Gene 7644 (Tetrahymena)
7644
Sequence
Protein domains of 7644.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 7644.AA | Ciliate-C8 | 2-149 | 47 | 4.4e-54 | 185.99 | In-house | 101-238 (238) | Show / Hide |
Range on Protein: 2-149 Range on HMM: 101-238/238 Sequence Identity: 47% (78 aa) NLKQLFDFFRNTQ-PPPNEIKEVIAIQMLEGLNNLHVKNIMHRDIKPHNYLVSPSQTYGFTIKLCKKFQLSLNLSIQKIIKTKGDLGFASTVTKSKSHYL ||||.||..|..| .| ...||.|||||....|.||..|||||||||||.||...|.|..|||||. | . .| .|.|||| ..|.||||. NLKQYFDRCRKKQSYPSQQMKEIIAIQMIDSVNYLHCFNIMHRDIKPHNFLVCFDQQYQPTIKLCD-F-----K-KQ------CDFGFASQLPKNKSHYH SKK--GTDAY-----------FAPEVEKGQSRIQ--VFKQNQSLNYQFNFNAQKSDIFSLGLVL ||| |||.| |||||||.||||| .| . ||..|.|||| SKKFKGTDQYIEMYFCGNWGYFAPEVEKKQSRIQSDIFSKK-------------SDSYSVGLVL |
|||||||||
| Kinase | 7644.AA | C8 | 1-121 | 52 | 8.8e-49 | 167.41 | In-house | 104-216 (226) | Show / Hide |
Range on Protein: 1-121 Range on HMM: 104-216/226 Sequence Identity: 52% (69 aa) ENLKQLFDFFRNTQPP-PNEIKEVIAIQMLEGLNNLHVKNIMHRDIKPHNYLVSPSQTYGFTIKLCKKFQLSLNLSIQKIIKTKGDLGFASTVTKSKSHY .|||||.|..||.| . ..|.|| |||||..|.|..|.||||||||||||.|| ..|.|||.|||| |.||||.|.|.|||. QNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLC-------------------DFGFASQVSKNKSHI LSKK----GTDAYFAPEVEKG------QSRIQ .||| ||.||||||.||. |.||| QSKKMNTCGTWAYFAPEIEKKQDNQYKQYRIQ |
|||||||||
| Kinase | 7644.AA | C2 | 2-162 | 29 | 8.2e-24 | 78.32 | In-house | 104-245 (245) | Show / Hide |
Range on Protein: 2-162
Range on HMM: 104-245/245
Sequence Identity: 29% (52 aa)
NLKQLFDFFRNTQ-PPPNEIKEVIAIQMLEGLNNLHVKNIMHRDIKPHNYLVSPSQTYGFTIKLCK---KFQLSLNLSIQKIIKTKGDLGFASTVTKSKS
|||| |. |. . | ...|...||||. . | || ..| |||||| | |.. .| ||||| ..|
NLKQYFNRCRKQNSYPCQQMKMIMAIQMMDSINYLHRFDIVHRDIKPSNFLYQFDQQGIPTIKLCDYHIQYQKK--------------------------
HYLSKKGTDAYFAPEVEKGQSRIQVFKQNQSLNY---------QFNFNAQKSDIFS-LGLVLLELDNLNVLNDNW
.| || ... .||| . |.. . | . | .||.|| .|.||||||| . . .
-------CDFDFASKLKYNKSRIHFSKFKWTQQYYQHIFAPEVYQNIYKKNSDLFSTVGYVLLELDNMQQYTICC
|
|||||||||
| Kinase | 7644.AA | PEK | 24-152 | 18 | 1.4e-12 | 39.44 | In-house | 432-587 (655) | Show / Hide |
Range on Protein: 24-152 Range on HMM: 432-587/655 Sequence Identity: 18% (34 aa) IAIQMLEGLNNLHVKNIMHRDIKPHNYLVSPSQTYGFTIKLCKKFQLSLNLSIQKIIKTKGDLGFAS-----------------------TVTKSKSHYL |. |.||||| .| . ..|||.||.|.... ... .. ...| || | | ..... IFRQILEGLNYIHSQGMIHRDLKPSNIFLDCDGQHHQ-----------------MQVKI-GDFGLATNHEMLSQSQKNYNQQDQSYWKYVANDNCQWWNT SKK----------------------------------GTDAYFAPEVEKGQSRIQVFKQNQSLNYQFNFNAQKSDIFSLGLVLLEL ... || | .||...|| .|| . .|.|..|||....|. NQQNSPTGQDTHMWSNNYHIQPTSMFYCEHCHHTGGVGTCLYMSPEQLSGQ------------HYQKSHYNHKVDMYSLGIIFFEM |
|||||||||
| Kinase | 7644.AA | CDK-DD1 | 27-54 | 57 | 4.9e-12 | 32.83 | In-house | 106-133 (379) | Show / Hide |
Range on Protein: 27-54 Range on HMM: 106-133/379 Sequence Identity: 57% (16 aa) QMLEGLNNLHVKNIMHRDIKPHNYLVSP | |||.| .|. |||||||| | |. . QLLEGINECHNQGIMHRDIKPANLLINN |
|||||||||
| Kinase | 7644.AA | Ciliate-B2 | 27-61 | 37 | 6e-12 | 24.28 | In-house | 112-146 (197) | Show / Hide |
Range on Protein: 27-61 Range on HMM: 112-146/197 Sequence Identity: 37% (13 aa) QMLEGLNNLHVKNIMHRDIKPHNYLVSPSQTYGFT |...|| ....||.| |||| | |.. . | .. QLIDGLIQFRMYNILHLDIKPQNILFMQNGNYVYC |
|||||||||
| Kinase | 7644.AA | Ciliate-E1 | 24-78 | 35 | 9e-11 | 31.73 | In-house | 114-169 (202) | Show / Hide |
Range on Protein: 24-78 Range on HMM: 114-169/202 Sequence Identity: 35% (20 aa) IAIQMLEGLNNLHVKNIMHRDIKPHNYLVSPSQTYGFT-IKLCKKFQLSLNLSIQK |..|...||. || .||.||||||.| |.. . | .. . ..|..... | ..|. IIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYCDFGISKFLKNNQNQQCQY |
|||||||||
| Kinase | 7644.AA | Ciliate-A1 | 6-52 | 39 | 7.2e-09 | 26.27 | In-house | 88-134 (301) | Show / Hide |
Range on Protein: 6-52 Range on HMM: 88-134/301 Sequence Identity: 39% (19 aa) LFDFFRNTQ-PPPNEIKEVIAIQMLEGLNNLHVKNIMHRDIKPHNYLV ||... . || | | |. ||. .| .||.|||.|| | |. LFNYCYQNDYMKKEEIYE-ICYQIIEGYADIHDHNILHRDLKPQNILI |
|||||||||
| Kinase | 7644.AA | Ciliate-E5 | 27-54 | 50 | 3.9e-07 | 19.06 | In-house | 111-138 (271) | Show / Hide |
Range on Protein: 27-54 Range on HMM: 111-138/271 Sequence Identity: 50% (14 aa) QMLEGLNNLHVKNIMHRDIKPHNYLVSP | ||. .| ||| | ||||.| | .. QLVKGLQDIHQKNIIHLDIKPANILLGY |
|||||||||
| Kinase | 7644.AA | Dicty3 | 95-151 | 28 | 1e-06 | 17.53 | In-house | 248-289 (351) | Show / Hide |
Range on Protein: 95-151 Range on HMM: 248-289/351 Sequence Identity: 28% (16 aa) SKSHYLSKKGTDAYFAPEVEKGQSRIQVFKQNQSLNYQFNFNAQKSDIFSLGLVLLE .|. . | ||. |.|||. .. . ||||.|||....| YKQKCYSICGTIHYMAPEIKLNNQCC---------------ACRKSDIWSLGCTVWE |
|||||||||
| Kinase | 7644.AA | Pkinase | 3-49 | 32 | 4e-06 | 22.62 | Pfam | 86-138 (293) | Show / Hide |
Range on Protein: 3-49 Range on HMM: 86-138/293 Sequence Identity: 32% (18 aa) LKQLFDFF------RNTQP--PPNEIKEVIAIQMLEGLNNLHVKNIMHRDIKPHN |. ..| | |.. ...|.| .. |.|.||. .| ..|.|||.|| | LY-VMDLFDYISTWRHGCFYFSEWECKFYMY-QILRGLEYCHSMGIIHRDLKPEN |
|||||||||
| Kinase | 7644.AA | Dicty3 | 16-49 | 37 | 1.1e-05 | 14.54 | In-house | 109-142 (351) | Show / Hide |
Range on Protein: 16-49 Range on HMM: 109-142/351 Sequence Identity: 37% (13 aa) PPNEIKEVIAIQMLEGLNNLHVKN-IMHRDIKPHN .. ||...| .. ...|| .| .. |.|||||. | NEHEISKII-CDLVKTLNYIHKNCHIIHRDIKCDN |
|||||||||
| Kinase | 7644.AA | Ciliate-E5 | 139-153 | 66 | 2.7e-05 | 12.94 | In-house | 257-271 (271) | Show / Hide |
Range on Protein: 139-153 Range on HMM: 257-271/271 Sequence Identity: 66% (10 aa) KSDIFSLGLVLLELD .|||.|||.| ||| QSDIYSLGIVFLELT |
|||||||||
| Kinase | 7644.AA | S_TKc | 1-215 | 12 | 7.1e-05 | -105.42 | SMART | 19-231 (231) | Show / Hide |
Range on Protein: 1-215 Range on HMM: 19-231/231 Sequence Identity: 12% (37 aa) ENLK----------------------------------------------------QLFDFFRNTQP-------PPNEIKEVIAIQMLEGLNNLHVKNIM . | |||. .. .. |. ... ... |....|. .| ..|. RHKKTGRIVAIKIIKEHIRREIQILKKHHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMY-QICCALEYCHSHGII HRDIKPHNYLVSPSQTYGFTIKLC-----KKFQLSLNLSIQKIIKTKGDLGFASTVTKSKSHYLSKKGTDAYFAPEVEKGQSRIQVFKQNQSLNYQFNFN |||.|| | |.. .||.| ... . || | |||| .. HRDLKPENILLDE------HIKICDFGLARQL-------------------------------TTFCGTPWYMAPEVL-------------------GYG AQKSDIFSLGLVLLELDNLNVLNDNWIDLETKAEIYKGKAIASKYQIDRKSNIYKIAEICLKPNYLERKSIGDLLY--------ELI |.|. |.| .| |. . . . ....| . . . ||. . .| .. ..| . . KCKCDWWSCGCILYEMLCGYPPFP------QMQMMFKKIG---------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
|||||||||
| Kinase | 7644.AA | C8 | 132-149 | 50 | 0.000245 | 11.09 | In-house | 209-226 (226) | Show / Hide |
Range on Protein: 132-149 Range on HMM: 209-226/226 Sequence Identity: 50% (9 aa) QFNFNAQKSDIFSLGLVL |. .. .||.||.|||| QYKQYRIQSDLFSVGLVL |
|||||||||
| Kinase | 7644.AA | Ciliate-B2 | 139-146 | 62 | 0.000445 | 5.37 | In-house | 190-197 (197) | Show / Hide |
Range on Protein: 139-146 Range on HMM: 190-197/197 Sequence Identity: 62% (5 aa) KSDIFSLG .|||.|.| QSDIYSMG |
|||||||||
| Kinase | 7644.AA | Ciliate-A1 | 139-152 | 42 | 0.002091 | 7.38 | In-house | 208-221 (301) | Show / Hide |
Range on Protein: 139-152 Range on HMM: 208-221/301 Sequence Identity: 42% (6 aa) KSDIFSLGLVLLEL .||..|||.....| QSDMYSLGCIICFL |
|||||||||
| Kinase | 7644.AA | Pkinase | 84-152 | 25 | 0.013866 | 10.22 | Pfam | 154-205 (293) | Show / Hide |
Range on Protein: 84-152 Range on HMM: 154-205/293 Sequence Identity: 25% (18 aa) GDLGFASTV-TKSKSHYLSKKGTDAYFAPEVEKGQSRIQVFKQNQSLNYQFNFNAQKSDIFSLGLVLLEL .| |.| . . ..| . . || | |||| |. . .|.|..|.|..| |. CDFGLAKQFDY-NNS-MTTFCGTPWYMAPEV------IR----------GGQYYGPKVDMWSCGCILYEM |
|||||||||