Gene 21184 (Tetrahymena)
21184
Group:
Other
Family:
Ciliate-E1
Sequence
Protein domains of 21184.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 21184.AA | Ciliate-E1 | 340-514 | 27 | 6e-43 | 137.57 | In-house | 1-202 (202) | Show / Hide |
Range on Protein: 340-514 Range on HMM: 1-202/202 Sequence Identity: 27% (55 aa) INSGGEADILEC-------RSKDGIFVLRFLFYKNEKNKEEIEKEYKIISSIKKQFNLTSQKDKIDIPDSNLIIILTDFYQQSLHEYLT----------- | .|....... ... ..... .|. ... .||...||| . .||.... | |.| .....||.......||..||. IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYWQQC -NSLNKFDQDTFVSFIYDMIFGLIELRYYNIQHFDIKPANILLDTNLKLYFNDFGLSN--KLKYGESFVPLGHTSAFSPQEQQ-------DYQQIDNYQS . |.|... ... |...|.|||||..||| |.||||.||| . . .. ..|||.| |.. .. . |.|. ..|.|| ...|..||.| QQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYCDFGISKFLKNNQNQQCQYKGYTHYYYPPEQYNCPEQEHNKNQKINYKS DIF ||. DIY |
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| Kinase | 21184.AA | Ciliate-B2 | 336-517 | 30 | 6.4e-35 | 79.49 | In-house | 3-197 (197) | Show / Hide |
Range on Protein: 336-517 Range on HMM: 3-197/197 Sequence Identity: 30% (59 aa) ITKFINSGGEADILECRSKDGIF-----VLRFLFYKNEKNKEEIEKEYKIISSIKKQFNLTSQKDKIDIPDSNLIIILTDFYQQSLHEYLT---NSLNKF ..|.||.||. | | | |. ... .| | . .||||..|.||... .. | | | | ... .. .. . || . | .| LCKYINKGGCGFICEGYKKHSIREYQDLAFKIYFNKQDCDKEEIQHEIKIMKMFEYNINVVKYIDHIQI-NETIDVLIMEKCECSLKQELQKIQKQQKCF DQDTFVSFIYDMIFGLIELRYYNIQHFDIKPANILLDTNLKLYFNDFGLSNKLKYGESFVPLGHTSAFSPQEQQDYQ------QIDNYQSDIFSLG . .. |...| |||..| ||| | ||||.|||. | . . ||| | | |.| .. . || . ..||||.|.| NNQKLYQMIFQLIDGLIQFRMYNILHLDIKPQNILFMQNGNYVYCDFGISSIKKDNQQIKIKGFTKKYASPEQMECDHNQTFVTNIDFQSDIYSMG |
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| S_TKc | 21184.AA | S_TKc | 334-571 | 18 | 3.7e-12 | 1.45 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 334-571 Range on HMM: 1-231/231 Sequence Identity: 18% (49 aa) LEITKFINSGGEADILECRSKD--GIFVLRFLFYKNEKNKEEIEKEYKIISSIKKQFNLTSQKDKIDIPDSNLIIILTDFYQQ---SLHEYLTNSLNK-- || . | .|. . || |. |. . . | |..| .| .. . |. .| .. . . . ... . .|..|. . . YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK--HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHGL ---FDQDTFVSFIYDMIFGLIELRYYNIQHFDIKPANILLDTNLKLYFNDFGLSNKLKYGESFVPLGHTSAFSPQ----EQQDYQQIDNYQSDIFSLGKT |. . ...| .. .| . .| | |.||.|||||. . ||||. .| .| .| | . . .|. |.| . RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCI FEVVMK---AFSKQNINLYNQQQKFFDNFKNLIVLMTKKEPQDRIKCDELLL--------RFT . . |. | .... . .|..| . .|.|..|. . |.| . LYEMLCGYPPFP-QMQMMFKKIG--SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | 21184.AA | Ciliate-E3 | 376-524 | 27 | 5.3e-10 | 27.67 | In-house | 51-202 (202) | Show / Hide |
Range on Protein: 376-524 Range on HMM: 51-202/202 Sequence Identity: 27% (43 aa) KEYKIISSIKKQFNLTSQKDKIDIPDSNLIIILTDFYQQSLHEYLTNSLNKFDQDTFVSFIYDMIFGLIELRYYNIQHFDIKPANILLDTNL---KLYFN .| . ..|. |. . .. | .. |. .| .|. ..|| . . .|. .| |.|.. || | |||| |||.|.|. . . QEFQNCQQINSQNVVKCHDQYYDQQNKMIFIVQEYCSNGDLYHYIK-QQNKTQNIIYDICIQ-IIQGMIAIHEKNIIHSDIKPDNILVDKNNNQLIIKIC DFGLSNKLKYGE---SFVPLGHTSAFSPQEQQDYQQIDNYQSDIFSLGKTFEVVM |||.| .|. . | |. ... || |.||| . ||. |.| | . DFGESKQLRKNKGHTHTQYQGWTPFYAAPEQNDQQQISK-ESDYYSVGAVFCQLC |
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| Kinase | 21184.AA | Ciliate-E5 | 450-482 | 54 | 8e-09 | 24.63 | In-house | 123-155 (271) | Show / Hide |
Range on Protein: 450-482 Range on HMM: 123-155/271 Sequence Identity: 54% (18 aa) NIQHFDIKPANILLDTNLKLYFNDFGLSNKLKY || | ||||||||| ..| ..|.|.| |.|. NIIHLDIKPANILLGYDNKWKYIDMGISRKFKH |
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| Kinase | 21184.AA | Ciliate-E2 | 401-517 | 19 | 1.5e-08 | 25.5 | In-house | 105-283 (365) | Show / Hide |
Range on Protein: 401-517 Range on HMM: 105-283/365 Sequence Identity: 19% (36 aa) DSNLIIILTDFYQQ-SLHEYLTNS-LN---------KFDQDTFVSFIYDMIF---------------GLIELRYYN-IQHFDIKPANILLDTNLKLYFND | | | . ....|. .| .|. |. .. .|. ... . .| .| | | | |||| |||. . | DDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----IKIID FGLSNKLKYGES---------FVPLGH------------------------TSAFSPQEQQDYQQIDN--------YQSDIFSLG |||| |.. . . . | . . | ....|| |..||.||| FGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLG |
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| Kinase | 21184.AA | SAK | 416-481 | 28 | 2.4e-08 | 24.24 | In-house | 86-151 (254) | Show / Hide |
Range on Protein: 416-481 Range on HMM: 86-151/254 Sequence Identity: 28% (19 aa) LHEYLTNSLNKFDQDTFVSFIYDMIFGLIELRYYNIQHFDIKPANILLDTNLKLYFNDFGLSNKLK .| |. . . | . .|. ... |.. | .| | |. .|||| .... |||| .|| MHRYMKHRMRPFTEEEARHFMHQIVIGMLYLHSHGIMHRDLTLSNILLTRDMHCKIADFGLATQLK |
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| Kinase | 21184.AA | ULK | 425-469 | 27 | 4.2e-08 | 24.46 | In-house | 125-183 (329) | Show / Hide |
Range on Protein: 425-469 Range on HMM: 125-183/329 Sequence Identity: 27% (16 aa) NKFDQDTFVSFIYDMIFGLIELRYYNIQHFDIKPANILLDTN--------------LKL ... .. ..|... . |. ||. || | ||||.|||.. . ||. KRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKI |
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| Kinase | 21184.AA | Ciliate-A1 | 425-480 | 31 | 5e-08 | 23.36 | In-house | 95-151 (301) | Show / Hide |
Range on Protein: 425-480 Range on HMM: 95-151/301 Sequence Identity: 31% (18 aa) NK-FDQDTFVSFIYDMIFGLIELRYYNIQHFDIKPANILLDTNLKLYFNDFGLSNKL |. . . . | .| |.. . || | |.|| |||. | . |.|.| | NDYMKKEEIYEICYQIIEGYADIHDHNILHRDLKPQNILIHFDDKWKICDLGMSKQL |
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| Kinase | 21184.AA | ULK | 425-469 | 27 | 5.5e-08 | 24.48 | In-house | 121-179 (324) | Show / Hide |
