Gene 18320 (Tetrahymena)
18320
Group:
Other
Family:
Ciliate-E1
Sequence
Protein domains of 18320.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 18320.AA | Ciliate-E1 | 297-470 | 19 | 1.5e-21 | 67.15 | In-house | 1-202 (202) | Show / Hide |
Range on Protein: 297-470 Range on HMM: 1-202/202 Sequence Identity: 19% (40 aa) INSGGEADIFTN--QNYD-YIVYRVIKLNGDEDLRKQEKELLRLQE-LQEQNIFNIDSSHLIEDKI-NHTKYIIYVMQKCKMSLQDEIL----------- | .|.....| ||. . |. .| . . . .. .... . ... .... . .|. .. . .| ....|..||.|.. IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYWQQC --SKKVFSLRETLKFISTSFHLLIVLRQKYIYHSDIKPGNILKIDDNNYQLSDFGASQ-----YVDFIDPFCDFEMYTPSFTPQ------KKEKNLPFYH .. |. . .. | .. || |.|. |.|.|||| |||. ...||...||| |. . .. .. ..| |. . .|... . QQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYCDFGISKFLKNNQNQQCQYKGYTHYYYPPEQYNCPEQEHNKNQKINYKS DIY ||| DIY |
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| Kinase | 18320.AA | Ciliate-B2 | 291-435 | 26 | 3.8e-18 | 39.17 | In-house | 1-151 (197) | Show / Hide |
Range on Protein: 291-435 Range on HMM: 1-151/197 Sequence Identity: 26% (41 aa) FKLGDHINSGGEADIFTNQ------NYDYIVYRVIKL--NGDEDLRKQEKELLRLQELQEQNIFNIDSSHLIEDKINHTKYIIYVMQKCKMSLQDEIL-- . |.. ||.||. |. | ..... ..|.. .| . . . | ... . ||. |. .|. . .|.||. ||..|. YYLCKYINKGGCGFICEGYKKHSIREYQDLAFKIYFNKQDCDKEEIQHEIKIMKMFEYNINVVKYIDHIQ-INETID-----VLIMEKCECSLKQELQKI --SKKVFSLRETLKFISTSFHLLIVLRQKYIYHSDIKPGNILKIDDNNYQLSDFGAS .| | .. | . || .| . | | |||| |||. .|| ..||| | QKQQKCFNNQKLYQMIFQLIDGLIQFRMYNILHLDIKPQNILFMQNGNYVYCDFGIS |
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| Kinase | 18320.AA | Ciliate-C6 | 382-436 | 42 | 1.4e-09 | 30.1 | In-house | 129-185 (306) | Show / Hide |
Range on Protein: 382-436 Range on HMM: 129-185/306 Sequence Identity: 42% (24 aa) KKVFSLRETLKFISTSFHLLIVLRQ-KYIYHSDIKPGNILKIDD-NNYQLSDFGASQ .. |. | ..| . .| .. | | |||| ||| .|| ||| |||||..| YEHFDENEIVQFCKQIGKTLADIYNECNIAHRDIKPSNILIMDDENNYYLSDFGCAQ |
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| Kinase | 18320.AA | Ciliate-E3 | 401-435 | 48 | 7.2e-08 | 20.93 | In-house | 116-153 (202) | Show / Hide |
Range on Protein: 401-435 Range on HMM: 116-153/202 Sequence Identity: 48% (19 aa) LIVLRQKYIYHSDIKPGNILKIDDNN----YQLSDFGAS .| . .| | |||||| ||| .| || . .|||.| MIAIHEKNIIHSDIKPDNIL-VDKNNNQLIIKICDFGES |
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| Kinase | 18320.AA | S_TKc | 291-536 | 15 | 3e-07 | -70.57 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 291-536
Range on HMM: 1-231/231
Sequence Identity: 15% (42 aa)
FKLGDHINSGGEADIFTNQNYD---YIVYRVIKLNGDEDLRKQEKELLRLQELQEQNIFNIDSSHLIEDKINHTKYIIYVMQKCKM---SLQDEILSKKV
......| .|. . . .. . . .|| . ..| ..|. . || .. . ... || | .| | | ...
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----EHIRREIQILKK---HHPNIVKLYDVFQD-------DHLYMVMEYCDGDLGDLFDYIKKRGR
------FSLRETLKFISTSFHLLIVLRQKYIYHSDIKPGNILKIDDNNYQLSDFGASQYVDFIDPFCDFEMYTPSFTP---QKKEKNLPFYH---DIYSF
|. .. ... . | . .. | | |.|| ||| .|. . ..||| . . . || . . .. . |..|.
HGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENIL-LDE-HIKICDFGLARQL-------TTFCGTPWYMAPEVL------GYGKCKCDWWSC
GKTIQKLLI-----QLENQSEISDELNKFIKEICKDDENSINLDCFKLQRKFINILME--FTNDEVIK--------AFF
| .. .| . .... .| |. .. . || . | | |. . .|
GCILYEMLCGYPPFP---------QMQMMFKKIG-------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
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| Kinase | 18320.AA | Ciliate-A1 | 409-446 | 36 | 2e-06 | 17.95 | In-house | 122-159 (301) | Show / Hide |
Range on Protein: 409-446 Range on HMM: 122-159/301 Sequence Identity: 36% (14 aa) IYHSDIKPGNILKIDDNNYQLSDFGASQYVDFIDPFCD | |.|.||.||| .|. . . |.| |. . || ILHRDLKPQNILIHFDDKWKICDLGMSKQLEQNQDCCD |
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| Kinase | 18320.AA | RAN | 409-433 | 62 | 2.2e-05 | 13.89 | In-house | 170-195 (324) | Show / Hide |
Range on Protein: 409-433 Range on HMM: 170-195/324 Sequence Identity: 62% (17 aa) IYHSDIKPGNILKID--DNNYQLSDFG ||| |||| ||| || | | | |.| IYHCDIKPENIL-IDGIDWNIYLCDWG |
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| Kinase | 18320.AA | FRAY | 411-435 | 56 | 2.7e-05 | 12.05 | In-house | 130-154 (277) | Show / Hide |
Range on Protein: 411-435 Range on HMM: 130-154/277 Sequence Identity: 56% (14 aa) HSDIKPGNILKIDDNNYQLSDFGAS | ||| |||| .| . |..||| | HRDIKAGNILIGEDGTIQIADFGVS |
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| Kinase | 18320.AA | Ciliate-E8 | 409-435 | 44 | 6e-05 | 11.41 | In-house | 110-138 (138) | Show / Hide |
Range on Protein: 409-435 Range on HMM: 110-138/138 Sequence Identity: 44% (13 aa) IYHSDIKPGNIL-KI-DDNNYQLSDFGAS | |.|.| ||| . || . . ||| | IIHCDFKLNNILVQRNDDTKIKIIDFGFS |
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| Kinase | 18320.AA | LKB | 409-433 | 52 | 6.6e-05 | 10.56 | In-house | 125-149 (265) | Show / Hide |
Range on Protein: 409-433 Range on HMM: 125-149/265 Sequence Identity: 52% (13 aa) IYHSDIKPGNILKIDDNNYQLSDFG . | ||||||.| || ..||| VVHKDIKPGNLLLTHDNTLKICDFG |
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| Kinase | 18320.AA | PHK | 409-433 | 56 | 0.000318 | 10.03 | In-house | 130-154 (273) | Show / Hide |
Range on Protein: 409-433 Range on HMM: 130-154/273 Sequence Identity: 56% (14 aa) IYHSDIKPGNILKIDDNNYQLSDFG | | | || ||| .|. | .|||| IVHRDLKPENILCDDNMNIKISDFG |
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