Gene 8041 (Tetrahymena)

8041

Species: Tetrahymena
Alias: 8041, PreTt08041, TTHERM_00500970, 3716.m00072, 63.m00219, 395
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: AGC
Family: AktR
Subfamily: Ciliate-E2b

Sequence

Name Sequence Type Origin Length Description Download
8041.AA Protein None 373 None Fasta, JSON
8041.kin_dom Protein Kinase Domain None 263 None Fasta, JSON
8041.NA RNA None 1122 None Fasta, JSON

Protein domain

Protein domains of 8041.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 8041.AA Ciliate-E2b 47-309 41 1.6e-175 537.59 In-house 1-272 (272) Show / Hide 
Range on Protein: 47-309
Range on HMM: 1-272/272
Sequence Identity: 41% (113 aa)

FEIVKSLGQGAYGNVYQVQK-KTSNKQFAMKAIKKSKLLQNGMDLQMLMEKNVLLKNKHPFLVTLKYSFQSDKKLYLVMDLCKGGELLSYISQLNRLGIS
....|.||.|..|.||.|.. |......|||.|.|....|..|...||.|||||.|..|||......||..|...|..|..|.|.||...|....||..|
MIYIKKLGFGQFGSVYLVWNTKNTKQYYAMKCISKNQIIQQNMEKHMLQEKNVLEKCNHPFIMKFIRSFKDDQHMYFMMEFCNGMELFDVIREIGRLLLS

QEVAKFIGAEVLLGLEYLQRKLKIMYRDLKPENILVCEDGHIKIADFGLAKHFYSENE---KCTTVCGTLEYLAPEIIQSLQPGFQGYGIEVDIWAFGIF
.....|..|...|.||||. ...|.|||.|||||.|...|..|..|.|.|||.|..||   ...|..||..|.|||||||||||..||...||||..||.
TYDSQFYIASICLCLEYLH-NQNIIYRDIKPENIMVDHKGYMKLIDMGTAKHMYKKNEQMTRTFTIIGTPHYMAPEIIQSLQPGGKGYTYKVDIWSVGIC

LFEIISGQPPFTHPKRNPEIIMKKVLQN--KVQFPSYFKEESK--DIILKCLQSNPQDRP--TWDQLKNHPFF
|.|...|..|.......|..|.......  ..|||||.|....  ...|.|||..|..|.  ....||.||.|
LYEFMCGYVPWAEDVQDPYEIYQEIIKKYDEIQFPSYCKDKMADKKLMLQCLQKMPEVRLGGSYSWLKSHPWF
Kinase 8041.AA AGC 47-309 27 4e-149 388.59 In-house 1-395 (395) Show / Hide 
Range on Protein: 47-309
Range on HMM: 1-395/395
Sequence Identity: 27% (113 aa)

FEIVKSLGQGAYGNVYQVQKK------TSNKQFAMKAIKKSK-LLQNG--MDLQMLME------------KNVLLKNK----------HPFLVT-LKYSF
||..| .|.|..| ||.|.||      ...|..||| .||..  ...   |  . . |            .|.| | .          |||.|  |.|||
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QSDKK--LYLVMDLCK---------GG-ELLSYISQL-NRLGISQEVAKFIGAE-------VLLGLEYLQRKLKIMYRD-LKPENILVCEDGHIKIADFG
|....  ||.||....         || ||....    ..   . |.|.|. ||       ..|.|||| ....| .|| |||||||  ||||||..|||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

LAKHFYSEN--------------------------------------------------EKCTTVCG--TLEYLAPEIIQSLQPGFQGYGIEVDIWA--F
|.| . ...                                                  ....| ||  | ||.||||.         || ..|.|.  .
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL---------YGKACDWWSFGL

GIFLFEIISGQPPFTH--------PKRNPEIIMKKVL------QNKVQFP----------SYFKEESKDIILKCLQSNPQDRPT----------WDQLKN
|....| ..|.|||..        | |||. ...|..      ..||.||          ..| .| ||.| |.|. .| .|..           ...||
GCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKN

HPFF
||.|
HPWF
Kinase 8041.AA AktR 47-309 44 1.6e-118 400.09 In-house 1-268 (268) Show / Hide 
Range on Protein: 47-309
Range on HMM: 1-268/268
Sequence Identity: 44% (122 aa)

FEIVKSLGQGAYGNVYQVQKK-TSNKQFAMKAIKKSKLLQNGMDLQMLMEKNVLL-KNKHPFLVTLKYSFQSDKKLYLVMDLCKGGELLSYISQLNRLGI
|.. | ||.||.|.|| |||| ...||.||| |||.|. .. .  ....|.|..  ...|||.| |.|.||...||...|. |.||||...... ..  .
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKK--F

SQEVAKFIGAEVLLGLEYLQRKLKIMYRDLKPENILVCEDGHIKIADFGLAK-HFYS-ENEKCTTVCGTLEYLAPEIIQSLQPGFQGYGIEVDIWAFGIF
| |.|.|. |..||.||||  ...|.||||||||||  ||||.||.||||.|  |   ..|| ...||| ||.|||.|.      .|..  ||.||||||
SEEQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKK----KGHNKSVDWWAFGIF

LFEIISGQPPFTHPKRNPEIIMKKVLQ-NKVQFPSYFKEESKDIIL-KCLQSNPQDRPT-----WDQLKNHPFF
..|...|.|||.| ..| .....|  | ||...|||| .. ||.|  |.|. ||. |..     |...|.||.|
IYEMVTGCPPFYHKNQNQMFQKIKIKQQNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase 8041.AA Akt 47-309 39 1.7e-103 331.75 In-house 1-264 (264) Show / Hide 
Range on Protein: 47-309
Range on HMM: 1-264/264
Sequence Identity: 39% (108 aa)

FEIVKSLGQGAYGNVYQVQKKTSNKQF-AMKAIKKSKLLQNGMDLQMLMEKNVLLKNKHPFLVTLKYSFQSDKKLYLVMDLCKGGELLSYISQLNRLGIS
|...| ||.|..| |..|.|| ..| . |||..||....|..   . . |.|.| . .|||.| |.||||. .|||.||| |.|||| ..... .|  .|
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRR--FS

QEVAKFIGAEVLLGLEYLQRKLKIMYRD-LKPENILVCEDGHIKIADFGLAKHF-YSENEKCTTVCGTLEYLAPEIIQSLQPGFQGYGIEVDIWA-FGIF
 . |.| .||. |..|.|     |.||| |||||||. .||||...||||.|    ....|..|.||| |||||||..    | .|..  ||.|. .|..
EDRARFYCAEIILAIEHLHS-KNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILN----G-NGHTKAVDWWGSLGCV

LFEIISGQPPFTHPKRNPEIIMKKVLQNKVQFP--SYFKEESKDIILKCLQSNPQDRP-----TWDQLKNHPFF
..| . |.||| .  .. .  .|| ....|.||  ...  | ||.| ..|. .|  |.     . ...|.||.|
MYEMMCGRPPFYN--QDHHQMFKKIKNQPVKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF
Kinase 8041.AA S_TKc 47-309 35 2.1e-100 340.79 SMART 1-231 (231) Show / Hide 
Range on Protein: 47-309
Range on HMM: 1-231/231
Sequence Identity: 35% (97 aa)

FEIVKSLGQGAYGNVYQVQKKTSNKQFAMKAIKKSKLLQNGMDLQMLMEKNVLLKNKHPFLVTLKYSFQSDKKLYLVMDLCKG--GELLSYISQLNRLG-
.||.. .|.||.| ||....| .....|.| ||           ... | ..| | .||..|.|...||. ..||.||..| |  |.|..|| . .| | 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---ISQEVAKFIGAEVLLGLEYLQRKLKIMYRDLKPENILVCEDGHIKIADFGLAKHFYSENEKCTTVCGTLEYLAPEIIQSLQPGFQGYGI-EVDIWAF
   ..  .|.|. ......|||. .. .|..|||||||||..|  ||||.|||||...       ||.|||..|.|||..        |||  ..|.|..
RFPFPE-HARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL--------GYGKCKCDWWSC

GIFLFEIISGQPPFTHPKRNPEIIMKKVLQNKVQFPSYFKEESKDIILKCLQSNPQDRPTWDQLKN-------HPFF
|. |.| ..|.|||     ... ..||..           .| ||.| |||| .|..|||  .. .       ||.|
GCILYEMLCGYPPFP----QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 8041.AA Ciliate-E2 47-309 27 8.2e-99 334.58 In-house 1-365 (365) Show / Hide 
Range on Protein: 47-309
Range on HMM: 1-365/365
Sequence Identity: 27% (105 aa)

FEIVKSLGQGAYG-----NVYQVQK------------------KTSNKQFAMKAIKKSKLLQNGMDLQML----------MEKNVLLKNKHPFLVTLKYS
....| .|||..|     .|..|||                  |. .|..||| .||... |  . ....          .|||.| ...||... ....
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FQ--SDKKLYLVMDLCKGGELLSYISQL-----------------NRLGISQEVAK-------FIGAEVLLGLEYLQRKLKIMYRDLKPENILVCEDGHI
||  .|...||||..|.||.|..|| .                   .. |......       |. |...|.||||  | .|..||.||||||.     |
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

KIADFGLAKHFYSENEKCT-------------------------------TVCGTLEYLAPEIIQSLQPG----FQGYGIEVDIWAFGIFLFEIISGQPP
||.||||.| .  .|...|                               |.|||..|.||||... . .    ..||. ..|||..|. |.| ..|.||
KIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP

FTHPKRNPEIIMKKVLQNKVQFP----------------SYFKEESK--DIILK----CLQSNPQDRPT-WDQLKNHPFF
|          ... .|.|..||                |..| . .  |.| |    .|| .|. |.| |.|..|||.|
F----------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 8041.AA RSK 50-309 37 1e-96 327.63 In-house 1-278 (278) Show / Hide 
Range on Protein: 50-309
Range on HMM: 1-278/278
Sequence Identity: 37% (106 aa)

VKSLGQGAYGNVYQVQKK---TSNKQFAMKAIKKSKLLQNGMDLQMLM-EKNVLLKNK-HPFLVTLKYSFQSDKKLYLVMDLCKGGELLSYISQLNRLG-
.| ||||.|| |....|.    .....||| .||.|. |.  |.   | | |.|.  . |||.|||.|.|| ..||||.|..|.||||.  ...  ..| 
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

ISQEVAKFIGAEVLLGLEYLQRKLKIMYRDLKPENILVCE---DGHIKIADFGLAKHFYSE-NEKCTTVCGTLEYLAPEIIQSLQPGFQGYGIEVDIWAF
.| . |.|. ||. | .|.|  ...| .|||||||||  .   .||||. |||..| |  . |..  | |.|.||.|||..   . .  |..  .|.| .
FSEDEACFYMAEIVLAVEHL-HQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRAN-QQGGHDKACDWWSL

GIFLFEIISGQPPFTHPKR-NPEIIMKKVLQNK--VQFP--SYFKEESKDIILKCLQSNPQDRPT-----WDQLKNHPFF
|. ..|  .|.|||..| . |.. |||.....|  . .|  .|  .| ||.| |.|. .|..|..      ...|.||.|
GVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase 8041.AA Pkinase 47-309 33 1.1e-89 309.01 Pfam 1-293 (293) Show / Hide 
Range on Protein: 47-309
Range on HMM: 1-293/293
Sequence Identity: 33% (101 aa)

