Gene 2623 (Tetrahymena)

2623

Species: Tetrahymena
Alias: 2623, 300, 3746.m00307, TTHERM_01015890, PreTt02623, 198.m00043
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: CAMK
Family: CDPK
Subfamily: Ciliate-E2a

Sequence

Name Sequence Type Origin Length Description Download
2623.AA Protein None 478 None Fasta, JSON
2623.kin_dom Protein Kinase Domain None 245 None Fasta, JSON
2623.NA RNA None 1437 None Fasta, JSON

Protein domain

Protein domains of 2623.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 2623.AA CDPK 45-288 50 4.3e-182 563.02 In-house 1-271 (271) Show / Hide 
Range on Protein: 45-288
Range on HMM: 1-271/271
Sequence Identity: 50% (138 aa)

FKI-NILRTGAFGVVRLVEQR-QTGLRR-AMKSIKKSNIIKEEE-EKMFAEVNILSTLTHPNIIQLFELYQDEQNYYLITE--YCSGGELFEKIRQMEQF
.|| ..| .|.||.||.| .. .|. .| ||| |.||.....|. ...| |..||..| |||||...| ||||.|||...|  ||.|||||..| .. .|
YKIKKVLGKGHFGQVRKVKHKQKTNQERVAMKIIPKSRVKDKEQQQQFFNEIEILKQLDHPNIIKIYEFYQDEKNYYIVMETEYCTGGELFDYIIEKGHF

SERE------------VYCHSLGIVHRDLKPENLLFDSNKPNA----NLKVIDFGTSRRFDSS-----KKMTKRLGTPYYIAPEVLQRSYDQKCDVWSCG
.|.|            .|||| .||||||||||.||||.|...    |.||||.|||..||..     |||..|.||||||||||||..|..|||.||||
TEKEAAYIMRQILSAVNYCHSNNIVHRDLKPENILFDSKKDDSWVIYNIKVIDWGTSKKFDQNQKIEDKKMSQRCGTPYYIAPEVLQKKYNEKCDIWSCG

VILYILLCGYPPFNGRTEEQILKSVAEDDFTFEDTEWSCISKEAKDLISRMLKKNPEERITAQQAYDDVWV
|||||||||||||.|.....|...| .  ..||. ||..||.||||||..|| ..|. |..||||... |.
VILYILLCGYPPFYGKNDQEIMEKVKKGKYSFEGPEWDHISDEAKDLIRKMLCYDPKKRMSAQQALQHPWF
Kinase 2623.AA Ciliate-E2a 44-288 42 1.4e-155 461.37 In-house 1-275 (275) Show / Hide 
Range on Protein: 44-288
Range on HMM: 1-275/275
Sequence Identity: 42% (118 aa)

PFKINILRTGAFGVVRLVEQRQTGLR-RAMKSIKKSNIIKEEEEKMFAEVNILSTLTHPNIIQLFELYQDEQNYYLITEYCSGGELF-------------
...|.....|.||.|.|....||| . ...| ||| ...|...|... |.||...| |||||.|.| |.||.||||..|||.||||.             
YKFIKKIGKGNFGSVYLAQHKQTGKQFAMKKFIKKMYQQKKGKEYFMNEINIMRQLDHPNIIKLYEVYEDENNYYLVMEYCEGGELYDKIKQCKRFFEEI

-EKIRQMEQFS-EREVYCHSLGIVHRDLKPENLLFD---SNK-PNANLKVIDFGTSRRF--DSSKKMTKRLGTPYYIA------PEV-LQRSYDQKCDVW
 |  ..| |.  .   |.|...|.||||||||.||.   .|. .|...|.||||.....  |. |.| .. |||.|.|      .|| ....||.|||.|
QEICDIMQQLLWQGLHYMHQRNIMHRDLKPENILFKNCSKNSIQNSDIKIIDFGLATFIDKDEKKYMFQKCGTPGYVAPEVLNNKEVLKHKQYDTKCDMW

