Gene 20748 (Tetrahymena)

20748

Species: Tetrahymena
Alias: TTHERM_00149880, PreTt20748, 20748, 12.m00422, 526, 3700.m00143
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-E2
Subfamily: Ciliate-E2-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
20748.AA Protein None 650 None Fasta, JSON
20748.kin_dom Protein Kinase Domain None 227 None Fasta, JSON
20748.NA RNA None 1954 None Fasta, JSON

Protein domain

Protein domains of 20748.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Ank 20748.AA Ank 180-213 41 1.4e-07 31.56 Pfam 1-33 (33) Show / Hide 
Range on Protein: 180-213
Range on HMM: 1-33/33
Sequence Identity: 41% (14 aa)

FGRTVLHLASIRGSLECVQYILENNLCDINQQDH
 |.| ||||...|..|.|.. |. . .|.| || 
DGFTPLHLACRCGHTEVVKMLLQ-HGADVNAQDD
Ank 20748.AA Ank 214-246 36 4.9e-07 29.65 Pfam 1-33 (33) Show / Hide 
Range on Protein: 214-246
Range on HMM: 1-33/33
Sequence Identity: 36% (12 aa)

SKSTALHYASANNHDQIVKILLDHKIDASVKND
   |.||.|. ..| ..|| ||.|  |  ...|
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank 20748.AA Ank 147-179 27 0.003627 15.68 Pfam 1-33 (33) Show / Hide 
Range on Protein: 147-179
Range on HMM: 1-33/33
Sequence Identity: 27% (9 aa)

DNYNAAHYACIHGNRQILERLNQIGCNFQAVTS
| . . |.||..|. .... | | |..  |.. 
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Kinase 20748.AA AGC 401-562 32 6.2e-108 279.6 In-house 142-395 (395) Show / Hide 
Range on Protein: 401-562
Range on HMM: 142-395/395
Sequence Identity: 32% (83 aa)

SLEEDIARMYIAE-------LVLAIEFLHN-KGIIYRD-LKPENVLIDIDGHIKLVDFGLVKTGMNRR--------------------------------
...|. || |.||       .|||.|.||. .|||.|| |||||.|.| ||||||.|||| | |||..                                
RFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFGLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPN

------------------KKTKSFCG--TPSYLSPEMIKQKGHNHAVDWYG--VGILTYELLYGENPFQGN----------DAKQVFNSVQ------NKR
                  ..|..|||  || |..||..    ...|.||..  .|.| ||.|.|  ||.|.          . ...|....      |..
NWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWK

LNKP----------SGLSQEGWDFIQKLMCKDPSKRLGTQS-------SDEVKNHPWF
.  |          . .|.| .|.|.||.||||.||||..         .|.||||||
VKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase 20748.AA Akt 404-562 50 1.5e-82 263.69 In-house 99-264 (264) Show / Hide 
Range on Protein: 404-562
Range on HMM: 99-264/264
Sequence Identity: 50% (84 aa)

EDIARMYIAELVLAIEFLHNKGIIYRD-LKPENVLIDIDGHIKLVDFGLVKTG-MNRRKKTKSFCGTPSYLSPEMIKQKGHNHAVDWYG-VGILTYELLY
|| || |.||..||||.||.|.||||| |||||.|.| ||||.| |||| | . . .  |||.||||| ||.||.....||  ||||.| .|...||...
EDRARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMC

GENPFQGNDAKQVFNSVQNKRLNKP--SGLSQEGWDFIQKLMCKDPSKRLG--TQSSDEVKNHPWF
|  ||   | .| |   .|. .. |  . .|.|  |.| .|  |||.||||   .  .|.|.||||
GRPPFYNQDHHQMFKKIKNQPVKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF
Kinase 20748.AA SGK 401-562 47 1.3e-79 245.42 In-house 121-283 (283) Show / Hide 
Range on Protein: 401-562
Range on HMM: 121-283/283
Sequence Identity: 47% (78 aa)

SLEEDIARMYIAELVLAIEFLHNKGIIYRDLKPENVLIDIDGHIKLVDFGLVKTGMNRRKKTKSFCGTPSYLSPEMIKQKGHNHAVDWYGVGILTYELLY
.. || || | ||.|.|.| || . ||||||||||.| | .||..| |||| | |.   ..|..||||| || ||... ..|  .|||.  |.. ||..|
HFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEGIKTNDTTFTFCGTPEYLAPEVLRKQPHDRTVDWWCLGCVLYEMMY

GENPFQGNDAKQVFNSVQNKRLNKPSGLSQEGWDFIQKLMCKDPSKRLGTQ-SSDEVKNHPWF
|  ||  .. .| .    |. |. | . | . || || |  |||.|||||   . |.||||.|
GLPPFYSRNKQQMYDNIINQPLQIPPQMSNDAWDLIQGLLQKDPKKRLGTKRDFMEIKNHPFF
Kinase 20748.AA Ciliate-E2-Unclassified 336-562 22 1.4e-77 264.03 In-house 1-352 (352) Show / Hide 
Range on Protein: 336-562
Range on HMM: 1-352/352
Sequence Identity: 22% (80 aa)

FLLIRQLGTGGFGEVNLVQYMKNKQFYAIKIMRKDMIIR----RSAEKYIIQERISISCIQ-------------------CQNIYKGDSLE---------
. .|.|.|.||||.| ..|  |.||.||.|.| | .|.     .. .  |..| . . ...                   . .|.|    .         
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV

-------------------------------------EDIAR-----MYIAELVLAIEFLHNKG-IIYRDLKPENVLIDIDG---HIKLVDFGL------
                                     |  |.      |.|......|.|| |. ||.||.||||.|.| .|   .||. |||.      
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQ

---------VKTGMNRRKKTKSFCGTPSYL----SPEMIKQKGHN----HAVDWYGVGILTYELLYGENPFQGNDAKQ----------------VFNSVQ
         .|...........|||||.|.    .||........    ...|....|.. ||.|.|. ||..|. .|                ...  .
NNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIK

NKRLNKPS--------GLSQEGWDFIQKLMCKDPSKRLGTQ-SSDEVKNHPWF
.| ...|.        ..|.|..|||..|..|.. |...   . ....|||||
QKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 20748.AA AktR 402-562 47 1e-76 261.2 In-house 98-268 (268) Show / Hide 
Range on Protein: 402-562
Range on HMM: 98-268/268
Sequence Identity: 47% (82 aa)

LEEDIARMYIAELVLAIEFLHNK-GIIYRDLKPENVLIDIDGHIKLVDFGLVK-TGMN-RRKKTKSFCGTPSYLSPEMIKQ-KGHNHAVDWYGVGILTYE
..|. || |.|. .||.|.||..  |||||||||| |.| |||.|..|||| |  .|. .. |..|||||| |..||||.. |||| .|||. .||. ||
FSEEQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYE

LLYGENPFQGNDAKQVFNSVQNKR---LNKPSGLSQEGWDFIQ-KLMCKDPSKRLG--TQSSDEVKNHPWF
...|  ||. .. .| | . ..|.    ..|| .|..  |.|| ||.||.| ||||  . . .|.|.||||
MVTGCPPFYHKNQNQMFQKIKIKQQNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase 20748.AA RSK 396-562 44 2.2e-72 246.78 In-house 92-278 (278) Show / Hide 
Range on Protein: 396-562
Range on HMM: 92-278/278
Sequence Identity: 44% (84 aa)

IYKGDS---LEEDIARMYIAELVLAIEFLHNKGIIYRDLKPENVLIDI---DGHIKLVDFGLVKTGMNR-RKKTKSFCGTPSYLSPEMIK----QKGHNH
..|  .   . || |..|.||.|||.|.|| .|||.|||||||.| |    .|||||.|||. | . ..  ..|..||.|  |. |||.|    |.||..
LQKEKHFGCFSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDK

AVDWYGVGILTYELLYGENPFQG---NDAKQVFNSVQNKR--LNKP--SGLSQEGWDFIQKLMCKDPSKRLG--TQSSDEVKNHPWF
|.||.  |.| ||.| |  ||||   |..|.... .|...  |. |  . ||||  |.|.|....||.||||   |  .|.|.||||
ACDWWSLGVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase 20748.AA RSK-Unclassified 404-562 36 2.9e-67 210.16 In-house 100-283 (283) Show / Hide 
Range on Protein: 404-562
Range on HMM: 100-283/283
Sequence Identity: 36% (68 aa)

EDIARMYIAELVLAIEFLHNKGIIYRDLKPENVLIDIDGHIKLVDFGLVKTG---------------------MNRRKKTKSFCGTPSYLSPEMIKQKGH
|| .|.|..| ..| | || ...|||||||.|.. . .||..| ||.| . .                     .    .|.|||||  || ||||.  ||
EDDVRFYASEVTAALEYLHKRDFIYRDLKPDNIVLHQEGHVMLTDFDLSIQAKDSKKPVMKGSAQSTYVDTKICDHGFRTNSFCGTEEYLAPEMIRRCGH

NHAVDWYGVGILTYELLYGENPFQGNDAKQVFNSVQNKRLNKP--SGLSQEGWDFIQKLMCKDPSKRLGTQSS--DEVKNHPWF
  ||||.  ||. ||.| |  |. ||    .|. .  . .  |  | .|..  | | ||. . |.||||  .   |..| || |
TKAVDWWTLGIVMYEMLFGCPPYYGNNKNETFYNIEKNHVKFPHDSYISNNCRDLIKKLLQRNPAKRLGCKMGDADDIKRHPFF
Kinase 20748.AA PKC 402-562 41 7.1e-67 215.75 In-house 97-262 (262) Show / Hide 
Range on Protein: 402-562
Range on HMM: 97-262/262
Sequence Identity: 41% (69 aa)

LEEDIARMYIAELVLAIEFLHNKGIIYRDLKPENVLIDIDGHIKLVDFGLVKTGMNRRKKTKSFCGTPSYLSPEMIKQKGHNHAVDWYGVGILTYELLYG
..|  || | || ..|  |||.||||||||| .|||.| .||||..|||. |..|.....|..||||| |..|| .. .  ...|||   |.| ||.. |
FKEEHARFYAAEIICALQFLHEKGIIYRDLKLDNVLLDHEGHIKIADFGMCKENMWNGDTTSTFCGTPDYIAPEILQYQEYGKSVDWWAFGVLMYEMMAG

ENPFQGNDAKQVFNSVQNKRLNKPSGLSQEGWDFIQKLMCKDPSKRLGTQSSD-----EVKNHPWF
  || | |  ..|.|. ...   |  ||.|  . ....| |.|.|||| . ..     ... || |
QSPFHGEDEDELFQSIMHDNPHYPRWLSKEAVSICKGFMTKNPEKRLGCHPQQEEGEQDIREHPFF
Kinase 20748.AA S_TKc 336-562 28 2.5e-63 217.62 SMART 1-231 (231) Show / Hide 
Range on Protein: 336-562
Range on HMM: 1-231/231
Sequence Identity: 28% (75 aa)

FLLIRQLGTGGFGEVNLVQYMKNKQFYAIKIMRKDMIIRRSAEKYIIQERISISCIQCQNIYK----------GDS--------------------LEED
. ..|..| |.||.| ...  | .. .||||..    ..   |  | ..      ...  ..            |                     . | 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-

IARMYIAELVLAIEFLHNKGIIYRDLKPENVLIDIDGHIKLVDFGLVKTGMNRRKKTKSFCGTPSYLSPEMIKQKGHNH-AVDWYGVGILTYELLYGENP
 || |......|.|..|..|||.|||||||.|.|   |||. |||| .         ..||||| |..||..   |... ..||. .|.. ||.|.|. |
HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPP

FQGNDAKQVFNSVQNKRLNKPSGLSQEGWDFIQKLMCKDPSKRLGTQSSDE----VKNHPWF
|.  . ...|. .           |.|..|||.|...|||.||..     .    .|.||||
FP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 20748.AA PKA 401-562 42 3.8e-62 212.79 In-house 96-263 (263) Show / Hide 
Range on Protein: 401-562
Range on HMM: 96-263/263
Sequence Identity: 42% (72 aa)

SLEEDIARMYIA-ELVLAIEFLHNKGIIYRDLKPENVLIDIDGHIKLVDFGLVKTGMNRRKKTKSFCGTPSYLSPEMIKQK-GHNHAVDWYGVGILTYEL
.. ...|. |.| . |||.|.||.. |||||||||| ||| .||||. ||| .|   .    |.. |||| || ||.|. | ||. .|||   ||| ||.
RFSNPHAKFYAASQIVLALEYLHSQNIIYRDLKPENILIDKNGHIKITDFGFAKKVDD---RTWTLCGTPEYLAPEIIQSKNGHGKSVDWWALGILIYEM

LYGENPFQGN--DAKQVFNSVQNKRLNKPSGLSQEG---WDFIQKLMCKDPSKRLGTQSS--DEVKNHPWF
| |  ||  .  |  | ..  .| ... |. ...      |.| ||. .|..||.|....  . .|||.||
LAGYPPFYDHNRDPMQIYEKICNGKIKFPRHFDSDANYFKDLIKKLLQVDLTKRYGNMKNGVNDIKNHKWF
Kinase 20748.AA Pkinase 396-562 30 3.2e-55 194.56 Pfam 95-293 (293) Show / Hide 
Range on Protein: 396-562
Range on HMM: 95-293/293
Sequence Identity: 30% (63 aa)

IY--KGDSL--EEDIARMYIAELVLAIEFLHNKGIIYRDLKPENVLIDIDGHI----KLVDFGLVKTG-MNRRKKTKSFCGTPSYLSPEMIK-QKGHNHA
|   .. ..  .|. ...|. ... ..|..|..|||.|||||||.||| .|||    |. |||| |     .   ...||||| |..|| |. .... ..
ISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPK

VDWYGVGILTYELLYGENPFQGN------DAKQVFNSVQNKRLNKPSGLS---------------------QEGWDFIQKLMCKDPSKRLGTQSSDEVKN
||....|.. ||.| |. ||.|       | .|... .  ..|  ..  .                     .|. ||| .. ||||.||..    .....
VDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT---AEQILQ

HPWF
||||
HPWF
Kinase 20748.AA MAST 460-562 36 2.7e-39 117.27 In-house 223-337 (337) Show / Hide 
Range on Protein: 460-562
Range on HMM: 223-337/337
Sequence Identity: 36% (42 aa)

KKTKSFCGTPSYLSPEMIKQKG-HNHAVDWYGVGILTYELLYGENPFQGNDAKQ-VFNSVQN--KRLNKPSG--------LSQEGWDFIQKLMCKDPSKR
.. |. |||| |..|| |  .| .. .|||. .||  ||.| |. ||.|      .|... |  .... |..        .| |  | |.||  ..|.||
HQNKQCCGTPDYIAPEVILGQGTYGKPVDWWSMGIIMYEFLVGCPPFNGDTPEEMIFQNIINHDREIEWPEEGDPNDDDCMSPEAQDLIKKLLQPNPKKR

LGTQSSDEVKNHPWF
||.. .||.|.|| |
LGANGADEIKQHPFF
Kinase 20748.AA MAST 399-459 57 1.4e-36 108.76 In-house 96-156 (337) Show / Hide 
Range on Protein: 399-459
Range on HMM: 96-156/337
Sequence Identity: 57% (35 aa)

GDSLEEDIARMYIAELVLAIEFLHNKGIIYRDLKPENVLIDIDGHIKLVDFGLVKTGMNRR
| ...|..|.|||||.||..|.||..||. |||||.|.||| .|||||.|||| | | . .
GNCMPEWMAKMYIAETVLCLEYLHSYGIVHRDLKPDNMLIDSNGHIKLTDFGLSKVGFMDK
Kinase 20748.AA AGC 336-385 21 3.1e-19 44.96 In-house 1-71 (395) Show / Hide 
Range on Protein: 336-385
Range on HMM: 1-71/395
Sequence Identity: 21% (15 aa)

FLLIRQLGTGGFGEVNLVQYM------KNKQFYAIKIMRKDM-IIRRS--AEKYIIQE------------R
| ... .|.|.||.| ||.         ....||.|...|.  |...    ..... |            |
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEER
Kinase 20748.AA RSK-Unclassified 336-385 38 2.8e-13 37.55 In-house 1-50 (283) Show / Hide 
Range on Protein: 336-385
Range on HMM: 1-50/283
Sequence Identity: 38% (19 aa)

FLLIRQLGTGGFGEVNLVQYMKNKQFYAIKIMRKDMIIRRSAEKYIIQER
|  .| .| | ||.| ||.  . .| ||.|.. |. .||.   ||.. |.
FIKHRLIGQGDFGKVYLVRKKDTQQIYAMKVLHKHKMIRHNKIKYVMTEQ
Kinase 20748.AA Akt 336-385 35 1.2e-12 36.69 In-house 1-51 (264) Show / Hide 
Range on Protein: 336-385
Range on HMM: 1-51/264
Sequence Identity: 35% (18 aa)

FLLIRQLGTGGFGEVNLVQYMKNKQFY-AIKIMRKDMIIRRSAEKYIIQER
| ... || | || | ||.  .....| |.|. .||.|| .   .....||
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTER
Kinase 20748.AA SGK 336-385 24 4.5e-12 33.1 In-house 1-75 (283) Show / Hide 
Range on Protein: 336-385
Range on HMM: 1-75/283
Sequence Identity: 24% (18 aa)

FLLIRQLGTGGFGEVNLVQYMKN------------------KQFYAIKIMRKDMII-------RRSAEKYIIQER
| ..  .| |.||.| .|.  .                   ..|||.|. .|. ||       ..  .|.|  ||
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAER
Kinase 20748.AA AktR 336-385 41 3e-11 39.88 In-house 1-51 (268) Show / Hide 
Range on Protein: 336-385
Range on HMM: 1-51/268
Sequence Identity: 41% (21 aa)

FLLIRQLGTGGFGEVNLVQYM-KNKQFYAIKIMRKDMIIRRSAEKYIIQER
| ... || |.||.| |||   .|...||.|. .|  ||.| .....|.||
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITER
Kinase 20748.AA PKC 336-373 42 1e-10 30.8 In-house 1-38 (262) Show / Hide 
Range on Protein: 336-373
Range on HMM: 1-38/262
Sequence Identity: 42% (16 aa)

FLLIRQLGTGGFGEVNLVQYMKNKQFYAIKIMRKDMII
| ... || | || | |.   .....||||...||.||
FNFLKVLGKGSFGKVMLAERKGTDEYYAIKVLKKDVII
Kinase 20748.AA MAST 336-375 27 4.4e-10 26.32 In-house 1-40 (337) Show / Hide 
Range on Protein: 336-375
Range on HMM: 1-40/337
Sequence Identity: 27% (11 aa)

FLLIRQLGTGGFGEVNLVQYMKNKQFYAIKIMRKDMIIRR
|  |. .. |..| | ||.  | ....|.|..... .|..
FEFIKCISKGAYGAVYLVKHKKTNDRFAMKVINCQDTIDK
Kinase 20748.AA PKA 336-375 40 3.4e-09 36.89 In-house 1-40 (263) Show / Hide 
Range on Protein: 336-375
Range on HMM: 1-40/263
Sequence Identity: 40% (16 aa)

FLLIRQLGTGGFGEVNLVQYMKNKQFYAIKIMRKDMIIRR
| .|. |||| || | |..  .....||.|...|. |.|.
FEIIQTLGTGSFGRVMLCRHKHSGNYYAMKMLKKQEIVRL
Kinase 20748.AA TyrKc 336-575 17 7.1e-09 -79.17 SMART 1-280 (280) Show / Hide 
Range on Protein: 336-575
Range on HMM: 1-280/280
Sequence Identity: 17% (54 aa)

FLLIRQLGTGGFGEVNLVQYMKNKQFYAIKIMRKDMIIRRSAEKYIIQERISISCI--QCQNI--YKGDSLEE---------------------------
  |...|| | |||| . ..    .  |.| ...|       .. ...|    . .  . .||    |  ...                           
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

DIAR-MYIAELVL-------AIEFLHNKGIIYRDLKPENVLIDIDGHIKLVDFGLVKTGMNR-----RKKTKSFC---GTPS-----YLSPEMIKQKGHN
.  .    ..|.          |.|| |..| |||   |.|.. ....|  |||| . . .      .|....     |. .      ..|| |. .  .
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

HAVDWYGVGILTYELL-YGENPFQG-----NDAKQVFNSVQNK-RLNKPSG--------LSQEGWDFIQKLMCKDPSKRLGTQSSDEVKNHPWFKNINWE
.. | .  |.. .|.. ||. |  |      ....|.. |..  |. .|           ..|  . ...    ||..|            | |..|   
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDR------------PTFSEI---

DVYQKKL
    ...
---HECF
Kinase 20748.AA RSK 339-385 31 4.6e-07 22.24 In-house 1-51 (278) Show / Hide 
Range on Protein: 339-385
Range on HMM: 1-51/278
Sequence Identity: 31% (16 aa)

IRQLGTGGFGEVNLVQYM---KNKQFYAIKIMRKDMIIRRSA-EKYIIQER
...||.||.|.| |..     ...| || |. .| .|..|    ..  .||
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTER
Kinase 20748.AA Pkinase 336-370 28 7e-06 21.85 Pfam 1-35 (293) Show / Hide 
Range on Protein: 336-370
Range on HMM: 1-35/293
Sequence Identity: 28% (10 aa)

FLLIRQLGTGGFGEVNLVQYMKNKQFYAIKIMRKD
. ..|..| |.||.| . .  .. . .|.||..|.
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR