22819

Species: Tetrahymena
Alias: 873, 22819, TTHERM_00936610, PreTt22819, 169.m00059
External Links: Tetrahymena Genome Database (TGD) ,
Annotation:

Classification

Group: Other
Family: Ciliate-C8
Subfamily: C8

Sequence

Name Sequence Type Origin Length Description Download
22819.AA Protein None 1596 None Fasta, JSON
22819.kin_dom Protein Kinase Domain None 96 None Fasta, JSON
22819.NA RNA None 4791 None Fasta, JSON

Protein domain

Protein domains of 22819.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 22819.AA Ciliate-B2 388-569 38 1.8e-75 176.96 In-house 1-197 (197) Show / Hide
Range on Protein: 388-569
Range on HMM: 1-197/197
Sequence Identity: 38% (75 aa)

YALGSCIEQGGESFIYEDI---I---NKNVIIKIIYV---QMNQTIDMQKKIFDILKDEKNFLQLIDHIKIYDNLHIFIHEKFQKNLQQELENFNKDKNI
| |.  | .||. ||.|     .    .....|| ..      . |.   ||  ..  . |  ..||||.|  . ...| ||..  |.|||.  .| .  
YYLCKYINKGGCGFICEGYKKHSIREYQDLAFKIYFNKQDCDKEEIQHEIKIMKMFEYNINVVKYIDHIQINETIDVLIMEKCECSLKQELQKIQKQQKC

FTEQNLIKMIFNLIHGLIDLKNKNILHLDIKPKNILVDNRGNYIYTDFGISEIYQ-EGNMQIRGKTDNYSSQEQRNQD-----VNKISYKSDVYSLG
|..|.|..|||.|| ||| .. .|||||||||.|||. . |||.|.||||| | . . . .|.| |  | | || ..|     | .| ..||.||.|
FNNQKLYQMIFQLIDGLIQFRMYNILHLDIKPQNILFMQNGNYVYCDFGISSIKKDNQQIKIKGFTKKYASPEQMECDHNQTFVTNIDFQSDIYSMG

Kinase 22819.AA Ciliate-E1 394-566 35 4.6e-46 147.83 In-house 1-202 (202) Show / Hide
Range on Protein: 394-566
Range on HMM: 1-202/202
Sequence Identity: 35% (72 aa)

IEQGGESFIYEDIINKN----VIIKIIYVQMNQT-------IDMQKKIFDILKDEKNFLQLIDHIKIYDN-LHIFIHEKFQKNLQQELE---------NF
|..|..|.... ....|    |..||| .. |..       |  ..||.. .| |.. .|.|| ||| .| ..|.| |. ...|...|.          .
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYWQQC

NKDKNIFTEQNLIKMIFNLIHGLIDLKNKNILHLDIKPKNILVDNRGNYIYTDFGISEIYQ---EGNMQIRGKTDNYSSQEQRN------QDVNKISYKS
....| ||.|.....||.||.|||.|...||.|.||||.|||..| |||.|.||||| ...   . ..|..| |..|...|| |      .. .||.|||
QQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYCDFGISKFLKNNQNQQCQYKGYTHYYYPPEQYNCPEQEHNKNQKINYKS

DVY
|.|
DIY

Kinase 22819.AA Ciliate-E3 438-576 30 4.1e-13 37.51 In-house 62-202 (202) Show / Hide
Range on Protein: 438-576
Range on HMM: 62-202/202
Sequence Identity: 30% (44 aa)

KNFLQLIDHIKIYDNLHIFIHEKFQKNLQQELENFNKDKNIFTEQNLIKMIFNLIHGLIDLKNKNILHLDIKPKNILVDNRGN---YIYTDFGISEIYQE
.| ..  | .   .|  |||  ..  |   .| .. | .   |.. ..... ..| |.|..  ||| | |||| |||||.. |       ||| |   . 
QNVVKCHDQYYDQQNKMIFIVQEYCSN--GDLYHYIK-QQNKTQNIIYDICIQIIQGMIAIHEKNIIHSDIKPDNILVDKNNNQLIIKICDFGESKQLRK

GN--MQIR--GKTDNYSSQEQRNQDVNKISYKSDVYSLGKTLLKVI
 .   .    | |  |.. ||  |  ..||  || ||.|  .. ..
NKGHTHTQYQGWTPFYAAPEQNDQ--QQISKESDYYSVGAVFCQLC

Kinase 22819.AA Ciliate-A1 456-569 25 8.9e-13 39.76 In-house 78-215 (301) Show / Hide
Range on Protein: 456-569
Range on HMM: 78-215/301
Sequence Identity: 25% (36 aa)

FIHEKFQKNLQQELENFNKDKNIFTEQNLIKMIFNLIHGLIDLKNKNILHLDIKPKNILVDNRGNYIYTDFGISEIYQEGN-------------------
.| |. |.....   |. . ..   .   . .   .| |..|.  .||||.|.|| |||. .   .   |.|.| .    .                   
IIMEYCQYGNLF---NYCYQNDYMKKEEIYEICYQIIEGYADIHDHNILHRDLKPQNILIHFDDKWKICDLGMSKQLEQNQDCCDDVNGCSFSKQVNKHY

MQI-RGKTDNYSSQEQ-----RNQDV--NKISYKSDVYSLG
  . .| .  | | ||     | |    |||. .||.||||
HTCKKGGNLYYMSPEQYQMHYRDQMFIENKIYKQSDMYSLG

Kinase 22819.AA C8 462-572 25 2e-12 39.57 In-house 103-226 (226) Show / Hide
Range on Protein: 462-572
Range on HMM: 103-226/226
Sequence Identity: 25% (31 aa)

QKNLQQELENFNKDKNIFTEQNLIKMIFNLIHGLIDLKNKNILHLDIKPKNILVDNRGNYI----YTDFGISEIYQEGNMQIRGKT------DNYSSQEQ
..||.|  . . . .  |....  ..   .| |.  .. |||.| ||||.|.||   .||.      |||..   ..   .|  |       . |.  |.
EQNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSKKMNTCGTWAYFAPEI

RNQ---DVNKISYKSDVYSLGKTL
 ..   .. . . .||..|.|  |
EKKQDNQYKQYRIQSDLFSVGLVL

Kinase 22819.AA TKL 501-569 20 9.1e-10 31.36 In-house 159-276 (364) Show / Hide
Range on Protein: 501-569
Range on HMM: 159-276/364
Sequence Identity: 20% (24 aa)

KNILHLDIKPKNILVDNRGN--------------YIYTDFGISEIYQEGN---------------------MQIRGKTDNYSSQEQRNQDVN--------
..|.| |.|.||||||. ..                 .|||.|   .. .                        .. | .. . |  ... |        
PPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGID

------KISYKSDVYSLG
      . | |.|||| |
EFCKGFEYSEKCDVYSFG

Kinase 22819.AA S_TKc 388-626 17 6.7e-09 -46.43 SMART 1-231 (231) Show / Hide
Range on Protein: 388-626
Range on HMM: 1-231/231
Sequence Identity: 17% (47 aa)

YALGSCIEQG--GESFIYEDII-NKNVIIKIIYVQMNQTIDMQKKIFDILKDEKNFLQLIDHIKIYDNLHIFIHEKFQKNL-------QQ---ELENFNK
| ..  | .|  |. .   ..  .. | ||||               . .. | . |.  .|  |   . .| .    ..|        .   .|  . |
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------------EHIRREIQILKK-HHPNIVKLYDVFQD----DHLYMVMEYCDGDLGDLFDYIK

DKNI------FTEQNLIKMIFNLIHGLIDLKNKNILHLDIKPKNILVDNRGNYIYTDFGISEIYQEGNMQIRGKTDNYSSQEQRNQDVNKISY-KSDVYS
...       |.|    ...  .. .|  . ...|.| |.|| |||.|.  .   .|||.. ..          | .| . |       . .. |.|..|
KRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----TTFCGTPWYMAPEVL-----GYGKCKCDWWS

LGKTLLKVIE-----RFKELNGQSKFIKFAKSIQDIVKKSMVQEDINQRDDCYLIHS----QFSDQLF
.| .|   .      .  ...   | |.  ..  |   . . | | ..|  .  .        ... |
CGCILYEMLCGYPPFP--QMQMMFKKIG-SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase 22819.AA STE 479-569 21 1.7e-08 26.28 In-house 148-255 (359) Show / Hide
Range on Protein: 479-569
Range on HMM: 148-255/359
Sequence Identity: 21% (25 aa)

FTEQNLIKMIFNLIHG-LIDLKNKNILHLDIKPKNILVDNRGNYIYTDFGISEIYQE-------------------GNMQIRGKTDNYSSQEQRNQD---
| |. ...... ...| |  | ...| | |||| |||.        .|||.. . ..                    .  . |    . . |  .|.   
FPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP--WMAPEVIQQNGQG

-VNKISYKSDVYSLG
 ... ..|.|..|||
RDKGYDTKCDIWSLG

Kinase 22819.AA Ciliate-E4 462-517 33 2.7e-08 24.24 In-house 87-142 (150) Show / Hide
Range on Protein: 462-517
Range on HMM: 87-142/150
Sequence Identity: 33% (19 aa)

QKNLQQELENFNKDKNIFTEQNLIKMIFNLIHGLIDLKNKNILHLDIKPKNILVDN
||.|||.. . ..    |.|. .  . | .| ..  |  .|| | |.|| ||..|.
QKDLQQHIKQHKQQGQHFDESEIWQIAFCCINAMYYLQQVNITHGDLKPSNIFFDQ

Kinase 22819.AA Ciliate-E2-Unclassified 388-569 22 5.5e-08 23.81 In-house 1-257 (352) Show / Hide
Range on Protein: 388-569
Range on HMM: 1-257/352
Sequence Identity: 22% (58 aa)

YALGSCIEQGG--ESFIYEDIINK--------NVIIKIIYVQMNQT-------IDMQKK-------IFDILKDEKNFLQLIDHIKIYDNLHIF-------
| .. .| |||  . .  ... .|        ..|...   |...        . |..|       . .|...    |. ..|. |.  ...|       
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQ---ILLNHPHPFIVKMFYCFQDKQNIY

-IHEKF-QKNLQQELENFNKDK-------------NIFTEQNLI-----KMIFNLIHGL-IDLKNKNILHLDIKPKNILVDNRG---NYIYTDFGISE--
 . |.. ...|.| .....| |             .|||||. .     ...  .. ||    ...||.| |||| |||.|| |   .   .|||||   
IVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKY

---------------IYQEGNMQIRGKTDNYS----SQEQRNQDVNKIS--YKSDVYSLG
               |... .|. .  | ||     . |   .  .  |  ||.|..|||
QQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLG

Kinase 22819.AA CAMK 500-536 27 1.5e-07 19.66 In-house 197-250 (425) Show / Hide
Range on Protein: 500-536
Range on HMM: 197-250/425
Sequence Identity: 27% (15 aa)

NKNILHLDIKPKNILVDNR-----------------GNYIYTDFGISEIYQEGN
..|| |.|.|| |||.|..                 .|   .||| . ....|.
SHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGE

Kinase 22819.AA Pkinase 500-569 28 2e-06 23.48 Pfam 126-199 (293) Show / Hide
Range on Protein: 500-569
Range on HMM: 126-199/293
Sequence Identity: 28% (22 aa)

NKNILHLDIKPKNILVDNRGNY----IYTDFGISE---IYQEGNMQIRGKTDNYSSQEQRNQDVNKISYKSDVYSLG
...|.| |.|| |||.||.|.       .|||...   .   . |. .  | .| . |   .. .....|.|..|.|
SMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEV-IRGGQYYGPKVDMWSCG