Gene 24195 (Tetrahymena)
24195
Sequence
Protein domains of 24195.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 24195.AA | Ciliate-E2-Unclassified | 134-340 | 26 | 2.5e-66 | 226.69 | In-house | 69-352 (352) | Show / Hide |
Range on Protein: 134-340 Range on HMM: 69-352/352 Sequence Identity: 26% (76 aa) RILSG--LNHPNIIKNHGFYIDTTKKTCYIIMEKAEGLTLSQCTVDS-----------------YIFTNYKMS-----QITKSLLQTLNYLHLNH-ICHR .|. ||||.... . ||....|...||.||..||..|.|. .. ||| .... .... .|| |.||| .. |.|| KIMQQILLNHPHPFIVKMFYCFQDKQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHR DITPNNIFYNQDLG--NCLVNG---------------------------KMYSQNGNIVYM----APEVLQGKVYD----KSVDVWGVGITILTTFLGYN ||.|.||..... . .. . . .|... |.. || |||||||. || ...|.|..|. . || DIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYY PFVDENQNIQQQTTSG-----YELSSIRNICEKELDFTEYK------QIDPSAINLLQ----QMLQKDPEKRITVEKALKHEWL || |.|....||.... |.. ..||..|...| ... ...|.|..... .||.|.|.|||| |..|.| |. PFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF |
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| Kinase | 24195.AA | Ciliate-E2 | 94-340 | 20 | 9e-63 | 214.3 | In-house | 1-365 (365) | Show / Hide |
Range on Protein: 94-340 Range on HMM: 1-365/365 Sequence Identity: 20% (80 aa) YEILEKIGEVNFF-----RNILT--------IHSTI----------QQFLYELKGG--------SSVVKQWR-------------ILSGLNHPNIIKNHG |....|||. || ..... | .. ....|..| ... ...| ||. |||||||| . YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYE FYIDTTKKTCYIIMEKAEGLTLSQCTVDSYI-----------FTNYKMSQITKSLLQ---------------TLNYLHLNH-ICHRDITPNNIFYNQDLG ..........|..|| ..| .| .. .... || .....|.| .|| |.||| .. |.|||| |.||.. CFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----- NCLVNGKMYSQN-------------------------------------------GNIVYMAPEVLQ---------GKVYDKSVDVWGVGITILTTFLGY . . .|.. |. |||||.|. .| ||...|.| .|... |. -IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGK NPFVDENQNIQQQTTSGYELSSIRNICEKELDFT----------------EYKQIDPSAINLLQQ----MLQKDPEKRIT-VEKALKHEWL || ...|.....|| ..|........|... ||||||||||| |..|.|.|. PPF-------------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF |
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| Kinase | 24195.AA | CAMK | 134-340 | 20 | 1e-45 | 144.85 | In-house | 86-425 (425) | Show / Hide |
Range on Protein: 134-340
Range on HMM: 86-425/425
Sequence Identity: 20% (71 aa)
RILSG----LNHPNIIKNHGFYID-----------TTKK-------TCYIIM---EKAEGL----TLSQCTVDS---------------YIFTNYKMSQI
. |.| |.|||||| . .| | | .| .|..| | ..| | . |. || ...
KKLQGIGNKLDHPNIIKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRY
TKSLLQTLNYLHLNHICHRDITPNNIFYNQD--------------------------LGNCLVNGK-------------------------MYSQNGNIV
. ... ..|.| ..|.|||. | || .... . | . |. |. . |
FRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPE
YMA-PEVLQGKV--------------YDKSVDVWGVGITILTTFLGYNPFVDENQNIQQQTTSGYELSSIR----------NICEKELDFTEYKQIDPS-
||| ||||.|| |....|.| .|. . || || ....| . . | . .|.. . || ... ..|
YMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICE-D---E----WIGMNDYELFEKIMKGKYDFPPPYFSPISC
---------------------AINLLQQMLQKDPEKRITVEKALKHEWL
...|...|||.|||||.|.| .|.|.|.
NYGPEWWDDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
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| Kinase | 24195.AA | Pkinase | 134-340 | 25 | 1.5e-36 | 130.3 | Pfam | 52-293 (293) | Show / Hide |
Range on Protein: 134-340 Range on HMM: 52-293/293 Sequence Identity: 25% (65 aa) RILSGLNHPNIIKNHGFYIDTTKKTCYIIMEKAEGL----TLSQCTVDS-------YIFTNYKMSQITKSLLQTLNYLHLNHICHRDITPNNIFYNQDLG .|. ||||||.. .... | |. .|..|| .|| |. .. | | |. . . .|. |.|.| . |.|||. | ||..... QIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLF--DYISTWRHGCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGH N----------------CLVNGKMYSQNGNIVYMAPEVLQ-GKVYDKSVDVWGVGITILTTFLGYNPFVDE----NQNIQQQTTSGYELSSIRNICEKEL . |. |.. | . ||||||.. |. |...||.|..|... ..|. || .. | . |.| |..| ...| IDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQM--------ICRIMGPPL DFTEYKQID-------------------PSAINLLQQMLQKDPEKRITVEKALKHEWL .| ... .. .... .. .|.|||.||.| | .|.|.|. HFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF |
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| Kinase | 24195.AA | S_TKc | 94-340 | 24 | 3.4e-35 | 124.15 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 94-340
Range on HMM: 1-231/231
Sequence Identity: 24% (69 aa)
YEILEKIGE-----VNFFRNIL--------TIHSTIQQFLYELKGGSSVVKQWRILSGLNHPNIIKNHGFYIDTTKKTCYIIMEKAEG--LTLSQCTVDS
||||.|||. | |.. |. .. . .||. .||||.| .... | . |..|| ..| .| . ..
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKR
YI------FTNYKMSQITKSLLQTLNYLHLNHICHRDITPNNIFYNQ-----DLGNCLVNGKMYSQNGNIVYMAPEVLQGKVYDK-SVDVWGVGITILTT
|. ... ... |.|.| ..|.|||. | ||. .. | | . . ... | ||||||| |.| ..|.| .|...
GRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDEHIKICDFGLARQL---TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEM
FLGYNPFVDENQNIQQQTTSGYELSSIRNICEKELDFTEYKQIDPSAINLLQQMLQKDPEKRITVEKALK-------HEWL
. || || . | . .. .|.|.......||||||||.|. .||. |.|.
LCGYPPFP-QMQMMFKKIG------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
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| Kinase | 24195.AA | MSK | 140-340 | 26 | 2.2e-29 | 96.47 | In-house | 59-277 (277) | Show / Hide |
Range on Protein: 140-340 Range on HMM: 59-277/277 Sequence Identity: 26% (59 aa) NHPNIIKNHGFYIDTTKKTCYIIMEKAEGLTLSQCTVDSYIFTNYKMSQITKSLLQTLNYLHLNHICHRDITPNNIFYNQD------------LGNCLVN .|||| . |. . | .. |..|| . | | . |. ..| .| . ..| .| |||. | || . . . ... QHPNIVNLHYAFQDQCH--TYLVMEYCNGGELFTHIRKREHFDESECRMIMRELVMAVDHMHQKGIIHRDLKPENILFDDEEDNGHVKLIDFGFARLFPQ G---KMYSQNGNIVYMAPEVLQ----GKV-YDKSVDVWGVGITILTTFLGYNPFVDENQNIQQQTTSGYELSSIRNICEKELDFT--EYKQIDPSAINLL . .|.| . . |||||.|. ... ||...|.|..|.. | | || . . .| . .| |.. . ||..| |. . ....| | .|. DEEWRMKSPCFTLHYMAPEMLRRGYAQDGGYDEACDWWSLGVILYTMLTGQVPFQQNEDDRQHSCNSHHEIM--KRICKGEFSFPGMAWQNMSPDAKDLI QQMLQKDPEKRITVEKALKHEWL |..|.|||.|| ... ..|||. QWLLTKDPKKRLGMNDLRAHEWK |
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| Kinase | 24195.AA | CAMKL | 197-340 | 27 | 2.6e-28 | 87.36 | In-house | 140-297 (297) | Show / Hide |
Range on Protein: 197-340 Range on HMM: 140-297/297 Sequence Identity: 27% (46 aa) LNYLHLNHICHRDITPNNIFYNQDL-----------GNCLV------NGKMYSQNGNIVYMAPEVLQG--KVYD-KSVDVWGVGITILTTFLGYNPFVDE .||.| ..|.|||| | || .. .| . |. . | |||||..|| | || . ||.| |.. . || || |. VNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDD NQNIQQQTTSGYELSSIRNICEKELDFTEY--KQIDPSAINLLQQMLQKDPEKRITVEKALKHEWL . | . | . .... . . .... ....|...|||..||||.|.. ..|.|. TYN-K----QGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM |
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| Kinase | 24195.AA | RSK | 187-340 | 24 | 2.8e-24 | 85.84 | In-house | 107-278 (278) | Show / Hide |
Range on Protein: 187-340 Range on HMM: 107-278/278 Sequence Identity: 24% (44 aa) SQITKSLLQTLNYLHLNHICHRDITPNNIFYNQ----------DLGNCLV-----NGKMYSQNGNIVYMAPEVLQ---GKV-YDKSVDVWGVGITILTTF ... . .. .|| .| |||. | || |.. | | | |..... . | |||||.| ... .||..|.| |. . . . CFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGVLMYEML LGYNPFVDENQNIQQQTTSGYELSSIRNICEKE--LDFTEYKQIDPSAINLLQQMLQKDPEKRIT-----VEKALKHEWL |. || .|.| .... ...|.... |.. . . . . | .|...||..||.||.. .| ..|.|. TGCPPFQGPNDNNRKEI--------MKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF |
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| Kinase | 24195.AA | STE | 134-264 | 27 | 6.3e-20 | 67.14 | In-house | 80-259 (359) | Show / Hide |
Range on Protein: 134-264 Range on HMM: 80-259/359 Sequence Identity: 27% (50 aa) RILSGLN--HPNIIKNHGFYIDT---TKK--TCYIIMEKAEGLTLSQCTVDSY--------------IFTNYKMSQITKSLLQT-LNYLHLNHICHRDIT .|.. .| ||||.| .| |.. .| ...|.|| .| .|.. | | . |....|. |.||| .|| |||| KIMKKCNHMHPNIVKYYGCYFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIK PNNIFYNQDLGN-----CLVN------------------GKMYSQNGNIVYMAPEVLQG------KVYDKSVDVWGVGITIL | ||. | . .|.. .| .. | .|||||.|. | || ..|.| .|.||. PANILL-VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTII |
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| Kinase | 24195.AA | Ciliate-E2a | 301-340 | 36 | 1.7e-18 | 51.11 | In-house | 235-275 (275) | Show / Hide |
Range on Protein: 301-340 Range on HMM: 235-275/275 Sequence Identity: 36% (15 aa) LDFTE-YKQIDPSAINLLQQMLQKDPEKRITVEKALKHEWL .. .| ..... ....|...||.|||.|||| . ||.| | FNCPECWEKCSKECKDLMKKMLEKDPKKRITAQQALNHPWF |
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| Kinase | 24195.AA | Ciliate-E2a | 135-218 | 35 | 1.2e-16 | 45.53 | In-house | 52-136 (275) | Show / Hide |
Range on Protein: 135-218 Range on HMM: 52-136/275 Sequence Identity: 35% (31 aa) ILSGLNHPNIIKNHGFYIDTTKKTCYIIMEKAEGLTLSQCTVDSY-IFTN-YKMSQITKSLL-QTLNYLHLNHICHRDITPNNIFYN |.. |.|||||| ...|.| ... |..|| || .| . . . .|.. .....| . || | |.|.| ..| |||. | ||... IMRQLDHPNIIKLYEVYED--ENNYYLVMEYCEGGELYDKIKQCKRFFEEIQEICDIMQQLLWQGLHYMHQRNIMHRDLKPENILFK |
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| Kinase | 24195.AA | CAMK-Tt | 229-340 | 27 | 3.7e-15 | 48.42 | In-house | 293-396 (396) | Show / Hide |
Range on Protein: 229-340 Range on HMM: 293-396/396 Sequence Identity: 27% (32 aa) KMYSQNGNIVYMAPEVLQGKV-YDKSVDVWGVGITILTTFLGYNPFVDENQNIQQQTTSGYELSSIRNICEKELDFT--EYKQIDPSAINLLQQMLQKDP || | . . |||. .. || ..|.| |. | |. || | | |. ||. . | ..| | | . |. .| KMWTYTGTVAFSAPEIFNEDCCYDETIDMWSAGCILYTMLCGQEPFQAE-----------YVHDLIKKICQADYNFPSHVWQHISEEAKDLIKKCLTINP EKRITVEKALKHEWL |.||. ...|.| |. EQRIKPDQMLQHPWI |
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| Kinase | 24195.AA | CAMK-Unique | 235-340 | 20 | 1.4e-14 | 44.36 | In-house | 237-363 (363) | Show / Hide |
Range on Protein: 235-340 Range on HMM: 237-363/363 Sequence Identity: 20% (26 aa) GNIVYMAP--------------EVLQGKVYDKSV----DVWGVGITILTTFLGYNPFVDENQNIQQQTTSGYELSSIRNICEK-ELDFTEYKQ---IDPS | . |||| ||. . || . | | | . . . |. || |. . ....|. ... ..| . | .. GTPCYMAPEIVFCKNYQEMTRDEVINMQCYDQQCSPASDIWSLGVIMYYMLCGCPPFDCECEDRDYENHDKEIFECIC-KGDYCNFDWKMWHGPDYISQE AINLLQQMLQKDPEKRITVEKALKHEWL |...... .. || .|.. . .|.|.|. AKDFVKCCMTVDPDHRWSAKELLEHQWI |
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| Kinase | 24195.AA | CAMK-Unique | 134-218 | 20 | 9.6e-12 | 34.84 | In-house | 68-191 (363) | Show / Hide |
Range on Protein: 134-218 Range on HMM: 68-191/363 Sequence Identity: 20% (26 aa) RILSGLNHPNIIKNHGF----YIDTTK-------------KTCYIIMEKAEGLTLSQCTVD--------------------SYIFTN--YKMSQITKSLL .|. ..|||||| .. . | .. .||.|| ..| .|.. .. .|. . ..| .|| QIWKMVDHPNIIKLYDWNNPIFCDRKYPLCDLIIKTPRALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLL QTLNYLHLNHICHRDITPNNIFYN . ..|.| . | |||. . || .. SAVAYMHSQDIVHRDLKLENIMVC |
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| Kinase | 24195.AA | TyrKc | 94-340 | 18 | 1.2e-08 | -82.78 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 94-340 Range on HMM: 1-280/280 Sequence Identity: 18% (54 aa) YEILEKIGEVNF---FRNILTIHSTIQQFLYE-----LKGGSSVVKQW----RILSGL--NHPNIIKNHGFYIDTTK-----KTCYIIMEKAEGLTLSQC . ..|.|| .| .. ... .. || .. .. ||.. | .||||.. .| .. . .|.|| ... | . ITLGKKLGEGAFGEVYKGTWK---------IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY TVDSYI-FTNYKMSQITKSLLQTLNYLHLNHICHRDITPNNIFYNQDL------------GNCL----VNGKMYSQ----NGN----IVYMAPEVLQGKV .. ... .. .. . .||| ... |||. |. .. .. . .....|.. .|. | ||||... .. LRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK YDKSVDVWGVGIT---ILTTFLGYNPFVD------ENQNIQQQTTSGYELSSIRNICEKELDFTEYKQIDPSAINLLQQMLQKDPEKRITVEKALKHEWL . ||| |.. |.| .| | . .|| . .. .|| . |.. .. | . .. .| . |||.| | . || . FTTKSDVWSFGVCMWEIFT--YGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY--PMSF---VCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF |
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| Kinase | 24195.AA | STE | 311-340 | 37 | 2.4e-08 | 25.68 | In-house | 328-359 (359) | Show / Hide |
Range on Protein: 311-340 Range on HMM: 328-359/359 Sequence Identity: 37% (12 aa) PSAINLLQQMLQKDPEKRITVEKALK--HEWL |. .. ... |||||.|| |... || |... PEFKDFINKCLQKDPNKRPTASQLLKSEHPFI |
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| Kinase | 24195.AA | CAMK-Tt | 187-220 | 50 | 6.2e-08 | 22.95 | In-house | 227-260 (396) | Show / Hide |
Range on Protein: 187-220 Range on HMM: 227-260/396 Sequence Identity: 50% (17 aa) SQITKSLLQTLNYLHLNHICHRDITPNNIFYNQD |.| | .|. .|.| | .|||| |||| | | SKIFKQILDAIKYMHENYVCHRDLKPNNILCNED |
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| Kinase | 24195.AA | CAMK-Tt | 129-164 | 47 | 6.3e-07 | 19.39 | In-house | 82-117 (396) | Show / Hide |
Range on Protein: 129-164 Range on HMM: 82-117/396 Sequence Identity: 47% (17 aa) VVKQWRILSGLNHPNIIKNHGFYIDTTKKTCYIIME |.. ... ||||||.| ||| || | ||| VIREFKNIRELNHPNIVKVYELYIDETKGRIYTIME |
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| Kinase | 24195.AA | CAMKL | 134-171 | 31 | 6.6e-07 | 17.91 | In-house | 64-110 (297) | Show / Hide |
Range on Protein: 134-171 Range on HMM: 64-110/297 Sequence Identity: 31% (15 aa) RILSGLN---HPNIIKNHGFYIDTTK----KTCYIIMEKAEGLT--L .|.. || |||||| . . . .. | .|..|| ..| | QIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVMEYCSGGEMDL |
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| Kinase | 24195.AA | Ciliate-E2a | 239-261 | 37 | 1.1e-05 | 12.71 | In-house | 176-204 (275) | Show / Hide |
Range on Protein: 239-261 Range on HMM: 176-204/275 Sequence Identity: 37% (11 aa) YMA------PEVLQGKVYDKSVDVWGVGI |.| .|||..| ||...|.| .|. YVAPEVLNNKEVLKHKQYDTKCDMWSCGV |
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| Kinase | 24195.AA | STE | 94-106 | 46 | 0.275458 | 0.45 | In-house | 1-13 (359) | Show / Hide |
Range on Protein: 94-106 Range on HMM: 1-13/359 Sequence Identity: 46% (6 aa) YEILEKIGEVNFF .|..||||. .|. WEGIEKIGKGAFG |
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| Kinase | 24195.AA | Ciliate-E2-Unclassified | 94-102 | 44 | 0.29482 | 0.14 | In-house | 1-9 (352) | Show / Hide |
Range on Protein: 94-102 Range on HMM: 1-9/352 Sequence Identity: 44% (4 aa) YEILEKIGE |.|...||. YKIIKQIGQ |
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