Gene 23052 (Tetrahymena)

23052

Species: Tetrahymena
Alias: 7.m00501, TTHERM_00105520, 34, PreTt23052, 23052
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: AGC
Family: AGC-Sar
Subfamily: Ciliate-E2b

Sequence

Name Sequence Type Origin Length Description Download
23052.AA Protein None 829 None Fasta, JSON
23052.kin_dom Protein Kinase Domain None 261 None Fasta, JSON
23052.NA RNA None 2490 None Fasta, JSON

Protein domain

Protein domains of 23052.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
CNMP_binding 23052.AA cNMP_binding 120-205 31 2.2e-21 76.06 Pfam 1-91 (91) Show / Hide 
Range on Protein: 120-205
Range on HMM: 1-91/91
Sequence Identity: 31% (29 aa)

YCELQEGETIIKEEDNASTFFILEQGRIQVSVKDNVKR-----DIVPGEGFGELALLYNA-PRSASCKALQKCHLWGIDRATFRRVVEEMIT
  ....||.|... | .. |.|...|...|.. |   |      . ||. |||.||..|  ||.|...||  |..| |.|..||.....   
VRHYKKGEVIFHQGDPCDHFYIVLSGKVKVYK-DEDGREQILGFLGPGDFFGEMALFTNQNPRTATVVALTDCECWRIPREDFRQLMQQHPE
CNMP 23052.AA cNMP 102-215 26 1.8e-20 75.24 SMART 1-123 (123) Show / Hide 
Range on Protein: 102-215
Range on HMM: 1-123/123
Sequence Identity: 26% (33 aa)

VFYNLQDSQLETLVNEMFYCELQEGETIIKEEDNASTFFILEQGRIQVSVK---------DNVKRDIVPGEGFGELALLYNAPRSASCKAL-QKCHLWGI
.| || ...|. |.. |.  ... ||.|... | ...|.|...|...| ..         . . . . ||. ||||||| ..||.|...|. . | .| |
MFKNLDEQELRELCDHMEPRHYPAGEYIFRQGDPGDHFYIIVSGWVRVYKTRVQHMEDGREQIVGFLGPGDFFGELALL-RRPRTAAARACCECCTIWRI

DRATFRRVVEEMITKEYEQNRKFI
|.  |.. ....  . |.  ....
DFQHFMQQLQQHPQHMYRMLQQLA
CNMP_binding 23052.AA cNMP_binding 260-346 29 4.1e-23 82.02 Pfam 1-91 (91) Show / Hide 
Range on Protein: 260-346
Range on HMM: 1-91/91
Sequence Identity: 29% (27 aa)

DQKFQKDQIIVSEDDPASSFYIIKEGSVSVMRGGAEVR-----TLQGGDSFGETALLQGVHKRAMTVKAQSDVKCLALGRDVLTRILGDQVE
 ....|...|....||...|||...|.|.| . . . |     .|. || ||| ||... ..|. ||.|..|..|... |... ... .  |
VRHYKKGEVIFHQGDPCDHFYIVLSGKVKVYK-DEDGREQILGFLGPGDFFGEMALFTNQNPRTATVVALTDCECWRIPREDFRQLMQQHPE
CNMP 23052.AA cNMP 242-356 20 5.9e-17 63.57 SMART 1-123 (123) Show / Hide 
Range on Protein: 242-356
Range on HMM: 1-123/123
Sequence Identity: 20% (26 aa)

SKKNLTVEQKNSVAGVLIDQKFQKDQIIVSEDDPASSFYIIKEGSVSVMRG---------GAEVRTLQGGDSFGETALLQGVHKRAMTVKAQ-SDVKCLA
  |||. ..  ... ..  ..... ..|. . ||...|||| .|.| |..          . .|..|. ||.||| |||     |. ...|  ...... 
MFKNLDEQELRELCDHMEPRHYPAGEYIFRQGDPGDHFYIIVSGWVRVYKTRVQHMEDGREQIVGFLGPGDFFGELALL--RRPRTAAARACCECCTIWR

LGRDVLTRILGDQVEVIIYKNISKW
. .. . ..|... .  ..  ..  
IDFQHFMQQLQQHPQHMYRMLQQLA
CNMP_binding 23052.AA cNMP_binding 381-410 40 0.402441 6.43 Pfam 1-29 (91) Show / Hide 
Range on Protein: 381-410
Range on HMM: 1-29/91
Sequence Identity: 40% (12 aa)

