Gene 7361 (Tetrahymena)
7361
Group:
Other
Family:
Ciliate-D1
Sequence
Protein domains of 7361.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 7361.AA | Ciliate-E2-Unclassified | 232-336 | 19 | 7.5e-11 | 33.89 | In-house | 249-352 (352) | Show / Hide |
Range on Protein: 232-336 Range on HMM: 249-352/352 Sequence Identity: 19% (23 aa) FKSDIFSLGCMIFYILTGGKVPFMSSATTYDFQYKN-----AYEQPSRYIQDVIKTALNCVKNDIC-------QQFSQQAEEAIEVFKQFMSLIAQCLLP .|.||.|||. ....|.| || . . ..|... | |.. ... ... . . .. |..|.. |. |. ..| YKCDIWSLGVILYEMLFGY-YPFYDNNCEQHQQLITQWINNA------YRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFIN------DLLQKMLKK NPSERPIINTIFHHDFL ||..|. .. |. | .. NPNKRITFEQILNHPWF |
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| Kinase | 7361.AA | Ciliate-E2 | 232-336 | 16 | 1.9e-09 | 28.57 | In-house | 275-365 (365) | Show / Hide |
Range on Protein: 232-336 Range on HMM: 275-365/365 Sequence Identity: 16% (20 aa) FKSDIFSLGCMIFYILTGGKVPFMSSATTYDFQYKNAYEQPSRYIQDVIKTALNCVKNDICQQFSQQAEE--------------AIEVFKQFMSLIAQ-- .|.||.||| .|.|.. || || .. . .... . .| .. .. . || . YKCDIWSLG-VILYEMLFGKPPF--------------------------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFG --CLLPNPSERPI-INTIFHHDFL .| .|..|. .. |. | .. KRMLQKDPEKRITGWEQILNHPWF |
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| Kinase | 7361.AA | Ciliate-A7 | 233-336 | 26 | 1.5e-08 | 27.12 | In-house | 255-360 (360) | Show / Hide |
Range on Protein: 233-336 Range on HMM: 255-360/360 Sequence Identity: 26% (29 aa) KSDIFSLGCMIFYILTGGKVPF-MSSATTYDFQ-YKNAYEQPSR--YIQDVIKTALNCVK---NDICQQFSQQAEEAIEVFKQFMSLIAQCLLPNPSERP |.|.|..| .| || .. || ... .| ||. . ... .... |.. .| . |. . ..|| .. |. |. |. .| ||||.|. KCDVFAFGVSFFQILFQQN-PFCCEACHQNDPYKYKHYFQKTYSKFWQWMQIQWMWNHFQKEIQDMIKNTDQQ-QQDIDQMKD---LLNKMLCPNPSQRY IINTIFHHDFL |. | | .. CIKQILQHPWF |
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| Kinase | 7361.AA | IRE | 235-254 | 55 | 6.9e-08 | 22.97 | In-house | 214-233 (292) | Show / Hide |
Range on Protein: 235-254 Range on HMM: 214-233/292 Sequence Identity: 55% (11 aa) DIFSLGCMIFYILTGGKVPF ||||.|| ..|..|.|. || DIFSMGCVFYYVMTNGQHPF |
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| Kinase | 7361.AA | PLK2 | 311-336 | 46 | 8.9e-07 | 17.55 | In-house | 232-257 (257) | Show / Hide |
Range on Protein: 311-336 Range on HMM: 232-257/257 Sequence Identity: 46% (12 aa) SLIAQCLLPNPSERPIINTIFHHDFL .|||. | |.| .|| . | ||| HLIARMLSPDPEDRPSLDHIIRHDFF |
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| Kinase | 7361.AA | PLK | 311-336 | 46 | 1e-06 | 17.54 | In-house | 233-258 (258) | Show / Hide |
Range on Protein: 311-336 Range on HMM: 233-258/258 Sequence Identity: 46% (12 aa) SLIAQCLLPNPSERPIINTIFHHDFL .||.. | .||.||| |. |. |.|. DLIQKMLNWNPDERPTIDQILQHPFF |
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| S_TKc | 7361.AA | S_TKc | 53-336 | 10 | 8e-06 | -91.23 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 53-336
Range on HMM: 1-231/231
Sequence Identity: 10% (33 aa)
LQYKQEL--------ISFRRSDCTENYYVKVTCGETAEPSELLKHFQILNDLKKASQFTTLAPSKCANFSNKSNSFFLLQAGPS--AENPEIVFD-----
. ... | . . . .|. ... ||| . . . . . .. .. . . . .. .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-----HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRHG
-----SLNSKIEAIKSLIFSIYSIHDNDMIHTQIVPSNLLFFENNSQQRFQL--------QCFPFLQYCPCQQPKEEQRYIFGPIHTFTAPEIRGLADRK
. .. .. . .|.. || . |.|.|. | .. . . . | . . |||.
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-------HIKICDFGLARQL---------------TTFCGTPW-YMAPEVL------
ATKIADPFKSDIFSLGCMIFYILTGGKVPFMSSATTYDFQYKNAYEQPSRYIQDVIKTALNCVKNDICQQFSQQAEEAIEVFKQFMSLIAQCLLPNPSER
...|.|. |.||... |. |. || ... .|. ... ..| .|| .|..|
---GYGKCKCDWWSCGCILYEMLC-GYPPFP----QMQMMFKKIG------------------------------------SPEAKDFIRKCLQKDPEKR
PIINTIFH-------HDFL
| . ... | ..
PTA-EALQDEWDIKCHPWF
|
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| Kinase | 7361.AA | STE7-Unclassified | 307-336 | 35 | 1.3e-05 | 15.88 | In-house | 271-301 (301) | Show / Hide |
Range on Protein: 307-336 Range on HMM: 271-301/301 Sequence Identity: 35% (11 aa) KQFMSLIAQCLLPNPSERPIINTIFH-HDFL | ||..|..|. .| ||| | . |... KEFMDFISKCCKKHPRERPDIHQLLNEHPWI |
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| Kinase | 7361.AA | TBCK | 311-336 | 26 | 1.6e-05 | 15.65 | In-house | 321-346 (346) | Show / Hide |
Range on Protein: 311-336 Range on HMM: 321-346/346 Sequence Identity: 26% (7 aa) SLIAQCLLPNPSERPIINTIFHHDFL ..| .|| ..|..|| . . |. . QIIRKCLQMCPMKRPSPTELMEHPMF |
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| Kinase | 7361.AA | Ciliate-B2 | 232-240 | 66 | 2.3e-05 | 8.47 | In-house | 189-197 (197) | Show / Hide |
Range on Protein: 232-240 Range on HMM: 189-197/197 Sequence Identity: 66% (6 aa) FKSDIFSLG |.|||.|.| FQSDIYSMG |
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| Pkinase | 7361.AA | Pkinase | 214-336 | 14 | 2.7e-05 | 19.81 | Pfam | 179-293 (293) | Show / Hide |
Range on Protein: 214-336 Range on HMM: 179-293/293 Sequence Identity: 14% (20 aa) APEIRGLADRKATKIADPFKSDIFSLGCMIFYILTGGKVPFMSS-----ATTYDFQYKNAYEQPSRYIQDV-------IKTALNCVKNDICQQFSQQAEE |||. . . .. |.|..|.||.... |. |. || .. .. . ... . .... .. ... . . ... APEV--IR----GGQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRH-W-H----------F-HWT AIEVFKQFMSLIAQCLLPNPSERPIINTIFHHDFL ... . . ..| || ..|..|| . |..|... FHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF |
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| Kinase | 7361.AA | WEE | 232-253 | 40 | 0.0003 | 10.24 | In-house | 215-236 (297) | Show / Hide |
Range on Protein: 232-253 Range on HMM: 215-236/297 Sequence Identity: 40% (9 aa) FKSDIFSLGCMIFYILTGGKVP .|.||||||..|. . .. .| YKADIFSLGITIYELACNMDLP |
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| Kinase | 7361.AA | WEE | 309-336 | 28 | 0.001184 | 8.21 | In-house | 270-297 (297) | Show / Hide |
Range on Protein: 309-336 Range on HMM: 270-297/297 Sequence Identity: 28% (8 aa) FMSLIAQCLLPNPSERPIINTIFHHDFL . .||.. . |.|. || .. .. |. | LKQLIKWMMHPDPEQRPTCQQLLQHPVL |
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| Kinase | 7361.AA | PLK2 | 232-249 | 44 | 0.037526 | 2.41 | In-house | 182-199 (257) | Show / Hide |
Range on Protein: 232-249 Range on HMM: 182-199/257 Sequence Identity: 44% (8 aa) FKSDIFSLGCMIFYILTG ..||| .||| . .|.| CESDIWALGCIMYTMLCG |
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| Kinase | 7361.AA | PLK | 232-249 | 38 | 0.121609 | 1.24 | In-house | 181-198 (258) | Show / Hide |
Range on Protein: 232-249 Range on HMM: 181-198/258 Sequence Identity: 38% (7 aa) FKSDIFSLGCMIFYILTG ...|. ||||.. .|.| YEVDCWSLGCIMYTLLIG |
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