27560

Species: Tetrahymena
Alias: 27560, 88, PreTt27560, 3836.m02366, TTHERM_00355740, 37.m00277
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-E2
Subfamily: Ciliate-E2a

Sequence

Name Sequence Type Origin Length Description Download
27560.AA Protein None 681 None Fasta, JSON
27560.kin_dom Protein Kinase Domain None 264 None Fasta, JSON
27560.NA RNA None 2046 None Fasta, JSON

Protein domain

Protein domains of 27560.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 27560.AA Ciliate-E2a 1-265 47 3.7e-153 454.14 In-house 6-275 (275) Show / Hide
Range on Protein: 1-265
Range on HMM: 6-275/275
Sequence Identity: 47% (129 aa)

MIGKGGFSRVFLAQDKFSRENYAIKVITKDKLLQQTKGIKSLLNEIQIMKELDNVNGCLKLIGVYETDSSVNLILEYIKGGELVKKIKLKDKQNFTIENM
.|||| | .|.||| |   ...|.|.. | |. ||.|| ... |||.||..||. | ..||..|||....  |..||..|||| .||| ...... |...
KIGKGNFGSVYLAQHKQTGKQFAMKKFIK-KMYQQKKGKEYFMNEINIMRQLDHPN-IIKLYEVYEDENNYYLVMEYCEGGELYDKIKQCKRFFEEIQEI

RQLMQNIL-IALAHIHQRKIIHRDLKPDNILIED-DINS---TKIKIADFGLATYDSTVLNDFLFKKCGTPGFLAPEVLSNKD--THKLYDHKVDVFSAG
...||..|  .|...|||.|.||||||.|||... . ||   ..|||.||||||. ..  ....|.||||||..||||| ||.  .|| ||.|.|..|.|
CDIMQQLLWQGLHYMHQRNIMHRDLKPENILFKNCSKNSIQNSDIKIIDFGLATFIDKDEKKYMFQKCGTPGYVAPEVLNNKEVLKHKQYDTKCDMWSCG

VIFYILLCGQQPFKGSNHRQVVEQNKKCEIDFQILDSNQKIPQAAKILVKQMLAKDPINRPTSQECLNSPFF
|||||||||..|||| .......|||||.|||.. .. .|.....| |.|.|| |||..|.| |..||.|.|
VIFYILLCGKPPFKGKTYNEILQQNKKCKIDFNCPECWEKCSKECKDLMKKMLEKDPKKRITAQQALNHPWF

Kinase 27560.AA CAMK1 1-265 40 1.7e-93 272.12 In-house 6-276 (276) Show / Hide
Range on Protein: 1-265
Range on HMM: 6-276/276
Sequence Identity: 40% (114 aa)

MIGKGGFSRVFLAQDKFS---RENYAIKVIT-KDKLLQ---QTKGIKSLLNEIQIMK---ELDNVNGCLKLIGVYETDSSVNLILEYIKGGELVKKIKLK
.||.| || |.|...| .    ..||||.|  |. . .   | |  ..|.|||.|||   ..|  | . |.. .||.|. . |..|...||||  .|  |
EIGRGAFSEVYLCTHKETQTNGKQYAIKCIDKKKFMKKKDMQ-K-QEALENEIEIMKKVSKIDHPN-IIKFYEWYESDNHFYLVMELVTGGELFDRIVEK

DKQNFTIENMRQLMQNILIALAHIHQRKIIHRDLKPDNILIEDDINSTKIK--IADFGLATYDSTVLND--FLFKKCGTPGFLAPEVLSNKDTHKLYDHK
.  |.| .. | .|..|| |. ..|.. | |||||| |.| .|  .  |||  ||||||...   . .|  .... |||||. ||||| .|   | || .
G--NYTEKDARHIMKQILSAVEYMHSKGIVHRDLKPENLLYYDKDEDSKIKRSIADFGLSKI---FDHDENLMKTACGTPGYVAPEVLECKK-DKPYDKA

VDVFSAGVIFYILLCGQQPFKGSN-HRQVVEQNKKCEIDFQILDSN--QKIPQA-AKILVKQMLAKDPINRPTSQECLNSPFF
.|..|.|||.|||||| .|| ..| . .  |..||||..|   .|.   .|    || ..|.|| .|| .|.| ..||| |..
CDMWSIGVITYILLCGYPPFYDENVDNELFEKIKKCEYEF---PSPWWDNISDQEAKDFIKHMLEVDPKKRYTCEQCLNHPWI

Kinase 27560.AA Ciliate-E2 1-265 27 3.3e-88 299.34 In-house 6-365 (365) Show / Hide
Range on Protein: 1-265
Range on HMM: 6-365/365
Sequence Identity: 27% (103 aa)

MIGKGGFSRVFLAQDKFSRENYAIKVITKDKLLQQT------------------KGIKSLLNEIQIMKELD---------------NVNGCLKLIGVYE-
.||.|.|. |......  ....|||.|. .|. |..                  ..|.....||.||.|..               | .  .|.. ... 
KIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQ-QRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYECFQE

-TDSSVNLILEYIKGGELVKKIKLKDKQ---------NFTIENMRQLMQNIL---------------IALAHIHQRK-IIHRDLKPDNILIEDDINSTKI
 .|... |..||..||.| . || ..|.         .||.. ....|. ||                || ..|... |||||.||.|||.        |
KDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF--------I

KIADFGLATYDSTVLN---------DFLFKK----------------------CGTPGFLAPEVLSNKD-----THKLYDHKVDVFSAGVIFYILLCGQQ
||.||||... ..  .          ..| |                      |||||..|||.|..|.     ..| ||.|.|..|.|||.|..|.|. 
KIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKP

PFKGSNHRQVVEQNKKCEIDFQILD-------------SNQKIPQAAKILVKQ----MLAKDPINRPT-SQECLNSPFF
||         .|.|.|.|||.  .             |..|..| .| | |.    || ||| .|.|  ...|| |.|
PF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF

Kinase 27560.AA CAMK 1-265 23 5.7e-86 276.92 In-house 1-425 (425) Show / Hide
Range on Protein: 1-265
Range on HMM: 1-425/425
Sequence Identity: 23% (102 aa)

MIGKGGFSRVFLAQDKFSR------------ENYAIKVITKDKLLQ------------------------QTKGIKSLLNEIQIMKELD------NVNGC
 .|.|.|. |.|...| .             . .|||.| |.||                          . |  |....||.||| |       .    
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

LKLIGVYE------------TDSS--------VNLIL---EYIKGGEL----VKKIKLKDK-------------QNFTIENMRQLMQNILIALAHIHQRK
.||. |||            | |         . ...   ||. ||||      .|. . .               || .  |.... |. |....|...
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

IIHRDLKPDNILIEDDINST--------------KIKIADFGLATY----------------------DSTVLNDFLFKKCGTPGFLA-PEVLSNKDT--
|.||||||.|||. |. ...              .|||.|||.|..                      ...  .. .   ||||.. | ||||. | .  
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

--------HKLYDHKVDVFSAGVIFYILLCGQQPFKGS-------------NHRQVVEQNKKCEIDFQILD--------------------SNQKIPQAA
        .. |. |.|. |.||| ||.|||  || |.             | ..  |. .|.. ||                        .. .. | .
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHH-FVSQEC

KILVKQMLAKDPINRPTSQECLNSPFF
| |...|| .|| .|.| ..||| |..
KDLIRKMLQVDPEKRMTIEQCLNHPWM

Kinase 27560.AA S_TKc 1-265 30 3.4e-78 267.0 SMART 6-231 (231) Show / Hide
Range on Protein: 1-265
Range on HMM: 6-231/231
Sequence Identity: 30% (86 aa)

MIGKGGFSRVFLAQDKFSRENYAIKVITKDKLLQQTKGIKSLLNEIQIMKELDNVNGCLKLIGVYETDSSVNLILEYIKG--GELVKKIKLKDKQN----
 ||||.|..|.....| . . .|||.|            .....||||.|.  .     ||..|... ... ...||. |  |.| . || . ..     
KIGKGAFGKVYKCRHKKTGRIVAIKIIK-----------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

FTIENMRQLMQNILIALAHIHQRKIIHRDLKPDNILIEDDINSTKIKIADFGLATYDSTVLNDFLFKKCGTPGFLAPEVLSNKDTHKLYDH-KVDVFSAG
|.    | .|. |. ||...|...||||||||.|||. .      |||.|||||.             |||| ..|||||        |.. |.|. | |
FPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL--------TTFCGTPWYMAPEVL-------GYGKCKCDWWSCG

VIFYILLCGQQPFKGSNHRQVVEQNKKCEIDFQILDSNQKIPQAAKILVKQMLAKDPINRPTSQECLN-------SPFF
.|.|..|||. ||   .. .. .. .               .. || .....| ||| .|||  |.|.        |.|
CILYEMLCGYPPFP--QMQMMFKKIG---------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase 27560.AA Pkinase 2-265 29 1.1e-74 259.2 Pfam 7-293 (293) Show / Hide
Range on Protein: 2-265
Range on HMM: 7-293/293
Sequence Identity: 29% (89 aa)

IGKGGFSRVFLAQDKFSRENYAIKVITKDKLLQQTKGIKSLLNEIQIMKEL--DNVNGCLKLIGVYETDSSVNLILEYIKGG----ELVKKIKLKDKQNF
||.|.|..|.....| ... .|.|.| |..   . . .. .|.||||||.|  .|.   ..|....|..... ...||  ||    .|   |. ... .|
IGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNI---VRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCF

--TIENMRQLMQNILIALAHIHQRKIIHRDLKPDNILIE-DDINSTKIKIADFGLA----TYDSTVLNDFLFKKCGTPGFLAPEVLSNKDTHKLYDHKVD
  . .  .  |  || .|...|...||||||||.||||  .. .....||.|||||    .  .. ...|    ||||...||||.    ... |..|||
YFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTF----CGTPWYMAPEVIR---GGQYYGPKVD

VFSAGVIFYILLCGQQPFKGS------NHRQVVEQNKKCEIDFQILDSNQ----------------KIPQAAKILVKQMLAKDPINRPTSQECLNSPFF
..|.|.|.|..|||. ||.|.      ...|...........|..  ..                 ......| ..| .|.|||  ||| ...|..|.|
MWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF

Kinase 27560.AA AGC 1-265 21 3.8e-74 190.22 In-house 6-395 (395) Show / Hide
Range on Protein: 1-265
Range on HMM: 6-395/395
Sequence Identity: 21% (86 aa)

MIGKGGFSRVFLAQDK------FSRENYAIKVITKDK-LLQQTK-GIKSLLNE------------IQIMKELDN---------VNGCLK-LIGVYETDSS
.||||.|..|.|...|       . . ||.||. |..  ..  |  ..  ..|             .|......              | |   ..... 
VIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSFQDKDH

--VNLILEYIK---------GG-ELVKKIKLK-DKQNFTIENMRQLMQN-------ILIALAHIHQ-RKIIHRD-LKPDNILIEDDINSTKIKIADFGLA
  . ...||..         || ||   .. . ... |. |  |  .         |. || ..|. ..||||| |||.|||. .|     ||..||||.
TYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDED---GHIKLTDFGLC

TY------------------------------------------------DSTVLN--DFLFKKCG--TPGFLAPEVLSNKDTHKLYDHKVDVFS--AGV
.                                                 |.|  .  |     ||  || ..|||.|        |.. .|  |   |.
KEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTR-KKRDRTWTFCGPCTPEYMAPEIL--------YGKACDWWSFGLGC

IFYILLCGQQPFKGSN---------HRQVVEQNKK-------CEIDFQ-----ILDSNQKIPQAAKILVKQMLAKDPINRPT----------SQECLNSP
..| .|.|. || | |         ..  . |. .       ... |        . .... . || |.|..| ||| .|..           .|  | |
LMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHP

FF
.|
WF

Kinase 27560.AA CAMKL 2-265 29 2.4e-62 197.69 In-house 7-297 (297) Show / Hide
Range on Protein: 2-265
Range on HMM: 7-297/297
Sequence Identity: 29% (88 aa)

IGKGGFSRVFLAQD-KFSRENYAIKVITKDKLLQQTKGIKS-----------LLNEIQIMKELD---NVNGCLKLIGVYETDSS------VNLILEYIKG
.|||.|. | ||.. .. .| .|||.| |.|.   ..  |            .  |||||| |.     |   ||  |.||..       ..|..||. |
LGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPN-IIKLYEVIETPEHDIETKKIYLVMEYCSG

GE--LVKKIKLKDKQN--FTIENMRQLMQNILIALAHIHQRKIIHRDLKPDNILIEDDINSTKIKIADFGLATY-DS--TVLNDFLFKKCGTPGFLAPEV
||  |  .|. . . .  .. .  |.. . |. |....|...|.|||.||.|||. .. |. .|||.|||.... .      ...|   ||.| . |||.
GEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNN-NIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYMAPEI

LSNKDTHKLYD-HKVDVFSAGVIFYILLCGQQPFKGSNHR-----QVVEQNKKCEIDFQILDSNQKIPQAAKILVKQMLAKDPINRPTSQECLNSPFF
..   ..| ||  |||. |.||| | ..||. ||.. ..       . .  .|  ..    .   ...  .. | ..|| ..|  ||| .. .| |..
FQG--NNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM

Kinase 27560.AA CDPK 2-265 34 2.3e-60 183.96 In-house 7-271 (271) Show / Hide
Range on Protein: 2-265
Range on HMM: 7-271/271
Sequence Identity: 34% (95 aa)

IGKGGFSRVFLAQDK-FSRENY-AIKVITKDKLLQQTKGIKSLLNEIQIMKELD--NVNGCLKLIGVYETDSSVNLILE--YIKGGELVKKIKLKDKQNF
.|||.|. |.....|  . .   |.|.| |... .. . .....||| |.|.||  |.   .|.  .|. .  . ...|  | .||||  .|. | .  |
LGKGHFGQVRKVKHKQKTNQERVAMKIIPKSRVKDKEQ-QQQFFNEIEILKQLDHPNI---IKIYEFYQDEKNYYIVMETEYCTGGELFDYIIEKGH--F

TIENM-RQLMQNILIALAHIHQRKIIHRDLKPDNILIEDDINST----KIKIADFGLAT-YDSTVLN---DFLFKKCGTPGFLAPEVLSNKDTHKLYDHK
| | . .. |. || |....|...|.|||||| ||| . . ...     ||. |.|... .|.  .    . . ..||||  .|||||     .| |. |
T-EKEAAYIMRQILSAVNYCHSNNIVHRDLKPENILFDSKKDDSWVIYNIKVIDWGTSKKFDQN-QKIEDKKMSQRCGTPYYIAPEVL----QKK-YNEK

VDVFSAGVIFYILLCGQQPFKGSNHRQVVEQNKKCEIDFQILDSNQKIPQAAKILVKQMLAKDPINRPTSQECLNSPFF
.|. |.||| ||||||  || | |  ...|. ||.. .|   .  ..| . || |...|| .|| .| ..|..|. | |
CDIWSCGVILYILLCGYPPFYGKNDQEIMEKVKKGKYSFE-GPEWDHISDEAKDLIRKMLCYDPKKRMSAQQALQHPWF

Kinase 27560.AA RSK 1-265 30 3.4e-59 202.98 In-house 3-278 (278) Show / Hide
Range on Protein: 1-265
Range on HMM: 3-278/278
Sequence Identity: 30% (85 aa)

MIGKGGFSRVFLAQDK---FSRENYAIKVITKDKLLQQTKGIKSLLNEIQIMKELDNVNGCLKLIGVYETDSSVNLILEYIKGGELVKKIK-LKDKQNFT
. |.||.  ||| . .    ..  || ||. | |. |  | ..  . |..|...  .     .|  ...|.. . ||.||..|||| ....  | .  |.
VLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGCFS

IENMRQLMQNILIALAHIHQRKIIHRDLKPDNILIED-DINSTKIKIADFGLATYDSTVLNDFLFKKCGTPGFLAPEVLSNKDTHKL-YDHKVDVFSAGV
 .  .. | .|  |. |.||..||||||||.||| .| . |.  ||. |||.. . .   |  . . |.|  ..|||.|   . ..  .|. .|..| ||
EDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDES-NEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRAN-QQGGHDKACDWWSLGV

IFYILLCGQQPFKG---SNHRQVVEQNKKCEIDFQILDSNQKIPQAAKILVKQMLAKDPINRPT-----SQECLNSPFF
. | .| |. ||.|   .|. .. .. .|.....  .. .|.. |.|| |...|| .|| .|..      .| ...|.|
LMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLT-MPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF

Kinase 27560.AA ULK 1-265 27 1.7e-58 200.66 In-house 6-324 (324) Show / Hide
Range on Protein: 1-265
Range on HMM: 6-324/324
Sequence Identity: 27% (90 aa)

MIGKGGFS-RVFLA--QDKF-SRENYAIKVITKDKLLQQTKG------IKSLLNEIQIMKELD------NVNGCLKLIGVYETD--SSVNLILEYIKGGE
..||| |   |. .  ...  . . .|.|.| |.|. .. .       ...| |||||||.|.      . . . ||. ..||.    . .|.||  || 
CLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNH-H-IVKLYDWFETSNHNNIYIIMEYCNGGD

LVKKIKLK-------DKQNFTIENMRQLMQNILIALAHIHQRKIIHRDLKPDNILIEDDI---NSTK------IKIADFGLATY-DSTVLNDFLFK-KC-
| . || .        |.... .  .| .. |. .. ..|...|||||.||.|||| ...   .|.|      .||||||.|   |.  .......  . 
LEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQTCVN

-----GTPGFLAPEVLSNK-DTHKLYDHKVDVFSAGVIFYILLCGQQPFKGSNHRQVVEQ--------------NKKCEIDFQILDSNQKIPQAAKILVK
     ||| . ||..|...    . ||.|.|..| |.||| .| |. ||...  .. ...               |.  |.|.. ....|| .  | | .
EKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKDLIR

QMLAKDPINRPTSQECLNSPFF
.|| .|.  | . .| .| |.|
RMLQYDEKDRISWEEIFNHPWF

Kinase 27560.AA ULK 1-265 28 2.5e-58 200.08 In-house 6-329 (329) Show / Hide
Range on Protein: 1-265
Range on HMM: 6-329/329
Sequence Identity: 28% (95 aa)

MIGKGGFSRVFLAQDKFSR----ENYAIKVITKDKLLQQTKG------IKSLLNEIQIMKELD--------NVNGCLKLIGVYETD--SSVNLILEYIKG
..||| | .|. . .| .     | .|.|.| |.|. |. .       ...| |||.|||.|.        . | . ||. ..||.    . .|.||  |
CLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPN-IVKLYDWFETSNHNNIYIIMEYCNG

GELVKKIKLK--------DKQNFTIENMRQLMQNILIALAHIHQRKIIHRDLKPDNILIEDDI---NSTK------IKIADFGLATY-DST-----VLND
| | . || .         |.... .  .| .. || .. ..|...|||||.||.|||| ...   .|.|      .||||||.|   |.      ..  
GDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQMMMT

FL----FKKCGTPGFLAPEVLSNK-DTHKLYDHKVDVFSAGVIFYILLCGQQPFKGSNHRQVVEQNKKCE----------IDFQILD-----SNQKIPQA
..    .  |||| . ||..|...    . ||.|.|..| |.||| .| |. ||...  .. ..|... .          |. | |.     ....| . 
CVNEKRL--CGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISPE

AKILVKQMLAKDPINRPTSQECLNSPFF
 | | ..|| .|.  | . .| .| |.|
CKDLIRRMLQYDEKDRISWEELFNHPWF

Kinase 27560.AA TyrKc 1-265 22 8.3e-16 32.9 SMART 6-280 (280) Show / Hide
Range on Protein: 1-265
Range on HMM: 6-280/280
Sequence Identity: 22% (68 aa)

MIGKGGFSRVFLAQDKFSRENYAIKVITKDKLLQQTKGIKSLLNEIQIMKEL--DNVNGCLKLIGVYETD-------SSVNLILEYIKGGELVKKIKLKD
..| | | .|.... |   .. |.|.. .|.       .. ...|..||..|  .. |  ..|.||  ..         . ...|| ..| | . .. . 
KLGEGAFGEVYKGTWK---IQVAVKMLKEDA-------REDFMREARIMCKLGGHHPN-IVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

KQNFTIENMRQLMQNILIALAHIHQRKIIHRDLKPDNILIEDDINSTKIKIADFGLA--TYDS------TVLNDFLFKKCGTPGF----LAPEVLSNKDT
.. .. . . . .  |    ...|....|||||   |.|. ..     .||.||||.   ||       .   .   .|.|   .    .|||..     
PK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI----N

HKLYDHKVDVFSAGVIFY-ILLCGQQPFKG-----SNHRQVVEQNKKCEIDFQILD-----SNQKIPQAAKILVKQMLAKDPINRPTSQECLNSPFF
.. . .| ||.| ||  . |.  ||||  |      . ..|.|. |. .   |  .     .    |..   . ||  . || .||| .|.    .|
YGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSF-VCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF

Kinase 27560.AA Pkinase_Tyr 39-148 28 3e-13 45.5 Pfam 47-158 (270) Show / Hide
Range on Protein: 39-148
Range on HMM: 47-158/270
Sequence Identity: 28% (33 aa)

IKSLLNEIQIMKEL-DNVNGCLKLIGVYE-TDSS--VNLILEYIKGGELVKKIKLK--DKQNFTIENMRQLMQNILIALAHIHQRKIIHRDLKPDNILIE
......|..|||.| .. |  ..|.||    . .  . ...|| ..| | .  . .  |||..|.. . |  . |  .... .....|||||   |.|..
REDFMREAKIMKQLGHHPN-IVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVT

DDINSTKIKIADFGLA
.   . ..||.|||||
E---NNVVKICDFGLA