SCGVILYILLCGYPPFNGRTEEQILKSVAEDDFTFEDTE-WSCISKEAKDLISRMLKKNPEERITAQQAYDDVWV
|||||.||||||.|||.|.|...||... .  . |...| |...|||.|||...||.|.|..|||||||... |.
SCGVIFYILLCGKPPFKGKTYNEILQQNKKCKIDFNCPECWEKCSKECKDLMKKMLEKDPKKRITAQQALNHPWF
Kinase 2623.AA CAMK1 52-288 36 1.5e-128 375.83 In-house 9-276 (276) Show / Hide 
Range on Protein: 52-288
Range on HMM: 9-276/276
Sequence Identity: 36% (99 aa)

TGAFGVVRLVEQRQT---GLRRAMKSIK-KSNIIKEEE---EKMFAEVNILST---LTHPNIIQLFELYQDEQNYYLITEYCSGGELFEKIRQMEQFSER
.|||..|.|.....|   |   |.| |. |... |...   |..  |..|. .   . |||||...| |...  .||..|...|||||..| . ....|.
RGAFSEVYLCTHKETQTNGKQYAIKCIDKKKFMKKKDMQKQEALENEIEIMKKVSKIDHPNIIKFYEWYESDNHFYLVMELVTGGELFDRIVEKGNYTEK

E------------VYCHSLGIVHRDLKPENLLFDSNKPNANLK--VIDFGTSRRFDSSK-KMTKRLGTPYYIAPEVLQR----SYDQKCDVWSCGVILYI
.             |.||.|||||||||||||. ...... .|  ..||| |..||.   .|... |||.|.||||| .     ||..||.||.|||.||
DARHIMKQILSAVEYMHSKGIVHRDLKPENLLYYDKDEDSKIKRSIADFGLSKIFDHDENLMKTACGTPGYVAPEVLECKKDKPYDKACDMWSIGVITYI

LLCGYPPFNGRT-EEQILKSVAEDDFTFEDTEWSCISKE-AKDLISRMLKKNPEERITAQQAYDDVWV
||||||||.. . ...... . . ...|   .|  ||.. |||.|. ||...|..|.|..|. .. |.
LLCGYPPFYDENVDNELFEKIKKCEYEFPSPWWDNISDQEAKDFIKHMLEVDPKKRYTCEQCLNHPWI
Kinase 2623.AA CAMK 49-288 26 1.1e-118 384.19 In-house 1-425 (425) Show / Hide 
Range on Protein: 49-288
Range on HMM: 1-425/425
Sequence Identity: 26% (112 aa)

ILRTGAFGVVRLVEQRQTG------------LRRAMKSIKKSNII--------------------------KEEEEKMFAEVNILST-------LTHPNI
.| .|.||.|.|.....|.             . |.| |.|. .                            . ..... |..|...       | ||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

IQLFELYQD-------------------EQNYYLIT---EYCSGGEL----FEKIRQMEQ---------------FSERE------------VYCHSLGI
|.|.| |.|                   ....|...   ||||||||    |..|.. ..               |.|||             ||||..|
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

VHRDLKPENLLFDSNKPN--------------ANLKVIDFGTSRRFDSSK------------------------KMTKRLGTPYYIA-PEVLQRS-----
|||||||||.|.|.|...              .|.|.|||| ...||...                        ||. . |||.|.| ||||...     
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

----------YDQKCDVWSCGVILYILLCGYPPFNGR-------------TEEQILKSVAEDDFTFEDTE------------WSCISKE--------AKD
          |..|||.|||||||||.|||||||.|              ....... . . ...|.. .            |..||.|        .||
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

LISRMLKKNPEERITAQQAYDDVWV
||..||...||.|.|..|. .. |.
LIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 2623.AA S_TKc 44-288 35 3.3e-91 310.24 SMART 1-231 (231) Show / Hide 
Range on Protein: 44-288
Range on HMM: 1-231/231
Sequence Identity: 35% (98 aa)

PFKINILRTGAFGVVRLVEQRQTGLRRAMKSIKKSNIIKEEEEKMFAEVNILSTLTHPNIIQLFELYQDEQNYYLITEYCSG--GELFEKIRQMEQ----
  .....  ||||.|...  . || . |.| ||         |..  |..||.   ||||..|.. .|| ...|...|||.|  |.||. |...      
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--FSEREV------------YCHSLGIVHRDLKPENLLFDSNKPNANLKVIDFGTSRRFDSSKKMTKRLGTPYYIAPEVLQRSYDQ-KCDVWSCGVILYI
  |.| ..            ||||.||.||||||||.|.|.     ..|..||| .|..      |   |||.|.|||||  .|.  |||.||||.|||.
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL------TTFCGTPWYMAPEVL--GYGKCKCDWWSCGCILYE

LLCGYPPFNGRTEEQILKSVAEDDFTFEDTEWSCISKEAKDLISRMLKKNPEERITAQQAYD-------DVWV
.|||||||   ......| .               |.||||.|...|.|.||.|.|| .|         . |.
MLCGYPPFP--QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 2623.AA CAMKL 52-288 35 7.4e-91 290.17 In-house 9-297 (297) Show / Hide 
Range on Protein: 52-288
Range on HMM: 9-297/297
Sequence Identity: 35% (103 aa)

TGAFGVVRLVEQ-RQTGLRRAMKSIKKSNII-KEEEEKMFA------------EVNILSTLT---HPNIIQLFELYQDEQN------YYLITEYCSGGE-
.|.||.|.| .  | || . |.| |.|. |  ..  .|..             |..|.. |    |||||.|.| ......      .||..||||||| 
KGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVMEYCSGGEM

-LFEKIRQMEQ----FSEREV------------YCHSLGIVHRDLKPENLLFDSNKPNANLKVIDFGTSRRFDS-----SKKMTKRLGTPYYIAPEVLQR
 ||..|.. .     ..|.|             ||||.||||||.||||.|.|.|. | |.|.|||| |  ..       .|.. . |.| | |||..|.
DLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNN-NIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYMAPEIFQG

---SYD-QKCDVWSCGVILYILLCGYPPFNGRTE------EQILKSVAEDDFTFEDTEWSCISKEAKDLISRMLKKNPEERITAQQAYDDVWV
   .|| .| |.|||||||| ..||| ||.. |        . ..   .    .... |. .| ...|||..||..|||.|.|..|   . |.
NNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM
Kinase 2623.AA CAMK-Unique 46-288 25 1.1e-88 292.91 In-house 3-363 (363) Show / Hide 
Range on Protein: 46-288
Range on HMM: 3-363/363
Sequence Identity: 25% (93 aa)

KINILRTGAFGVVRLVEQRQTGLRRAMKSIKK---SNIIKEE---------------EEKMFAEVNILSTLTHPNIIQLFEL----YQDEQ---------
...|. .|.||.|. .  | ||  .|.|..||   .|... .               . |   |..|. .. |||||.|..     ..|..         
MHRIIGHGNFGHVYECMDRETGKKWACKMVKKQTHGNKKQKQQRNFDLRYKITEKRRDMKLKREHQIWKMVDHPNIIKLYDWNNPIFCDRKYPLCDLIIK

------NYYLITEYCSGGELFEKIRQ--------------------MEQFSE--REV------------YCHSLGIVHRDLKPENLLFDSNKP-------
      ..|...||| ||.||..| .                      .|||  ...            | ||..|||||||.||... .. .       
TPRALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNNHHRD

------NANLKVIDFGTSRRFDSSKKMT---KRLGTPYYIAP--------------EVLQ-RSYDQKC----DVWSCGVILYILLCGYPPFNGRTEE---
      | ..|..||| .. ....|. .   .. |||.|.||              ||.  . |||.|    | ||.|||.|..|||.|||.. .|.   
FPYDWSNWHIKLCDFGLCCHYNHNKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTRDEVINMQCYDQQCSPASDIWSLGVIMYYMLCGCPPFDCECEDRDY

-----QILKSVAEDDF-TFEDTEWSC---ISKEAKDLISRMLKKNPEERITAQQAYDDVWV
      |...    |. .|.   |.    ||.||||.. . ..  |  |..| ....  |.
ENHDKEIFECICKGDYCNFDWKMWHGPDYISQEAKDFVKCCMTVDPDHRWSAKELLEHQWI
Kinase 2623.AA Ciliate-E2 46-288 27 5.8e-86 291.89 In-house 3-365 (365) Show / Hide 
Range on Protein: 46-288
Range on HMM: 3-365/365
Sequence Identity: 27% (104 aa)

KINILRTGAFGVVRLVEQRQTG-----------------------LRRAMKSIKKSN-IIKEEEEKMFAEVN----------ILSTLTHPNIIQLFELYQ
.|... .|.||.|.........                          |||..||.. .... |.... |.|          ||..| |||||...| .|
FIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYECFQ

--DEQNYYLITEYCSGGELFEKIRQM-----------EQFSEREV---------------------------YCHSLG-IVHRDLKPENLLFDSNKPNAN
  |..|.||..|||.||.||. |...           ..|.|.|.                           |.|| . |.|||.||||.||        
EKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF--------

LKVIDFGTSRRFDSS-----------KKMTKR----------------------LGTPYYIAPEVLQRS----------YDQKCDVWSCGVILYILLCGY
.|.||||.|...| .           ..|  .                      .|||.| |||.|..           || |||.||.|||||..|.|.
IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGK

PPFNGRTEEQILKSVAEDDFTFEDT------------EWSCISKEAKDLISR----MLKKNPEERIT-AQQAYDDVWV
|||      |. .   . || ...             .|  .|.|.||||..    ||.|.||.||| ..|. .  | 
PPF------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 2623.AA MAPKAPK 44-288 31 4.2e-83 257.08 In-house 1-292 (292) Show / Hide 
Range on Protein: 44-288
Range on HMM: 1-292/292
Sequence Identity: 31% (94 aa)

PFKINILRTGAFGVVRLVEQRQTGLRRAMKSIKKSNIIKEEEEKMFAEVNILS-TLTHPNIIQLFELYQD----EQNYYLITEYCSGGELFEKIRQ--ME
     .|  |. | |.  ....|| . | | ....       .| . ||.... . .||||.|. . . .    ... ||. |   |||||..| |    
KLWKEVLGEGIYGKVQTCVHKRTGQEYAVKILEDQ--PGHSRQKARREVELHWHCQGHPNIVQIIDWFENMYQFDKCFYLVMECMEGGELFQHIQQRGHK

QFSEREV------------YCHSLGIVHRDLKPENLLFDSNKPNANLKVIDFGTSRR-------FDS--SKKMTKRLGTPYYIAPEVLQR-S----YDQK
 |.|||.            ..||..| ||||||||.|. ....|. .|  |||   .        ..  . ...   .||||.||||. . .    || .
HFTEREASQIMKDICSAVDFLHSMNIAHRDLKPENILCTDTNHNCPVKLCDFGFAKEIHLNHDCTTPITTPELMTPCYTPYYMAPEVVGAFKEAHTYDKS

CDVWSCGVILYILLCGYPPFNGRTE-EQILKS---------------VAEDDFTFEDTEWSCISKEAKDLISRMLKKNPEERITAQQAYDDVWV
|| || |||.||.||||||| ...  |.. ..                .|  ..| | |||.||.||||||...|...|..|.|..|  .  |.
CDMWSLGVIMYIMLCGYPPFYSNCGDEDCSWDRGEACRDCQNMMFHRIQEGQYEFPDEEWSHISEEAKDLIRKLLRRDPTQRLTIEQVMNHPWI
Kinase 2623.AA RSK 53-288 33 6.4e-81 275.14 In-house 10-278 (278) Show / Hide 
Range on Protein: 53-288
Range on HMM: 10-278/278
Sequence Identity: 33% (91 aa)

GAFGVVRLVEQRQTGLRRAMKSIKKSNIIKEE--EEKMFAEVNILSTLT-HPNIIQLFELYQDEQNYYLITEYCSGGELFEKIRQMEQ---FSEREV---
|.. ..| .....||   ||| .||. |.. .   .  ..|.|||.. . ||.|..|.. .|.|.  |||.|||.|||||..... ..   |||.|.   
GKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGCFSEDEACFY

---------YCHSLGIVHRDLKPENLLFDSNKPN-ANLKVIDFGTSRRFDSS--KKMTKRLGTPYYIAPEVLQ----RS-YDQKCDVWSCGVILYILLCG
         . |..||.|||||||| |.|. . | . .|..||| .. |. .  ... .  .|  |.|||.|     .. .|. ||.|| ||..| .| |
MAEIVLAVEHLHQQGIIHRDLKPENILYDDES-NEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGVLMYEMLTG

YPPFNG---RTEEQILKSVAEDDFTFEDTEWSCISKEAKDLISRMLKKNPEERIT-----AQQAYDDVWV
.||| |    . ..|.| . . .|...  .|. .|.||||||..||...|. |..     |..  .. | 
CPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase 2623.AA Ciliate-E2-Unclassified 46-288 29 3.6e-79 269.31 In-house 3-352 (352) Show / Hide 
Range on Protein: 46-288
Range on HMM: 3-352/352
Sequence Identity: 29% (103 aa)

KINILRTGAFGVVRLVEQRQTGLRRAMKSIKKSNIIK----------------EEEEKMFAEVN--------ILSTLTHPNIIQLFELYQDEQNYYLITE
.| .. .|.||.|..........  ||| .||..|.|                ... |.   ..        ||. . ||.|. .|.  ||.|| |...|
IIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKK-YHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVME

YCSGGELFEKIRQMEQ-----------------FSEREV-----------------YCHSLG-IVHRDLKPENLLFDSNKPNANLKVIDFGTSRRFD---
|| ||.|.. |.....                 |.|...                 |.|. . |.|||.||||.|||.|. | ..|.|||| |.. .   
YCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNN

-------------SSKKMTKRLGTPYYI----APEVLQR-SYD----QKCDVWSCGVILYILLCGYPPFNGRTEEQ----------------ILKSVAED
             ....|. . |||.|.    ||||||.  ||     |||.||.||||| .| ||.||.....||                ...   . 
NCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQK

DFTFEDTEW----SCISKEAKDLIS----RMLKKNPEERITAQQAYDDVWV
.. |   .|      .|.||||.|.    .||||||..|||..|.    | 
NIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 2623.AA Pkinase 144-288 37 2.1e-58 205.16 Pfam 123-293 (293) Show / Hide 
Range on Protein: 144-288
Range on HMM: 123-293/293
Sequence Identity: 37% (65 aa)

YCHSLGIVHRDLKPENLLFD-SNKPNANLKVIDFGTSRR--FDSSKKMTKRLGTPYYIAPEVLQ--RSYDQKCDVWSCGVILYILLCGYPPFNGR-----
|||| ||.||||||||.|.|  . ..| .|..||| ..     ..  || . |||.|.||||..  . |..|.|.||||.|||..|||.||| |.     
YCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN

-TEEQILKSVAEDDFTFEDTEWSCIS-----------------KEAKDLISRMLKKNPEERITAQQAYDDVWV
 .. |... . . .. |.  .|..||                 .|.||.|...|.|.|..|.||.|.  . |.
HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 2623.AA Pkinase 53-143 32 4.6e-22 79.1 Pfam 10-110 (293) Show / Hide 
Range on Protein: 53-143
Range on HMM: 10-110/293
Sequence Identity: 32% (33 aa)

GAFGVVRLVEQRQTGLRRAMKSIKKSNIIKEEEEKMFA--EVNILSTLTHPNIIQLFELYQDEQNYYLITEYCSGG----ELFEKIR--QMEQF--SERE
|.||.|..   . || . |.| |||... .....  .   |. |.  | ||||..|.. ..|....|...||| ||    .||. |.  .   |  ||.|
GSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWE

V
.
C
Kinase 2623.AA TyrKc 44-286 21 2.4e-14 9.26 SMART 1-280 (280) Show / Hide 
Range on Protein: 44-286
Range on HMM: 1-280/280
Sequence Identity: 21% (62 aa)

PFKINILRTGAFGVVRLVEQRQTGLRRAMKSIKKSNIIKEEEEKMFAEVNILSTL--THPNIIQLFELYQDE-------QNYYLITEYCSGGELFEKIRQ
  .. .|  ||||.|.. . .   .  | |..|..      .| .  | .|.. |   ||||..|.    ..       . .....||...| | . .| 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

MEQ-FSEREV------------YCHSLGIVHRDLKPENLLFDSNKPNANLKVIDFGTSRRFDSS------KKMTKRL---GTP-----YYIAPEVLQRS-
 .  .. ..             | || ...||||   | | ..|.     |. ||| ||  ..       |.. .     |.         |||... . 
HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK

YDQKCDVWSCGVILY-ILLCGYPPFNG-----RTEEQILKSVAEDDFTFEDTE-----WSCISKEAKDLISRMLKKNPEERITAQQAYDDV
.  | |||| || .. |.  | .|  |      . ..... | . .      .       | ..|  .....  . .||.| | .. ... 
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase 2623.AA Pkinase_Tyr 71-128 28 9.7e-08 26.83 Pfam 32-94 (270) Show / Hide 
Range on Protein: 71-128
Range on HMM: 32-94/270
Sequence Identity: 28% (18 aa)

AMKSIKKSNIIKEE--EEKMFAEVNILSTL-THPNIIQLFELYQ-DEQN--YYLITEYCSGGEL
| |.. | .  .|.   |....|..|...|  ||||..|      ...   .|...||. .| |
AVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDL
Efhand 2623.AA efhand 334-362 34 0.000775 18.46 Pfam 1-29 (29) Show / Hide 
Range on Protein: 334-362
Range on HMM: 1-29/29
Sequence Identity: 34% (10 aa)

ELLKTFKGLDQNGDGLLEKHELVEGYLQV
|| . || .|..||| ... |..|.. ..
ELKEMFKEFDKDGDGYIDFEEFCEMMKKL
EFh 2623.AA EFh 334-362 24 0.002992 16.85 SMART 1-29 (29) Show / Hide 
Range on Protein: 334-362
Range on HMM: 1-29/29
Sequence Identity: 24% (7 aa)

ELLKTFKGLDQNGDGLLEKHELVEGYLQV
|. . |. .|..||| ....|....   .
EFKEMFRMFDKDGDGYIDFEEFKDMMKSL
Efhand 2623.AA efhand 372-389 27 0.065753 11.4 Pfam 1-18 (29) Show / Hide 
Range on Protein: 372-389
Range on HMM: 1-18/29
Sequence Identity: 27% (5 aa)

FVNKIFDEIDVNSSGKVD
 ....|.|.|.. .|..|
ELKEMFKEFDKDGDGYID
EFh 2623.AA EFh 372-397 17 0.208332 1.99 SMART 1-29 (29) Show / Hide 
Range on Protein: 372-397
Range on HMM: 1-29/29
Sequence Identity: 17% (5 aa)

FVNKIFDEIDVNSSGKVD---CTAAMQRE
 ....|...|.. .|..|     ..|.. 
EFKEMFRMFDKDGDGYIDFEEFKDMMKSL
Efhand 2623.AA efhand 404-432 34 5.7e-08 33.59 Pfam 1-29 (29) Show / Hide 
Range on Protein: 404-432
Range on HMM: 1-29/29
Sequence Identity: 34% (10 aa)

KIEKAFKMFDTDGNGFIDRHELQNILGGG
.....||.||.||.|.||. |.....   
ELKEMFKEFDKDGDGYIDFEEFCEMMKKL
EFh 2623.AA EFh 404-432 34 8.5e-08 33.15 SMART 1-29 (29) Show / Hide 
Range on Protein: 404-432
Range on HMM: 1-29/29
Sequence Identity: 34% (10 aa)

KIEKAFKMFDTDGNGFIDRHELQNILGGG
.....|.|||.||.|.|| .|.. ..   
EFKEMFRMFDKDGDGYIDFEEFKDMMKSL
EFh 2623.AA EFh 439-467 27 1.1e-05 26.12 SMART 1-29 (29) Show / Hide 
Range on Protein: 439-467
Range on HMM: 1-29/29
Sequence Identity: 27% (8 aa)

TWNSILVECDQNGDGKISQNEFIDLLVKK
 .. .  . |..|||.|. .||.|.. ..
EFKEMFRMFDKDGDGYIDFEEFKDMMKSL
Efhand 2623.AA efhand 439-467 31 1.7e-05 24.54 Pfam 1-29 (29) Show / Hide 
Range on Protein: 439-467
Range on HMM: 1-29/29
Sequence Identity: 31% (9 aa)

TWNSILVECDQNGDGKISQNEFIDLLVKK
 .. .  | |..|||.|. .||.... |.
ELKEMFKEFDKDGDGYIDFEEFCEMMKKL