20456

Species: Tetrahymena
Alias: 20456, 3682.m00047, PreTt20456, 141.m00113, 649, TTHERM_00823880
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-E2

Sequence

Name Sequence Type Origin Length Description Download
20456.AA Protein None 956 None Fasta, JSON
20456.kin_dom Protein Kinase Domain None 264 None Fasta, JSON
20456.NA RNA None 2871 None Fasta, JSON

Protein domain

Protein domains of 20456.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 20456.AA Ciliate-E2-Unclassified 12-275 24 6.9e-77 261.75 In-house 1-352 (352) Show / Hide
Range on Protein: 12-275
Range on HMM: 1-352/352
Sequence Identity: 24% (85 aa)

YEILLTKGNGNIGSVFQAKKDKEY------YAIKMINKNQLESMESFYNLMQKMEHLDYGG-------------------NNNVVRIYEFFQNPFNIFIS
|.|. . |.|. |.|......|..      |..|.....|.  |..  ..|..|...                       . ..|. .. ||. .||.| 
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV

MEYCNQGNLLQYMLKQPE---------------KRLDCFKAI-----ELFAHILNGFKFLHKNN-IQHRNLKPQNILMHNN----KPKITDYGLYMLYN-
||||..|.|.||. |..                |......|.      .||.||.|...||..| | ||..||.|||..||    ..||.|.|. . |. 
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQ

-------------------GKQQYQMREFM----APENYERTSDQGS--HLCDIWGLGVLLFFMIFNTWPFKDFDEIKKYTYSKQ-------FALDLFLK
                    ... .  ..|    ||| ...    .|  . ||||.|||.|..|.|...||.| ..........|       . |    |
NNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIK

EKEIQKPSTL------QTNQQAMNMLTEIFQGLFAYQSKNRMSFWKLCNHEIF
.|.||.|.        . ...| .......| .. .. ..|..|....|| .|
QKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF

Kinase 20456.AA Ciliate-E2 12-275 20 4.9e-72 245.62 In-house 1-365 (365) Show / Hide
Range on Protein: 12-275
Range on HMM: 1-365/365
Sequence Identity: 20% (80 aa)

YEILLTKGNGNIGSVFQAKKDKE-------------------------YYAIKMINKNQLESMESFYNLMQKMEHLD-----------YGGNNNVVRIYE
|...   |.|| |||...|..|.                         .||.|...|||.|....  ..|..... .              ..|....||
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINC-FYKKINEKNILEQLNHPNIIKMYE

FFQ--NPFNIFISMEYCNQGNLLQYMLKQPEKR---------LDCFKAIELFAHILN---------------GFKFLHKNN-IQHRNLKPQNILMHNNKP
.||  .  ||.. ||||..|.|..|. ... ||         ............||.               ....||..| | ||..||.|||.    .
CFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----I

KITDYGLYMLYNGKQQ------------------------------------YQMREFMAPENYERTSDQ-------GSHLCDIWGLGVLLFFMIFNTWP
||.| ||   |. ..|                                    . . ..||||.... ...        .. |||| |||.|..|.|. .|
KIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP

FKDFDEIKKYTYSKQFALDLFLKEKEIQKP---------STLQTNQQAMNMLTEIFQG--LFAYQSKNRMS-FWKLCNHEIF
|          . ..   .. . ..| ||.         |...  |......   | |  .. .. ..|.. .... ||..|
F----------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKK-F-GKRMLQKDPEKRITGWEQILNHPWF

Kinase 20456.AA CAMK 17-208 17 1.6e-35 111.44 In-house 1-336 (425) Show / Hide
Range on Protein: 17-208
Range on HMM: 1-336/425
Sequence Identity: 17% (60 aa)

TKGNGNIGSVFQAKK--DK------------EYYAIKMINKNQLE----------------------------SMESFYNLMQKMEHLDYGG----NNNV
| | |. | |. ..   ..            . .|||.|.|..|                             ....... .. | .|  .|      |.
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VRIYEFFQNPFN-------------------IFISM---EYCNQG----NLLQYMLKQPE-------------KRLDCFKAIELFAHILNGFKFLHKNNI
...||....|..                   ... |   |||  |     |..|  ...              .|..   |  .|  |. . ...|..||
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

QHRNLKPQNILM-HN-----------------NKPKITDYGLYMLYNGKQ----------------------------QYQMREFMA-PENYER-T----
 || ||| |||. .|                 |. ||.| |.   .....                            .    |.|| ||  .. .    
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

-------SDQGSHLCDIWGLGVLLFFMIFNTWPFKD
        .  .  ||.| .||.|..|   . || .
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYG

Kinase 20456.AA ULK 19-155 35 9.9e-34 117.08 In-house 8-184 (324) Show / Hide
Range on Protein: 19-155
Range on HMM: 8-184/324
Sequence Identity: 35% (64 aa)

GNGNIG-SVFQA--KKD---KEYYAIKMIN-----KNQLE--------SMESFYNLMQKMEHLDYGGNNN--VVRIYEFFQNP--FNIFISMEYCNQGNL
| |  |  |...  ||.   ..|.|.|||.     |...|        . ..  ..|.|. .|    ..|  .|. |..|...   ||.| |||||.|.|
GKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKEL---KHPNHHIVKLYDWFETSNHNNIYIIMEYCNGGDL

LQYMLKQPE-------KRLDCFKAIELFAHILNGFKFLHKNNIQHRNLKPQNILMHNNKPK-------------ITDYGL
 ||. |. .       |||   .||. | .|.||||.|||.|| || .||||||.||..||             |.| |.
EQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGF

Kinase 20456.AA ULK 19-155 35 5.2e-33 112.62 In-house 8-188 (329) Show / Hide
Range on Protein: 19-155
Range on HMM: 8-188/329
Sequence Identity: 35% (65 aa)

GNGNIGSVFQA--KKDK----EYYAIKMINKNQLESMESFYN-------------LMQKMEHLDYGGNN---NVVRIYEFFQNP--FNIFISMEYCNQGN
| |  | |...  ||.|    |..|.||| |...   .  ..             .|.|. .   ...|   |.|. |..|...   ||.| |||||.|.
GKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPN-RHKNHHPNIVKLYDWFETSNHNNIYIIMEYCNGGD

LLQYMLKQPE--------KRLDCFKAIELFAHILNGFKFLHKNNIQHRNLKPQNILMHNNKPK-------------ITDYGL
| ||. |. .        |||   .||. | .||||||.|||.|| || .||||||.||..||             |.| |.
LEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGF

Kinase 20456.AA S_TKc 12-275 21 1.2e-30 109.1 SMART 1-231 (231) Show / Hide
Range on Protein: 12-275
Range on HMM: 1-231/231
Sequence Identity: 21% (61 aa)

YEILLTKGNGNIGSVFQAKKDK--EYYAIKMINKNQLESMESFYNLMQKMEHLDYGGNNNVVRIYEFFQNPFNIFISMEYCNQ--GNLLQYMLKQPEKR-
|||| . | |  |.|..... |  ...|||.|.       |.... .| ...    .  |.|..|..||.  .... ||||..  |.|..|. |.. .. 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK----HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---LDCFKAIELFAHILNGFKFLHKNNIQHRNLKPQNILMHNNKPKITDYGLYMLYNGKQQYQMREFMAPENYERTSDQGSH-LCDIWGLGVLLFFMIFN
   ..   |  ... |... ...|...| || |||.|||. .   ||.| ||  ..  . .   ...||||       . ..  ||.| .|..|. |.  
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-HIKICDFGLARQL--TTFCGTPWYMAPEVL-----GYGKCKCDWWSCGCILYEMLCG

TWPFKDFDEIKKYTYSKQFALDLFLKEKEIQKPSTLQTNQQAMNMLTEIFQGLFAYQSKNRMSFWKLCN-------HEIF
  ||        ..  |.                          ..  . .... .  ..|..  .. .       |. |
YPPFP-----QMQMMFKKIG---------------------SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase 20456.AA Pkinase 12-208 25 2.4e-25 90.69 Pfam 1-214 (293) Show / Hide
Range on Protein: 12-208
Range on HMM: 1-214/293
Sequence Identity: 25% (57 aa)

YEILLTKGNGNIGSVFQAKKDKEY--YAIKMINKNQLESME-------SFYNLMQKMEHLDYGGNNNVVRIYEFFQNPFNIFISMEYCNQG----NLLQY
|.|. . | |. |.|..... ..   .|.| |.|   .| .       |   .|... |       |.||.|..|... .| . ||||. |     |   
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNH------PNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLF-D

MLK-QPEKRL--DCFKAIELFAHILNGFKFLHKNNIQHRNLKPQNILMH-NNKP----KITDYGL-YML-YNGKQQYQM----REFMAPENYERTSDQGS
... . ....  .   ..  .  || | ...|...| || |||.|||.. |. .    ||.| ||   . |  .. ..     ...||||    ..   .
YISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIR-GGQYYG

HLCDIWGLGVLLFFMIFNTWPFKD
. .|.|..|..|. |..   ||..
PKVDMWSCGCILYEMLCGRPPFPG

Kinase 20456.AA Ciliate-E2b 19-206 24 3.3e-23 67.53 In-house 8-210 (272) Show / Hide
Range on Protein: 19-206
Range on HMM: 8-210/272
Sequence Identity: 24% (49 aa)

GNGNIGSVFQAKK---DKEYYAIKMINKNQLESMESFYNLMQKMEHLDYGGNNNVVRIYEFFQNPFNIFISMEYCNQGNLLQYMLKQPEKRLDCFKAIEL
|.|. |||.. ..   .|.|||.| |.|||.   .    ..|  . |      .... .  |.   ..   ||.|| . |. ..  .    |    .   
GFGQFGSVYLVWNTKNTKQYYAMKCISKNQIIQQNMEKHMLQEKNVLEKCNHPFIMKFIRSFKDDQHMYFMMEFCNGMELFDVIREIGRLLLSTYDSQFY

FAHILNGFKFLHKNNIQHRNLKPQNILMHN-NKPKITDYGLYMLYNGKQQ-----YQMR---EFMAPENYE--RTSDQG-SHLCDIWGLGVLLFFMIFNT
.| |. ... ||..|| .| .|| ||. ..   .|. | |.  .  .|..     . ..   ..||||  .  .   .| .   ||| .|. |.....  
IASICLCLEYLHNQNIIYRDIKPENIMVDHKGYMKLIDMGTAKHMYKKNEQMTRTFTIIGTPHYMAPEIIQSLQPGGKGYTYKVDIWSVGICLYEFMCGY

WPF
 |.
VPW

Kinase 20456.AA CAMKL 12-155 26 9.2e-21 62.85 In-house 1-175 (297) Show / Hide
Range on Protein: 12-155
Range on HMM: 1-175/297
Sequence Identity: 26% (48 aa)

YEILLTKGNGNIGSVFQAKKD---KEYYAIKMIN--KNQL-ESMESF---------------YNLMQKME---HLDYGGNNNVVRIYEFFQNPFN-----
|.|. | | |. | |  |.     .| .|||.|.  | .. . |..                ...|...    |       |....|| ...| .     
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHP------NIIKLYEVIETPEHDIETK

-IFISMEYCNQGN--LLQYMLKQPEKR--LDCFKAIELFAHILNGFKFLHKNNIQHRNLKPQNILMHNNK---PKITDYGL
 |.. ||||  |.  |..|  |....|  ..   |  .|  |. . ...|...| || .|| |||  .|.    ||.| |.
KIYLVMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGF

Kinase 20456.AA MELK 12-208 27 2.1e-20 66.18 In-house 1-202 (254) Show / Hide
Range on Protein: 12-208
Range on HMM: 1-202/254
Sequence Identity: 27% (56 aa)

YEILLTKGNGNIGSVFQAKK--DKEYYAIKMINKNQLESMESFYNLMQKMEHLDYGGNNNVVRIYEFFQNPFNIFISMEYCNQGNLLQYMLKQPEKRLDC
||.  . | |  . |  |      .  |||...|||| .   .  .   |. |      .. ..| . .    ||. ||||  |... |...|  .||. 
YEVHDEIGTGGFAKVKLACHILTNQMVAIKIMDKNQLGHD--LPRVKTEMDALKNLRHQHICQLYHYIETEDKIFMVMEYCPGGEMFDYIIRQ--DRLEE

FKAIELFAHILNGFKFLHKNNIQHRNLKPQNILMHNN-KPKITDYGLYMLYNGKQQYQ-------MREFMAPENYERTSDQGSHLCDIWGLGVLLFFMIF
  .  .|  |.    ..|     ||.|||.|.|. .. . |. |.||     |.. |           . |||  .  .  ||   |.| .|.||. .. 
EETRHFFRQIVSAIAYVHSQGYAHRDLKPENLLFDEDHHLKLIDFGLCAKTKGRKDYHNLQTCCGSPAYAAPELIQGKQYIGSE-ADVWSMGILLYVLMC

NTWPFKD
   || |
GFLPFDD

Kinase 20456.AA Ciliate-E2c 9-155 28 6.9e-19 62.9 In-house 1-160 (310) Show / Hide
Range on Protein: 9-155
Range on HMM: 1-160/310
Sequence Identity: 28% (47 aa)

INGYEILLTKGNGNIGSVFQAKKDK------EY------YAIKMINKNQL----ESMESFY-NLMQKMEHLDYGGNNNVVRIYEFFQNPFNIFISMEYCN
|.  .||   | |. |.|. |.. .      .       .||||.  . .     .  .    ...  . .    . .....|...|   .|.. |||||
IDRNNIL---GSGSYGKVYKAYYCEDYQNEINNVQMNQLFAIKMTCLKNKDIHMINEKDIKESIIREINMMKHMNHPHIIKFYDAKQTDKHIYLIMEYCN

QGNLLQYMLKQPEKRLDCFKAIELFAHILNGFKFLHKN-NIQHRNLKPQNILMHNNKPKITDYGL
.|.|.||  . |  ..     . .|  |...|| |||. || || .|| ||| ||  .|| | |.
GGTLEQYIYHKP--KPNEKQCLYYFSQIISAFKYLHKEKNIFHRDIKPENILIHNGMIKIADFGF

Kinase 20456.AA MARK 12-155 29 2.1e-17 53.62 In-house 1-152 (262) Show / Hide
Range on Protein: 12-155
Range on HMM: 1-152/262
Sequence Identity: 29% (46 aa)

YEILLTKGNGNIGSVFQA--KKDKEYYAIKMINKNQL---ESMESFY---NLMQKMEHLDYGGNNNVVRIYEFFQ--NPFN-IFISMEYCNQGNLLQYML
|..| | | |. . |  |  |. .. .|||...|..|   ..|....   ..|.|..|       |... .. ..  .. . |.. |||.  |.|..|. 
YKMLKTIGHGSYAKVKLACHKHTGRKVAIKIYEKFKLNDPQWMKNVMREIEIMKKLDHP------NIIKLFHVIEQDTEQHQIYLIMEYASGGELYDYIK

KQPEKRLDCFKAIELFAHILNGFKFLHKNNIQHRNLKPQNILMHNN---KPKITDYGL
..|  ||    |  .|  |. . ...|..|| || .||.|||.  |   . ||.| |.
AHPNGRLHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDFGF

Kinase 20456.AA TyrKc 12-275 21 1.7e-10 -53.07 SMART 1-280 (280) Show / Hide
Range on Protein: 12-275
Range on HMM: 1-280/280
Sequence Identity: 21% (65 aa)

YEILLTKGNGNIGSVFQAKKDKEYYAIKMINKNQLESMESFYNLMQKMEHLDYG-GNNNVVRIYEFFQNP-------FNIFISMEYCNQGNLLQYMLKQP
 . . . |.|. | |.... . .  |.||....    .| |.. .. | .|  |  . |.||.|     .         ..| |||.  |.|..|  |  
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA---REDFMREARIMCKL--GGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

EKRLDCFKAIELFAHILNGFKFLHKNNIQHRNLKPQNILMHNNK-PKITDYGL-YMLYNG------KQQYQM-----REF------MAPENYERTSDQG-
.| |   . ..    | .|  .||..|. || |   |.| ..|.  ||.| ||   .|..      |. | .     . .      ||||      . | 
PK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI----NYGK

-SHLCDIWGLGVLLFFMIFNTWPFKDFDE-IKKYTYSKQFALDLFLKEKEIQKPSTLQTNQQ----AMNMLTEIFQGLFAYQSKNRMSFWKLCNHEIF
 ..  |.|  ||... .   |   .   . |..   | | .. .  . .   .|            .   . .| .   ... ..| .|. .  ||.|
FTTKSDVWSFGVCMWEIF--TYGQQPYPGMIQQ-MMSNQEVIEYVKQGYRMPQPPNDY-P-MSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF

Kinase 20456.AA ULK 170-275 22 2e-06 19.1 In-house 213-324 (324) Show / Hide
Range on Protein: 170-275
Range on HMM: 213-324/324
Sequence Identity: 22% (26 aa)

FMAPENYE---RTSDQGSHLCDIWGLGVLLFFMIFNTWPFKDFDEIKKYTYSKQFALDL------FLKEKEIQKPSTLQTNQQAMNMLTEIFQGLFAYQS
.|||.  .      ..... |||| ||.... |...  ||.     . | | .|  ..       . | . ||.|.    ...  . . ....... |. 
YMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLY-IQKLINNGKEQQIYIKNQPIQFPKPP-KDPKISPECKDLIRRMLQYDE

KNRMSFWKLCNHEIF
| |.|.  . ||..|
KDRISWEEIFNHPWF

Kinase 20456.AA MARK 188-214 41 2e-06 17.3 In-house 188-218 (262) Show / Hide
Range on Protein: 188-214
Range on HMM: 188-218/262
Sequence Identity: 41% (13 aa)

DIWGLGVLLFFMIFNTWPFK--D--FDEIKK
||| |||.|.||.  ..||.  .  . |..|
DIWSLGVVLYFMVCGYFPFDGDTQDYKELYK

Kinase 20456.AA CAMKL 188-220 33 1.2e-05 13.8 In-house 218-255 (297) Show / Hide
Range on Protein: 188-220
Range on HMM: 218-255/297
Sequence Identity: 33% (13 aa)

DIWGLGVLLFFMIFNTWPFKDFDE------IKKYTYSKQ
||| .||.|..|.. ..||.| .        . | | |.
DIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKI

Kinase 20456.AA Ciliate-E2c 188-220 31 1.9e-05 15.12 In-house 201-238 (310) Show / Hide
Range on Protein: 188-220
Range on HMM: 201-238/310
Sequence Identity: 31% (12 aa)

DIWGLGVLLFFMIFNTWPFK-----DFDEIKKYTYSKQ
||| |||.|..|..   |..     |   | .  |. .
DIWSLGVTLYYMLCYKLPWESIQEYDSHNICNHCYPWW

Kinase 20456.AA ULK 170-207 29 3.3e-05 14.21 In-house 217-257 (329) Show / Hide
Range on Protein: 170-207
Range on HMM: 217-257/329
Sequence Identity: 29% (12 aa)

FMAPENYE-R--TSDQGSHLCDIWGLGVLLFFMIFNTWPFK
.|||.  . .    ..... |||| ||.... |...  ||.
YMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFY

Kinase 20456.AA ULK 250-275 30 0.009918 5.46 In-house 304-329 (329) Show / Hide
Range on Protein: 250-275
Range on HMM: 304-329/329
Sequence Identity: 30% (8 aa)

EIFQGLFAYQSKNRMSFWKLCNHEIF
....... |. | |.|.  | ||..|
DLIRRMLQYDEKDRISWEELFNHPWF