Gene 12577 (Tetrahymena)

12577

Species: Tetrahymena
Alias: 837, TTHERM_00227670, 12577, 19.m00369, PreTt12577
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-E1

Sequence

Name Sequence Type Origin Length Description Download
12577.AA Protein None 1233 None Fasta, JSON
12577.kin_dom Protein Kinase Domain None 182 None Fasta, JSON
12577.NA RNA None 3702 None Fasta, JSON

Protein domain

Protein domains of 12577.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 12577.AA Ciliate-B2 304-385 24 7.6e-14 28.85 In-house 1-85 (197) Show / Hide 
Range on Protein: 304-385
Range on HMM: 1-85/197
Sequence Identity: 24% (21 aa)

YFLCRLIKQESQILMFDGY-QETNSRFKDLTFKVYYQ---RENKLIDKEFFIINYYQKKLKDKKILLDYLQITNDLNILALDKQEY
|.||  | .  . . ..||  . . ...|| ||.|..    . . |..|  |.  .... .  | ..|..|| .. ..| ..| |.
YYLCKYINKGGCGFICEGYKKHSIREYQDLAFKIYFNKQDCDKEEIQHEIKIMKMFEYNINVVK-YIDHIQINETIDVLIMEKCEC
Kinase 12577.AA Ciliate-B2 439-524 24 8e-06 9.6 In-house 1-85 (197) Show / Hide 
Range on Protein: 439-524
Range on HMM: 1-85/197
Sequence Identity: 24% (22 aa)

YYLSNYISDSDKQEENLQFFTGYQMRSLSQNNDLIFQMQHE---IDNQKLHREQNIIEMIEVDCQEQIKQDYFKFEENIHVTIFKQKQY
||| .||    |  . .  . || . |. .  ||.|  . .    | . .  | .|. | |   .     |... .|.|.| |    ..
YYLCKYI---NKGGCGF-ICEGYKKHSIREYQDLAFKIYFNKQDCDKEEIQHEIKIMKMFEYNINVVKYIDHIQINETIDVLIMEKCEC
Kinase 12577.AA Ciliate-E2 554-564 18 0.222777 0.47 In-house 370-380 (365) Show / Hide 
Range on Protein: 554-564
Range on HMM: 370-380/365
Sequence Identity: 18% (2 aa)

SIKELKNHQIL
......||...
GWEQILNHPWF
Kinase 12577.AA Ciliate-B2 632-761 40 9.3e-56 129.58 In-house 77-197 (197) Show / Hide 
Range on Protein: 632-761
Range on HMM: 77-197/197
Sequence Identity: 40% (56 aa)

VLVLEKCRYSLRDELNQQTDKVKIIQSRVKQNEFQDEYNPFGVQKLMKIFSDLLDGLIEMRSHRIIHSDIKPSNILIKDNLDYVYCDFGVSLIIQDDSQR
||..|||..||..||..       ||  .|.         |  |||.... .|.||||..|.  |.| ||||.|||.  | .|||||||.| |..|..| 
VLIMEKCECSLKQELQK-------IQKQQKC---------FNNQKLYQMIFQLIDGLIQFRMYNILHLDIKPQNILFMQNGNYVYCDFGISSIKKDNQQI

QPLGYTIIYACPEALNLN-------TISFKSDVYSLG
.  | |. || || ..          | |.||.||.|
KIKGFTKKYASPEQMECDHNQTFVTNIDFQSDIYSMG
Kinase 12577.AA Ciliate-E1 610-758 36 2.3e-39 125.8 In-house 48-202 (202) Show / Hide 
Range on Protein: 610-758
Range on HMM: 48-202/202
Sequence Identity: 36% (60 aa)

IFKFIIEESKIDIQNEID-IMN--RVLVLEKCRYSLRDELNQQTDKVKIIQSR-VKQNEFQDEYNPFGVQKLMKIFSDLLDGLIEMRSHRIIHSDIKPSN
|.||. |.. |.|.. |.  .|   ....|.| .|| |.|...       . | ......| ..| |  |..|.|. .|.|||||.....|||.||||.|
IMKFKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNH-------N-RLEYWQQCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQN

ILIKDNLDYVYCDFGVSL--IIQDDSQRQPLGYTIIYACPEALN--------LNTISFKSDVY
|||...  |||||||.|.  . ....| |  |||  |..|| .|         ..|..|||.|
ILINNQGNYVYCDFGISKFLKNNQNQQCQYKGYTHYYYPPEQYNCPEQEHNKNQKINYKSDIY
Kinase 12577.AA Ciliate-E3 675-768 35 3.7e-23 69.28 In-house 103-202 (202) Show / Hide 
Range on Protein: 675-768
Range on HMM: 103-202/202
Sequence Identity: 35% (35 aa)

QKLMKIFSDLLDGLIEMRSHRIIHSDIKPSNILIKDNLD---YVYCDFGVSLIIQDDS---QRQPLGYTIIYACPEALNLNTISFKSDVYSLGKTFREVL
. ...|.  .. |.|.  .  ||||||||.|||.  |.       |||| |   . .    . |  | |..|| || .  . ||. || ||.|  | .. 
NIIYDICIQIIQGMIAIHEKNIIHSDIKPDNILVDKNNNQLIIKICDFGESKQLRKNKGHTHTQYQGWTPFYAAPEQNDQQQISKESDYYSVGAVFCQLC
Kinase 12577.AA ULK 679-761 25 2e-17 58.44 In-house 130-239 (324) Show / Hide 
Range on Protein: 679-761
Range on HMM: 130-239/324
Sequence Identity: 25% (28 aa)

KIFSDLLDGLIEMRSHRIIHSDIKPSNILIKDNLDYV------------YCDFGVSLIIQDDSQRQPLGYTII----------YACPEALNLN----TIS
..| ... |. |...| ||| ||||.||||...  .              .||| . ....... | . .|.           | .|. |. .      .
QFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYY

-FKSDVYSLG
 .|.|..|||
DYKCDIWSLG
Kinase 12577.AA ULK 679-761 27 9.7e-17 55.03 In-house 134-243 (329) Show / Hide 
Range on Protein: 679-761
Range on HMM: 134-243/329
Sequence Identity: 27% (30 aa)

KIFSDLLDGLIEMRSHRIIHSDIKPSNILIKDNLDYV------------YCDFGVSLIIQDDSQRQPLGYTII----------YACPEALNLN----TIS
..| ..| |. |...|.||| ||||.||||...  .              .||| .  ...|.. | . .|            | .|. |. .      .
QFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYY

-FKSDVYSLG
 .|.|..|||
DYKCDIWSLG
Kinase 12577.AA STE 679-761 28 5.8e-14 45.79 In-house 155-255 (359) Show / Hide 
Range on Protein: 679-761
Range on HMM: 155-255/359
Sequence Identity: 28% (31 aa)

KIFSDLLDG-LIEMRSHRIIHSDIKPSNILIKDNLDYVYCDFGVSLIIQD-----------------DSQRQPLGYTIIYACPEALNL------NTISFK
.|  ..| | |    ||.||| ||||.|||.        |||||. ...|                 ...|. .  |  .  || ..       .  ..|
YICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTK

SDVYSLG
.|..|||
CDIWSLG
Kinase 12577.AA Ciliate-B2 580-629 35 1.9e-13 27.91 In-house 1-53 (197) Show / Hide 
Range on Protein: 580-629
Range on HMM: 1-53/197
Sequence Identity: 35% (19 aa)

YFINSYISQGGFSIVLEGYKQISLGKCVGVIFKFIIE---ESKIDIQNEIDIM
|..  || .||. .. |||| .|...   ..||   .     | .||.|| ||
YYLCKYINKGGCGFICEGYKKHSIREYQDLAFKIYFNKQDCDKEEIQHEIKIM
Kinase 12577.AA C8 578-764 21 2.8e-13 42.54 In-house 1-226 (226) Show / Hide 
Range on Protein: 578-764
Range on HMM: 1-226/226
Sequence Identity: 21% (49 aa)

