Gene 12415 (Tetrahymena)

12415

Species: Tetrahymena
Alias: PreTt12415, TTHERM_00523000, 65.m00233, 3717.m00112, 12415, 384
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-E2
Subfamily: Ciliate-E2a

Sequence

Name Sequence Type Origin Length Description Download
12415.AA Protein None 613 None Fasta, JSON
12415.kin_dom Protein Kinase Domain None 264 None Fasta, JSON
12415.NA RNA None 1842 None Fasta, JSON

Protein domain

Protein domains of 12415.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 12415.AA Ciliate-E2a 147-410 48 3.1e-182 541.19 In-house 1-275 (275) Show / Hide 
Range on Protein: 147-410
Range on HMM: 1-275/275
Sequence Identity: 48% (134 aa)

FIVTKMIGKGSFAKVYLATKKSQNIQYAIKAFNKEFMQNQHKGKESLINEISIMRQLNNDHLIRLYEVYETTNSIYFVVDLLNGGELLHRIREKGSINEK
. ..|.||||.|..||||..| .. |.|.|.|.| .|..|.||||...|||.|||||.....|.||||||. |..|.| ....||||...|.......|.
YKFIKKIGKGNFGSVYLAQHKQTGKQFAMKKFIK-KMYQQKKGKEYFMNEINIMRQLDHPNIIKLYEVYEDENNYYLVMEYCEGGELYDKIKQCKRFFEE

--ELRVLIRNLI-LALEHLHQKNIMHRDLKPENLLLK--SKQSD--SEIVVADFGLATRI--DIPNILFKRCGTPGFVAPEVLLYKE--GDPFYTTQCDI
  | . ....|.  .|...||.|||||||||||.|.|  ||.|.  |.|...||||||.|  |... .|..|||||.|||||| .||   ...|.|.||.
IQEICDIMQQLLWQGLHYMHQRNIMHRDLKPENILFKNCSKNSIQNSDIKIIDFGLATFIDKDEKKYMFQKCGTPGYVAPEVLNNKEVLKHKQYDTKCDM

FSAGIIFYLLLVGKQPFQGKDYKQILRANKACEIRYDLPE-FEKISNAAKDLLKKMLDARPEHRFSATQCLQHPFL
.|.|.|||.||.||.||.||.|..||  ||.|.| .. || .||.|...|||.||||.  |..|..|.|.|.||. 
WSCGVIFYILLCGKPPFKGKTYNEILQQNKKCKIDFNCPECWEKCSKECKDLMKKMLEKDPKKRITAQQALNHPWF
Kinase 12415.AA CAMK1 147-410 41 3.8e-156 457.44 In-house 1-276 (276) Show / Hide 
Range on Protein: 147-410
Range on HMM: 1-276/276
Sequence Identity: 41% (117 aa)

FIVTKMIGKGSFAKVYLATKKSQ---NIQYAIKAFN-KEFMQN---QHKGKESLINEISIMR---QLNNDHLIRLYEVYETTNSIYFVVDLLNGGELLHR
....|.||.|.|..|||.|.|.    . |||||... |.||..   | | .|.| |||.||.   ...  . | .||.||..| .|.|..|..||||..|
YEFGKEIGRGAFSEVYLCTHKETQTNGKQYAIKCIDKKKFMKKKDMQ-K-QEALENEIEIMKKVSKIDHPNIIKFYEWYESDNHFYLVMELVTGGELFDR

IREKGSINEKELRVLIRNLILALEHLHQKNIMHRDLKPENLLLKSKQSDSEIV--VADFGLATRIDIPN-ILFKRCGTPGFVAPEVLLYKEGDPFYTTQC
| |||. .||. | ...... |.|..|.|.|.||||||||||...|  ||.|.  .|||||....|  . .....|||||.|||||| .|. | .|   |
IVEKGNYTEKDARHIMKQILSAVEYMHSKGIVHRDLKPENLLYYDKDEDSKIKRSIADFGLSKIFDHDENLMKTACGTPGYVAPEVLECKK-DKPYDKAC

DIFSAGIIFYLLLVGKQPFQGKD-YKQILRANKACEIRYDLPEFEKISNA-AKDLLKKMLDARPEHRFSATQCLQHPFL
|..|.|.|.| ||.| .||.... ...... .| ||.... |.. .||.  |||..|.||.  |. |....|||.||..
DMWSIGVITYILLCGYPPFYDENVDNELFEKIKKCEYEFPSPWWDNISDQEAKDFIKHMLEVDPKKRYTCEQCLNHPWI
Kinase 12415.AA CAMK 152-410 24 1.5e-107 347.73 In-house 1-425 (425) Show / Hide 
Range on Protein: 152-410
Range on HMM: 1-425/425
Sequence Identity: 24% (103 aa)