Range on Protein: 425-469 Range on HMM: 121-179/324 Sequence Identity: 27% (16 aa) NKFDQDTFVSFIYDMIFGLIELRYYNIQHFDIKPANILLDTN--------------LKL ... .. ..|... . |. ||. || | ||||.|||. . ||. KRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKI |
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| Kinase | 21184.AA | RAN | 451-482 | 51 | 1.9e-07 | 20.93 | In-house | 170-202 (324) | Show / Hide |
Range on Protein: 451-482 Range on HMM: 170-202/324 Sequence Identity: 51% (17 aa) IQHFDIKPANILLD-TNLKLYFNDFGLSNKLKY | | |||| |||.| .. | |.||| . || IYHCDIKPENILIDGIDWNIYLCDWGLSTTDKY |
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| Kinase | 21184.AA | Ciliate-A1 | 542-573 | 28 | 0.093205 | 1.68 | In-house | 270-301 (301) | Show / Hide |
Range on Protein: 542-573 Range on HMM: 270-301/301 Sequence Identity: 28% (9 aa) FDNFKNLIVLMTKKEPQDRIKCDELLLRFTGF | ||| | .||. |.. .... | FEELQNLIFKMMQYEPNNRCSLQQCIDCLYIF |
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| Kinase | 21184.AA | ULK | 529-567 | 26 | 0.139263 | 1.46 | In-house | 279-319 (324) | Show / Hide |
Range on Protein: 529-567 Range on HMM: 279-319/324 Sequence Identity: 26% (11 aa) KQNINLYN--QQQKFFDNFKNLIVLMTKKEPQDRIKCDELL .|.|. .. ...|. ...|.|| | .... ||| .|.. NQPIQFPKPPKDPKISPECKDLIRRMLQYDEKDRISWEEIF |
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| Kinase | 21184.AA | ULK | 504-567 | 20 | 0.270315 | 0.38 | In-house | 230-324 (329) | Show / Hide |
Range on Protein: 504-567 Range on HMM: 230-324/329 Sequence Identity: 20% (20 aa) QQIDNYQSDIFSL---------GKTF---EVVMKAFSKQNINLYNQ----------QQKFFD----------NFKNLIVLMTKKEPQDRIKCDELL .. ..| .||.|| ||. .. . .....|.|. |. |. ..|.|| | .... ||| .||. KPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISPECKDLIRRMLQYDEKDRISWEELF |
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| TPR | 21184.AA | TPR | 660-693 | 14 | 0.975419 | 0.68 | SMART | 1-34 (34) | Show / Hide |
Range on Protein: 660-693 Range on HMM: 1-34/34 Sequence Identity: 14% (5 aa) LFGLYCIGFAYYIQSKYYQSAKILNTCFQIGIQL .|..| .|| . .| . . .. . .. . AEAWYNLGNCYYKMGDYDEAIECYQKALELDPNN |
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| TPR_2 | 21184.AA | TPR_2 | 660-693 | 17 | 40.657978 | 0.96 | Pfam | 1-34 (34) | Show / Hide |
Range on Protein: 660-693 Range on HMM: 1-34/34 Sequence Identity: 17% (6 aa) LFGLYCIGFAYYIQSKYYQSAKILNTCFQIGIQL ..|..| .|| | .| . .. .. . .. . AEAWYNLGQCYYKQGDYDEAIEYYEKALKLDPNN |
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| TPR_2 | 21184.AA | TPR_2 | 701-734 | 26 | 0.016539 | 12.96 | Pfam | 1-34 (34) | Show / Hide |
Range on Protein: 701-734 Range on HMM: 1-34/34 Sequence Identity: 26% (9 aa) IDLANAIGACYINLGLYKEAYDLYKASIKQLDKI .. ...| ||...| |.|| ..|....| . AEAWYNLGQCYYKQGDYDEAIEYYEKALKLDPNN |
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| TPR | 21184.AA | TPR | 701-734 | 23 | 0.049598 | 12.05 | SMART | 1-34 (34) | Show / Hide |
Range on Protein: 701-734 Range on HMM: 1-34/34 Sequence Identity: 23% (8 aa) IDLANAIGACYINLGLYKEAYDLYKASIKQLDKI .. . .| || ..| |.|| . |. ... . AEAWYNLGNCYYKMGDYDEAIECYQKALELDPNN |
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| TPR_1 | 21184.AA | TPR_1 | 701-734 | 23 | 0.089614 | 10.18 | Pfam | 1-34 (34) | Show / Hide |
Range on Protein: 701-734 Range on HMM: 1-34/34 Sequence Identity: 23% (8 aa) IDLANAIGACYINLGLYKEAYDLYKASIKQLDKI . . .|.|| ..| |.|| . |. .. . AEAWYNLGNCYYKMGNYDEAIECYQKALELNPNN |
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| TPR | 21184.AA | TPR | 744-777 | 20 | 0.000367 | 21.07 | SMART | 1-34 (34) | Show / Hide |
Range on Protein: 744-777 Range on HMM: 1-34/34 Sequence Identity: 20% (7 aa) CQICSNFAECLLTAGKLDEAEKLYNQSIKIFKEL ....| ..|.. |..|||.. |...... . AEAWYNLGNCYYKMGDYDEAIECYQKALELDPNN |
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| TPR_2 | 21184.AA | TPR_2 | 744-777 | 23 | 0.002061 | 16.16 | Pfam | 1-34 (34) | Show / Hide |
Range on Protein: 744-777 Range on HMM: 1-34/34 Sequence Identity: 23% (8 aa) CQICSNFAECLLTAGKLDEAEKLYNQSIKIFKEL .. | ..|.. .|..|||...|....|.. . AEAWYNLGQCYYKQGDYDEAIEYYEKALKLDPNN |
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| TPR_1 | 21184.AA | TPR_1 | 744-777 | 20 | 0.029585 | 11.86 | Pfam | 1-34 (34) | Show / Hide |
Range on Protein: 744-777 Range on HMM: 1-34/34 Sequence Identity: 20% (7 aa) CQICSNFAECLLTAGKLDEAEKLYNQSIKIFKEL ....| . |.. |..|||.. |.. ... . AEAWYNLGNCYYKMGNYDEAIECYQKALELNPNN |
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| TPR_1 | 21184.AA | TPR_1 | 786-819 | 17 | 2.4e-05 | 22.66 | Pfam | 1-34 (34) | Show / Hide |
Range on Protein: 786-819 Range on HMM: 1-34/34 Sequence Identity: 17% (6 aa) SQILNNIATYQNDQKKYQDALQNYTQCLQVKRNL .....|.. . ...|..|.. | ..|.. .| AEAWYNLGNCYYKMGNYDEAIECYQKALELNPNN |
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| TPR | 21184.AA | TPR | 786-819 | 17 | 2.8e-05 | 24.79 | SMART | 1-34 (34) | Show / Hide |
Range on Protein: 786-819 Range on HMM: 1-34/34 Sequence Identity: 17% (6 aa) SQILNNIATYQNDQKKYQDALQNYTQCLQVKRNL .....|.. ...|..|.. |...|.. .| AEAWYNLGNCYYKMGDYDEAIECYQKALELDPNN |
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| TPR_2 | 21184.AA | TPR_2 | 786-819 | 20 | 0.223341 | 8.96 | Pfam | 1-34 (34) | Show / Hide |
Range on Protein: 786-819 Range on HMM: 1-34/34 Sequence Identity: 20% (7 aa) SQILNNIATYQNDQKKYQDALQNYTQCLQVKRNL ...|.. |..|..|.. | ..|. | AEAWYNLGQCYYKQGDYDEAIEYYEKALKLDPNN |
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| TPR_2 | 21184.AA | TPR_2 | 898-931 | 17 | 0.001729 | 16.43 | Pfam | 1-34 (34) | Show / Hide |
Range on Protein: 898-931 Range on HMM: 1-34/34 Sequence Identity: 17% (6 aa) SKFQNSLATLYMAKGEYEQALNQMNEVLQMNELI . . |. .|...|.|..|.. ....|. .. AEAWYNLGQCYYKQGDYDEAIEYYEKALKLDPNN |
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| TPR | 21184.AA | TPR | 898-931 | 17 | 0.027432 | 14.31 | SMART | 1-34 (34) | Show / Hide |
Range on Protein: 898-931 Range on HMM: 1-34/34 Sequence Identity: 17% (6 aa) SKFQNSLATLYMAKGEYEQALNQMNEVLQMNELI .. . |. .|...|.|..|.. ...|.... AEAWYNLGNCYYKMGDYDEAIECYQKALELDPNN |
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| TPR_1 | 21184.AA | TPR_1 | 898-929 | 21 | 0.12381 | 9.69 | Pfam | 1-32 (34) | Show / Hide |
Range on Protein: 898-929 Range on HMM: 1-32/34 Sequence Identity: 21% (7 aa) SKFQNSLATLYMAKGEYEQALNQMNEVLQMNE .. . |. .|...|.|..|. ...|..|. AEAWYNLGNCYYKMGNYDEAIECYQKALELNP |
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| TPR | 21184.AA | TPR | 938-971 | 23 | 0.000143 | 22.43 | SMART | 1-34 (34) | Show / Hide |
Range on Protein: 938-971 Range on HMM: 1-34/34 Sequence Identity: 23% (8 aa) ALISFNLADMYLQIQQYENAKKYCLQAINILQQN | . .||. .|.. .|. | ... .|. . .| AEAWYNLGNCYYKMGDYDEAIECYQKALELDPNN |
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| TPR_2 | 21184.AA | TPR_2 | 938-971 | 26 | 0.000165 | 20.04 | Pfam | 1-34 (34) | Show / Hide |
Range on Protein: 938-971 Range on HMM: 1-34/34 Sequence Identity: 26% (9 aa) ALISFNLADMYLQIQQYENAKKYCLQAINILQQN | . .||.. |.. ..|. |..|. .|. . .| AEAWYNLGQCYYKQGDYDEAIEYYEKALKLDPNN |
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| TPR_1 | 21184.AA | TPR_1 | 938-971 | 23 | 0.000244 | 19.13 | Pfam | 1-34 (34) | Show / Hide |
Range on Protein: 938-971 Range on HMM: 1-34/34 Sequence Identity: 23% (8 aa) ALISFNLADMYLQIQQYENAKKYCLQAINILQQN | . .||. |.. ..|. | ... .|. . .| AEAWYNLGNCYYKMGNYDEAIECYQKALELNPNN |
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| TPR | 21184.AA | TPR | 980-1012 | 23 | 1.033269 | 0.46 | SMART | 1-34 (34) | Show / Hide |
Range on Protein: 980-1012 Range on HMM: 1-34/34 Sequence Identity: 23% (8 aa) SVALNSYGKILEIL-KSNEAIDYLIKAVEIKEKY . |.. | ... . . .|||... ||.|. ... AEAWYNLGNCYYKMGDYDEAIECYQKALELDPNN |
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| TPR_1 | 21184.AA | TPR_1 | 996-1012 | 35 | 2.270622 | 5.28 | Pfam | 18-34 (34) | Show / Hide |
Range on Protein: 996-1012 Range on HMM: 18-34/34 Sequence Identity: 35% (6 aa) NEAIDYLIKAVEIKEKY .|||... ||.|. ... DEAIECYQKALELNPNN |
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| TPR_2 | 21184.AA | TPR_2 | 997-1012 | 37 | 60.813229 | 0.34 | Pfam | 19-34 (34) | Show / Hide |
Range on Protein: 997-1012 Range on HMM: 19-34/34 Sequence Identity: 37% (6 aa) EAIDYLIKAVEIKEKY |||.|. ||... ... EAIEYYEKALKLDPNN |
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