INHHKDGEVVIQQGTPIKNAIIILLEGQIK
. | | |||...|| |  . . |.|.|..|
VRHYKKGEVIFHQGDP-CDHFYIVLSGKVK
Kinase 23052.AA Ciliate-E2b 499-759 68 3.1e-209 641.63 In-house 1-272 (272) Show / Hide 
Range on Protein: 499-759
Range on HMM: 1-272/272
Sequence Identity: 68% (186 aa)

LIVIKKLGFGQFGSVFLVKE-KGKKKLYGLKCVSKAQVVEQSLEKHIQNEKQVMEFNNFPFVMKFLRSFKDDRCIYFLLEFIQGMELFDVIREIG--LLS
.|.||||||||||||.||.. | .|..|..||.||.|...|..|||...||.|.|..|.||.|||.||||||...||..||..||||||||||||  |||
MIYIKKLGFGQFGSVYLVWNTKNTKQYYAMKCISKNQIIQQNMEKHMLQEKNVLEKCNHPFIMKFIRSFKDDQHMYFMMEFCNGMELFDVIREIGRLLLS

TYDSQFYIGSLILTLEYLHSNYIIYRDIKPENIMVDHAGYLKLIDMGTAKIMKSKAGTVTRTFTIIGTPHYMAPEVIS-----GKGYNFLVDLWSVGICL
||||||||.|..|.|||||...|||||||||||||||.||.|||||||||.|..|....||||||||||||||||.|.     ||||.. ||.|||||||
TYDSQFYIASICLCLEYLHNQNIIYRDIKPENIMVDHKGYMKLIDMGTAKHMYKKNEQMTRTFTIIGTPHYMAPEIIQSLQPGGKGYTYKVDIWSVGICL

YEFMCGYVPFAEEAEDPYEIYEEIIKK--EIQFPAYMKDAVA-KQLMLQLLNKIPEIRLGGSYNALKSNAWF
|||||||||.||...||||||.|||||  |||||.|.||..| |.||||.|.|.||.||||||..|||..||
YEFMCGYVPWAEDVQDPYEIYQEIIKKYDEIQFPSYCKDKMADKKLMLQCLQKMPEVRLGGSYSWLKSHPWF
Kinase 23052.AA AGC 499-759 24 7.79999999999e-107 276.7 In-house 1-395 (395) Show / Hide 
Range on Protein: 499-759
Range on HMM: 1-395/395
Sequence Identity: 24% (99 aa)

LIVIKKLGFGQFGSVFLVKEK------GKKKLYGLKCVSKAQ-VVEQS--LEKHIQNE------------KQVMEFNN----------FPFVMK-FLRSF
  ..| .| | || |.||..|      . .|.| .|...|.  .|.     ..|...|            ....|  |           ||. |    ||
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

KDDRC--IYFLLEFIQ----------GMELFDVIR---EIGLLSTYDSQFYIGS-------LILTLEYLHS-NYIIYRD-IKPENIMVDHAGYLKLIDMG
.|..   .||..|...          |.|||  ..     | ..   ..||.         ..| |||||| . ||.|| .|||||. |. |..|| | |
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

TAKIMKSKAGT-----------------------------------------------VTRTFTIIG--TPHYMAPEVISGKGYNFLVDLWS--VGICLY
 .|..... .                                                  || |. |  ||.|||||..    |.. .| ||  .|...|
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

EFMCGYVPFAEEA--------EDPYEIYEEII------KKEIQFPAYM---------KDAVAKQLMLQLLNKIPEIRLG--GS------YNALKSNAWF
|...|| ||  .         ..|.|... |.      .....|| ..          .  || |. .||.| || |||  |.      .. .|.  ||
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase 23052.AA Ciliate-E2 499-759 27 1.9e-94 320.09 In-house 1-365 (365) Show / Hide 
Range on Protein: 499-759
Range on HMM: 1-365/365
Sequence Identity: 27% (105 aa)

LIVIKKLGFGQFGSVFLVKE-----------------------KGKKKLYGLKCVSKAQVVEQSLEKHIQ----------NEKQVMEFNNFPFVMKFLRS
 ..|||.|.|.||||...|                        | |.|.| .|...| |. ... |.||           |||...|..|.|...|.  .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FK--DDRCIYFLLEFIQGMELFD-------------------VIREIGLLSTYDSQ-------FYIGSLILTLEYLHSNY-IIYRDIKPENIMVDHAGYL
|.  || .||. .|..||..|||                   ...||. ....  |       |||...|| ||||||.  ||.||||||||..     .
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

KLIDMGTAK----------------IMKSKAGTVTRTFT-------------IIGTPHYMAPEVISGKG---------YNFLVDLWSVGICLYEFMCGYV
|.||.|..|                ...   .  .||..             |.|||.|||||...||.         |.. .|.||.|..|||...|. 
KIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKP

PFAEEAEDPYEIYEEIIKKEIQFP----------------AYMKDAVA-KQLMLQ----LLNKIPEIRLGGSYNALKSNAWF
||          ...|....|.||                 . |     |.|. .    .|.| || |.. ... .. . ||
PF----------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRIT-GWEQILNHPWF
Kinase 23052.AA PKA 499-759 37 8.3e-78 264.81 In-house 1-263 (263) Show / Hide 
Range on Protein: 499-759
Range on HMM: 1-263/263
Sequence Identity: 37% (101 aa)

LIVIKKLGFGQFGSVFLVKEKGKKKLYGLKCVSKAQVVEQSLEKHIQNEKQVMEFNNFPFVM-KFLRSFKDDRCIYFLLEFIQGMELFDVIREIGLLSTY
   |. || | || | |...|. .. | .|. .|...|    . |. |||...   ..||.  |   .|.||| .|...|...| |.|. .|  | .| .
FEIIQTLGTGSFGRVMLCRHKHSGNYYAMKMLKKQEIVRLKQVEHVHNEKNILQNIKHPFIVKKMYWTFQDDRYLYMVMEYVPGGEMFSYLRKSGRFSNP

DSQFYIG-SLILTLEYLHSNYIIYRDIKPENIMVDHAGYLKLIDMGTAKIMKSKAGTVTRTFTIIGTPHYMAPEVISGK-GYNFLVDLWSVGICLYEFMC
...||.    .|.||||||  ||||| |||||. |  |..|. | | || ...      ||.|. ||| |.|||.|..| |..  || |. ||  ||.. 
HAKFYAASQIVLALEYLHSQNIIYRDLKPENILIDKNGHIKITDFGFAKKVDD------RTWTLCGTPEYLAPEIIQSKNGHGKSVDWWALGILIYEMLA

GYVPFAEEAEDPYEIYEEIIKKEIQFPAYMKDAV--AKQLMLQLLNKIPEIRLGGSYN---ALKSNAWF
|| || ..  || .||| |.. .|.|| ..  ..   | |  .||.. .. |.|   |     |   ||
GYPPFYDHNRDPMQIYEKICNGKIKFPRHFDSDANYFKDLIKKLLQVDLTKRYGNMKNGVNDIKNHKWF
Kinase 23052.AA S_TKc 499-759 29 1.7e-71 244.78 SMART 1-231 (231) Show / Hide 
Range on Protein: 499-759
Range on HMM: 1-231/231
Sequence Identity: 29% (80 aa)

LIVIKKLGFGQFGSVFLVKEKGKKKLYGLKCVSKAQVVEQSLEKHIQNEKQVMEFNNFPFVMKFLRSFKDDRCIYFLLEFIQG--MELFDVIREIGL---
  ...|.| | ||.|.....|. .... .|...          .||..| |...  . |.. |.. .| |  ..|. .|.. |   .|||.|.. |    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---LSTYDSQFYIGSLILTLEYLHSNYIIYRDIKPENIMVDHAGYLKLIDMGTAKIMKSKAGTVTRTFTIIGTPHYMAPEVISGKGYNF-LVDLWSVGIC
   ..  . .||.  ... |||.||. ||.||.|||||..|.   .|..| | |...           |..|||.||||||.   ||..  .| ||.|..
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCI

LYEFMCGYVPFAEEAEDPYEIYEEIIKKEIQFPAYMKDAVAKQLMLQLLNKIPEIRLGGSYNAL-----KSNAWF
|||..||| ||     ....... |            .  ||... ..|.| || |..           |.  ||
LYEMLCGYPPFP----QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 23052.AA AktR 500-759 35 5.6e-70 238.79 In-house 2-268 (268) Show / Hide 
Range on Protein: 500-759
Range on HMM: 2-268/268
Sequence Identity: 35% (96 aa)

