Gene 19112 (Tetrahymena)
19112
Sequence
Protein domains of 19112.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 19112.AA | AGC | 217-387 | 27 | 4.1e-75 | 192.78 | In-house | 132-395 (395) | Show / Hide |
Range on Protein: 217-387
Range on HMM: 132-395/395
Sequence Identity: 27% (75 aa)
LKLQRR----FVDASQVRFFAVE-------ICLALEEFHS-RGVVYKD-LIPENILINDKGHVFLTDFGNARFNILQD----------------------
| || | | ...||.| | |.|||| || .|... | | |||||....||. ||||| . .. .
LHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFGLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKS
--------------------------DHQPPDTIIT----CYTAPEVLKGEDYSKLSDYWC--FGVLLYELLTGVPPFYSENLE----------LQYKLI
... |. | |||.| |.| |.|. .|.|.||.||| ||||..| . ...|
NMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKI
L------EDELEFPSF--------LNISYPCQQLIKQLLQKDPKKRLGS--ED----GFQDLMNHDWF
. .....||. ..| .. |||.||.|||.||||. .| |.....|| ||
MNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
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| Kinase | 19112.AA | Ciliate-E2-Unclassified | 215-387 | 25 | 5.9e-62 | 212.14 | In-house | 126-352 (352) | Show / Hide |
Range on Protein: 215-387 Range on HMM: 126-352/352 Sequence Identity: 25% (59 aa) YKLKLQRRFVDASQVR-----FFAVEICLALEEFHSRG-VVYKDLIPENILINDKG---HVFLTDFGNAR---------------FNILQDDHQPPDTII .. ..||. .. |.. |.. .|...|| |. . ... |. |||||....| .. ..|||... ..|...... . FHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGT TCYT----APEVLKGEDYS----KLSDYWCFGVLLYELLTGVPPFYSENLEL----------------QYKLILEDELEFPSFLN------ISYPCQQLI .| |||||.|. |. . .|.|..||.|||.|.| .|||..| | .|. |.. ...||.| . .| .. .| PNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFI KQLLQKDPKKRLGSEDGFQDLMNHDWF ..||||..||.... .|....|| || NDLLQKMLKKNPNKRITFEQILNHPWF |
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| Kinase | 19112.AA | Ciliate-E2 | 220-387 | 24 | 1.3e-58 | 199.77 | In-house | 146-365 (365) | Show / Hide |
Range on Protein: 220-387
Range on HMM: 146-365/365
Sequence Identity: 24% (57 aa)
QRRFVDASQVR-------FFAVEICLALEEFHSRG-VVYKDLIPENILINDKGHVFLTDFGNARF--------------NILQDDHQPPDTIITC-----
..... . ... |....|.||||. ||.. ... |. |||||. ....|||.... ..... .. .. ...
EIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQII
-------------YTAPEVLKGED---------YSKLSDYWCFGVLLYELLTGVPPFYSENLELQYKLILEDELEFP----------------SFLNISY
| |||.|.|.. |.. .|.|..||.|||.|.| ||| .. |.. ...|| |....|
QQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQ
PCQQLIKQ----LLQKDPKKRLGSEDGFQDLMNHDWF
|..|||. .|||||.||.. |.....|| ||
ECKDLIKKFGKRMLQKDPEKRIT---GWEQILNHPWF
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| Kinase | 19112.AA | AktR | 217-387 | 35 | 7.1e-53 | 181.97 | In-house | 92-268 (268) | Show / Hide |
Range on Protein: 217-387 Range on HMM: 92-268/268 Sequence Identity: 35% (64 aa) LKLQRRFVDASQVRFFAVEICLALEEFHSR-GVVYKDLIPENILINDKGHVFLTDFGNARFNILQDDHQPPDTII--TCYTAPEVLKG-EDYSKLSDYWC || ...| . .|.||....|.|||| .|.. ..| || |||||. ||| .|||| .. . .. .. ... | |||... . . | .|.|. LKKKKKF-SEEQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWA FGVLLYELLTGVPPFYSENLELQYKLILEDE-LEFPSFLNISYPCQQLIK-QLLQKDPKKRLG-SEDGFQDLMNHDWF ||...||..|| ||||..| . ...|.. . ..|| ..| |. ||. .||.|.|.|||| . |.... .| || FGIFIYEMVTGCPPFYHKNQNQMFQKIKIKQQNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF |
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| Kinase | 19112.AA | RSK | 215-387 | 35 | 7.4e-44 | 152.03 | In-house | 90-278 (278) | Show / Hide |
Range on Protein: 215-387 Range on HMM: 90-278/278 Sequence Identity: 35% (68 aa) YKLKLQRRF--VDASQVRFFAVEICLALEEFHSRGVVYKDLIPENILIND---KGHVFLTDFGNARFNILQDDHQPPDTIITCYT----APEVLK----G ..|. ...| . . ..| . || ||.| |..|... || ||||| .| ||. ||||| .. . |. |. .| ||| |||.|| . THLQKEKHFGCFSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQF-RCDHNQWTMTF--CYTIEYMAPEMLKRANQQ EDYSKLSDYWCFGVLLYELLTGVPPFYS---ENLELQYKLILEDE--LEFPSFLNISYPCQQLIKQLLQKDPKKRLGS-EDGFQDLMNHDWF . ..| |.| .|||.||.||| |||.. .| . | |.. . |..| ..| ... ||...|..||.||||. .. ... .| || GGHDKACDWWSLGVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF |
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| Kinase | 19112.AA | PKC | 220-387 | 36 | 5.2e-42 | 133.85 | In-house | 94-262 (262) | Show / Hide |
Range on Protein: 220-387 Range on HMM: 94-262/262 Sequence Identity: 36% (64 aa) QRRFVDASQVRFFAVEICLALEEFHSRGVVYKDLIPENILINDKGHVFLTDFGNARFNILQDDHQPPDTIITC----YTAPEVLKGEDYSKLSDYWCFGV |||| . .. || |.||..|| .|..|..| || .|.|. ||. ..||| . |....| | | | |||.|....|.| |.| ||| QRRF-KEEHARFYAAEIICALQFLHEKGIIYRDLKLDNVLLDHEGHIKIADFGMCKENMWNGDT----TSTFCGTPDYIAPEILQYQEYGKSVDWWAFGV LLYELLTGVPPFYSENLELQYKLILEDELEFPSFLNISYPCQQLIKQLLQKDPKKRLGS----EDGFQDLMNHDWF |.||.. | .|| |. . . |..|. .| | | ...|....|.|.||||. |.|.|| . | | LMYEMMAGQSPFHGEDEDELFQSIMHDNPHYPRWL--SKEAVSICKGFMTKNPEKRLGCHPQQEEGEQDIREHPFF |
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| Kinase | 19112.AA | Akt | 293-387 | 41 | 4e-40 | 125.91 | In-house | 168-264 (264) | Show / Hide |
Range on Protein: 293-387 Range on HMM: 168-264/264 Sequence Identity: 41% (40 aa) YTAPEVLKGEDYSKLSDYWC-FGVLLYELLTGVPPFYSENLELQYKLILEDELEFPSFLNISYPCQQLIKQLLQKDPKKRLG-SEDGFQDLMNHDWF | |||.|.| ...| .| | .|...||...| ||||... . .|.|.. ...|| .|| |. ||..||.|||||||| ... |....| || YLAPEILNGNGHTKAVDWWGSLGCVMYEMMCGRPPFYNQDHHQMFKKIKNQPVKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF |
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| Kinase | 19112.AA | SGK | 293-387 | 44 | 6.1e-39 | 117.58 | In-house | 191-283 (283) | Show / Hide |
Range on Protein: 293-387 Range on HMM: 191-283/283 Sequence Identity: 44% (42 aa) YTAPEVLKGEDYSKLSDYWCFGVLLYELLTGVPPFYSENLELQYKLILEDELEFPSFLNISYPCQQLIKQLLQKDPKKRLGSEDGFQDLMNHDWF | |||||... ... | || | .|||...| ||||| | .. | |. .| .| . .| .. ||..|||||||||||. ..| . || .| YLAPEVLRKQPHDRTVDWWCLGCVLYEMMYGLPPFYSRNKQQMYDNIINQPLQIPPQ--MSNDAWDLIQGLLQKDPKKRLGTKRDFMEIKNHPFF |
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| Kinase | 19112.AA | Pkinase | 219-387 | 27 | 7.3e-37 | 131.42 | Pfam | 95-293 (293) | Show / Hide |
Range on Protein: 219-387 Range on HMM: 95-293/293 Sequence Identity: 27% (58 aa) LQ---RRFV--DASQVRFFAVEICLALEEFHSRGVVYKDLIPENILINDKGHV----FLTDFGNAR-FNILQDDHQPPDTIITC---YTAPEVLK-GEDY .. .. . . ...|.. .|. .|| ||.|... || ||||||...||. ..||| |. |. ... | ... | ||||.. |..| ISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD---Y-NNS-MTTFCGTPWYMAPEVIRGGQYY SKLSDYWCFGVLLYELLTGVPPFYSE------NLELQYKLILEDELEFPSFLNIS-------------------YPCQQLIKQLLQKDPKKRLGSEDGFQ .. .| | .|..|||.|.| |||... . ...|.. .|.|... .| .|...|| .|.||||||.. .. GPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT----AE DLMNHDWF ....|.|| QILQHPWF |
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| Kinase | 19112.AA | RSK-Unclassified | 293-387 | 38 | 3.5e-31 | 94.81 | In-house | 188-283 (283) | Show / Hide |
Range on Protein: 293-387 Range on HMM: 188-283/283 Sequence Identity: 38% (37 aa) YTAPEVLKGEDYSKLSDYWCFGVLLYELLTGVPPFYSENLELQYKLILEDELEFPSFLNISYPCQQLIKQLLQKDPKKRLGSEDG-FQDLMNHDWF | |||.... | | | |...||.| |.||.| .| . .. |. .. || || |. ||| |||. | ||||. | .| | | YLAPEMIRRCGHTKAVDWWTLGIVMYEMLFGCPPYYGNNKNETFYNIEKNHVKFPHDSYISNNCRDLIKKLLQRNPAKRLGCKMGDADDIKRHPFF |
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| S_TKc | 19112.AA | S_TKc | 163-387 | 27 | 4.1e-31 | 110.62 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 163-387 Range on HMM: 1-231/231 Sequence Identity: 27% (72 aa) LTKLGLISESEKSKVYLVKYGEKSTNKFALKEIKASDCKISEKIQLQIKDNSYKLKLQRRFV----------------------------------DASQ ..| .| . .|||... . . ..|.|.|| . ..| |. . . || |. . . YEILRKIGKGAFGKVYKCRHKK-TGRIVAIKIIK--EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-H VRFFAVEICLALEEFHSRGVVYKDLIPENILINDKGHVFLTDFGNARFNILQDDHQPPDTIITCYTAPEVLKGEDYSK-LSDYWCFGVLLYELLTGVPPF .||.. .||.||| ||.|... || |||||... |. ..||| ||. | ||||| |.| .| | .|..|||.|.| ||| ARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPF YSENLELQYKLILEDELEFPSFLNISYPCQQLIKQLLQKDPKKRLGSEDGFQ---DLMNHDWF . .... .|.|. | .. ..|...|||||.||.. . .| | ..| || P--QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | 19112.AA | PKA | 293-387 | 37 | 2.2e-25 | 90.67 | In-house | 164-263 (263) | Show / Hide |
Range on Protein: 293-387 Range on HMM: 164-263/263 Sequence Identity: 37% (37 aa) YTAPEVLKGE-DYSKLSDYWCFGVLLYELLTGVPPFYSE--NLELQYKLILEDELEFPSFLNISY-PCQQLIKQLLQKDPKKRLGSED-GFQDLMNHDWF | |||..... . | | |..|.| ||.|.|.|||| . . |. |.. ...||.... |||.|||.|..||.|. . | .| || || YLAPEIIQSKNGHGKSVDWWALGILIYEMLAGYPPFYDHNRDPMQIYEKICNGKIKFPRHFDSDANYFKDLIKKLLQVDLTKRYGNMKNGVNDIKNHKWF |
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| Kinase | 19112.AA | SGK | 227-272 | 54 | 3.1e-19 | 55.6 | In-house | 125-170 (283) | Show / Hide |
Range on Protein: 227-272 Range on HMM: 125-170/283 Sequence Identity: 54% (25 aa) SQVRFFAVEICLALEEFHSRGVVYKDLIPENILINDKGHVFLTDFG ...|| | || .|||. || ..| || ||||| ..||. ||||| DRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFG |
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| Kinase | 19112.AA | RSK-Unclassified | 228-272 | 51 | 8.8e-19 | 55.14 | In-house | 102-146 (283) | Show / Hide |
Range on Protein: 228-272 Range on HMM: 102-146/283 Sequence Identity: 51% (23 aa) QVRFFAVEICLALEEFHSRGVVYKDLIPENILINDKGHVFLTDFG .|||.| |. .||| | |...| || |.||. ||| ||||. DVRFYASEVTAALEYLHKRDFIYRDLKPDNIVLHQEGHVMLTDFD |
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| Kinase | 19112.AA | Akt | 227-272 | 51 | 1.7e-14 | 42.7 | In-house | 100-146 (264) | Show / Hide |
Range on Protein: 227-272 Range on HMM: 100-146/264 Sequence Identity: 51% (24 aa) SQVRFFAVEICLALEEFHSRGVVYKD-LIPENILINDKGHVFLTDFG .. ||.. || ||.| ||....| | | |||||. .||. ||||| DRARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFG |
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| Kinase | 19112.AA | PKA | 230-272 | 54 | 5.2e-12 | 46.22 | In-house | 103-146 (263) | Show / Hide |
Range on Protein: 230-272 Range on HMM: 103-146/263 Sequence Identity: 54% (24 aa) RFFAV-EICLALEEFHSRGVVYKDLIPENILINDKGHVFLTDFG .| | .|.|||| || .| || ||||||...||. .|||| KFYAASQIVLALEYLHSQNIIYRDLKPENILIDKNGHIKITDFG |
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| TyrKc | 19112.AA | TyrKc | 163-381 | 16 | 3.6e-07 | -106.64 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 163-381 Range on HMM: 1-280/280 Sequence Identity: 16% (47 aa) LTKLGLISESEKSKVYLVKYGEKSTNKFALKEIKASDCKISE-----KIQLQI---------------KD-------NSYK--------------LKLQR .|.. . | . .||. .. . | | .|.. . . .| .. .. . |. | ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR RFVDASQVRFFAVEICLALEEFHSRGVVYKDLIPENILINDKGHVFLTDFGNARFNILQ-------DDHQP----PDT--IITCYTAPEVLKGEDYSKLS . . .. |.. |. | ||.... || |.|......| .||| .|. | . . .|||... .. | PKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKS DYWCFGVLLYELLT-GVPPFYS------ENLELQYKLILEDELEFPSFLN------ISYPCQQLIKQLLQKDPKKRLGSEDGFQDL | | |||...|..| | .| . .| |. .. . .. | . |..|| . ||..| .. ... DVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF |
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| Kinase | 19112.AA | Pkinase_Tyr | 294-328 | 37 | 4.9e-05 | 17.68 | Pfam | 181-217 (270) | Show / Hide |
Range on Protein: 294-328 Range on HMM: 181-217/270 Sequence Identity: 37% (14 aa) TAPEVLKGEDYSKLSDYWCFGVLLYELLT-GVPP-FY .|||... .. || | ||||..|..| | | .. MAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYP |
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