Gene 7412 (Tetrahymena)
7412
Group:
Other
Family:
Ciliate-D1
Sequence
Protein domains of 7412.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 7412.AA | Ciliate-E1 | 33-224 | 20 | 6.8e-16 | 48.57 | In-house | 1-202 (202) | Show / Hide |
Range on Protein: 33-224 Range on HMM: 1-202/202 Sequence Identity: 20% (43 aa) LGYGSLGPVFQASQKCDD---VCQNIVIKSFS-CTQTLYDQIANQVNQTKVFQNSQNVLKFQIKKV-AENGDHVATAFEMELCQKSLQQYIA-------- .|.|| . ||.| |. . |.| |. | ....|.| .. . | |.. ....... . .| .. . .|.|..||..|. IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICI---IIFECCCCSLKDYLQNHNRLEYW -EIKEGKANPTKSEVLVYFIQALNGLLELQENGYQHHNLKSSNILISEDDTIKISDSSFTLELSQKIYNKPQQYNRFLSINYLSPEYT--SLIDGKGQVE .... . . | ... ..|.. || ||. .. | ..| .||||. .. ...| . . | .. |. .||. ... | ...|. . . . . QQCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYCDFGISKFL-KNNQNQQCQYKGYTHYYYPPEQYNCPEQ-EHNKNQK ISNSSDVF |. ||.. INYKSDIY |
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| Kinase | 7412.AA | Ciliate-E2 | 107-234 | 20 | 1.3e-15 | 50.02 | In-house | 113-290 (365) | Show / Hide |
Range on Protein: 107-234 Range on HMM: 113-290/365 Sequence Identity: 20% (38 aa) MELCQK-SLQQYIA--EIKEGKA-----NPTKSEVLVYFIQALN---------------GLLELQENG-YQHHNLKSSNILISEDDTIKISDSSFTLELS ||.|| .|..|| .|... ..| |.. .. | |. .| .| ... | ..| .|||. |||.| . ... MEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----IKIIDFGLSKKYD QK----IYNKPQQYNRFLSIN---------------------YLSPEYTSL--IDGKG------QVEISNSSDVFSLGVIFLELI .. .. |.|... | . .|.| . . ||. | . . ..|..|||||. |.. DDNQNRTH-KQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEML |
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| Kinase | 7412.AA | TKL | 154-238 | 20 | 9e-14 | 45.98 | In-house | 163-287 (364) | Show / Hide |
Range on Protein: 154-238 Range on HMM: 163-287/364 Sequence Identity: 20% (25 aa) HHNLKSSNILISEDDT--------------IKISDSSFTLELSQKI----------------YNKPQQYNRFLSINYLSPEYTS-LIDGKGQV------- | .|||.|||. |. | .||.| . ..||. |. . ... ......|| .. . | HRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCK --EISNSSDVFSLGVIFLELIGQEI | | ..||.| |... |.. .. GFEYSEKCDVYSFGIVLWEILTRCR |
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| Kinase | 7412.AA | Ciliate-C8 | 91-230 | 22 | 5.3e-12 | 39.6 | In-house | 84-238 (238) | Show / Hide |
Range on Protein: 91-230 Range on HMM: 84-238/238 Sequence Identity: 22% (36 aa) IKKVAENGDHVATAFEMELCQ--KSLQQYIAEIKEGKANPTKSEVLVYFIQALNGLLELQENGYQHHNLKSSNILISED----DTIKISD--------SS ||| . .|||.|| .|.||. . .. . |.. . .. || . .. | . | | .|.| ..| |||..| . IKK-------SFFVMEMEKCQQNCNLKQYFDRCRKKQSYPSQQMKEIIAIQMIDSVNYLHCFNIMHRDIKPHNFLVCFDQQYQPTIKLCDFKKQCDFGFA FTLELSQK-IYNKP----QQYNRFL---SINYLSPEYTSLIDGKGQVEISNSSDVFSLGVIF |. .. .. | .||. .. . | || . . | ||..|.|... SQLPKNKSHYHSKKFKGTDQYIEMYFCGNWGYFAPEVEKKQSRIQSDIFSKKSDSYSVGLVL |
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| Kinase | 7412.AA | ULK | 107-174 | 29 | 5.6e-12 | 38.18 | In-house | 99-185 (329) | Show / Hide |
Range on Protein: 107-174 Range on HMM: 99-185/329 Sequence Identity: 29% (26 aa) MELCQK-SLQQYIAEIKE------GKANPTKSEVLVYFIQALNGLLELQENGYQHHNLKSSNILISEDD------------TIKISD ||.|. |.||| . |. | . . .|.. .|.| |||. ||..... | .| .||||.... ..||.| MEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIAD |
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| Kinase | 7412.AA | ULK | 107-174 | 29 | 6.1e-12 | 38.71 | In-house | 96-181 (324) | Show / Hide |
Range on Protein: 107-174 Range on HMM: 96-181/324 Sequence Identity: 29% (25 aa) MELCQK-SLQQYIAEIKE-----GKANPTKSEVLVYFIQALNGLLELQENGYQHHNLKSSNILISEDD------------TIKISD ||.|. |.||| . |. | . . .|.. .|.| .||. ||..... | .| .||||.... ..||.| MEYCNGGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIAD |
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| S_TKc | 7412.AA | S_TKc | 27-294 | 16 | 2.5e-11 | -10.71 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 27-294 Range on HMM: 1-231/231 Sequence Identity: 16% (46 aa) TVITKSLGYGSLGPVFQASQKCDDVCQNIVIKSFSCTQTLYDQIANQVNQTKVFQNSQNVLKFQIKKVAENGDHVATAFEMELCQK---SLQQYIAEIKE | . .| |. | |... | . || . . . .. .. . ... | .. . ||.| .| .|| . . YEILRKIGKGAFGKVYKCRHKK--TGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGR GKAN--PTKSEVLVYFIQALNGLLELQENGYQHHNLKSSNILISEDDTIKISDSSFTLELSQKIYNKPQQYNRFLSINYLSPEYTSLIDGKGQVEISN-S .. . . .. |. | ...| . ..| | || .|||..| .|||.| . .| . . .|..|| . . HGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----------TTFCGTPWYMAPEVL---------GYGKCK SDVFSLGVIFLELIGQEI---NIVSAIKLKSGIFEGVQVKEGFQDLASFICENMLCYLPQDRKTITWLIE----AFSEQFF .|. |.|.|. |.. . .. .|. . | . ...|.. |..| |. . . . . ..| CDWWSCGCILYEMLCGYPPFPQMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | 7412.AA | Ciliate-E2-Unclassified | 28-234 | 19 | 8.6e-10 | 30.16 | In-house | 2-264 (352) | Show / Hide |
Range on Protein: 28-234 Range on HMM: 2-264/352 Sequence Identity: 19% (52 aa) VITKSLGYGSLGPVFQASQKCDDVC----QNIVIKSFSCTQTLYD----QIANQVNQTK-------------VFQNSQNVLKFQIKKVAENGDHVATAFE | | .| |. | |... .| .. ....|.... | .. ......|. | ..|... .. .|.. . | . KIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFI--VKMFYCFQDKQNIYIV MELC-QKSLQQYIAEIKE------------GKAN-PTKSEVL-----VYFIQALNGL-LELQENGYQHHNLKSSNILISEDD---TIKISDSSFTLELSQ ||.| ...|.||| . | . . | ... || | |.|| ..|. | ..| .|||.... |||.| .. .. | MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQ KIYNKPQQ---------YNRFLSI----NYL----SPEYTSLIDGKGQVEIS-NSSDVFSLGVIFLELI .... . .... .. ||. .|| ...|... . . ..|..|||||. |.. NNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPE---VLQGQNYDHSKAYKCDIWSLGVILYEML |
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| Kinase | 7412.AA | Ciliate-A1 | 154-237 | 32 | 7.3e-09 | 26.25 | In-house | 124-225 (301) | Show / Hide |
Range on Protein: 154-237 Range on HMM: 124-225/301 Sequence Identity: 32% (34 aa) HHNLKSSNILISEDDTIKISDS--SFTLELSQ------------KIYNKP-QQYNRFLSINYLSPEY-------TSLIDGKGQVEISNSSDVFSLGVIFL | || |||| .|| .|| | | || .| | || . . .. | ||| .|..| |. ||..|||.|.. HRDLKPQNILIHFDDKWKICDLGMSKQLEQNQDCCDDVNGCSFSKQVNKHYHTCKKGGNLYYMSPEQYQMHYRDQMFIENK----IYKQSDMYSLGCIIC ELIGQE .| ..| FLCYKE |
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| Kinase | 7412.AA | Ciliate-E5 | 195-234 | 24 | 1.4e-08 | 23.83 | In-house | 215-271 (271) | Show / Hide |
Range on Protein: 195-234 Range on HMM: 215-271/271 Sequence Identity: 24% (14 aa) FLSINYLSPEYTSLIDGKG-----------------QVEISNSSDVFSLGVIFLELI ... .| ||| .. ... .. | .||..|||..|||| GFTQCYSSPEQYQCYHNQMFYILIRNLPDIKYIQSFKKKITKQSDIYSLGIVFLELT |
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| TyrKc | 7412.AA | TyrKc | 27-289 | 17 | 2e-06 | -118.01 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 27-289 Range on HMM: 1-280/280 Sequence Identity: 17% (54 aa) TVITKSLGYGSLGPVFQASQKCDDVCQNIVIKSFSCTQTLYDQIANQVNQTKVFQNSQNVLKFQIKKVAENG-DH--------VATAFE----------- . | || | | |... | .. .|. . . .. . | .| |.| . ITLGKKLGEGAFGEVYKGTWK-----IQVAVKMLKEDA-------------------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMI -MELCQK-SLQQYIAEIKEGKANPTKSEVLVYFIQALNGLLELQENGYQHHNLKSSNILISEDDTIKISDSSFTLELSQK-------IYNKPQQ--YNRF ||.. . .|..|. . .. . .. | . .|. .| | .... | | |.|..|. |.|||| . .. . | .... .. VMEYMPHGDLKDYLRKHRPK---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKT -LSINYLSPEYTSLIDGKGQVEISNSSDVFSLGVI---FLELIGQEINI-----VSAIKLKSGIFEG---VQVKE--------GFQDLASFICENMLCYL | | ..|| .. .|| . |||.| || . . .| .|.. . . .| | .. ... . | . . MLPIRWMAPE--CINYGK----FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ-IMKQCWHED PQDRKTITWLIEAF | || | . ..| | PEDRPTFSEIHECF |
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| Kinase | 7412.AA | Ciliate-E3 | 214-234 | 42 | 2e-06 | 16.53 | In-house | 182-202 (202) | Show / Hide |
Range on Protein: 214-234 Range on HMM: 182-202/202 Sequence Identity: 42% (9 aa) QVEISNSSDVFSLGVIFLELI | ||. || |.|..|..|. QQQISKESDYYSVGAVFCQLC |
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| Kinase | 7412.AA | Pkinase | 157-234 | 23 | 2.2e-05 | 20.1 | Pfam | 134-206 (293) | Show / Hide |
Range on Protein: 157-234 Range on HMM: 134-206/293 Sequence Identity: 23% (20 aa) LKSSNILISEDDTI----KISD--SSFTLELSQKIYNKPQQYNRFLSINYLSPEYTSLIDGKGQVEISNSSDVFSLGVIFLELI ||..||||.....| ||.| .. .. . |.. . . ...|..|| . |. ... ..|..|.|.|. |.. LKPENILIDNNGHIDACVKICDFGLAKQFD----Y-NNS-MTTFCGTPWYMAPEV--IR---GGQYYGPKVDMWSCGCILYEML |
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| Kinase | 7412.AA | Ciliate-E3 | 107-174 | 27 | 0.000111 | 10.86 | In-house | 83-149 (202) | Show / Hide |
Range on Protein: 107-174 Range on HMM: 83-149/202 Sequence Identity: 27% (20 aa) MELCQK-SLQQYIAEIKEGKANPTKSEVLVYFIQALNGLLELQENGYQHHNLKSSNILISEDD---TIKISD .|.| . .|. || . | |. ... .||.. |.... | | .| .|||... .|||.| QEYCSNGDLYHYIKQQ-----NKTQNIIYDICIQIIQGMIAIHEKNIIHSDIKPDNILVDKNNNQLIIKICD |
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| Kinase | 7412.AA | ULK | 208-230 | 36 | 0.064598 | 2.66 | In-house | 218-242 (324) | Show / Hide |
Range on Protein: 208-230 Range on HMM: 218-242/324 Sequence Identity: 36% (9 aa) LIDGKG-QVEISNS-SDVFSLGVIF .. |.| | . ... .|..|||.|| ILQGQGEQKPYYDYKCDIWSLGCIF |
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| Kinase | 7412.AA | ULK | 208-230 | 36 | 0.0806 | 2.24 | In-house | 222-246 (329) | Show / Hide |
Range on Protein: 208-230 Range on HMM: 222-246/329 Sequence Identity: 36% (9 aa) LIDGKG-QVEISNS-SDVFSLGVIF .. |.| | . ... .|..|||.|| ILQGQGEQKPYYDYKCDIWSLGCIF |
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