RKYFINSYISQGGFSIVLEGYKQISLGKCVGVIFKFIIEESKIDIQNEIDIM-----------NRVLVLE-KCRYSLRDELNQQTDK-VKIIQSRVKQNE
 . |   |.|.|....||....     .   .. || . ..| ||||.. ||              .|.| .| |    . ... ..  ||.| ..|   
FNNF--QYLSFGAYGMVLKAKNVK---DNREIVLKFQKCQNKQDIQNIESIMKEYEMPQVFQQYDFYVNEYDCFYEMYEVFEEEKCSNEKIVQTEEKSCF

FQD-----------------EYNPFGVQKLMKIFSDLLDGLIEMRSHRIIHSDIKPSNILIKDNLDYV----YCDFGVSLIIQDDSQ-RQPLGY----TI
 ..                 .  .|  ..  .|   ..||.  . .. |.| ||||.|.|.. .  |.     ||||..  .... .  |   .    | 
VMEMELCEQNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSKKMNTCGTW

IYACPEALNL-----NTISFKSDVYSLGKTF
 |  || ..         . .||..|.|   
AYFAPEIEKKQDNQYKQYRIQSDLFSVGLVL
Kinase 12577.AA S_TKc 580-811 19 1.3e-12 8.12 SMART 1-231 (231) Show / Hide 
Range on Protein: 580-811
Range on HMM: 1-231/231
Sequence Identity: 19% (51 aa)

YFINSYISQGGFSIVLEGYKQISLGKCVGVIFKFIIEESKIDIQNEIDIMN-RVLVLEKCRYSLRDELNQQTDKVKIIQSRVKQ--NEFQDEYNP-----
| |   | .|.|. |  ...         |  | |     ..|..||.|.  .   . |. .. .|      |.. ..   . .   .  |         
YEILRKIGKGAFGKVYKCRHKK---TGRIVAIKIIK----EHIRREIQILKKHHPNIVKLYDVFQD------DHLYMVMEYCDGDLGDLFDYIKKRGRHG

----FGVQKLMKIFSDLLDGLIEMRSHRIIHSDIKPSNILIKDNLDYVYCDFGVSLIIQDDSQRQPLGYTIIYACPEALNLNTISF-KSDVYSLGKTFRE
    |      ...  ....|  . ||.||| |.||.|||. .      ||||.. ..        .  |  |  || |     .. |.|..|.| .. |
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYE

VLRVYNKLNNKTQFIMQIEKIINENMV------LE-NASDRYDCLKLHQ--------LFF
 |  |       | .... .   . .       |. . ..|. . .. |         .|
MLCGYPPFP-QMQMMFKKIG--SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 12577.AA TKL 693-761 20 1.6e-12 41.37 In-house 150-276 (364) Show / Hide 
Range on Protein: 693-761
Range on HMM: 150-276/364
Sequence Identity: 20% (26 aa)

SHR--------IIHSDIKPSNILIKDNLD--------------YVYCDFGVSLIIQDDS--------------------QRQPLGYTIIYACPEALNLN-
|..        ||| |.|..|||...|.                  |||| |  .. ..                    .. . . |. .  ||.|. . 
SMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQM

---------------TISFKSDVYSLG
               . | |.|||| |
NYTEKVGIDEFCKGFEYSEKCDVYSFG
Kinase 12577.AA Ciliate-E2 580-761 17 8.8e-12 36.7 In-house 1-283 (365) Show / Hide 
Range on Protein: 580-761
Range on HMM: 1-283/365
Sequence Identity: 17% (52 aa)

YFINSYISQGGFSIVLEGYK-------------------------QISLGKCVGVIFK-FIIEESKIDIQNEID-------------------IMNRV--
| ..  | ||.|..| .. .                         .|..     .. .  .. ...|.| .||.                   |.. .  
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

----------LVLEKCRY-SLRDELNQQ-TDKVKIIQSRVKQNEFQDEYNPFGVQKLMKIFSDLLD---------------GLIEMRSHR-IIHSDIKPS
          ||.| | . .|.| .... . . ..|.        . . ..|  ..  .|.  .|.               .| .. |   ||| ||||.
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIE--------K-D-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPE

NILIKDNLDYVYCDFGVSLIIQDDSQRQ---PLGY-----------------------------TIIYACPEALNLNT---------ISFKSDVYSLG
|||.        .||| | ...||.|..   .. .                             |  | .|| ||             ..|.|..|||
NILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLG
Kinase 12577.AA Pkinase 693-761 32 9.1e-12 42.69 Pfam 126-199 (293) Show / Hide 
Range on Protein: 693-761
Range on HMM: 126-199/293
Sequence Identity: 32% (25 aa)

SHRIIHSDIKPSNILIKDNLDY----VYCDFGVSLI--IQDDSQRQPLGYTIIYACPEALN-LNTISFKSDVYSLG
|..||| |.||.||||..| .       ||||..    .  .|  . .  |. |. || ..  . .. |.|..|.|
SMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCG
Kinase 12577.AA Ciliate-A1 680-761 25 1.2e-11 35.87 In-house 106-215 (301) Show / Hide 
Range on Protein: 680-761
Range on HMM: 106-215/301
Sequence Identity: 25% (28 aa)

IFSDLLDGLIEMRSHRIIHSDIKPSNILIKDNLDYVYCDFGVSLIIQDDS-------------------QRQPLGYTIIYACPEA---------LNLNTI
| . .  |.. . .| |.|.|.|| |||| .   .  ||.| | .                        .    | .  |  ||          .  | |
ICYQIIEGYADIHDHNILHRDLKPQNILIHFDDKWKICDLGMSKQLEQNQDCCDDVNGCSFSKQVNKHYHTCKKGGNLYYMSPEQYQMHYRDQMFIENKI

SFKSDVYSLG
. .||.||||
YKQSDMYSLG
Kinase 12577.AA TyrKc 580-810 14 2e-06 -119.42 SMART 1-280 (280) Show / Hide 
Range on Protein: 580-810
Range on HMM: 1-280/280
Sequence Identity: 14% (45 aa)

YFINSYISQGGFSIVLEGY-------KQISLGKCVGVIFKFIIEESKIDIQNEIDIMNRV------------LVLEK-------CRYSLRDELNQQTDKV
   .  .  | | .| .|        | .  ..             . |. .|. || ..             ....         . .  |.    |  
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDA-------------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLK

KIIQSRVKQNEFQDEYNPFGVQKLMKIFSDLLDGLIEMRSHRIIHSDIKPSNILIKDNLDYVYCDFGVSLIIQDD--------SQRQ----PLG--YTII
. .... ..         . ...| ..  .  .|     |...|| |.   |.|...|.    .||| |  | ||          |.           | 
DYLRKHRPK---------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIR

YACPEALNLNTISFKSDV----------YSLGKTFREV-----LRVYNKLNNKTQF-IMQIEKI--------INENMVL-------ENASDRYDCLKLHQ
   ||..| .. ..||||          ...|..  .      .  .  ...  |   | . .           . |         |...||     .|.
WMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHE

LF
.|
CF
Kinase 12577.AA Ciliate-E1 586-600 46 0.017662 4.45 In-house 1-15 (202) Show / Hide 
Range on Protein: 586-600
Range on HMM: 1-15/202
Sequence Identity: 46% (7 aa)

ISQGGFSIVLEGYKQ
|..|.||||.....|
IGNGSFSIVFKAKQQ
Kinase 12577.AA Ciliate-E3 580-594 26 0.041743 2.71 In-house 1-15 (202) Show / Hide 
Range on Protein: 580-594
Range on HMM: 1-15/202
Sequence Identity: 26% (4 aa)

YFINSYISQGGFSIV
|..   . .|.|..|
YTVQQILGCGQFGRV
WD40 12577.AA WD40 945-959 60 1.5e-05 18.61 Pfam 25-39 (39) Show / Hide 
Range on Protein: 945-959
Range on HMM: 25-39/39
Sequence Identity: 60% (9 aa)

ILATASYDHTIRLWD
.||..| |.|||.||
YLASGSRDGTIRIWD
WD40 12577.AA WD40 926-959 20 0.088749 7.0 SMART 1-46 (46) Show / Hide 
Range on Protein: 926-959
Range on HMM: 1-46/46
Sequence Identity: 20% (10 aa)

QQEEIKKNKLKNK------MQSNRV--------ILATASYDHTIRLWD
. . ... |  ..      .. .          .||..| |.|||.||
T-KCVHTFKGHTGNSWVTCVCWHPDGGSDDYPNYLASGS-DGTIRIWD
WD40 12577.AA WD40 1019-1058 22 2.6e-07 31.53 SMART 1-46 (46) Show / Hide 
Range on Protein: 1019-1058
Range on HMM: 1-46/46
Sequence Identity: 22% (11 aa)

SKIPVFAYDGYKN--NVTSIGFNQDS------KWIYTGSEDGSIQIHH
.  .|. ..| ..   ||.. ...|.      .....|| ||.| | .
T-KCVHTFKGHTGNSWVTCVCWHPDGGSDDYPNYLASGS-DGTIRIWD
WD40 12577.AA WD40 1020-1058 25 7.1e-07 22.41 Pfam 1-39 (39) Show / Hide 
Range on Protein: 1020-1058
Range on HMM: 1-39/39
Sequence Identity: 25% (10 aa)

KIPVFAYDGYKNNVTSIGFNQD-SKWIYTGSEDGSIQIHH
. ..  . | .. ||.. ...| .... .||.||.| |  
WKCKHTF-GHTHWVTCCAWHPDMGHYLASGSRDGTIRIWD
WD40 12577.AA WD40 1061-1099 25 0.001342 18.49 SMART 1-46 (46) Show / Hide 
Range on Protein: 1061-1099
Range on HMM: 1-46/46
Sequence Identity: 25% (12 aa)

MQGVPKIFS-NKE--PVSQVVLHPNE------VDLISVDQDGILKIWD
   . ..|.  .   .|. |  ||.         |.| . || ..|||
T-KCVHTFKGHTGNSWVTCVCWHPDGGSDDYPNYLASGS-DGTIRIWD
WD40 12577.AA WD40 1061-1099 25 0.004267 11.53 Pfam 1-39 (39) Show / Hide 
Range on Protein: 1061-1099
Range on HMM: 1-39/39
Sequence Identity: 25% (10 aa)

MQGVPKIFSNKEPVSQVVLHPN-EVDLISVDQDGILKIWD
 . . ..   . .|. .  ||.    |.|   || ..|||
WKCKHTF-GHTHWVTCCAWHPDMGHYLASGSRDGTIRIWD
WD40 12577.AA WD40 1103-1143 10 0.916213 0.6 SMART 1-46 (46) Show / Hide 
Range on Protein: 1103-1143
Range on HMM: 1-46/46
Sequence Identity: 10% (5 aa)

ESQCRKEIVLAPKI--GLRSVSIATNA------QFFCAADSSGTLFIQN
. .| ...  . .   . ..|..  .       .......  ||. | .
T-KCVHTFK-GHTGNSWVTCVCWHPDGGSDDYPNYLASGS-DGTIRIWD
WD40 12577.AA WD40 1151-1201 19 1.5e-08 27.23 Pfam 1-39 (39) Show / Hide 
Range on Protein: 1151-1201
Range on HMM: 1-39/39
Sequence Identity: 19% (10 aa)

ISQQKIENAHNDYILKCQISPFAKWVWDVSYGCDGQFLFSCSSDNTAKLWK
  . ..  .|.. .  | ..|            .|..|.|.| |.| ..|.
WKCKHTF-GHTHWVTCCAWHPD-----------MGHYLASGSRDGTIRIWD
WD40 12577.AA WD40 1162-1201 22 3e-06 27.95 SMART 1-46 (46) Show / Hide 
Range on Protein: 1162-1201
Range on HMM: 1-46/46
Sequence Identity: 22% (11 aa)

DYILKCQISPFAK--WVWDVSYGCDG------QFLFSCSSDNTAKLWK
.  . . ..   .  ||..|..  ||      ..|.|.| |.| ..|.
T-KCVHTFKGHTGNSWVTCVCWHPDGGSDDYPNYLASGS-DGTIRIWD
WD40 12577.AA WD40 1208-1228 33 0.017173 9.79 Pfam 1-20 (39) Show / Hide 
Range on Protein: 1208-1228
Range on HMM: 1-20/39
Sequence Identity: 33% (7 aa)

QVEYQIFKGHTQTVNCVAIND
    ..| ||| .|.|.|...
WKCKHTF-GHTHWVTCCAWHP