FEIVKSLGQGAYGNVYQVQKKTSNKQFAMKAIKKSKLLQNGMDLQML-MEKNVLLKNKHPFLVTLKYSFQSDKKLYLVMDLCKGG----ELLSYIS--QL
..|.. .|.|..| ||. ..| ..|..|.| |||..   .      . .|  .... .||. |.|...|......|.||..| ||    .| .|||  . 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

NRLGISQEVAKFIGAEVLLGLEYLQRKLKIMYRDLKPENILVCEDGHI----KIADFGLAKHF-YSENEKCTTVCGTLEYLAPEIIQSLQPGFQGYGIEV
...  | ...||.  ..| ||||. .  .|..|||||||||. ..|||    ||.||||||.| |  |. .||.|||..|.|||.|.    | |.|| .|
GCFYFSEWECKFYMYQILRGLEYCHS-MGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIR----GGQYYGPKV

DIWAFGIFLFEIISGQPPFTHP----KRNPEIIMKKVLQNKVQFPSYFK---------------------EESKDIILKCLQSNPQDRPTWDQLKNHPFF
|.|..|. |.| ..|.||| .     ....  ....... .. |... .                     || ||.| .||. .|..|||..|...||.|
DMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 8041.AA SGK 47-309 35 2.1e-87 269.93 In-house 1-283 (283) Show / Hide 
Range on Protein: 47-309
Range on HMM: 1-283/283
Sequence Identity: 35% (103 aa)

FEIVKSLGQGAYGNVYQVQKKTS------------------NKQFAMKAIKKSKLL-------QNGMDLQMLMEKNVLLKN-KHPFLVTLKYSFQSDKKL
|.. | .|.| .| ||||..|                     | .||| ..|   .       ..      . |.||.||| ||||.| |.|.|| ..||
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHPFIVNLHYAFQTKWKL

YLVMDLCKGGELLSYISQLNRLGISQEVAKFIGAEVLLGLEYLQRKLKIMYRDLKPENILVCEDGHIKIADFGLAKHFYSENEKCTTVCGTLEYLAPEII
|.|||   |||. ...   ...  .  .|.|  ||. . ||||  ...| ||||||||||   .||... ||||.|    .|.. .| |||.||||||..
YFVMDYVNGGEMFYHLQREKHF--PEDRARFYAAEIVCALEYL-HSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEGIKTNDTTFTFCGTPEYLAPEVL

QSLQPGFQGYGIEVDIWAFGIFLFEIISGQPPFTHPKRNPEIIMKKVLQNKVQFPSYFKEESKDIILKCLQSNPQDRPTWD----QLKNHPFF
.      |... .|| |  |..|.| ..| ||| .  || ..   . .  . |.| ..  . .|.|   || .|..|        . ||||||
RK-----QPHDRTVDWWCLGCVLYEMMYGLPPFYS--RNKQQMYDNIINQPLQIPPQMSNDAWDLIQGLLQKDPKKRLGTKRDFMEIKNHPFF
Kinase 8041.AA Ciliate-E2-Unclassified 47-309 27 5.1e-83 282.12 In-house 1-352 (352) Show / Hide 
Range on Protein: 47-309
Range on HMM: 1-352/352
Sequence Identity: 27% (97 aa)

FEIVKSLGQGAYGNVYQVQKKTSNKQF-----AMKAIKKSKLLQNGMDLQMLMEKNVLLKNK-------------------HPFLVTLKYSFQSDKKLYL
..|.| .|||..| ||..|.|  . |.     ..|.......... .| ....|.. . ..|                   |||.| . | ||.....|.
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYI

VMDLCKGGELLSYISQ---------------LNRLGISQEVAK-----FIGAEVLLGLEYLQRKLKIMYRDLKPENILVCEDG---HIKIADFGLAKHFY
||..|.||.|. ||..               ..|  .. . ||     |. |..|.||||| .|..| .||.||||||. ..|   .|||.|||..|.  
VMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQ

SE---------------NEKCTTVCGTLEYL----APEIIQSLQPG---FQGYGIEVDIWAFGIFLFEIISGQPPFTHPKRNP--------------EII
.                .....|.|||..|.    |||..|. ...   .    ...|||..|. |.|.. |..||  ....               ...
QNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKA----YKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQL

MKKVLQNKVQFPS--------YFKEESKDIIL----KCLQSNPQDRPTWDQLKNHPFF
 .. .|...|||.           .| ||.|     |.|. ||  |.|..|..|||.|
YQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 8041.AA RSK 47-309 33 1e-78 267.85 In-house 1-271 (271) Show / Hide 
Range on Protein: 47-309
Range on HMM: 1-271/271
Sequence Identity: 33% (93 aa)

FEIVKSLGQGAYGNVYQVQKK---TSNKQFAMKAIKKSKLLQNGMDLQMLMEKNVLLKNKHPFLVTLKYSFQSDKKLYLVMDLCKGGELLSYISQLNRLG
.|. . .|||... || ..|.    .|...||| |||...       .  .| ..|    ||| |.|.|.||. .|.|..||...||.|.  ..    . 
YELHECIGQGSFSKVYVCKKCQHKDTNQHYAMKIIKKATRDVKDR-VCWEEERIILRYGHHPFIVKLHYVFQDEGKVYMIMDFMRGGDLFDRLLKQKMF-

ISQEVAKFIGAEVLLGLEYLQRKLKIMYRDLKPENILVCED----GHIKIADFGLAKHFYSENEKCTTVCGTLEYLAPEIIQSLQPGFQGYGIEVDIWAF
 | . .||. ||..| .|||  ...| .|||||||||. ..    |||||.|||.||   .||..  | |.| .|.|||..       ||..  .|.| |
-SEREVKFYMAEIALAMEYL-HSQGIVHRDLKPENILYDDESGNPGHIKICDFGFAKQLRDENGMLMTFCYTANYMAPEVLKR-----QGHDQACDWWSF

GIFLFEIISGQPPFTH-PKRNPEIIMKKVLQNK----VQFPSYFKEESKDIILKCLQSNPQDRPTW-----DQLKNHPFF
|. ..|  .| .|| . |.  |. | ...   .       ...  .| || . . |  .|. |..       | |.||.|
GVLMYEMLTGCTPFQNKPRDTPMNIIQRIKLGMFSMTHGNWDFISDEAKDLLRMMLHRDPHNRLGAGPNGVEQIKQHPWF
Kinase 8041.AA PKA 47-309 41 1.6e-74 253.93 In-house 1-263 (263) Show / Hide 
Range on Protein: 47-309
Range on HMM: 1-263/263
Sequence Identity: 41% (114 aa)

FEIVKSLGQGAYGNVYQVQKKTSNKQFAMKAIKKSKLLQNGMDLQMLMEKNVLLKNKHPFLVT-LKYSFQSDKKLYLVMDLCKGGELLSYISQLNRLGIS
|||...||.| .| |.....|.| . .||| .||..  .       . |||.|.  ||||.|. ....|| |..||.||... |||. ||.    |.  |
FEIIQTLGTGSFGRVMLCRHKHSGNYYAMKMLKKQEIVRLKQVEHVHNEKNILQNIKHPFIVKKMYWTFQDDRYLYMVMEYVPGGEMFSYLRKSGRF--S

QEVAKFIGA-EVLLGLEYLQRKLKIMYRDLKPENILVCEDGHIKIADFGLAKHFYSENEKCTTVCGTLEYLAPEIIQSLQPGFQ-GYGIEVDIWAFGIFL
  .|||. | .. | ||||  .. |.||||||||||  ..|||||.||| ||   .      |.||| ||||||||||       |.|  || ||.||  
NPHAKFYAASQIVLALEYL-HSQNIIYRDLKPENILIDKNGHIKITDFGFAKKVDD---RTWTLCGTPEYLAPEIIQS-----KNGHGKSVDWWALGILI

FEIISGQPPFTHPKRNPEIIMKKVLQNKVQFPSYFKEES---KDIILKCLQSNPQDRP-TWDQ----LKNHPFF
.|  .| |||.   |.|  | .| .. |..||..|       || | | || ..  |  . ..     |||..|
YEMLAGYPPFYDHNRDPMQIYEKICNGKIKFPRHFDSDANYFKDLIKKLLQVDLTKRYGNMKNGVNDIKNHKWF
Kinase 8041.AA TyrKc 47-309 24 2.5e-26 94.68 SMART 1-280 (280) Show / Hide 
Range on Protein: 47-309
Range on HMM: 1-280/280
Sequence Identity: 24% (72 aa)

FEIVKSLGQGAYGNVYQVQKKTSNKQFAMKAIKKSKLLQNGMDLQMLMEKNVLLKN--KHPFLVTLKYSFQSD-------KKLYLVMDLCKGGELLSYIS
 .  | || ||.| ||. . |    | | | .|...         .. | ... |   .|| .| |     ..       . |..|| ....| |..|. 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

QLNRLGISQEVAKFIGAEVLLGLEYLQRKLKIMYRDLKPENILVCEDGHIKIADFGLAKHFYSE-------NEKCTTV--CGT----LEYLAPEIIQSLQ
   .  .. .    .   .  | ||| .| ..  |||   |.|| |....||.||||..  |..         . ..   .|     .  .||| |    
KHRPK-LCMKDLLSFCWQIACGMEYLHSK-NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI----

PGFQG-YGIEVDIWAFGIFLFEIIS-GQPPFTHP---KRNPEIIMKKVLQN-KVQFPSY--------FKEESKDIILKCLQSNPQDRPTWDQLKNHPFF
  . | . .. |.|.||. ..|| . ||.|   .   . ... ....| |      | .          .|  .|...| . .| ||||  ..  | .|
--NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase 8041.AA Pkinase_Tyr 178-309 27 1.5e-12 43.11 Pfam 141-270 (270) Show / Hide 
Range on Protein: 178-309
Range on HMM: 141-270/270
Sequence Identity: 27% (38 aa)

NILVCEDGHIKIADFGLAKHFYSENEKCTTVCG----TLEYLAPEIIQSLQPGFQGYGIEVDIWAFGIFLFEIIS-GQPPFTHPKRNPEIIMKKVLQNKV
|.|| |....||.|||||.  |.. .  ... |        .||| |.        . .. |.|.||. ..||.. |. | | |   .| ..... ..  
NCLVTENNVVKICDFGLARDIYNDDYY-YRKRGGGKLPIKWMAPECINYGK-----FTTKSDVWSFGVLMWEIFTYGEQP-TYPGMSNEEVYEYIYEDGY

QFPSYF--KEESKDIILKCLQSNPQDRPTWDQLKNHPFF
. |      .|  |....| . .|.||||  ..  | ..
RMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEI--HEQL
Kinase 8041.AA Pkinase_Tyr 47-135 26 6e-05 17.39 Pfam 1-97 (270) Show / Hide 
Range on Protein: 47-135
Range on HMM: 1-97/270
Sequence Identity: 26% (26 aa)

FEIVKSLGQGAYGNVYQVQKK-TSNKQFAMKAIKKSKLLQNGMDLQ-----MLMEKNVLLKN-KHPFLVTLKYSFQ-SDKK--LYLVMDLCKGGELLSY
 .. | ||.||.|.||.   |    ..    |.|. |  .. |. |     .. | ... .  .|| .| |       ..   .|.|| ....| ||.|
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLK--EGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDY