Gene 4854 (Tetrahymena)
4854
Group:
Other
Family:
Ciliate-E1
Sequence
Protein domains of 4854.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 4854.AA | Ciliate-C5 | 62-307 | 33 | 1.3e-38 | 124.55 | In-house | 17-260 (260) | Show / Hide |
Range on Protein: 62-307 Range on HMM: 17-260/260 Sequence Identity: 33% (83 aa) EAQKCGMVVIIKCKLVQSLEKMNEYIDLIKKLKSVPHINHFIEGIFSTDVKFFYYITQKLNCNLEQIMLNSQQKQKVLPFNQIVGLAIQVTKAIIGMQSQ ||. .| .|| .. .||..| ...| || |.. . ||... .| |... ||| .|| . ...| || |||.|.|||. .| . EAKYNEEIVAVKCSKPN-FEKIKEEEKIMKLLKDTPYVFKSIEEFLNEKKSKYYQISKRYSCNLKDIMQSFFDQKKTLPLNQIIGFAIQMSTVFEKIQQN STFHLTINPQKILYSVEKNSFYLSDYGYINMRNNHINQSNLKLEQKKYLAPEILFNSQKPSNRSDIYSLGLILLELTTGFFVENSKAFQLKKSFKLKDNI | . |. ||| . |.|.||| . .|| .|| |||| . . ||| ||.|||||| | |.|.. ... || | NLIHSDVKPENILYDSQEKCFNLCDYGESKSFKDGSKTYDLKGFTRKYAAPEITDDNGFFNIKYDIYGLGIILLELTLGKFLEDEDCTFIRNG-KLP-NY YSEAKQHQELNEIIQQMLLIDKKKRINAQNLLKKLDYLR-QLEQLYY |. . .|..| || .|| . ..||.. .| |.|. || .||. . ISKNALYQDINQIIIKMLEKMPQNRIDSFELTKQLNELRLKLESQFI |
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| Kinase | 4854.AA | PEK | 209-298 | 24 | 6e-12 | 37.15 | In-house | 555-655 (655) | Show / Hide |
Range on Protein: 209-298 Range on HMM: 555-655/655 Sequence Identity: 24% (25 aa) YLAPEILFNS----QKPSNRSDIYSLGLILLELTTGFFVEN-SKAFQLKKSFKLKD------NIYSE---AKQHQELNEIIQQMLLIDKKKRINAQNLLK | .|| | .. . ...|.||||.|..|. .|| . .. |. .|.| .... .. . .. ..||.|| .| ..| .|| .|. YMSPEQLSGQHYQKSHYNHKVDMYSLGIIFFEMWYPFFTTMMERVKTLT---DLRDESIQFPGDFPPKWFDNKYPKQADFIQWMLSHDPQQRPSAQQILQ KLDY . . HEFF |
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| Kinase | 4854.AA | ULK | 209-288 | 25 | 3.9e-11 | 35.19 | In-house | 217-319 (329) | Show / Hide |
Range on Protein: 209-288 Range on HMM: 217-319/329 Sequence Identity: 25% (26 aa) YLAPEILFNS--QKPSN-R-SDIYSLGLILLELTTGFFV-ENSKAFQLK-----KSFKLKDNIY----SEAKQ----------HQELNEIIQQMLLIDKK | ||.|| . ||| . .||.||| |. |. .| ... ..... | ........ .. | .|. ..|..|| .| | YMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISPECKDLIRRMLQYDEK KRIN .||. DRIS |
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| Kinase | 4854.AA | Ciliate-E1 | 68-228 | 22 | 1.3e-10 | 31.17 | In-house | 23-202 (202) | Show / Hide |
Range on Protein: 68-228 Range on HMM: 23-202/202 Sequence Identity: 22% (41 aa) MVVIIKCKLVQS----LEKMNEYIDLIKKLKSVPHINHFIEGIFSTDVKFFYYITQKLNCNLEQIML---------NSQQKQKVLPFNQIVGLAIQVTKA ...||.|. .. ... .||. . | .|. | .|. |.. . .... |.....|.|.. . ||.|. . | |.. ...| .. AQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYWQQCQQNQNQFTFQQKMQIIFQLIDG IIGMQSQSTFHLTINPQKILYSVEKNSFYLSDYGYIN-MRNNHINQSNLKLEQKKYLAPEILF-------NSQKPSNRSDIY .| .... |. |.||.||.. . . . ..| | || ..|.. | ....| || .. ..|| . |||| LIELHQYNIIHRDIKPQNILINNQ-GNYVYCDFGISKFLKNNQNQQCQYKGYTHYYYPPEQYNCPEQEHNKNQKINYKSDIY |
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| Kinase | 4854.AA | ULK | 209-288 | 26 | 5.3e-10 | 31.74 | In-house | 213-314 (324) | Show / Hide |
Range on Protein: 209-288 Range on HMM: 213-314/324 Sequence Identity: 26% (27 aa) YLAPEILFNS--QKPSN-R-SDIYSLGLILLELTTGF--FVEN-SKAF----QL----------KKSFKLKDNIYSEAKQH--QELNEIIQQMLLIDKKK | ||.|| . ||| . .||.||| |. |. .| |... .. . .| | ... .... . .. .|. ..|..|| .| |. YMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSWFNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPP-KDPKISPECKDLIRRMLQYDEKD RIN ||. RIS |
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| Kinase | 4854.AA | Ciliate-B2 | 117-231 | 26 | 1.2e-09 | 18.79 | In-house | 79-197 (197) | Show / Hide |
Range on Protein: 117-231 Range on HMM: 79-197/197 Sequence Identity: 26% (32 aa) ITQKLNCNLEQIMLNSQQKQKVLPFNQIVGLAIQVTKAIIGMQSQSTFHLTINPQKILYSVEKNSFYLSDYGYINMRNNHINQSNLKLEQKKYLAPEILF |..| | |.| . |..|| . . .. . | . | . . || |.|| || . ... . ..|.| ... | . | . ||| || . IMEKCECSLKQELQKIQKQQKCFNNQKLYQMIFQLIDGLIQFRMYNILHLDIKPQNILFM-QNGNYVYCDFGISSIKK-DNQQIKIKGFTKKYASPEQME NS------QKPSNRSDIYSLG . . .|||||.| CDHNQTFVTNIDFQSDIYSMG |
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| Kinase | 4854.AA | Pkinase | 209-296 | 18 | 2.1e-08 | 30.82 | Pfam | 177-293 (293) | Show / Hide |
Range on Protein: 209-296 Range on HMM: 177-293/293 Sequence Identity: 18% (22 aa) YLAPEILFNSQKPSNRSDIYSLGLILLELTTGFFVENSK-----AFQLKKSFKLKDNIYSEAKQ----------------------HQELNEIIQQMLLI |.|||.. .|. . ..|..|.|.|| |. .| . .. . |... .. .. .... . ..|. ..| .| YMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCK DKKKRINAQNLLKK--L | |||..|. .|. . DPKKRPTAEQILQHPWF |
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| Kinase | 4854.AA | C8 | 124-234 | 23 | 2.2e-08 | 25.36 | In-house | 105-226 (226) | Show / Hide |
Range on Protein: 124-234
Range on HMM: 105-226/226
Sequence Identity: 23% (29 aa)
NLEQIMLNSQQKQKVLPFNQIVGLAIQVTKAIIGMQSQSTFHLTINPQKILYSVEKNSF---YLSDYG---YINMRNNHINQSN-LKLEQKKYLAPEILF
||.|. . ..||. .. .. .|||. . ... | | |. .| ..|. |.| | .. .|| . . .. ..|.||||.
NLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSKKMNTCGTWAYFAPEIEK
N----SQKPSNRSDIYSLGLIL
.. . .||..|.||.|
KQDNQYKQYRIQSDLFSVGLVL
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| Kinase | 4854.AA | GCN2 | 209-298 | 25 | 2.9e-08 | 24.59 | In-house | 419-511 (511) | Show / Hide |
Range on Protein: 209-298 Range on HMM: 419-511/511 Sequence Identity: 25% (24 aa) YLAPEILFNSQKPSNRSDIYSL-GLILLELTTG-FFVENSKAF---QLKKSFKLKDNIYSEAKQHQE-LNEIIQQMLLIDKKKRINAQNLLKKLDY | .||.. . . . |.||| |.|..|. . | .. ... ||. |... .. . . |.. ...|...| .| .|| .|| ||. .. YMCPEQQ--KSHYNQKVDMYSLGGIIFFEMWYPPFCTQMERVQILKQLR-SCEFPQDFDKKVDNHHKDQQDMIRWCLNHDPQKRPSAQQLLQHEFL |
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| S_TKc | 4854.AA | S_TKc | 46-299 | 16 | 3.1e-08 | -56.15 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 46-299 Range on HMM: 1-231/231 Sequence Identity: 16% (46 aa) YTVIGLL------------NNDYENPKLEAQKCGMVVIIKCKLVQSLEKMNEYIDLIKKLKSVPHINHFIEGIFSTDVKFFYYITQKLNC---NLEQIML |... .. ... | .| ||. |.. |.. || |.| .... . . ...| .. .. .| ... YEILRKIGKGAFGKVYKCRHKK----------TGRIVAIKIIK----EHIRREIQILKK--HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIK NSQQ--KQKVLPFNQIVGLAIQVTKAIIGMQSQSTFHLTINPQKILYSVEKNSFYLSDYGYINMRNNHINQSNLKLEQKK------YLAPEILFNSQKPS . . .....| .. .. |. .|. . |. | . |. || . ..| | . |.|||.| . . KRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL-------------TTFCGTPWYMAPEVL----GYG N-RSDIYSLGLILLELTTGFFVENSKAFQLKKSFKLKDNIYSEAKQHQELNEIIQQMLLIDKKKRINAQNLLK------KLDYL ..|..|.| || |. .| |... ||. .|. ..|...| | .||. | .|. . .. KCKCDWWSCGCILYEMLCGYPPFP----QMQMMFKKIG--------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | 4854.AA | STE | 209-299 | 18 | 1.1e-07 | 23.37 | In-house | 228-359 (359) | Show / Hide |
Range on Protein: 209-299 Range on HMM: 228-359/359 Sequence Identity: 18% (24 aa) YLAPEILFN-----SQKPSNRSDIYSLGLILLELTTGFFVENSKAFQLKKSFKLKDNIYSEA---------------KQH-------------------- . |||.. . ... . ..||.|||. ..|. || .. .. .. | .|..... ..| WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATG-KPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKW -QELNEIIQQMLLIDKKKRINAQNLLKK-LDYL .|... |.. | .| .|| .|. ||| . SPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI |
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| Kinase | 4854.AA | Ciliate-E3 | 211-238 | 39 | 1.1e-07 | 20.32 | In-house | 176-202 (202) | Show / Hide |
Range on Protein: 211-238 Range on HMM: 176-202/202 Sequence Identity: 39% (11 aa) APEILFNSQKPSNRSDIYSLGLILLELT |||.....| .|. ||.||.| ....| APEQNDQQQ-ISKESDYYSVGAVFCQLC |
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| Kinase | 4854.AA | Dicty3 | 209-236 | 48 | 5.7e-07 | 18.84 | In-house | 261-289 (351) | Show / Hide |
Range on Protein: 209-236 Range on HMM: 261-289/351 Sequence Identity: 48% (14 aa) YLAPEILFNSQK-PSNRSDIYSLGLILLE | ||||. |.|. . |||.|||....| YMAPEIKLNNQCCACRKSDIWSLGCTVWE |
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| Kinase | 4854.AA | Dicty3 | 273-293 | 28 | 0.010735 | 4.5 | In-house | 331-351 (351) | Show / Hide |
Range on Protein: 273-293 Range on HMM: 331-351/351 Sequence Identity: 28% (6 aa) EIIQQMLLIDKKKRINAQNLL ..||. . || ..|... .|. NFIQHCWQIDPNHRWDMHELI |
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