Gene 21266 (Tetrahymena)

21266

Species: Tetrahymena
Alias: 29.m00227, 3696.m00048, 565, TTHERM_00307630, 21266, PreTt21266
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-E2
Subfamily: Ciliate-E2c

Sequence

Name Sequence Type Origin Length Description Download
21266.AA Protein None 767 None Fasta, JSON
21266.kin_dom Protein Kinase Domain None 262 None Fasta, JSON
21266.NA RNA None 2304 None Fasta, JSON

Protein domain

Protein domains of 21266.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 21266.AA Ciliate-E2c 78-347 49 4e-175 588.07 In-house 1-310 (310) Show / Hide 
Range on Protein: 78-347
Range on HMM: 1-310/310
Sequence Identity: 49% (152 aa)

IDSNSILGSGQYGNVYKG-------YEINN--YGRLFAIKETLLSRKNVNLDTFTKKKEAAIREINSLKELNHPNIIRFINAKKTDKHLYLIMEYCSGGS
||.|.|||||.||.|||.       .||||  ...|||||.|.|..|..........||..|||||..|..|||.||.|..||.||||.|||||||.||.
IDRNNILGSGSYGKVYKAYYCEDYQNEINNVQMNQLFAIKMTCLKNKDIHMINEKDIKESIIREINMMKHMNHPHIIKFYDAKQTDKHIYLIMEYCNGGT

LEKFIEEN-RPEERECLYLFSQIINAFKYLIKEKKRRHGDIKPANILLNNGLIKIADFGFSKQFVEENDQFYS----YTGSPLYTALQILEG-KAYTTKS
||..|... .|.|..|||.|||||.|||||.|||...|.||||.|||..||.||||||||||.....|.|...    ..|.|.|.|.||||| ..||.||
LEQYIYHKPKPNEKQCLYYFSQIISAFKYLHKEKNIFHRDIKPENILIHNGMIKIADFGFSKICQDDNIQNTQGFNTCCGTPMYMAPQILEGKNYYTEKS

EIWSLGVTLYFMLCYNPERR-----------EASFPWWGGTDVHLVKNIKQ--------------NPVLKFSQENEEKLSPQIKQLLHKMLQVEEEKRID
.|||||||||.||||.....           ....|||..|..||...|..              .....|....|...|...|||.||||||.||||||
DIWSLGVTLYYMLCYKLPWESIQEYDSHNICNHCYPWWQNTMKHLKQHIWEYFNPQASAAGVSPITQNIHFPENYEQNISQEVKQLIHKMLQVDEEKRID

WDELFTCPIF
|||.|  ...
WDEIFNHECI
Kinase 21266.AA Ciliate-E2 78-347 25 9.8e-87 294.46 In-house 1-365 (365) Show / Hide 
Range on Protein: 78-347
Range on HMM: 1-365/365
Sequence Identity: 25% (97 aa)

IDSNSILGSGQYGNVYKGYEINNYGRL-----------------FAIKETLLSRKNVNLDTFTKKKEAAIREIN----------SLKELNHPNIIRFINA
.. . ..|.|..| |||.  ...  .                  ..||.  . ... |   ..|...  .||||           |..|||||||... .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

KK--TDKHLYLIMEYCSGGSLEKFIEEN------------RPEERECLYLFSQIIN---------------AFKYLIKEKKRRHGDIKPANILLNNGLIK
 .  .|...||.||||.||.|...|..|            .. |.|..|.. ||..               |..|| ....  | |||| |||.    ||
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----IK

IADFGFSKQFVEEND-------------------------------QFYSYTGSPLYTALQILEGKA---------YTTKSEIWSLGVTLYFMLCYNPER
|.|||.||.. ..|.                               .|... |.| | | .||.||          |..|. ||||||.||.||. .|  
IIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF

REASFPWWGGTDVHLVKNIKQNPVLKFSQE--------------NEEKLSPQIKQLLHK----MLQVEEEKRID-WDELFTCPIF
                 .....  ..|...              . .|.|.. |.|. |    |||...||||. |....  |.|
----------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 21266.AA ULK 78-347 31 2.7e-75 256.46 In-house 1-329 (329) Show / Hide 
Range on Protein: 78-347
Range on HMM: 1-329/329
Sequence Identity: 31% (107 aa)

IDSNSILGSGQYGNVYKGYEINNY---GRLFAIKETL---LSRKNVNLD-TFTKKKEAAIREINSLKELN--------HPNIIRFINAKKTD--KHLYLI
.  | .||.|..| ||||. ...    . ..|.|  .   ...|| . .  . ..    ..||  .|.|.        ||||....  ..|.  ...|.|
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQ--LLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYII

MEYCSGGSLEKFIEENRP-----------EERECLYLFSQIINAFKYLIKEKKRRHGDIKPANILLNNGL-------------IKIADFGFSKQ-FVE--
|||| || ||..|..|..           .| |..  | ||.|.||.| | ..  | ||||.|||..||              .|||||||.|.   .  
MEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHK-HNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNM

ENDQFYSYT------GSPLYTALQILE----GKAYT-TKSEIWSLGVTLYFMLC-YNPERREASFPWWGGTDVH---LVKNIKQ---------NPVLKFS
|........      |.||| | |||.    .| |.  |. |||||. .| ||  . |      | .|  .|     . |.|..         .  |.| 
EQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPP------FYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFP

QE-NEEKLSPQIKQLLHKMLQVEEEKRIDWDELFTCPIF
.  |. ..||..|.|. .|||..|..||.|.|||  |.|
KDGNDPQISPECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase 21266.AA ULK 78-347 31 3.5e-75 256.09 In-house 1-324 (324) Show / Hide 
Range on Protein: 78-347
Range on HMM: 1-324/324
Sequence Identity: 31% (107 aa)

IDSNSILGSGQYG-NVYKGYEINNY--GRLFAIKETLLSRKNVNLDTFTKKKE---------AAIREINSLKELN---HPN--IIRFINAKKTD--KHLY
.  | .||.|..|  ||||. ...   . ..|.|        .... . |||            ..||. .|.|.   |||  |....  ..|.  ...|
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKM-------IDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIY

LIMEYCSGGSLEKFIEENRP----------EERECLYLFSQIINAFKYLIKEKKRRHGDIKPANILLNNGL-------------IKIADFGFSKQ-FV--
.||||| || ||..|..|..          .| |..  | ||.|.||.| | ..  | ||||.|||..||              .|||||||.|. .   
IIMEYCNGGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHK-HNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNN

EENDQFYSYT------GSPLYTALQILE----GKAYT-TKSEIWSLGVTLYFMLC-YNPERREASFPWWGGTD-V----HLVKN------IKQNPVLKFS
.| ......       |.||| | |||.    .| |.  |. |||||. .| ||  . |      | .|  .| .     |..|      . .|  ..| 
MEQQMCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYP------FFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFP

QE-NEEKLSPQIKQLLHKMLQVEEEKRIDWDELFTCPIF
   .. |.||..|.|. .|||..|..||.|.|.|  |.|
KPPKDPKISPECKDLIRRMLQYDEKDRISWEEIFNHPWF
Kinase 21266.AA S_TKc 78-347 28 3.4e-62 213.85 SMART 1-231 (231) Show / Hide 
Range on Protein: 78-347
Range on HMM: 1-231/231
Sequence Identity: 28% (83 aa)

IDSNSILGSGQYGNVYKGYEINNYGRLFAIKETLLSRKNVNLDTFTKKKEAAIREINSLKELNHPNIIRFINAKKTDKHLYLIMEYCSG--GSLEKFIEE
 .   ..|.| .| |||.....  ||..|||.                 | ..|||. ||. .||||.... .  . .|||..||||.|  |.| ..|..
YEILRKIGKGAFGKVYKCRHKK-TGRIVAIKIIK---------------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKK

NRP-------EERECLYLFSQIINAFKYLIKEKKRRHGDIKPANILLNNGLIKIADFGFSKQFVEENDQFYSYTGSPLYTALQILEGKAYTT-KSEIWSL
...        | .. ... ||..| .|. .  .  | |.||.||||..  |||.|||...|.       ... |.| | |  .|    |.. |. .||.
RGRHGLRFPFPE-HARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE-HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSC

GVTLYFMLC-YNPERREASFPWWGGTDVHLVKNIKQNPVLKFSQENEEKLSPQIKQLLHKMLQVEEEKRIDWDELFT-------CPIF
|..|| ||| | | .          ..  . |.|.               ||. |... |.||.. |||.   |...        | |
GCILYEMLCGYPPFP----------QMQMMFKKIG---------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 21266.AA Ciliate-E2-Unclassified 78-347 23 3.3e-55 189.75 In-house 1-352 (352) Show / Hide 
Range on Protein: 78-347
Range on HMM: 1-352/352
Sequence Identity: 23% (85 aa)

IDSNSILGSGQYGNVYKGYEINNYGRLFAIKETLLSRKNV-----NLDTFTKKKEAAIREIN-------------SLKELNHPNIIRFINAKKTDKHLYL
   . ..|.|..| ||| ......  ..|.|.   ....      | |   . .. .. ...             .|. ..||.|.... ........|.
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYI

IMEYCSGGSLEKFIEE------------------NRPEERECL-----YLFSQIINAFKYLIKEKKRRHGDIKPANILLNNG----LIKIADFGFSKQFV
.|||| ||.|...|..                  .. .|....     ..| ||.....||.....  | |||| |||..|.     |||.|||.||.  
VMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQ

EENDQ---------------FYSYTGSPLYT----ALQILEGKAYT----TKSEIWSLGVTLYFMLC-----YNPERRE-----------ASFPWWGGTD
. |..               ... .|.| |     |  .|.|. |      |. |||||| ||.||      | . . .           |       ..
QNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNA-------YR

VHLVKNIKQNPVLKFSQEN---EEKLSPQIK----QLLHKMLQVEEEKRIDWDELFTCPIF
  | .||||... ......     ..||. |    .||.|||..  .|||......  |.|
KQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 21266.AA STE 78-347 21 1.5e-54 187.51 In-house 1-359 (359) Show / Hide 
Range on Protein: 78-347
Range on HMM: 1-359/359
Sequence Identity: 21% (79 aa)

IDSNSILGSGQYGNVYKGYEINNY--------------GRLFAIKETLLSRKNV---------NLDTFTKKKEAAIREINSLKELN--HPNIIRFINAKK
 .  ...|.| .| |||.. ..|               |...|||.  |...|          . ........  ..||. .|..|  ||||.... .  
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

TD-------KHLYLIMEYCSGGSLEKFIEE--NRPE-------------ERECLYLFSQIINAFKYLIKEKKRRHGDIKPANILLNNGLIKIADFGFSKQ
 .        .|...|||..||||...|..   ...             | .  |   ||. .. |.. .... | |||||||||    .|..|||...|
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL----VKLCDFGVCGQ

FVEEND----------------QFYSYTGSPLYTALQILEG------KAYTTKSEIWSLGVTLYFMLCYNPERREASFPWWGGTDVHLVKNI--------
......                . .. .|.| . |  ....      | |.||. ||||| |.  |.. .|.  . . .       .  .|.        
LTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPM---RAMFMIPFNYHMQQQFEQ

-----KQNPVLKFSQENE-------------EKLSPQIKQLLHKMLQVEEEKRIDWDELFT--CPIF
     .. | |.   ...             .|.||  |. . | || . .|| . ..|     | .
LCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 21266.AA Pkinase 78-347 25 3.4e-54 191.15 Pfam 1-293 (293) Show / Hide 
Range on Protein: 78-347
Range on HMM: 1-293/293
Sequence Identity: 25% (81 aa)

IDSNSILGSGQYGNVYKGYEINNYGRLFAIKETLLSRKNVNLD-----TFTKKKEAAIREINSLKELNHPNIIRFINAKKTDKHLYLIMEYCSGG----S
.   ...||| .| |||......   ..|.|.  ..... . |     .         .||  .|.||||||.|.. .  ...|.|..|||| ||    .
YHIGRKIGSGSFGCVYKCHHKGTGK-IVAVKIIKKRHEKSWKDQTHRRL---------SEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMD

LEKFIE---ENRP--EERECLYLFSQIINAFKYLIKEKKRRHGDIKPANILLN-NGLI----KIADFGFSKQF-VEENDQFYSYTGSPLYTALQILE-GK
|  .|.   ...   .|.||   . ||. . .|. . ..  | |.||.|||.. || |    ||.|||..|||    |  .....|.| | |  ..  |.
LFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHS-MGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQ

AYTTKSEIWSLGVTLYFMLCYNPERREASFPWWGG------TDVHLVKNIKQNPVLKFSQENEEKL----------------SPQIKQLLHKMLQVEEEK
 |..|. .||.|..|| |||         .|..|       .. .....|.. |.   ...  ..                 |.  |... ..|..  .|
YYGPKVDMWSCGCILYEMLC-------GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKK

RIDWDELFTCPIF
|. .....  | |
RPTAEQILQHPWF
Kinase 21266.AA Ciliate-E2b 78-276 30 6.9e-54 162.19 In-house 1-205 (272) Show / Hide 
Range on Protein: 78-276
Range on HMM: 1-205/272
Sequence Identity: 30% (64 aa)

IDSNSILGSGQYGNVYKGYEINNYGRLFAIKETLLSRKNVNLDTFTKKKEAAIREINSLKELNHPNIIRFINAKKTDKHLYLIMEYCSGGSLEKFIEENR
..    ||.||.|.|| . . .|  ...|.|    |   .     .|     ..|.| |. .|||.|..|| ..|.|.|.|..||.|.|..|.  | |  
MIYIKKLGFGQFGSVYLVWNTKNTKQYYAMK--CISKNQIIQQNMEKH---MLQEKNVLEKCNHPFIMKFIRSFKDDQHMYFMMEFCNGMELFDVIREIG

---PEERECLYLFSQIINAFKYLIKEKKRRHGDIKPANILLNN-GLIKIADFGFSKQFVEEND---QFYSYTGSPLYTALQILE-----GKAYTTKSEIW
     . . .  . .|. ...||  ...  ..|||| ||.. . | .|..|.| .| . ..|.     ..  | | | | .|..     || ||.|. ||
RLLLSTYDSQFYIASICLCLEYLH-NQNIIYRDIKPENIMVDHKGYMKLIDMGTAKHMYKKNEQMTRTFTIIGTPHYMAPEIIQSLQPGGKGYTYKVDIW

SLGVTLYFMLC
|.|..||...|
SVGICLYEFMC
Kinase 21266.AA CAMK 83-336 22 6.3e-52 165.23 In-house 1-414 (425) Show / Hide 
Range on Protein: 83-336
Range on HMM: 1-414/425
Sequence Identity: 22% (95 aa)

ILGSGQYGNVYKGYEINNYG-----------RLFAIKE--------------------TLLSRKNVNLDTFTKKKEAAIREINSLKE-------LNHPNI
.||.|..| |......|. |           . .|||                          |. . ..  |...   |||. .|        |.||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

IRFIN---------------AKKT-----DKHLYLIM---EYCSGG----SLEKFIEENRP----------------EERECLYLFSQIINAFKYLIKEK
|...                  ..     |||.|..|   ||||||     |  .| |...                .|||. ..| ||. | .|.    
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYC---H

KRR--HGDIKPANILL-NN-----------------GLIKIADFGFSKQFVE-----------------------ENDQFYSYTGSPLYTA-LQILEG--
..   | |.|| |||| .|                 . |||.||||...| .                       |.. .. . |.| | |   .|.|  
SHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKG

------------KAYTTKSEIWSLGVTLYFMLCYNPERREASFPWWGG-------------TDVHLVKNIKQNPVLKFSQENEE----------------
            . |. |. .||.|| ||.|||         .|..|              .|  | ..|..      . .  .                
HCNMQNATDEEKPYYGPKCDMWSCGVILYIMLC-------GYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDE

---KLSPQIKQLLHKMLQVEEEKRI
   ..|.. |.|. |||||. |||.
FHHFVSQECKDLIRKMLQVDPEKRM
Kinase 21266.AA CAMKL 76-336 32 6.7e-50 157.35 In-house 1-286 (297) Show / Hide 
Range on Protein: 76-336
Range on HMM: 1-286/297
Sequence Identity: 32% (99 aa)

YLIDSNSILGSGQYGNVYKGYEINNYGRLFAIKETLLSRKNVNLDTFTKKK------EAAI---REINSLKELN---HPNIIRFINAKKTDKH------L
| |     || | .| |  .  | . |.  |||   . .|  ..|...||.      |.     |||. .| ||   |||||..     |..|      .
YRIGK--TLGKGSFGKVKLATHIRTTGEKVAIK--IIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKI

YLIMEYCSGGS--LEKFIEEN-----RPEERECLYLFSQIINAFKYLIKEKKRRHGDIKPANILLN-NG--LIKIADFGFSKQFVE----ENDQFYSYTG
||.|||||||.  |  .|...     | .|.|.  .| ||. | .|. . .   | |||| ||||  ||   |||.||||| .. .    ... .    |
YLVMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHG-IVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCG

SPLYTALQILEG--KAYT-TKSEIWSLGVTLYFMLCYNPERREASFPWWGGTDV-----HLVKNIKQNPVLKFSQENEEKLSPQIKQLLHKMLQVEEEKR
|| | |  |..|  | |   |  |||.||.||.|.|         .|. . |.      .  .  ... .. .      ..| . ..|..|||||  |||
SPPYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVC-------GYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKR

I
.
P
Kinase 21266.AA NEK 84-279 33 7.9e-37 127.38 In-house 7-224 (286) Show / Hide 
Range on Protein: 84-279
Range on HMM: 7-224/286
Sequence Identity: 33% (73 aa)

LGSGQYGNVYKGYEINNYGRLFAIKETLLSRKNVNLDT-FTKKKEAAI-REINSLKELNHPNIIRFINAKKTDK--HLYLIMEYCS-GGSLEKF---IEE
.|.|..| ||| ..  . |. ..  | |.  |..|..    |.|..|.  |.. ||.|.||||......   ..  .|. .||||  || |...   |..
IGQGSFGKVYK-VRRKSDGKHLV--EKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKSIKK

N-----RPEERECLYLFSQIINAFKYLIKEK----KRRHGDIKPANILLN-NGL----IKIADFGFSKQFVEENDQFYS-YTGSPLYTALQILEGKAYTT
.       ||.. .  | |.. | ||. ..|    |  | ||||.|| |. |.     .|| ||| ||..  ..|  |. ..| | | .  ....| |. 
QKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDMAYTTQVGTPYYMSPEVCQNKPYNN

KSEIWSLGVTLYFMLCY--NP
|| |||||. || | .   ..
KSDIWSLGCVLYEMCTLKPKH
Kinase 21266.AA Pkinase_Tyr 78-184 26 7.8e-14 47.47 Pfam 1-108 (270) Show / Hide 
Range on Protein: 78-184
Range on HMM: 1-108/270
Sequence Identity: 26% (31 aa)

IDSNSILGSGQYGNVYKGYEI---NNYGRLFAIKETLLSRKNVNLDTFTKK---KEAAIREINSLKEL-NHPNIIRFINAKK-TDKH--LYLIMEYCSGG
|  .  ||.|..|.||||.      | .   |.|           .. ...   .|. .||.. .|.| .||||.|.. .    ...  .|..|||. .|
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLK--------EGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHG

SLEKFIEENRPEERECL
.| ..  ..| |... |
DLLDYLRKHR-EDKQPL
Kinase 21266.AA TyrKc 78-347 20 1e-13 -0.76 SMART 1-280 (280) Show / Hide 
Range on Protein: 78-347
Range on HMM: 1-280/280
Sequence Identity: 20% (64 aa)

IDSNSILGSGQYGNVYKGYEINNYGRLFAIKETLLSRKNVNLDTFTKKKEAAIREINSLKEL--NHPNIIRFINAKKTD-------KHLYLIMEYCSGGS
|  . .||.|..| ||||  .    .  |.|    .            .|. .||.. ...|  .||||.|.. .  ..       . |...|||...|.
ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDA-----------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGD

LEKFIEENR--PEERECLYLFSQIINAFKYLIKEKKRRHGDIKPANILLNNGL-IKIADFGFSKQFVEE------NDQFYSYT--GSP--L---YTALQI
| ... ..|     .. |.   || .   || .  .  | |.   |.|..... .||.||| |.   ..       |   . .  |.   |    .|.  
LKDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSK-NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPEC

LEGKAYTTKSEIWSLGVTLYFMLCYNPERREASFPWWG-----GTDVHLVKNIKQNPVLKFSQENEEKL-----SPQIKQLLHKMLQVEEEKRIDWDELF
.  . .|||| .|| ||... .. |         |..|      .. ......||   ..  ..... .     .. . |.  .  . . |.|    |. 
INYGKFTTKSDVWSFGVCMWEIFTY------GQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYP-MSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI-

TCPIF
 . .|
-HECF
Kinase 21266.AA NEK 317-347 25 0.000153 12.36 In-house 256-286 (286) Show / Hide 
Range on Protein: 317-347
Range on HMM: 256-286/286
Sequence Identity: 25% (8 aa)

SPQIKQLLHKMLQVEEEKRIDWDELFTCPIF
|.. ..|...|||.. |.| . ....  |. 
SQDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase 21266.AA Ciliate-E2b 320-347 28 0.001596 6.76 In-house 247-272 (272) Show / Hide 
Range on Protein: 320-347
Range on HMM: 247-272/272
Sequence Identity: 28% (8 aa)

IKQLLHKMLQVEEEKRIDWDELFTCPIF
. |.| || .| ......| ...  | |
MLQCLQKMPEVRLGGSYSWLKSH--PWF
Kinase 21266.AA Pkinase_Tyr 212-226 50 0.170012 5.69 Pfam 141-156 (270) Show / Hide 
Range on Protein: 212-226
Range on HMM: 141-156/270
Sequence Identity: 50% (8 aa)

NILLN-NGLIKIADFG
|.|.. |. .||.|||
NCLVTENNVVKICDFG
Kinase 21266.AA Pkinase_Tyr 252-272 52 4.067315 1.02 Pfam 186-205 (270) Show / Hide 
Range on Protein: 252-272
Range on HMM: 186-205/270
Sequence Identity: 52% (11 aa)

ILEGKAYTTKSEIWSLGVTLY
| .|| .|||| .|| ||...
INYGK-FTTKSDVWSFGVLMW