Gene 7291 (Tetrahymena)

7291

Species: Tetrahymena
Alias: 7291, 3739.m00041, 118.m00119, TTHERM_00728890, 1007, PreTt07291
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-D1

Sequence

Name Sequence Type Origin Length Description Download
7291.AA Protein None 1371 None Fasta, JSON
7291.kin_dom Protein Kinase Domain None 230 None Fasta, JSON
7291.NA RNA None 4116 None Fasta, JSON

Protein domain

Protein domains of 7291.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 7291.AA ULK 25-256 23 1.4e-32 111.07 In-house 16-329 (329) Show / Hide 
Range on Protein: 25-256
Range on HMM: 16-329/329
Sequence Identity: 23% (74 aa)

YYGYNTKN----GKDVFIKIINQKK-IPDGSL-----IRINLENEIIIHQQLK----QKN-AKNVMALIDVAYTQ--NNIYLIYQNNKYDTLKNYLN---
| |.| |.    ...|..|.| ..| . .  .     .   |.||| | ..||     ||  .|.  |.|. .|.  ||||.|.      .|..|..   
YKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIMEYCNGGDLEQYIKKNK

-------YKQMLSEKECINYFIQIYYGYFESYSQKVKYRDITLNNILIGEEEA------------IRVDDFGLFKTLFYQ---KNSSLQYR---------
       .|. |||.|.|..|.||  |. | .....  ||| . |||| .  .            . . |||. |.. .    ..  . .          
KLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQMMMTCVNEKRLCGTP

INEAPE-TQQD--RKSYNREKSDSWSLGILLFQLLFLSEP----SFQLG-----QLVIP-------------------STRIISSQMAQLLFSLLQIDPA
.  ||.  |.   .| |.  |.| ||||......|.   |     ...      .|.                     .  .||... .|.  .||.|. 
LYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAWFNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISPECKDLIRRMLQYDEK

KRINWVQILSHDCI
.||.| ....| ..
DRISWEELFNHPWF
Kinase 7291.AA ULK 25-256 23 2e-30 105.17 In-house 17-324 (324) Show / Hide 
Range on Protein: 25-256
Range on HMM: 17-324/324
Sequence Identity: 23% (74 aa)

YYGYNTKN---GKDVFIKIINQKKI-PDGSL-----IRINLENEIIIHQQLK---QKNAKNVMALIDVAYTQ--NNIYLIYQNNKYDTLKNYLN------
| |.| |.   ...| .|.|..||.  . ..     .  .|.||| | ..||    .|  ..  |.|. .|.  ||||.|.      .|..|..      
YKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNH-HIVKLYDWFETSNHNNIYIIMEYCNGGDLEQYIKKNKKLP

---YKQMLSEKECINYFIQIYYGYFESYSQKVKYRDITLNNILIGEEEA------------IRVDDFGLFKTLFY---QKNSSLQYR---------INEA
   .|. |||.|.|..|.||  |. | .....  ||| . |||| .  .            . . |||. |....   ...   ..          .  |
ETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQTCVNEKRIKGTPLYMA

PE-TQQD--RKSYNREKSDSWSLGILLFQLLFLSEP----SFQLG--------------------QLVIP---STRIISSQMAQLLFSLLQIDPAKRINW
|.  |.   .| |.  |.| ||||......|. . |      ..                     .. .|   .  .||... .|.  .||.|. .||.|
PQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSWFNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKDLIRRMLQYDEKDRISW

VQILSHDCI
 .|..| ..
EEIFNHPWF
Kinase 7291.AA Ciliate-E2 25-256 21 6.8e-22 71.92 In-house 16-365 (365) Show / Hide 
Range on Protein: 25-256
Range on HMM: 16-365/365
Sequence Identity: 21% (75 aa)

YYGYNTKNGK------------------DVFIKIINQKKIPDGSLIRINLENEII---------IHQ---QLKQKNAKNVMALIDVAY--TQNNIYLIYQ
|.. . |..|                   | |||.. | .    .. |. |. |.         | .    |.| | .|.. .... .  ..|||||.  
YKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKI-NEKNILEQLNHPNIIKMYECFQEKDDNNIYLVME

NNKYDTLKNYLN--YKQM---------LSEKECINYFIQIYYGY--------------FESYSQ-K-VKYRDITLNNILIGEEEAIRVDDFGLFK-----
  .. .|. |..  .|.          ..|||..... || .|.              .|.  . . . .||| ..|||.     | . |||| |     
YCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----IKIIDFGLSKKYDDD

-----------TLFYQK-------------------NSSLQYRINEAPETQQDRKSY-------NREKSDSWSLGILLFQLLFLSEP---SFQLGQLVIP
            . . |                   |. .      |||  .  | .         .|.| ||||..|...||   |     . ... .|
NQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPFQQQIKQCKIDFP

----------------STRIISSQMAQLLFS----LLQIDPAKRIN-WVQILSHDCI
                |.  .| .. .|.      .|| || |||. | ||| |  .
CPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 7291.AA GIN4 55-256 32 1.6e-20 61.87 In-house 80-293 (293) Show / Hide 
Range on Protein: 55-256
Range on HMM: 80-293/293
Sequence Identity: 32% (70 aa)

NLENEIIIHQQLKQKNAKNVMALIDVAYTQNNIYLIYQNNKYDTLKNYLNYKQMLSEKECINYFIQIYYGYFESYSQKVKYRDITLNNILIGEEEA-IRV
..| ||.|   .|  .  |||.| ||  |.|..||.        | |||  .  | |.| |.|| ||  |     .  .  ||.   |.|. .    |..
GIEREIVI---MKLISHPNVMRLYDVWETNNDLYLVLEYAEKGELFNYLVDHGPLPEREAIHYFRQIIIGVSYCHAFNICHRDLKPENLLLDHKYNRIKI

DDFGLFKTLFYQK--NSSLQYRINEAPETQQDRKSYNREKSDSWSLGILLFQLL-----FLSE--------PSFQLGQLVIPSTRIISSQMAQLLFSLLQ
 |||.      .|  . |       |||    .  |.   || || |..|| ||     |  |           | |.  .||   ||..   |.  .| 
ADFGMAALETDNKLLETSCGSPHYAAPEIVMGI-PYHGFASDVWSCGVILFALLTGHLPFDEEDGNIRKLLLKVQKGKYEMPSDDEISREAQDLIRKILV

IDPAKRINWVQILSHDCI
.|| |||   .||.|  |
VDPEKRIKTRDILKHPLI
Kinase 7291.AA Ciliate-E2-Unclassified 38-206 18 8e-19 61.94 In-house 35-265 (352) Show / Hide 
Range on Protein: 38-206
Range on HMM: 35-265/352
Sequence Identity: 18% (44 aa)

IKIINQKKIPDGSLIRINLENEIIIHQ-------------QLKQKNAKNVMALIDVAYTQNNIYLIYQNNKYDTLKNYLN-----------------YKQ
|.|..||.|     . .| ..|. ...              |.. .  ... ....  ...|||....  .. .|..|..                 ...
IQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRK

MLSEKECI-----NYFIQIYYGYFESYSQK-VKYRDITLNNILIGEEE---AIRVDDFGLFK---------------------TLFYQKNSSLQYRINE-
...|....     .|| ||  |     ... . .|||...|||. ..     |.. |||..|                      .....  ...| . . 
IFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMP-QY

-APETQQDRKSYNR--EKSDSWSLGILLFQLLF
 |||  |  . ...  .|.| ||||..|...||
TAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLF
Kinase 7291.AA S_TKc 27-256 24 1e-14 38.84 SMART 18-231 (231) Show / Hide 
Range on Protein: 27-256
Range on HMM: 18-231/231
Sequence Identity: 24% (59 aa)

GYNTKNGKDVFIKIINQKKIPDGSLIRINLENEIIIHQQLKQKNAKNVMALIDVAYTQNNIYLIYQNNKY--DTLKNYLNYKQM------LSEKECINYF
....| |. | ||||.           .....|| |...    . .|.  |.|| .. ...|..         .|. |.  ..       ..| ..  |.
CRHKKTGRIVAIKIIK-----------EHIRREIQILKK----HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYM

IQIYYGYFESYSQKVKYRDITLNNILIGEEEAIRVDDFGLFKTLFYQKNSSLQYRINEAPETQQDRKSYNREKSDSWSLGILLFQLLFLSEPSFQLGQLV
 ||  .     |... .||.   |||. |   | . |||| . | .    .. |.   |||      .|...|.| ||.|..|. .|   .| |.  |. 
YQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-TTFCGTPWYM---APEVL----GYGKCKCDWWSCGCILYEMLC-GYPPFP--QMQ

IPSTRIISSQMAQLLFSLLQIDPAKRINWVQILS-------HDCI
    .| |... ...  .|| ||.||.   ..|        |  .
MMFKKIGSPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 7291.AA SAK 33-158 26 8.7e-10 29.23 In-house 24-146 (254) Show / Hide 
Range on Protein: 33-158
Range on HMM: 24-146/254
Sequence Identity: 26% (34 aa)

GKDVFIKIINQKKIPDGSLIRINLENEIIIHQQLKQKNAKNVMALIDVAYTQNNIYLIYQNNKYDTLKNYLNYK-QMLSEKECINYFIQIYYGYFESYSQ
...| ||.| .| .    ...    ||. || |||      .. |      .| .||.    .   .. |.. . .  .|.|  ... ||  |     | 
HQEVAIKMIDKKLMQKTGMVQ-RVRNEVEIHCQLKH---PSILELYNYFEDNNYVYLVLEMCHNGEMHRYMKHRMRPFTEEEARHFMHQIVIGMLYLHSH

KVKYRDITLNNILIGEEEAIRVDDFGL
 .  ||.|| |||.  .  ... ||||
GIMHRDLTLSNILLTRDMHCKIADFGL
Kinase 7291.AA MELK 10-205 24 3.5e-08 23.71 In-house 1-194 (254) Show / Hide 
Range on Protein: 10-205
Range on HMM: 1-194/254
Sequence Identity: 24% (49 aa)

YSIYSRKEDSILAENYYGYNTKNGKDVFIKIINQKKIPDGSLIRINLENEIIIHQQLKQKNAKNVMALIDVAYTQNNIYLIYQNNKYDTLKNYLNYKQML
| ..       .|          .. | |||...... .  | |.. | .      ||.   ...  |  .  |.. |... .      . .|.  .. |
YEVHDEIGTGGFAKVKLACHILTNQMVAIKIMDKNQLGH-DLPRVKTEMDA-----LKNLRHQHICQLYHYIETEDKIFMVMEYCPGGEMFDYIIRQDRL

SEKECINYFIQIYYGYFESYSQKVKYRDITLNNILIGEEEAIRVDDFGLFKTLFYQKNSS-LQ----YRINEAPETQQDRKSYNREKSDSWSLGILLFQL
.|.|   .| ||       .||   .||.  .|.|. |.  ... ||||      .|.   ||         |||  |  |.|  .  | ||.||||. |
EEEETRHFFRQIVSAIAYVHSQGYAHRDLKPENLLFDEDHHLKLIDFGLCAKTKGRKDYHNLQTCCGSPAYAAPELIQG-KQYIGSEADVWSMGILLYVL

L
.
M
Kinase 7291.AA CDC2 231-256 42 2e-06 15.16 In-house 276-301 (301) Show / Hide 
Range on Protein: 231-256
Range on HMM: 276-301/301
Sequence Identity: 42% (11 aa)

QLLFSLLQIDPAKRINWVQILSHDCI
.|| ..||.||.|||.  ..|.|  .
DLLMQMLQYDPQKRISAKEALQHPYF
Kinase 7291.AA TyrKc 20-256 18 5e-06 -124.82 SMART 1-280 (280) Show / Hide 
Range on Protein: 20-256
Range on HMM: 1-280/280
Sequence Identity: 18% (55 aa)

ILAEN----------YYGYNTKNGKDVFIKIINQKKIPDGSLIRINLENEIIIHQQLKQK--NAKNVMALIDVAYTQ-------NNIYLIYQNNKYDTLK
|  .           | |  .    .| .| ..  .       |  . .|. |   ...   . .|. .|. |. .|         ....    ..  ||
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-------REDFMREARI---MCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLK

NYLNYKQM-LSEKECINYFIQIYYG--YFESYSQKVKY--RDITLNNILIGEEEAIRVDDFGLFKTLFYQ---KNSSLQYRI----NE---------APE
.|| ...  |. |. ... .||  |  | .|     ..  ||.   |.|.||.  ... |||| . .        |.  ||     ..         |||
DYLRKHRPKLCMKDLLSFCWQIACGMEYLHSK----NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPE

TQQDRKSYNREKSDSWSLGILLFQLLFLSEPSFQL-----------------GQLVIPSTR-------IISSQMAQLLFSLLQIDPAKRINWVQILSHDC
. ...|    .||| || |.... .. . ..                     |    .          . .. | |.  .  . ||..| .  .|  |.|
CINYGKFT--TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HEC

I
.
F
Kinase 7291.AA MELK 225-256 40 1.3e-05 14.82 In-house 223-254 (254) Show / Hide 
Range on Protein: 225-256
Range on HMM: 223-254/254
Sequence Identity: 40% (13 aa)

ISSQMAQLLFSLLQIDPAKRINWVQILSHDCI
.| .  |||  .||.|| |||   ..| |. .
LSPESKQLLRHMLQVDPKKRISMKNLLNHPWV
Kinase 7291.AA CAMK 30-121 17 3e-05 12.09 In-house 29-188 (425) Show / Hide 
Range on Protein: 30-121
Range on HMM: 29-188/425
Sequence Identity: 17% (29 aa)

TKNGKDVFIKIINQKKIPD------------------------GSLIRINLENEIIIHQQLKQKN----AKNVMALIDVAY------------TQNN---
|. |. | ||||. ||..|                            | |...|| |...|....     .|.  |..|              | ..   
TN-GQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNIIKLYEVYEDPHYFKNTNDYET-SKQVF

-----IYLIY---QNNKYD----TLKNYLNYK---------------QMLSEKECINYFIQI
     .|..               | .|.  .                 ..|.|.  || ||
TKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQI
Kinase 7291.AA Pkinase 191-256 19 3.3e-05 19.51 Pfam 192-293 (293) Show / Hide 
Range on Protein: 191-256
Range on HMM: 192-293/293
Sequence Identity: 19% (20 aa)

KSDSWSLGILLFQLLFLSEPSFQL------GQLVIPSTRIIS-------------------------------SQMAQLLFSLLQIDPAKRINWVQILSH
|.| ||.|..|...|.   |  .        |...   || .                               . . ... ..|. ||.||... ||| |
KVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQM-ICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQH

DCI
. .
PWF
Kinase 7291.AA CAMKL 225-256 31 0.000101 10.83 In-house 267-297 (297) Show / Hide 
Range on Protein: 225-256
Range on HMM: 267-297/297
Sequence Identity: 31% (10 aa)

ISSQMAQLLFSLLQIDPAKRINWVQILSHDCI
.| .  .|. ..|| .| ||..  ||..|   
VS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM
Kinase 7291.AA CAMK 225-256 30 0.000177 9.56 In-house 386-425 (425) Show / Hide 
Range on Protein: 225-256
Range on HMM: 386-425/425
Sequence Identity: 30% (12 aa)

ISSQ--------MAQLLFSLLQIDPAKRINWVQILSHDCI
|| .          .|. ..|| || ||..  |.|.|  .
ISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 7291.AA Ciliate-E2-Unclassified 215-256 26 0.000298 10.68 In-house 301-352 (352) Show / Hide 
Range on Protein: 215-256
Range on HMM: 301-352/352
Sequence Identity: 26% (14 aa)

GQLVIPSTRI-----ISSQMA-----QLLFSLLQIDPAKRINWVQILSHDCI
... .|.        ..|. |     .|| ..|. .| |||.. ||| |  .
KNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 7291.AA CAMKL 27-90 25 0.00034 9.12 In-house 18-99 (297) Show / Hide 
Range on Protein: 27-90
Range on HMM: 18-99/297
Sequence Identity: 25% (21 aa)

GYNTKN-GKDVFIKIINQKKIPDGSLIRIN-----------LENEIIIHQQLKQKN-AKNVMALIDVAYTQNN------IYLI
. .... |. | ||||. ||| .   .. |           .. || |...|. .   .|.. | .| .|...      |||.
ATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLN-IGKHPNIIKLYEVIETPEHDIETKKIYLV
Kinase 7291.AA CDC2 72-158 27 0.00057 7.51 In-house 61-149 (301) Show / Hide 
Range on Protein: 72-158
Range on HMM: 61-149/301
Sequence Identity: 27% (25 aa)

KNVMALIDVAYTQNNIYLIYQNNKYDTLKNYLN----YKQMLSEKECINYFIQIYYGYFESYSQKVKYRDITLNNILIGEEEAIRVDDFGL
.|.  | || .  |..|..     .| ||.|.      .. ...    .|..||  |     ....  ||.   |||| .. .|.. ||||
PNIVKLHDVIHQ-NKLYMVFEYLDMD-LKKYMDMSIPKNKHMPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADFGL
Kinase 7291.AA CAMK 177-202 28 0.007189 4.28 In-house 288-325 (425) Show / Hide 
Range on Protein: 177-202
Range on HMM: 288-325/425
Sequence Identity: 28% (11 aa)

APETQQDR------------KSYNREKSDSWSLGILLF
|||  .              | |  .|.| ||.|..|.
APEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILY
Kinase 7291.AA CAMKL 177-206 38 0.007628 4.74 In-house 201-231 (297) Show / Hide 
Range on Protein: 177-206
Range on HMM: 201-231/297
Sequence Identity: 38% (12 aa)

APETQQD-RKSYNREKSDSWSLGILLFQLLF
|||  |.  |.|.  | | ||.|..|. ...
APEIFQGNNKPYDGPKVDIWSCGVILYAMVC
Kinase 7291.AA SAK 225-256 25 0.158666 0.65 In-house 223-254 (254) Show / Hide 
Range on Protein: 225-256
Range on HMM: 223-254/254
Sequence Identity: 25% (8 aa)

ISSQMAQLLFSLLQIDPAKRINWVQILSHDCI
.|     |.  .|. .|. ||    .| |  .
LSMEAQDLIHKMLRKNPHERITLSTVLCHPFM
Kinase 7291.AA Pkinase 27-121 24 0.472965 4.8 Pfam 18-117 (293) Show / Hide 
Range on Protein: 27-121
Range on HMM: 18-117/293
Sequence Identity: 24% (25 aa)

GYNTKNGKDVFIKIINQKKIPDGSLIR-INLENEIIIHQQLKQKNAKNVMALIDVAYTQNNIYLIYQNNKYD----TLKNYLN--YKQML--SEKECINY
... ..|| | .|||. ... .. ... ..| .|| |.. |.    .|.  |.|. .. ..||..      .     |. |.   ..  .  ||.||..|
CHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL-SEIQIMKRLN---HPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFY

FIQI
. ||
MYQI
Kinase 7291.AA Pkinase 129-158 35 4.356871 1.39 Pfam 125-158 (293) Show / Hide 
Range on Protein: 129-158
Range on HMM: 125-158/293
Sequence Identity: 35% (12 aa)

YSQKVKYRDITLNNILIGEEEAI----RVDDFGL
.|... .||. . |||| ..  |    .. ||||
HSMGIIHRDLKPENILIDNNGHIDACVKICDFGL
Patatin 7291.AA Patatin 1119-1295 16 8.3e-14 51.2 Pfam 1-163 (163) Show / Hide 
Range on Protein: 1119-1295
Range on HMM: 1-163/163
Sequence Identity: 16% (32 aa)

LLLSGGGCAISYQAGYMHGLSEFI---PKKILKEYRVGGVSSGSCIASFFVCSVYSDKDMKYWYEKYIRESLKSINNEKLGFFNATKYVKEQAVKAYLE-
| |||||.   ..||.....  .    ... ..  ...|.| |...|... |  .....|  .. .  |. ... .   ....| . . .  . . .|. 
LVLSGGGMRGIWHAGVLKAIE-MLWQEHEAGDHFDVICGTSAGAINAAMLACG-MDPDEMFDQC-EFWRNKFWD-F--WRHWWNRGGLFDGDYLREWLRS

---AKSLNVPFNGTLHLYISPRKYVVGITKQLIDNFTDSQEFGEAISCSCAIPFVT-----TGRFSDYYQGISAVDGGFTMALPFRNQD
   .   .  |. .  .   |       .  . ... .  .  .|. .|||.|..      .|.  .||     ||||.   .|..  .
WWMKMFGDH-FEDFK-RF-CP-------F-VF-YDD-PDGDLWDAVRASCAFPGFFPPVRIDGE--CYY-----VDGGVRDNNPIHIAW