IVIKKLGFGQFGSVFLVKEK-GKKKLYGLKCVSKAQVVEQSLEKHIQNEKQVME-FNNFPFVMKFLRSFKDDRCIYFLLEFIQGMELFDVIREIGLLSTY
 |.| || | || |.||..|   .|.| .| ..|   .|. ...|...|...||  .|.||  |.  .|.......|..|...| |||.... .. .|  
HVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSEE

DSQFYIGSLILTLEYLHSN-YIIYRDIKPENIMVDHAGYLKLIDMGTAK--IMKSKAGTVTRTFTIIGTPHYMAPEVISG-KGYNFLVDLWSVGICLYEF
...||.   .| |||||..  |||||.|||||. |  |..|..| | .|  .|...  .   . .. |||.|||||.|   ||.|. ||.|..|| .|| 
QARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEK---AYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEM

MCGYVPFAEEAEDPYEIYEEIIKKE-IQFPAYMKD-AVAKQLML-QLLNKIPEIRLG-G--SYNALKSNAWF
. |. ||  ....  .... |..|. ..|| ...    .| |   .||.| |. ||| .  .   .||  ||
VTGCPPF--YHKNQNQMFQKIKIKQQNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase 23052.AA Ciliate-E2-Unclassified 500-759 25 3e-64 219.75 In-house 2-352 (352) Show / Hide 
Range on Protein: 500-759
Range on HMM: 2-352/352
Sequence Identity: 25% (89 aa)

IVIKKLGFGQFGSVFLVKEKGKKKLYGLKCVSKAQVVEQSLEKH----IQNEKQVMEFN------------------NFPFVMKFLRSFKDDRCIYFLLE
..||..| |.||.|.....| .|..| .|  .|.|.. | . ..    ....|.... .                  . ||..|..  |.|. .||. .|
KIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVME

FIQGMELFDVIREI-----------------GLLSTYDSQ-----FYIGSLILTLEYLHSNY-IIYRDIKPENIMVDHAG---YLKLIDMGTAKIMKS--
...| .|.. |..                    .. . ..     ||.  ... |||||..  ||.||||||||..|  |   |.|.|| | .|  ..  
YCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNN

--KAGT---------VTRTFTIIGTPHYM----APEVISGKGYN----FLVDLWSVGICLYEFMCGYVPF-AEEAEDPY-------------EIYEEIIK
  . ..           .. |..||| ||    ||||. |..|.    . .| ||.|..|||.. || || ..  |. .             ..|..|..
NCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQ

KEIQFPA-------YMKDAVAKQLMLQLLNKIPEIRLG--GSYNALKSNAWF
|.||||        .  .  || .  .|| |... ...   ... ..   ||
KNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 23052.AA SGK 500-759 31 1.1e-63 195.39 In-house 2-283 (283) Show / Hide 
Range on Protein: 500-759
Range on HMM: 2-283/283
Sequence Identity: 31% (91 aa)

IVIKKLGFGQFGSVFLVKEKGK------------------KKLYGLKCVSKAQVV-------EQSLEKHIQNEK-QVMEFNNFPFVMKFLRSFKDDRCIY
. .|..| | || |..|| |..                  .|.| .|  .|....          ..|||. |.  ..   . ||  .   .|  .   |
DFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHPFIVNLHYAFQTKWKLY

FLLEFIQGMELFDVIREIGLLSTYDSQFYIGSLILTLEYLHSNYIIYRDIKPENIMVDHAGYLKLIDMGTAK-IMKSKAGTVTRTFTIIGTPHYMAPEVI
| .....| |.|  ..  . ..   . ||   ... ||||||  ||||| |||||. || |...| | | .|  .|    | . |||. ||| |.||||.
FVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEGIK----TNDTTFTFCGTPEYLAPEVL

SGKGYNFLVDLWSVGICLYEFMCGYVPFAEEAEDPYEIYEEIIKKEIQFPAYMKDAVAKQLMLQLLNKIPEIRLGGS--YNALKSNAWF
 ....   || |. |. |||.| |  ||  .  .  . |. ||....|.| .|  . |. |. .||.| |. |||        |.  .|
RKQPHDRTVDWWCLGCVLYEMMYGLPPF--YSRNKQQMYDNIINQPLQIPPQMS-NDAWDLIQGLLQKDPKKRLGTKRDFMEIKNHPFF
Kinase 23052.AA RSK 502-759 29 1.8e-61 210.57 In-house 1-278 (278) Show / Hide 
Range on Protein: 502-759
Range on HMM: 1-278/278
Sequence Identity: 29% (83 aa)

IKKLGFGQFGSVFLVKEK---GKKKLYGLKCVSKAQVVEQSL-EKHIQNEKQVMEFNN-FPFVMKFLRSFKDDRCIYFLLEFIQGMELFDVIREIGL---
.| || | .|.|||....    ....|  | ..|| .|      .|   | ...|  .  ||. .   .|...  .|  .|.. | |||. ... .    
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

LSTYDSQFYIGSLILTLEYLHSNYIIYRDIKPENIMVDH---AGYLKLIDMGTAKIMKSKAGTVTRTFTIIGTPHYMAPEVIS----GKGYNFLVDLWSV
.|  . .||.  ..|..|.||.  ||.||.|||||. |.    | .||.| | .|..  ..    .| | ..| .|||||..     ..|..  .|.|| 
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQF--RCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSL

GICLYEFMCGYVPFAE-EAEDPYEIYEEIIKKE--IQFP--AYMKDAVAKQLMLQLLNKIPEIRLG---GSYNALKSNAWF
|. .||   |..||.  . ... || . | |..    .|  .|.  . || |  ..| . |. |||   .  . .|...||
GVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYL-SQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase 23052.AA PKG 499-716 38 2.7e-59 203.29 In-house 1-213 (260) Show / Hide 
Range on Protein: 499-716
Range on HMM: 1-213/260
Sequence Identity: 38% (85 aa)

LIVIKKLGFGQFGSVFLVKEKGKK-KLYGLKCVSKAQVVEQSLEKHIQNEKQVMEFNNFPFVMKFLRSFKDDRCIYFLLEFIQGMELFDVIREIGLLSTY
| .|  || | || | ||. .. | . . |||  |...|..  . || .||..|.  . .|. .  | |.|.. .|.|.|   | ||  ..|. |    .
LKIIATLGVGGFGRVELVQYNHQKSRTFALKCMKKRHIVDTRQQEHIMSEKNIMMECRCDFIVRLYRTFRDQKYVYMLMEACMGGELWTILRDRGHFDDK

DSQFYIGSLILTLEYLHSNYIIYRDIKPENIMVDHAGYLKLIDMGTAKIMKSKAGTVTRTFTIIGTPHYMAPEVISGKGYNFLVDLWSVGICLYEFMCGY
 ..||..  .  ..|||.  ||||| ||||.| |. ||.||.| | ||    | |.  .| |  ||| | |||.|  ||  . || |. ||  .| . | 
TTRFYCACVVEAFDYLHRKNIIYRDLKPENLMLDNRGYCKLVDFGFAK----KIGQGRKTWTFCGTPEYVAPEIILNKGHDRSVDYWALGILMCELLTGN

VPFAEEAEDPYEIYEEIIK
 ||  .. ||  .|  | |
PPF--SGSDPMKTYNIILK
Kinase 23052.AA CAMK 504-759 19 3e-56 179.39 In-house 1-425 (425) Show / Hide 
Range on Protein: 504-759
Range on HMM: 1-425/425
Sequence Identity: 19% (82 aa)

KLGFGQFGSVFLVKEKGKK------------KLYGLKCVSKAQVVE-------------------------QSLEKHIQNEKQVMEF-------NNFPFV
.|| |.|| |.|...|  .            . .  | ..| .. .                         .. .| ...| ..|          . | .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

MKFLRSFKD-------------------DRCIYFLL---EFIQGMEL----FDVIREIGL---------------LSTYDSQFYIGSLILTLEYLHSNYI
 |..  . |                   |...|. .   |...| ||    || |.| |                ..  . ..|.  ..  ..|.||. |
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

IYRDIKPENIMVDHAG----------------Y-LKLIDMGTAKIMKSKAGTVTR--------------------TFTIIGTPHYMA-PEVISG------
. ||.|||||..|. .                . .|.|| | |...... .  .                       |  |||.||| |||..|      
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

--------KGYNFLVDLWSVGICLYEFMCGYVPFAEEAE-----------DPYEIYEEIIKKEIQFPAYMKDAV-----------------------AKQ
        ..|.. .| ||.|. ||   ||| || .. .           ..||..| |.| . .|| .. . .                       .|.
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

LMLQLLNKIPEIRLGGSYNALKSNAWF
|  ..|.. || |.  .    ..  |.
LIRKMLQVDPEKRM--TIEQCLNHPWM
Kinase 23052.AA Pkinase 499-759 29 7.8e-55 193.29 Pfam 1-293 (293) Show / Hide 
Range on Protein: 499-759
Range on HMM: 1-293/293
Sequence Identity: 29% (87 aa)

LIVIKKLGFGQFGSVFLVKEKGKKKLYGLKCVSKAQVVEQSLEKHIQ-NEKQVMEFNNFPFVMKFLRSFKDDRCIYFLLEFIQGM----ELFDVIR--EI
. ...|.| | ||.|.. ..||  |.. .|...|    .. .. |.  .| |.|   | |.. .....| |.. ||. .|. .|     .|||.|.  . 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GLL--STYDSQFYIGSLILTLEYLHSNYIIYRDIKPENIMVDHAGYL----KLIDMGTAKIMKSKAGTVTRTFTIIGTPHYMAPEVIS-GKGYNFLVDLW
| .  |  . .||.  ..  |||.||. ||.||.|||||..|. |..    |..| | || ..      . . |. |||.|||||||  |..|   || |
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD--Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMW

SVGICLYEFMCGYVPFAEE----AEDPYEIYEEIIKKEIQFPAYMKD--------------------AVAKQLMLQLLNKIPEIRLGGSYNALKSNAWF
|.|. |||..||. || ..      |.......| .... |. . ..                      .|...  .|.| |. |..     ..   ||
SCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT--AEQILQHPWF
Kinase 23052.AA TyrKc 499-757 19 2.5e-10 -55.61 SMART 1-280 (280) Show / Hide 
Range on Protein: 499-757
Range on HMM: 1-280/280
Sequence Identity: 19% (57 aa)

LIVIKKLGFGQFGSVFLVKEKGKKKLYGLKCVSKAQVVEQSLEKHIQNEKQVMEFN--NFPFVMKFLRSFKDD-------RCIYFLLEFIQGMELFDVIR
.  .|||| |.|| |.. . |       ...  |    .   .. . .| ..|     . | . ...    ..         .. ..|.  .  | | .|
ITLGKKLGEGAFGEVYKGTWK-------IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

EIGL-LSTYDSQFYIGSLILTLEYLHSNYIIYRDIKPENIMVDHAGYLKLIDMGTAKIMKSK--------AGTV-----TRT-FTIIGTPHYMAPEVISG
. .  |.. |   .        |||||. .| ||.   |..|.. .  |  | | ..  ...          ..     ..| . |      ||||.|  
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPI----RWMAPECINY

KGYNFLVDLWSVGICLYE-FMCGYVPFAEEAE---DPYEIYEEIIKK-EIQFPAY--------MKDAVAKQLMLQLLNKIPEIRLGGSYNALKSNA
. ...  | || |.|..| |  |  |  ....   ...|..| . .      |..        . |.. . .|.|  .  || |   . .....  
GKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ-IMKQCWHEDPEDRP--TFSEIHECF
Kinase 23052.AA Pkinase_Tyr 667-702 31 0.002762 11.75 Pfam 181-218 (270) Show / Hide 
Range on Protein: 667-702
Range on HMM: 181-218/270
Sequence Identity: 31% (12 aa)

MAPEVISGKGYNFLVDLWSVGICLYEFMC-GYVP-FAE
||||.|. . ..   | || |....| .  |  | ...
MAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPG
Kinase 23052.AA Pkinase_Tyr 499-515 47 0.105632 6.39 Pfam 1-17 (270) Show / Hide 
Range on Protein: 499-515
Range on HMM: 1-17/270
Sequence Identity: 47% (8 aa)

LIVIKKLGFGQFGSVFL
.. .|||| |.||.|..
ITFGKKLGEGAFGEVYK