Gene 15767 (Tetrahymena)
15767
Sequence
Protein domains of 15767.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 15767.AA | Ciliate-E2-Unclassified | 32-297 | 17 | 3.9e-29 | 98.21 | In-house | 1-352 (352) | Show / Hide |
Range on Protein: 32-297
Range on HMM: 1-352/352
Sequence Identity: 17% (62 aa)
INIYKHKGKGTLFQNFLVERDGRK------YILKVFNKN-----DNDDTESKVEWILDKFQKNDGVY--------------NNHLQKIIDVFHNLQQKYF
.| | |.| . ...... | |. |. ... .| .. . .. . .| . . . .. | ...| . | |.
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKK-YHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYI
VVEYFEEGNILEYML-------------NNNLS--RLDLKLAV-----KVLGDVFRGISRLHEK-RQYHMNLRLENIYFRNNMQ--SLAVCDYRI-----
| ||.| |. ..|. .|... ... . |. . . . |.. ||.| | .. .||| | ||.. . ..|. |
VMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQ
-------------------LYIDKIINYYFANEYLPPEMIGKGTIDLK----SEIWTLGVIFFVLVFGQFPFVDLQEIEEYTLKN-------NFNLKKLL
.. ... .... ..|..||.... | . . ||.||||.. ..||..|| | .......|.. ...|..
QNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNI
KDKQILDLDSDP----KQIQEHYEKLNN-FFSKIFEFMQAKRMSYIQLSQDPIF
|.|.| ... |....... . | ...|... . ||... |. . |.|
KQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
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| Kinase | 15767.AA | Ciliate-E2 | 88-297 | 15 | 4.7e-25 | 82.94 | In-house | 91-365 (365) | Show / Hide |
Range on Protein: 88-297 Range on HMM: 91-365/365 Sequence Identity: 15% (46 aa) NNHLQKIIDVFH--NLQQKYFVVEYFEEGNILEYMLNNNLSR---------LDLKLAVKVLGDVFR---------------GISRLHEKR-QYHMNLRLE .... |....| . . |.| ||.. |. ..|. ||...| ...| . .. ... .. ||.| | .. .| HPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPE NIYFRNNMQSLAVCDYRI-------------LYIDKIINYYF------------------------ANEYLPPEMIGKGT---------IDLKSEIWTLG || | . ..| . . . |.. . . .|..||..... | |. || || NILF------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLG VIFFVLVFGQFPFVDLQEIEEYTLKNNFNLKKLLKDKQILDLDSDPKQIQEHYEKLNNFFSK----IFEFMQAKRMS-YIQLSQDPIF ||.. ..||..|| .|.|.. .. ... . . .. . . . | ... .. ....| ... . ||.. . |. . |.| VILYEMLFGKPPF--QQQIKQCKIDFPCPEWQKD-TQ-CI-Q-CKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF |
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| Kinase | 15767.AA | S_TKc | 32-297 | 16 | 2.2e-13 | 19.4 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 32-297 Range on HMM: 1-231/231 Sequence Identity: 16% (48 aa) INIYKHKGKGTLFQNFLVER--DGRKYILKVFNKNDNDDTESKVEWILDKFQKNDGVYNNHLQKIIDVFHNLQQKYFVVEYFEE--GNILEYMLNNNL-- | .. |||. . ... .||.. .|. . . | . | .. |..|||.. . |.| || . |. ..|. ... YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK------HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHG --SRLDLKLAVKVLGDVFRGISRLHEKRQYHMNLRLENIYFRNNMQSLAVCDY---RILYIDKIINYYFANEYLPPEMIGKGTIDL-KSEIWTLGVIFFV .... | ... ..... .|... | | ||| . . . .|| |.| . .|..||.. . |. .| .|.|.. LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL-----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYE LVFGQFPFVDLQEIEEYTLKNNFNLKKLLKDKQILDLDSDPKQIQEHYEKLNNFFSKIFEFMQAKRMSYIQLSQ-------DPIF .. |. || . . . |... . . .| .|.... .||.. .. | .| | MLCGYPPFP-----------QMQMMFKKIG-----------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | 15767.AA | CAMK | 192-229 | 22 | 3.4e-08 | 21.77 | In-house | 284-336 (425) | Show / Hide |
Range on Protein: 192-229 Range on HMM: 284-336/425 Sequence Identity: 22% (12 aa) EYLP-PEMIGKGT--------------IDLKSEIWTLGVIFFVLVFGQFPFVD || . ||.. . . .. |. .| .||| .... | .|| . EYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYG |
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| Kinase | 15767.AA | ULK | 210-297 | 18 | 2.3e-07 | 22.29 | In-house | 235-324 (324) | Show / Hide |
Range on Protein: 210-297 Range on HMM: 235-324/324 Sequence Identity: 18% (17 aa) IWTLGVIFFVLVFGQFPFVD-LQEIEEYTLKNNFNLK---KLLKDKQILDLDSDPKQIQEHYEKLNNFFSKIFEFMQAKRMSYIQLSQDPIF || ||.||. ...|. ||. .. ..| .. | . ... .| .. .. | ... ... ..... ... . .|.| .. . |.| IWSLGCIFYEMLYGKYPFFSWFNDQYLY-IQKLINNGKEQQIYIKNQPIQFPKPP-KDPKISPECKDLIRRMLQYDEKDRISWEEIFNHPWF |
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| Kinase | 15767.AA | ULK | 210-297 | 20 | 7.5e-07 | 20.04 | In-house | 239-329 (329) | Show / Hide |
Range on Protein: 210-297 Range on HMM: 239-329/329 Sequence Identity: 20% (19 aa) IWTLGVIFFVLVFGQFPFVD-LQEIEEYTLKNNFNLKKLLKD---KQILDLDSDPKQIQEHYEKLNNFFSKIFEFMQAKRMSYIQLSQDPIF || ||.||. ...|. ||. .. .. .....|... ... || |. . | .. ... ..... ... . .|.| .| . |.| IWSLGCIFYEMLYGKPPFYAWFNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDG-NDPQISPECKDLIRRMLQYDEKDRISWEELFNHPWF |
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| Kinase | 15767.AA | AGC | 192-229 | 25 | 9.7e-07 | 11.89 | In-house | 272-307 (395) | Show / Hide |
Range on Protein: 192-229 Range on HMM: 272-307/395 Sequence Identity: 25% (10 aa) EYLPPEMIGKGTIDLKSEIWT--LGVIFFVLVFGQFPFVD ||..||.. . .|. ||.... ...|. || . EYMAPEIL----YGKACDWWSFGLGCLMYEMLTGYPPFYG |
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| Kinase | 15767.AA | SgK495 | 208-229 | 54 | 2e-06 | 16.32 | In-house | 98-119 (171) | Show / Hide |
Range on Protein: 208-229 Range on HMM: 98-119/171 Sequence Identity: 54% (12 aa) SEIWTLGVIFFVLVFGQFPFVD |..| |||. | ...||||| | SDMWALGVVLFTMLYGQFPFYD |
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| Kinase | 15767.AA | MARK | 210-235 | 36 | 3e-06 | 16.86 | In-house | 189-218 (262) | Show / Hide |
Range on Protein: 210-235 Range on HMM: 189-218/262 Sequence Identity: 36% (11 aa) IWTLGVIFFVLVFGQFPFV--D--LQEIEE ||.|||. ...| |.||| . . |... IWSLGVVLYFMVCGYFPFDGDTQDYKELYK |
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| Kinase | 15767.AA | Ciliate-E2a | 210-238 | 31 | 4e-06 | 14.12 | In-house | 199-233 (275) | Show / Hide |
Range on Protein: 210-238 Range on HMM: 199-233/275 Sequence Identity: 31% (11 aa) IWTLGVIFFVLVFGQFPFVD------LQEIEEYTL .| .||||. |..|. || ||..... . MWSCGVIFYILLCGKPPFKGKTYNEILQQNKKCKI |
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| Kinase | 15767.AA | CAMKL | 207-229 | 47 | 1.3e-05 | 13.77 | In-house | 216-238 (297) | Show / Hide |
Range on Protein: 207-229 Range on HMM: 216-238/297 Sequence Identity: 47% (11 aa) KSEIWTLGVIFFVLVFGQFPFVD | || .||| ...|.|..|| | KVDIWSCGVILYAMVCGYLPFDD |
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| Kinase | 15767.AA | Pkinase | 192-227 | 29 | 0.001794 | 13.36 | Pfam | 176-212 (293) | Show / Hide |
Range on Protein: 192-227 Range on HMM: 176-212/293 Sequence Identity: 29% (11 aa) EYLPPEMIG-KGTIDLKSEIWTLGVIFFVLVFGQFPF .|..|| | .. |. .| .|.|.. ...|..|| WYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPF |
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| Kinase | 15767.AA | ULK | 93-167 | 22 | 0.05455 | 2.84 | In-house | 82-166 (329) | Show / Hide |
Range on Protein: 93-167 Range on HMM: 82-166/329 Sequence Identity: 22% (19 aa) KIIDVFHNL--QQKYFVVEYFEEGNILEYMLNNNL--------SRLDLKLAVKVLGDVFRGISRLHEKRQYHMNLRLENIYFRNN | .|.| . |...|| . |. .|. .|. || . |.... . | ||... | . ..|| |. KLYDWFETSNHNNIYIIMEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNG |
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| Kinase | 15767.AA | ULK | 93-167 | 22 | 0.072025 | 2.49 | In-house | 79-162 (324) | Show / Hide |
Range on Protein: 93-167 Range on HMM: 79-162/324 Sequence Identity: 22% (19 aa) KIIDVFHNL--QQKYFVVEYFEEGNILEYMLNNNL-------SRLDLKLAVKVLGDVFRGISRLHEKRQYHMNLRLENIYFRNN | .|.| . |...|| . |. .|. .|. || . |.... . | ||.. | . ..|| |. KLYDWFETSNHNNIYIIMEYCNGGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNG |
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| Kinase | 15767.AA | SgK495 | 115-162 | 29 | 0.267724 | 0.07 | In-house | 1-46 (171) | Show / Hide |
Range on Protein: 115-162 Range on HMM: 1-46/171 Sequence Identity: 29% (14 aa) NILEYMLNNNLSRLDLKLAVKVLGDVFRGISRLHEKRQYHMNLRLENI |. ... || . .| . || | . ||.| | |.| |. NLQHHVIHEK--RLSERETVYIFHDVVRIVEALHQKNIVHRDLKLGNM |
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| Kinase | 15767.AA | Pkinase | 93-151 | 18 | 3.678357 | 1.65 | Pfam | 64-128 (293) | Show / Hide |
Range on Protein: 93-151 Range on HMM: 64-128/293 Sequence Identity: 18% (12 aa) KIIDVFHNLQQKYFVVEYFEEG----NILEYML---NNNLSRLDLKLAVKVLGDVFRGISRLHEKR ...|.|.. . |.| || | | .|. ..... .. . . ... ..||. .|... RLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFY-FSEWECKFYMYQILRGLEYCHSMG |
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