MIGKGSFAKVYLATKKSQN------------IQYAIKAFNKEFMQN------------------------QHKGKESLINEISIMRQ-------LNNDHL
 .|.|||.||.|.. |. .             ..|||  .|. ...                        . | .... .||.||..       |.  ..
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

IRLYEVYE------------TTNS--------IYFVV---DLLNGGEL----LHRIREKGS---------------INEKELRVLIRNLILALEHLHQKN
|.||||||            | .         .|.|    ..  ||||    . .|.|.|.               ..|.| | ..| .. |....|..|
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

IMHRDLKPENLLLKSKQSDSE--------------IVVADFGLATRIDIPN------------------------ILFKRCGTPGFVA-PEVLLYK----
|.||||||||.|| .. .||.              | ..|||.|...|  .                         .  .||||...| ||||..|    
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

------EGDPFYTTQCDIFSAGIIFYLLLVGKQPFQGK-------------DYKQILRANKACEIRYDLPEFEK------------ISNA--------AK
      |. | |. .||. |.|.| | .|.|. ||.|.             .......  .... ... |.| .            ||.         .|
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK

DLLKKMLDARPEHRFSATQCLQHPFL
||..|||   ||.|....|||.||..
DLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 12415.AA Ciliate-E2 147-410 26 4.7e-104 352.0 In-house 1-365 (365) Show / Hide 
Range on Protein: 147-410
Range on HMM: 1-365/365
Sequence Identity: 26% (100 aa)

FIVTKMIGKGSFAKVYLATKKSQNIQYA----------------IKAFNKEFMQNQHKGKESLINEISIMR----------------QLNNDHLIRLYEV
... |.||.|.|..||........ |.|                 |.. ..  .......|.. .||.|||                |||....|..||.
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

YE--TTNSIYFVVDLLNGGELLHRIREK-----------GSINEKELRVLIRNLIL---------------ALEHLHQKN-IMHRDLKPENLLLKSKQSD
..  ..|.||.| ....||.|...|...           ....||| . ... ..                |||.||.|| |.|||.||||.|.      
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------

SEIVVADFGLATRIDIP--------------------------------NILFKRCGTPGFVAPEVLLYKE-----GDPFYTTQCDIFSAGIIFYLLLVG
  | ..||||....|..                                |. .  |||||..|||.| .|.     .   |...|||.|.|.|.| .| |
--IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFG

KQPFQGKDYKQILRANKACEIRYDLPE--------------FEKISNAAKDLLKK----MLDARPEHRFS-ATQCLQHPFL
| ||        .. .| |.|... ||              ..|.|. .|||.||    ||.  || |.. . |.|.||..
KPPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 12415.AA S_TKc 147-410 29 6.1e-91 309.34 SMART 1-231 (231) Show / Hide 
Range on Protein: 147-410
Range on HMM: 1-231/231
Sequence Identity: 29% (83 aa)

FIVTKMIGKGSFAKVYLATKKSQNIQYAIKAFNKEFMQNQHKGKESLINEISIMRQLNNDHLIRLYEVYETTNSIYFVVDLLNG--GELLHRIREKGS--
. . . ||||.|.|||....|. . ..|||  .           |....||.|... . .....||.|... ...|.| ....|  |.|...|...|.  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHG

----INEKELRVLIRNLILALEHLHQKNIMHRDLKPENLLLKSKQSDSEIVVADFGLATRIDIPNILFKRCGTPGFVAPEVLLYKEGDPFYTT-QCDIFS
    ..| . | ... ...|||..|...|.||||||||.|| .     .| ..|||||...         |||| ..|||||        |..  ||. |
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL------TTFCGTPWYMAPEVL-------GYGKCKCDWWS

AGIIFYLLLVGKQPFQGKDYKQILRANKACEIRYDLPEFEKISNAAKDLLKKMLDARPEHRFSATQCLQ-------HPFL
 |.|.| .|.|. ||.  .......  .              |  |||...|.|.  ||.| .| ..||       ||..
CGCILYEMLCGYPPFP--QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 12415.AA CDPK 147-410 37 9.7e-89 272.3 In-house 1-271 (271) Show / Hide 
Range on Protein: 147-410
Range on HMM: 1-271/271
Sequence Identity: 37% (106 aa)

FIVTKMIGKGSFAKVYLATKK-SQNIQY-AIKAFNKEFMQNQHKGKESLINEISIMRQLNNDH--LIRLYEVYETTNSIYFV--VDLLNGGELLHRIREK
..  | .|||.|  |.....| ..|..  |.|  .|   ... . .....||| |..||  ||   |..||.|.  . .|.|    .. ||||. .| ||
YKIKKVLGKGHFGQVRKVKHKQKTNQERVAMKIIPKSRVKDKEQ-QQQFFNEIEILKQL--DHPNIIKIYEFYQDEKNYYIVMETEYCTGGELFDYIIEK

GSINEKELRVLIRNLILALEHLHQKNIMHRDLKPENLLLKSKQSDS----EIVVADFGLATRIDIP-----NILFKRCGTPGFVAPEVLLYKEGDPFYTT
|. .||| .  .| .. |. . |..||.||||||||.|..|| .||    .|.| |.|.... |       . . .|||||  .|||||   ..   |  
GHFTEKEAAYIMRQILSAVNYCHSNNIVHRDLKPENILFDSKKDDSWVIYNIKVIDWGTSKKFDQNQKIEDKKMSQRCGTPYYIAPEVL---QKK--YNE

QCDIFSAGIIFYLLLVGKQPFQGKDYKQILRANKACEIRYDLPEFEKISNAAKDLLKKMLDARPEHRFSATQCLQHPFL
.||| |.|.| | ||.|  || ||  ..|. . | .. ... ||...||. |||| .|||   |. |.|| |.||||  
KCDIWSCGVILYILLCGYPPFYGKNDQEIMEKVKKGKYSFEGPEWDHISDEAKDLIRKMLCYDPKKRMSAQQALQHPWF
Kinase 12415.AA DCAMKL 147-410 34 5.7e-82 254.72 In-house 1-279 (279) Show / Hide 
Range on Protein: 147-410
Range on HMM: 1-279/279
Sequence Identity: 34% (97 aa)

FIVTKMIGKGSFAKVYLATKKSQN-IQYAIKA-------------FNKEFMQNQHKGKESLI-NEISIMRQLNNDHLIRLYEVYETTNSIYFVVDLLNGG
. . ..||.| || |....... .  .|| |              | ..   .. |||| .| ||.|||.... .| |.|||...| ...| |  .  ||
YQIGRIIGDGNFAVVHECRHRETGDHKYAMKIRYQSTLQFSFPSKFFQQIDKRKCKGKEHMIDNEVSIMQKIKHPHIIQLYEHWDTETHYYLVMEYVQGG

ELLHRIREKGSINEKELRVLIRNLILALEHLHQKNIMHRDLKPENLLLKSKQSDSEIVV--ADFGLATRIDI-PNILFKRCGTPGFVAPEVLLYKEGDPF
 |   |.| . . |.. ......|  ||..|| .|| |||.||||||.. ...  |. .  .|||||. ..     |.  ||||  ||||.|  . |   
DLFDAITENTKFTERDAAIMMTCLCKALKYLHEMNIVHRDIKPENLLVCKHEDG-EKSLKLCDFGLACHVNGDFGPLYTVCGTPTYVAPEILM-ETG---

YTTQCDIFSAGIIFYLLLVGKQPFQGK--DYKQILRANKACEIRYDLPEFEKISNAAKDLLKKMLDARPEHRFSATQCLQHPFL
| . .|| .||.| | ||.|  ||..   |  .   .  ...  .. |.   || .|||| ..|| . || |..| | .|||  
YGCKVDIWAAGVILYILLCGFPPFRSPDNDQEELFDQIMQGKFEFPMPYWDNISDSAKDLISHMLQVDPEKRYTAEQIMQHPWV
Kinase 12415.AA Pkinase 147-410 28 2e-81 281.59 Pfam 1-293 (293) Show / Hide 
Range on Protein: 147-410
Range on HMM: 1-293/293
Sequence Identity: 28% (87 aa)

FIVTKMIGKGSFAKVYLATKKSQNIQYAIKAFNKEFMQNQHKGKESLIN--EISIMRQLNNDHLIRLYEVYETTNSIYFVVDLLNGG----ELLHRIR--
. . . ||.|||..||....|. ....|.| ..|.   . .. ......  ||.||. || .. .|||...|. ..||.| ....||    .| ..|.  
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR--HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTW

EKGSI--NEKELRVLIRNLILALEHLHQKNIMHRDLKPENLLLKSKQSD-SEIVVADFGLATR--IDIPNILFKRCGTPGFVAPEVLLYKEGDPFYTTQC
..|..   |.|..  .. .. .||..|...|.||||||||.|....    . . ..|||||    .     .  .||||...||||..   |.. |.. .
RHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIR---GGQYYGPKV

DIFSAGIIFYLLLVGKQPFQGK------DYKQILRANKACEIRYDLPEFEKIS-----------------NAAKDLLKKMLDARPEHRFSATQCLQHPFL
|..|.|.|.| .| |. ||.|.      | .|... .. .....| |.   ||                  ..||..|..|.  |. | .|.|.||||..
DMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 12415.AA ULK 147-410 29 4.3e-75 255.77 In-house 1-324 (324) Show / Hide 
Range on Protein: 147-410
Range on HMM: 1-324/324
Sequence Identity: 29% (95 aa)

FIVTKMIGKGSFA-KVYLAT-KKSQ--NIQYAIKAFNKE-FMQNQHK-----GKESLINEISIMRQLN------NDHLIRLYEVYETT--NSIYFVVDLL
... ...|||||. ||| .. ||..  | ..|.|  .|  . .....      ...|.|||.||..|.      . | ..||...||.  | ||..... 
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNH-HIVKLYDWFETSNHNNIYIIMEYC

NGGELLHRIR---------EKGSINEKELRVLIRNLILALEHLHQKNIMHRDLKPENLLLKSKQS--DSE-------IVVADFGLATRIDIPNILFKRC-
||| | . |          ||. ..|.| .  .. .. .. .||..||.|||.||.|.|.. .|   ||.       . .||||.|  .| .|     | 
NGGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQ

---------GTPGFVAPEVLLYK-EGDPFYTTQCDIFSAGIIFYLLLVGKQPFQGKDYKQIL--RANK----------ACEIRYDLP---EFEKISNAAK
         ||| . ||..|  . |. |.|.  |||.| |.||| .| || ||..  . .     ..            .    . |   .  |||.  |
TCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECK

DLLKKMLDARPEHRFSATQCLQHPFL
||...||   .. |.| .. ..||..
DLIRRMLQYDEKDRISWEEIFNHPWF
Kinase 12415.AA ULK 147-410 28 5.2e-75 255.52 In-house 1-329 (329) Show / Hide 
Range on Protein: 147-410
Range on HMM: 1-329/329
Sequence Identity: 28% (94 aa)

FIVTKMIGKGSFAKVYLAT-KKSQ---NIQYAIKAFNKE-FMQNQHKG-----KESLINEISIMRQLN--------NDHLIRLYEVYETT--NSIYFVVD
... ...|||||.||| .. ||..   |...|.|   |. . |...       ...|.||| ||..|.        . . ..||...||.  | ||....
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

LLNGGELLHRIREKGS----------INEKELRVLIRNLILALEHLHQKNIMHRDLKPENLLLKSKQS--DSE-------IVVADFGLATRIDIP-----
. ||| | . | ...           ..|.| .  .. .. .. .||..||.|||.||.| |.. .|   ||.       . .||||.|  .| .     
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

-NILFK----RCGTPGFVAPEVLLYK-EGDPFYTTQCDIFSAGIIFYLLLVGKQPFQGK--DYK-----QILRANKACE--IRYDLPEFEK------ISN
 .  ..     |||| . ||..|  . |. |.|.  |||.| |.||| .|.|| ||..   |..     . ..  . ..  |.   ..|.|      ||.
MMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAWFNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISP

AAKDLLKKMLDARPEHRFSATQCLQHPFL
  |||...||   .. |.| .. ..||..
ECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase 12415.AA CAMKL 147-410 30 8.4e-75 238.11 In-house 1-297 (297) Show / Hide 
Range on Protein: 147-410
Range on HMM: 1-297/297
Sequence Identity: 30% (92 aa)

FIVTKMIGKGSFAKVYLATK-KSQNIQYAIKAFNKEFMQNQHKGKES-----------LINEISIMRQLN---NDHLIRLYEVYETTNS------IYFVV
... | .|||||.|| |||  . .....|||  .|. ..|  . |             .  ||.||..||     . |.||||.|| .       || | 
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

DLLNGGE--LLHRIREK----GSINEKELRVLIRNLILALEHLHQKNIMHRDLKPENLLLKSKQSDSEIVVADFGLATRID-I----PNILFKRCGTPGF
 .  |||  |...|...    |.. |.| | . | .. |....|...| |||.||||.|| ....   | ..|||... .. .     . |  .||.| .
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNN-NIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPY

VAPEVLLY-KEGDPFYTTQCDIFSAGIIFYLLLVGKQPFQGKDYK------QILRANKACEIRYDLPEFEKISNAAKDLLKKMLDARPEHRFSATQCLQH
 |||...  .  .|..  . || |.|.| | ...|. || . .|.      . .  .|  .  |  | . ..|  ..||..|||   ||.|... | ..|
MAPEIFQGNN--KPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNH

PFL
|..
PWM
Kinase 12415.AA Ciliate-E2-Unclassified 147-410 22 1.4e-71 244.07 In-house 1-352 (352) Show / Hide 
Range on Protein: 147-410
Range on HMM: 1-352/352
Sequence Identity: 22% (80 aa)

FIVTKMIGKGSFAKVYLATKKSQNIQY-----AIKAFNKE-----FMQNQHKGKESLINEIS-------------IMRQLNNDHLIRLYEVYETTNSIYF
... | ||.|.|.|||.. .|.|. ||     ..|. ..      ... ... ..  .|...             |...... ........ .... ||.
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYI

VVDLLNGGELLHRIREKGS-----------------INEKELR-----VLIRNLILALEHLHQKN-IMHRDLKPENLLLKSKQSDSEIVVADFGLATRID
| ....||.|.  |.....                 . |.. .      ... ....||.||.|| | |||.||||.|......  .| ..|||.. ...
VMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQ

----------------IPNILFKRCGTPGFV----APEVLLYKEGDPFYTTQ----CDIFSAGIIFYLLLVGKQPFQGKDYKQ---------------IL
                .....  .||||..     |||||  .     | ..    |||.| |.|.| .| |. ||......|               .|
QNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQ----NYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQL

RANK-ACEIRYDLPEF----EKISNAAKDLLK----KMLDARPEHRFSATQCLQHPFL
. |. ...| ..  ..     ..|. |||...    |||. .|. | .. | |.||..
YQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 12415.AA Pkinase_Tyr 147-296 29 2.4e-19 66.17 Pfam 1-158 (270) Show / Hide 
Range on Protein: 147-296
Range on HMM: 1-158/270
Sequence Identity: 29% (48 aa)

FIVTKMIGKGSFAKVYLATKK----SQNIQYAIKAFNKEFMQNQHKGKESLINEISIMRQL-NNDHLIRLYEVYE-TTNS--IYFVVDLLNGGELLHRIR
 .  |..|.|.| .||..| |    ...|. |.|  .   |. |   .|....|..||.|| ......||| |      .  || |. .  .| ||.  |
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQN-CREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

E----KGSINEKELRVLIRNLILALEHLHQKNIMHRDLKPENLLLKSKQSDSEIVVADFGLA
.    |.... |.|    .    ..|.|..||. ||||   | |...   .  . ..|||||
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTE---NNVVKICDFGLA
Kinase 12415.AA TyrKc 147-410 22 3.4e-15 23.02 SMART 1-280 (280) Show / Hide 
Range on Protein: 147-410
Range on HMM: 1-280/280
Sequence Identity: 22% (66 aa)

FIVTKMIGKGSFAKVYLATKKSQNIQYAIKAFNKEFMQNQHKGKESLINEISIMRQL--NNDHLIRLYEVYETT-------NSIYFVVDLLNGGELLHRI
    |..| | | .||..| |   || |.|  ...        .| ...|..||..|  ......||| |  .          .. |. .  .| |....
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

REKGS-INEKELRVLIRNLILALEHLHQKNIMHRDLKPENLLLKSKQSDSEIVVADFGLATRIDIP-------NILFKRC--GTPGFV-----APEVLLY
|...  .. |.|           |.||.||. ||||   | |.....    . ..||||.  |.             |.   |. . .     |||.. |
RKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINY

KEGDPFYTTQCDIFSAGIIFY-LLLVGKQPFQG-----KDYKQILRANKACEIRYDLPE-----FEKISNAAKDLLKKMLDARPEHRFSATQCLQHPFL
..    .||. |..| |.  . ..  |.||  |     .. .....  |. . .   |.     |   . .  .. |.  .. || | . ...  | ..
GK----FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF