Gene 19962 (Tetrahymena)

19962

Species: Tetrahymena
Alias: PreTt19962, TTHERM_00534050, 3830.m00611, 68.m00251, 113, 19962
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-E2
Subfamily: Ciliate-E2-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
19962.AA Protein None 637 None Fasta, JSON
19962.kin_dom Protein Kinase Domain None 268 None Fasta, JSON
19962.NA RNA None 1914 None Fasta, JSON

Protein domain

Protein domains of 19962.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 19962.AA CDPK 70-337 42 1.5e-136 421.23 In-house 1-271 (271) Show / Hide 
Range on Protein: 70-337
Range on HMM: 1-271/271
Sequence Identity: 42% (118 aa)

YEFEPNILGHGHYGTVRLANHI-INKSKKYAVKTISKTKIKKDL--HLFRRELEILKSLDHPNVIKFYETYQDKKYFHLVME--YCSGGELLHRIAQDKM
| .. ..|| ||.|.||.. |  ... .. |.|.|.| ..|.      | .|.||||.|||||.||.||.|||.|....|||  ||.||||. .|.. ..
YKIK-KVLGKGHFGQVRKVKHKQKTNQERVAMKIIPKSRVKDKEQQQQFFNEIEILKQLDHPNIIKIYEFYQDEKNYYIVMETEYCTGGELFDYIIEKGH

ASEEKMVKIMKKIFLGVKYLHEKGICHRDLKPENFLFSNNSELS----EIKIIDFGLSTYIDE---IENEDDNGFFGNDLQTICGTANYLAPEVIKGKYD
 .| .  .||..|.  | | |...|.||||||||.|| .... |    .||.||.|.|.. |    |         .... ..|||  |.||||...||.
FTEKEAAYIMRQILSAVNYCHSNNIVHRDLKPENILFDSKKDDSWVIYNIKVIDWGTSKKFDQNQKI--------EDKKMSQRCGTPYYIAPEVLQKKYN

KRCDIWSLGVLLYFLLCGELPFSGNTNTEIFDKILNQKVEFQGNNWKKVSKEAKDLVKKLLVVNPDDRITLEQVLKHPWI
. |||||.|| || ||||. || | .  ||..|. ..| .| | .|...|.|||||..|.|...|..|.. .|.|.|||.
EKCDIWSCGVILYILLCGYPPFYGKNDQEIMEKVKKGKYSFEGPEWDHISDEAKDLIRKMLCYDPKKRMSAQQALQHPWF
Kinase 19962.AA CAMK1 70-337 43 6.7e-132 385.74 In-house 1-276 (276) Show / Hide 
Range on Protein: 70-337
Range on HMM: 1-276/276
Sequence Identity: 43% (124 aa)

YEFEPNILGHGHYGTVRLANHIIN--KSKKYAVKTIS-KTKIKKD----LHLFRRELEILKS---LDHPNVIKFYETYQDKKYFHLVMEYCSGGELLHRI
|||  ...| |  ..|.|..|. .    |.||.| |. |. .||.    . ....|.||.|.   .||||.||||| |.....|.||||...||||..||
YEFG-KEIGRGAFSEVYLCTHKETQTNGKQYAIKCIDKKKFMKKKDMQKQEALENEIEIMKKVSKIDHPNIIKFYEWYESDNHFYLVMELVTGGELFDRI

AQDKMASEEKMVKIMKKIFLGVKYLHEKGICHRDLKPENFLFSNNSELSEIK--IIDFGLSTYIDEIENEDDNGFFGNDLQTICGTANYLAPEVIKGK--
 . .  .|.. ..|||.|.  |.|.|.|||.|||||||| |.....| |.||  |.|||||...|. ||          ..| |||  | ||||...|  
VEKGNYTEKDARHIMKQILSAVEYMHSKGIVHRDLKPENLLYYDKDEDSKIKRSIADFGLSKIFDHDEN---------LMKTACGTPGYVAPEVLECKKD

--YDKRCDIWSLGVLLYFLLCGELPFSGNT-NTEIFDKILNQKVEFQGNNWKKVSKE-AKDLVKKLLVVNPDDRITLEQVLKHPWI
  ||| ||.|| || .|.||||  || ... . |.|.||.. ..||  . | ..|.. |||..|..|.|.|  |.| ||.|.||||
KPYDKACDMWSIGVITYILLCGYPPFYDENVDNELFEKIKKCEYEFPSPWWDNISDQEAKDFIKHMLEVDPKKRYTCEQCLNHPWI
Kinase 19962.AA Ciliate-E2a 70-337 42 2.4e-126 373.87 In-house 1-275 (275) Show / Hide 
Range on Protein: 70-337
Range on HMM: 1-275/275
Sequence Identity: 42% (125 aa)

YEFEPNILGHGHYGTVRLANHIINKSKKYAVKTISKTK---IKKDLHLFRRELEILKSLDHPNVIKFYETYQDKKYFHLVMEYCSGGELLHRIAQDKMAS
|.|. ...| | .| |.||.|.... |..|.| ..| |   .||. . | .|. |...|||||.||.||.|.|.... ||||||.||||...| |.|   
YKFI-KKIGKGNFGSVYLAQHKQTG-KQFAMKKFIK-KMYQQKKGKEYFMNEINIMRQLDHPNIIKLYEVYEDENNYYLVMEYCEGGELYDKIKQCKRFF

EE--KMVKIMKKIF-LGVKYLHEKGICHRDLKPENFLFS---NNS-ELSEIKIIDFGLSTYI--DEIENEDDNGFFGND---LQTICGTANYLA------
||  .. .||....  |. |.| ..| ||||||||.||     || ..|.||||||||.|.|  |             .   . ..|||. |.|      
EEIQEICDIMQQLLWQGLHYMHQRNIMHRDLKPENILFKNCSKNSIQNSDIKIIDFGLATFIDKD-------------EKKYMFQKCGTPGYVAPEVLNN

PEVIKGK-YDKRCDIWSLGVLLYFLLCGELPFSGNTNTEIFDKILNQKVEFQGNN-WKKVSKEAKDLVKKLLVVNPDDRITLEQVLKHPWI
.||.|.| ||. ||.||.|| .|.||||..|| | | .||. .. . |  |.... |.|.|||.|||.||.|...|  ||| .| |.||| 
KEVLKHKQYDTKCDMWSCGVIFYILLCGKPPFKGKTYNEILQQNKKCKIDFNCPECWEKCSKECKDLMKKMLEKDPKKRITAQQALNHPWF
Kinase 19962.AA CAMK 76-337 28 8.70000000001e-123 397.69 In-house 1-425 (425) Show / Hide 
Range on Protein: 76-337
Range on HMM: 1-425/425
Sequence Identity: 28% (121 aa)

ILGHGHYGTVRLANHIINKS-----------KKYAVKTISKTKIKK---------------------------DLHLFRRELEILKS-------LDHPNV
.||.| .|.|.|. |. ..            .|.|.| |.|.|.|.                           |.. .|||.||.|.       |||||.
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

IKFYETYQD-------------------KKYFHLVM---EYCSGGEL----LHRIAQD---------------KMASEEKMVKIMKKIFLGVKYLHEKGI
||.||.|.|                   .|....||   ||||||||    . .| .                .  .|.   .... |  .|.|.|...|
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

CHRDLKPENFLFSNNSELSE--------------IKIIDFGLSTYIDEIE-------NEDDNGFFGN---------DLQTICGTANYLA-PEVIKGK---
.|||||||| |...|.. |.              |||||||.....|. |       ... . .  |          ..| |||  | | |||..||   
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGE-M-HNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHC

------------YDKRCDIWSLGVLLYFLLCGELPFSGN-------------TNTEIFDKILNQKVEFQGNN------------WKKVSKE--------A
            |.. ||.||.||.||..|||..|| |              .  |.| ||.. | .|                |...|.|        .
NMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQEC

KDLVKKLLVVNPDDRITLEQVLKHPWI
|||..|.|.|.|..|.|.||.|.|||.
KDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 19962.AA Ciliate-E2 70-337 32 5.9e-107 361.64 In-house 1-365 (365) Show / Hide 
Range on Protein: 70-337
Range on HMM: 1-365/365
Sequence Identity: 32% (123 aa)

YEFEPNILGHGHYGTVRLANHIIN----------------------KSKKYAVKTISKTK---IKKDLHLFR---------RELEILKSLDHPNVIKFYE
|.|  ...| | .|.|...... .                      |.|.||.|...| .   ||. .|..|          |..||..|.|||.||.||
YKFI-KKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYE

TYQ--DKKYFHLVMEYCSGGELLHRIAQDKMAS-----------EEKMVKIMKKIFL---------------GVKYLHEKG-ICHRDLKPENFLFSNNSE
..|  |.... ||||||.||.|...| . |  .           |... .|||.|.                ...|||.|. |.|||.|||| ||     
CFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----

LSEIKIIDFGLSTYIDE---------------IENEDDNGFFG--------NDLQTICGTANYLAPEVIKGK----------YDKRCDIWSLGVLLYFLL
   |||||||||...|.                 . |... .|        |  .|||||..|.|||...||          ||. ||||||||.||..|
---IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEML

CGELPFSGNTNTEIFDKILNQKVEFQGN--------------NWKKVSKEAKDLVKK----LLVVNPDDRIT-LEQVLKHPWI
.|..||        ...|...|..|. .              .|||.|.|.||| ||    .|...|. |||  ||.|.|||.
FGKPPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 19962.AA S_TKc 70-337 33 6.1e-102 345.89 SMART 1-231 (231) Show / Hide 
Range on Protein: 70-337
Range on HMM: 1-231/231
Sequence Identity: 33% (95 aa)

YEFEPNILGHGHYGTVRLANHIINKSKKYAVKTISKTKIKKDLHLFRRELEILKSLDHPNVIKFYETYQDKKYFHLVMEYCSG--GELLHRIAQDKM---
||.  ...|.| .|.|... |.    ...|.| |.          .|||..|||. .|||..|.|...|| .....|||||.|  |.|...| . .    
YEIL-RKIGKGAFGKVYKCRHKK-TGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---ASEEKMVKIMKKIFLGVKYLHEKGICHRDLKPENFLFSNNSELSEIKIIDFGLSTYIDEIENEDDNGFFGNDLQTICGTANYLAPEVIKGKYDK-RC
    .|    ..|. |.....|.|..||.|||||||| |...     .|||.||||.. .                 |.||| .|.||||.  .|.| .|
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL----------------TTFCGTPWYMAPEVL--GYGKCKC

DIWSLGVLLYFLLCGELPFSGNTNTEIFDKILNQKVEFQGNNWKKVSKEAKDLVKKLLVVNPDDRITLEQVLK-------HPWI
|.||.|..|| .|||. ||.  .  ..|.||.              |.||||...|.|...|..|.|  ..|.       |||.
DWWSCGCILYEMLCGYPPFP--QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 19962.AA CAMKL 70-337 36 5.1e-100 319.88 In-house 1-297 (297) Show / Hide 
Range on Protein: 70-337
Range on HMM: 1-297/297
Sequence Identity: 36% (112 aa)

YEFEPNILGHGHYGTVRLANHIINKSKKYAVKTISKTKIKKDLHLF--------------RRELEILKSLD---HPNVIKFYETYQDKKY------FHLV
|....  ||.|..|.|.|| ||..  .|.|.| | | ||..| .                ||| .|.|.|.   |||.||.||.......      ..||
YRIGK-TLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLV

MEYCSGGE--LLHRIAQD----KMASEEKMVKIMKKIFLGVKYLHEKGICHRDLKPENFLFSNNSELSEIKIIDFGLSTYIDEIENEDDNGFFGND--LQ
||||||||  |...| .     .  .|.   .. . |  .|.|.|..||.|||.|||| |...|     |||||||.|......        ||..  | 
MEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNN-NIKIIDFGFSNMYRPC-------IFGPGQKLK

TICGTANYLAPEVIKG--K-YD-KRCDIWSLGVLLYFLLCGELPFSGNTN-----TEIFDKILNQKVEFQG-NNWKKVSKEAKDLVKKLLVVNPDDRITL
| ||. .| |||...|  | || .  ||||.||.||...||.||| . |.     . |  . . ...     . |..|| ...|| .|.|.|||..|.|.
TFCGSPPYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTI

EQVLKHPWI
.|...||| 
HQIMNHPWM
Kinase 19962.AA RSK 77-337 34 8e-94 318.01 In-house 7-278 (278) Show / Hide 
Range on Protein: 77-337
Range on HMM: 7-278/278
Sequence Identity: 34% (96 aa)

LGHGHYGTVRLANHIINKSKKYAVKTISKTKIKKD---LHLFRRELEILKSLD-HPNVIKFYETYQDKKYFHLVMEYCSGGELLHRIAQDKMA---SEEK
.| | . ..|  .|  .. . ||.| ..| ||..    .   ..| .||.    ||.... ....|......|.||||.||||. .. . |.    ||. 
GGYGKVFLCRKCTH-HDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGCFSEDE

MVKIMKKIFLGVKYLHEKGICHRDLKPENFLFSNNSEL-SEIKIIDFGLSTYIDEIENEDDNGFFGNDLQTICGTANYLAPEVIK----GK-YDKRCDIW
   .| .| | |..||..|| |||||||| |. . |    .||..|||.. .         .  ... ..| |.|..|.|||..|    .. .|| ||.|
ACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDES-NEGHIKLTDFGFCKQF--------RCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWW

SLGVLLYFLLCGELPFSG---NTNTEIFDKILNQKVEFQGNNWKKVSKEAKDLVKKLLVVNPDDRIT-----LEQVLKHPWI
|||||.| .| | .|| |   |.  ||...|.. |  . . ||...|.|||||..|.| ..| .|..     .|....|||.
SLGVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase 19962.AA Pkinase 70-337 32 1.1e-92 319.06 Pfam 1-293 (293) Show / Hide 
Range on Protein: 70-337
Range on HMM: 1-293/293
Sequence Identity: 32% (100 aa)

YEFEPNILGHGHYGTVRLANHIINKSKKYAVKTISKTKIKKDLH--LFR-RELEILKSLDHPNVIKFYETYQDKKYFHLVMEYCSGG----ELLHRIA--
|...  ..| | .|.|... |. .   ..|||.|.| ..|.. .  ..| .|..|.|.|.|||....|....||.. ..||||| ||    .| ..|   
YHIGR-KIGSGSFGCVYKCHHKGTGK-IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTW

QDKMA--SEEKMVKIMKKIFLGVKYLHEKGICHRDLKPENFLFSNNSEL-SEIKIIDFGLSTYIDEIENEDDNGFFGNDLQTICGTANYLAPEVIK--GK
...    ||.   ..|. |. |..|.|..||.||||||||.|..|| .. . .||.||||.  .|           .  ..|.||| .|.|||||.   .
RHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD--------Y-NNS-MTTFCGTPWYMAPEVIRGGQY

YDKRCDIWSLGVLLYFLLCGELPFSGN------TNTEIFDKILNQKVEFQGNNWKKVS-----------------KEAKDLVKKLLVVNPDDRITLEQVL
|....|.||.|..|| .|||..||.|       .  .....|.  ...|.  .|  .|                 .|.||..|..| ..| .|.| ||.|
YGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQIL

KHPWI
.|||.
QHPWF
Kinase 19962.AA Ciliate-E2-Unclassified 70-337 30 2.5e-92 313.05 In-house 1-352 (352) Show / Hide 
Range on Protein: 70-337
Range on HMM: 1-352/352
Sequence Identity: 30% (110 aa)

YEFEPNILGHGHYGTVRLANHIINKSKKYAVKTISKTKIKKDLH-------------LFRR----------ELE-ILKSLDHPNVIKFYETYQDKKYFHL
|..   ..|.| .|.|... |. .| ..|| |...| .|.|..              ....          ..  ||....||...|.... |||... .
YKII-KQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYI

VMEYCSGGELLHRIAQ-----------------DKMASEEKMV-----KIMKKIFLGVKYLHEKG-ICHRDLKPENFLFSNNSELSEIKIIDFGLSTYID
||||| ||.|.  | .                 .|. .|....     .... | .| .|||.|. |.|||.|||| ||.|| .  .|||||||.| ...
VMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQ

EIENEDDNG------FFGNDLQ-TICGTANYL----APEVIKG-KYDKR----CDIWSLGVLLYFLLCGELPFSGNTNTE----------------IFDK
. .|.| .       .. .... |.||| ||.    ||||..| .||..    ||||||||.||..| |..||..|. ..                ....
QNNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQN

ILNQKVEFQGNNW----KKVSKEAKDLVK----KLLVVNPDDRITLEQVLKHPWI
|......|.  .|    |..|.||||...    |.|..||. |||.||.|.|||.
IKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 19962.AA MARK 70-337 40 1.1e-90 296.68 In-house 1-262 (262) Show / Hide 
Range on Protein: 70-337
Range on HMM: 1-262/262
Sequence Identity: 40% (113 aa)

YEFEPNILGHGHYGTVRLANHIINKSKKYAVKTISKTKIK--KDLHLFRRELEILKSLDHPNVIKFYETYQ--DKKY-FHLVMEYCSGGELLHRIAQD--
|..    .||| |..|.|| |.  . .|.|.|.. |.|.   . .  ..||.||.|.|||||.||.... .  ...  ..|.|||.|||||...| .   
YKML-KTIGHGSYAKVKLACHKHTG-RKVAIKIYEKFKLNDPQWMKNVMREIEIMKKLDHPNIIKLFHVIEQDTEQHQIYLIMEYASGGELYDYIKAHPN

KMASEEKMVKIMKKIFLGVKYLHEKGICHRDLKPENFLFSNNSELSEIKIIDFGLSTYIDEIENEDDNGFFGNDLQTICGTANYLAPEVIKGK-YD-KRC
   .||   .| . |  .|.|.|.|.|.|||.|||| |   |     |||||||.|. | . .           | | |||  | |||....| || .  
GRLHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGN-HNIKIIDFGFSICIPPGQK----------LNTFCGTPPYMAPEIFLKKPYDGPKV

DIWSLGVLLYFLLCGELPFSGNT--NTEIFDKILNQKVEFQGNNWKKVSKEAKDLVKKLLVVNPDDRITLEQVLKHPWI
|||||||.|||..|| .|| | |  . |.. |||. | ..  .    ||||...|...||.|||..|.|.|...||||.
DIWSLGVVLYFMVCGYFPFDGDTQDYKELYKKILRGKYDIPCH----VSKECRNLIQRLLTVNPEERPTIEEIMKHPWM
Kinase 19962.AA CAMK-Unique 70-337 28 7.6e-89 293.41 In-house 1-363 (363) Show / Hide 
Range on Protein: 70-337
Range on HMM: 1-363/363
Sequence Identity: 28% (105 aa)

YEFEPNILGHGHYGTVRLANHIINKSKKYAVKTISKTKIK-KDLHL------------------FRRELEILKSLDHPNVIKFYET----YQDKK-----
|..  .|.||| .| |. .  . .. ||.|.| . | . . | ...                  ..||..|.|..|||| ||.|..    ..|.|     
YKMH-RIIGHGNFGHVYECMDRETG-KKWACKMVKKQTHGNKKQKQQRNFDLRYKITEKRRDMKLKREHQIWKMVDHPNIIKLYDWNNPIFCDRKYPLCD

----------YFHLVMEYCSGGELLHRIAQ--------------------DKMASE--EKMVKIMKKIFLGVKYLHEKGICHRDLKPENFLFSNNSE---
          |...||||| ||.|.  |..                        ||       || ..   |.|.|...| |||||.|| .....     
LIIKTPRALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNN

----------LSEIKIIDFGLSTYIDEIENEDDNGFFGND-LQTICGTANYLAP--------------EVIK-GKYDKRC----DIWSLGVLLYFLLCGE
           . ||..||||...... . .          .||.|||  |.||              |||.  .||  |    |||||||..|..|||.
HHRDFPYDWSNWHIKLCDFGLCCHYNHNKMC--------HMMQTMCGTPCYMAPEIVFCKNYQEMTRDEVINMQCYDQQCSPASDIWSLGVIMYYMLCGC

LPFSGNTNT--------EIFDKILNQKV-EFQGNNWKK---VSKEAKDLVKKLLVVNPDDRITLEQVLKHPWI
.|| ....         |||..|.  .. .|    |     .|.||||.||....| || |..... |.|.||
PPFDCECEDRDYENHDKEIFECICKGDYCNFDWKMWHGPDYISQEAKDFVKCCMTVDPDHRWSAKELLEHQWI
Kinase 19962.AA TyrKc 71-337 24 2.9e-16 40.23 SMART 1-280 (280) Show / Hide 
Range on Protein: 71-337
Range on HMM: 1-280/280
Sequence Identity: 24% (73 aa)

EFEPNILGHGHYGTVRLANHIINKSKKYAVKTISKTKIKKDLHLFRRELEILKSL--DHPNVIKFYETYQDK-------KYFHLVMEYCSGGELLHRIAQ
     .||.|..|.|...  .     . |||.. . .    .  |.||..|...|  .|||....|    ..       .   .||||...| |....  
ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

DKM-ASEEKMVKIMKKIFLGVKYLHEKGICHRDLKPENFLFSNNSELSEIKIIDFGLSTYIDEI----ENEDDNGF----FGNDLQTICGTANYLAPEVI
 .   . .......  |  |  |||.|.. ||||   | | ..|     .|| ||||| .|..     |..|         |...  |      .|||.|
HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPI----RWMAPECI

-KGKYDKRCDIWSLGVLLY-FLLCGELPFSG-----NTNTEIFDKILNQKVEFQGNN-----WKKVSKEAKDLVKKLLVVNPDDRITLEQVLKHPWI
 .||.    |.|| ||...  .  |. | .|      .|.|.. .. . .   |  |         ..|  .. |.    .|.|| | ...  |  .
NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase 19962.AA Pkinase_Tyr 70-194 26 3.6e-11 38.46 Pfam 1-137 (270) Show / Hide 
Range on Protein: 70-194
Range on HMM: 1-137/270
Sequence Identity: 26% (36 aa)

YEFEPNILGHGHYGTVRLANHI-INKSKKY--AVKTISKTKIKKD--LHLFRRELEILKSL-DHPNVIKFYETYQ-DKKY--FHLVMEYCSGGELLHRIA
 .|    ||.|..|.|...      ...|.  |||..  .  ...  .  | ||..|.|.| .|||....|     ...     .||||. .| ||.   
ITFG-KKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

Q----DKMASEEKMVKIMKKIFLGVKYLHEKGICHRDL
.    ..  . . ....   |  |  ||..|.. ||||
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDL
Kinase 19962.AA Pkinase_Tyr 247-291 39 0.026571 8.42 Pfam 181-228 (270) Show / Hide 
Range on Protein: 247-291
Range on HMM: 181-228/270
Sequence Identity: 39% (19 aa)

LAPEVIK-GKYDKRCDIWSLGVLLYFLLC-GELP-FSGNTNTEIFDKI
.|||.|. ||.    |.|| |||.. ..  || | . | .|.|....|
MAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYI
Efhand 19962.AA efhand 387-415 37 3.3e-07 30.81 Pfam 1-29 (29) Show / Hide 
Range on Protein: 387-415
Range on HMM: 1-29/29
Sequence Identity: 37% (11 aa)

ELKQIFRKIDTNNTGMIKIEELQSALKKV
|||..|...|... | | .||.....||.
ELKEMFKEFDKDGDGYIDFEEFCEMMKKL
EFh 19962.AA EFh 387-415 34 6.5e-07 30.22 SMART 1-29 (29) Show / Hide 
Range on Protein: 387-415
Range on HMM: 1-29/29
Sequence Identity: 34% (10 aa)

ELKQIFRKIDTNNTGMIKIEELQSALKKV
|.|..||..|... | |  ||.. ..|..
EFKEMFRMFDKDGDGYIDFEEFKDMMKSL
Efhand 19962.AA efhand 460-488 31 0.006453 15.09 Pfam 1-29 (29) Show / Hide 
Range on Protein: 460-488
Range on HMM: 1-29/29
Sequence Identity: 31% (9 aa)

RLWNVFKHFDVDDTNYITISNLREALARA
.| ..||.||.|   ||..  ..|.... 
ELKEMFKEFDKDGDGYIDFEEFCEMMKKL
EFh 19962.AA EFh 460-488 20 0.064064 6.12 SMART 1-29 (29) Show / Hide 
Range on Protein: 460-488
Range on HMM: 1-29/29
Sequence Identity: 20% (6 aa)

RLWNVFKHFDVDDTNYITISNLREALARA
 .  .|..||.|   ||.   ....... 
EFKEMFRMFDKDGDGYIDFEEFKDMMKSL
Efhand 19962.AA efhand 496-524 27 0.002778 16.43 Pfam 1-29 (29) Show / Hide 
Range on Protein: 496-524
Range on HMM: 1-29/29
Sequence Identity: 27% (8 aa)

ELQEIMNEVDFNLNQRIEWNQFVTIMTQT
||.|...|.| . . .|. . |...|...
ELKEMFKEFDKDGDGYIDFEEFCEMMKKL
EFh 19962.AA EFh 496-524 20 0.007067 13.84 SMART 1-29 (29) Show / Hide 
Range on Protein: 496-524
Range on HMM: 1-29/29
Sequence Identity: 20% (6 aa)

ELQEIMNEVDFNLNQRIEWNQFVTIMTQT
|..|.....| . . .|. . |...|.  
EFKEMFRMFDKDGDGYIDFEEFKDMMKSL