEGKLVDNEQ--------------------THNTLVGNAEHLSPELYYMYRRGET------
.|.|||.|..||| .| . . . .||.|| . ..... |..| .|. ...||. . .
PIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDE
---DIKYNPFKNDVYGIGVLLCQLASCEYRPSRKEEAKVDPYKNDKGPCDDLWNLR--------LQQTKQYYLENSDNVS------------KSIIEQYF
.|.. | ||| |..|. ..... | .|... . . . .. . . ... ...
FCKGFEYSE-KCDVYSFGIVLWEILTRCR------------------PYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMK
IIIKEMISYNPKQRPRFYQIMYQW
.... ...|..|| | .|. .
KLMQDCWDHDPEKRPSFQEILKRL
|
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| Kinase | 5902.AA | Ciliate-E1 | 498-673 | 19 | 1.7e-08 | 24.2 | In-house | 13-202 (202) | Show / Hide |
Range on Protein: 498-673 Range on HMM: 13-202/202 Sequence Identity: 19% (37 aa) YCYKYSNKEYAVKIYTEKKSESFTHILREISILDRINNVIKSDSIIRFHGFYFEILGNSIQFYIIMDKADGTLTEFIQ-------------QKYRFKMTE ..........|.|| . .. |.. || . | ...| ..|| . . . .. ... ..||... . .|.. .| .. |. .. KQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMKFKKECYIIQI--IDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYWQQCQQNQNQFTFQQ LLEITNQFIITFAELEGNGIAHRDIKTDNILYIRNSENKIMIKITDFSEGKLVDNEQT----HNTLVGNAEHL-SPELYYMYRRGETDIKYNPF ...|. | | ..||. ..| ||||| .|||. .. .| . .. . .|. .|.|. . . . |.. .||. .... . ..|.. . KMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQ-GNYVYCDFGISKFLKNNQNQQCQYKGYTHYYYPPEQYNCPEQ-EHNKNQKINYKSDIY |
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| TyrKc | 5902.AA | TyrKc | 481-768 | 17 | 1.6e-05 | -133.32 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 481-768
Range on HMM: 1-280/280
Sequence Identity: 17% (57 aa)
VTLLSIFGRGRIANGGVYCYKYSNKEYAVKIYTEKKSESFTHILREISILDRI--NNVIKSDSIIRFHGFYFEILGNSI----QFYIIMDKAD-GTLTEF
.||. . |.| | | || ... . ||| | . ..||..|. .. .. . |.|..| . .| . .|.| .. | | ..
ITLGKKLGEG--AFGEVYKGTWK-IQVAVKMLKEDA---REDFMREARIMCKLGGHH----PNIVRLYGVCTQQGRN-FMYIEPLMIVMEYMPHGDLKDY
IQQKYR-FKMTELLEITNQFIITFAELEGNGIAHRDIKTDNILYIRNSENKIMIKITDFSEGKLVDNE-------QTHNTLVGNAEH-------LSPELY
.. . . ..| .||.. | . |. ... |||. . |.|. .| .||.|| . .... .. . . .. ..||
LRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI
YMYRRGETDIKYNPFKNDVYGIGVLLCQLASCEYRPSRKEEAKVDPYKNDKGPCDDLWNLRLQQTKQYYLENSDN--------VSKSIIEQYFIIIKEMI
. |.. .| ||. ||.. . . | .. . . .. . . |... .| .. . | |.|.
-------NYGKFT-TKSDVWSFGVCMWEIFTYGQQPYPGMIQQ----------MMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEM---YQ-IMKQCW
SYNPKQRPRFYQIMYQWM
..|..||.| .| .. .
HEDPEDRPTFSEI-HECF
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| Kinase | 5902.AA | TKL | 492-564 | 17 | 0.214226 | 0.8 | In-house | 1-118 (364) | Show / Hide |
Range on Protein: 492-564
Range on HMM: 1-118/364
Sequence Identity: 17% (21 aa)
IANGG---VYCYKYSN----------KEYAVKIYTEKKSESFTHILREI-----------------SILDRINNVIK------SDSIIRFHGFYFEIL--
| || || |. . |. |||.. .. . .|| ...|. . ......|. . |..| |. ...
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG
-------GNSIQFYIIMD
|.. |..|.|.
CVCMHPVGPWGQLCIVME
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