Gene 26140 (Tetrahymena)

26140

Species: Tetrahymena
Alias: 26140, 569, 35.m00201, TTHERM_00343600, 3695.m00034, PreTt26140
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: ULK
Subfamily: ULK

Sequence

Name Sequence Type Origin Length Description Download
26140.AA Protein None 1067 None Fasta, JSON
26140.kin_dom Protein Kinase Domain None 257 None Fasta, JSON
26140.NA RNA None 3204 None Fasta, JSON

Protein domain

Protein domains of 26140.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 26140.AA Ciliate-E2 26-282 26 3.6e-88 299.23 In-house 1-365 (365) Show / Hide 
Range on Protein: 26-282
Range on HMM: 1-365/365
Sequence Identity: 26% (102 aa)

YKVVKQIGQGTFGTVYKCSTYKGYE------------------------YAIKQI--NNIKMKKMMNNELD-------------ALKSVNSKYVVRYYEV
||..|.||||.||.||||. .|  .                        ||.|..  |.|...|......               |...|.......||.
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FYD-KQDHPCIVLELCEGGTLSDLMK---KFHNHCIP------EKIALNLFVQILV---------------GFKEIQKAN-LIHRDVKLQNILLKNDQPK
|.. ....  .|.|.|.||.| |..|   |..||.|.      || ..... |||                ..... . |  |||| |..|||.    .|
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----IK

IADFGLVTQQQKD---------------------------------KVDGFAGTPMYMAPEILDGKN---------YDQQVDIWSLGVLLYAMMFNDFPI
|.|||| .....|                                  .. ..|||.||||||| ||.         || ..|||||||.|| |.|. .| 
IIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF

CEQTTYMQLERIKMVCTPEFNFEKAKKS---------KYQNIRQETVELLQK----MLNIDPSKRIT-LNQLLELPII
         ..... |  .|....  |          ..... ||.  |..|    ||. ||.||||  .|.|. |..
---------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 26140.AA Ciliate-E2-Unclassified 26-282 28 1.2e-84 287.57 In-house 1-352 (352) Show / Hide 
Range on Protein: 26-282
Range on HMM: 1-352/352
Sequence Identity: 28% (103 aa)

YKVVKQIGQGTFGTVYKCSTYKGYEYA-----IKQINNIKMKKMMN-----NELDALKSVNSKYVVR------------------YYEVFYD-KQDHPCI
||..|||||| ||.||||   | . ..     .|.|...|.|..||     ||...... .. |..|                  ....... ......|
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKK-YHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYI

VLELCEGGTLSDLMKKFHN---------------HCIPEKIAL-----NLFVQILVGF-KEIQKANLIHRDVKLQNILLKND----QPKIADFGLVTQQQ
|.|.||||.|.. .||...               ....|. |.     ..| |||.|. . ..| | |||| |..|||..|.    ..||.|||.  ..|
VMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQ

-----------------KDKVDGFAGTPMYM----APEILDGKNYDQQ----VDIWSLGVLLYAMMFNDFPI-CEQTTY--------------MQLERIK
                 ... . |.|||.||    |||.|.|.|||..    .|||||||.||.|.|. .|  ... .               .||....
QNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNI

MVC-TPEFNFEK----AKKSKYQNIRQETVELLQKMLNIDPSKRITLNQLLELPII
. . .  ..|..     . |. .    .  .||||||. .|.||||..|.|. |..
KQKNIQFPKFPWQQIPKHWSPEAKDFIN--DLLQKMLKKNPNKRITFEQILNHPWF
Kinase 26140.AA S_TKc 26-282 32 2.9e-80 273.9 SMART 1-231 (231) Show / Hide 
Range on Protein: 26-282
Range on HMM: 1-231/231
Sequence Identity: 32% (88 aa)

YKVVKQIGQGTFGTVYKCSTYK-GYEYAIKQINNIKMKKMMNNELDALKSVNSKYVVRYYEVFYDKQDHPCIVLELCEG--GTLSDLMKKFHNHC----I
|.....||.|.||.||||   | | ..|||.|.     ... .|.. ||. . ...|..|.||.|  || ..|.|.|.|  |.| |..||   |     .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----EHIRREIQILKK-HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

PEKIALNLFVQILVGFKEIQKANLIHRDVKLQNILLKNDQPKIADFGLVTQQQKDKVDGFAGTPMYMAPEILDGKNYDQ-QVDIWSLGVLLYAMMFNDFP
||  |  .. ||. . . . . . ||||.| .|||| . . ||.|||| .|      . | ||| |||||.|    |.   .|.||.|..|| |.    |
PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-HIKICDFGLARQL-----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPP

ICEQTTYMQLERIKMVCTPEFNFEKAKKSKYQNIRQETVELLQKMLNIDPSKRITLNQLLE-------LPII
 .  . .| ...|.                     .|  ....|.|. ||.||.|  ..|.        | .
FP--QMQMMFKKIG--------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 26140.AA ULK 26-282 28 6e-73 248.67 In-house 1-324 (324) Show / Hide 
Range on Protein: 26-282
Range on HMM: 1-324/324
Sequence Identity: 28% (92 aa)

YKVVKQIGQGTFG-TVYKC--STYK--GYEYAIKQINNIKMKK------------MMNNELDALKSVN---SKY--VVRYYEVFYDKQD-HPCIVLELCE
| . ...|.|.|| .|||      .  .  .|.|.|.  ||.|            . .||   .|  .   ...  .|..|..|..... . .|..|.|.
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

GGTLSDLMKKFHNH-------CIPEKIALNLFVQILVGFKEIQKANLIHRDVKLQNILLKNDQPK-------------IADFGLVTQ-----QQKDKVDG
||.|....|| ...        ..|..|.. | ||. ||||..| | |||| |.||||..|.|||             |||||.  .     .....   
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQT

FA------GTPMYMAPEILD----GKNYD-QQVDIWSLGVLLYAMMFNDFP----ICEQTTYMQLERIKM-------VCTPEFNFEKAKKSKYQNIRQET
.       |||.||||.||     .|.|.   .||||||...| | ..  |    ...|  | . . |..       ...  ..| | .  | ..| .|.
CVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSWFNDQYLY-IQKLINNGKEQQIYIKNQPIQFPKPP--KDPKISPEC

VELLQKMLNIDPSKRITLNQLLELPII
 .|...|| .|...||.  .... |..
KDLIRRMLQYDEKDRISWEEIFNHPWF
Kinase 26140.AA ULK 26-282 28 8.1e-71 241.58 In-house 1-329 (329) Show / Hide 
Range on Protein: 26-282
Range on HMM: 1-329/329
Sequence Identity: 28% (94 aa)

YKVVKQIGQGTFGTVYKC--STYK---GYEYAIKQINNIKMKK------------MMNNELDALKSVN----SKY----VVRYYEVFYDKQD-HPCIVLE
| . ...|.|.||.|||      |   .  .|.|.|   ||..            . .|| . .|  .    .|.    .|..|..|..... .  |..|
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

LCEGGTLSDLMKKFHNHC--------IPEKIALNLFVQILVGFKEIQKANLIHRDVKLQNILLKNDQPK-------------IADFGLVTQQQKD-----
.|.||.|....|| ...         ..|..|.. | ||| ||||..| | |||| |.||||..|.|||             |||||.  . ..|     
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

KVDGFA------GTPMYMAPEILD----GKNYD-QQVDIWSLGVLLYAMMFNDFP----ICEQT--TYMQLERIK-----MVCTPEFNFEKAKKSKYQNI
    .       |||.||||.||     .|.|.   .||||||...| | ..  |    ...|    ...| ...     ....  ..|.|.   . ..|
MMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAWFNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDG--NDPQI

RQETVELLQKMLNIDPSKRITLNQLLELPII
 .|. .|...|| .|...||.  .|.. |..
SPECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase 26140.AA Pkinase 26-282 30 1.6e-68 238.78 Pfam 1-293 (293) Show / Hide 
Range on Protein: 26-282
Range on HMM: 1-293/293
Sequence Identity: 30% (90 aa)

YKVVKQIGQGTFGTVYKCSTYKGYE-YAIKQINNIKMKKMMN------NELDALKSVNSKYVVRYYEVFYDKQDHPCIVLELCEGG----TLSDLMK-KF
|.....||.|.||.||||   .  . .|.|.|.  . |. ..      .|.  .|..|....||.|..|.|  ||...|.|.||||     |.|... . 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-KDHIYMVMEYCEGGLYVMDLFDYISTWR

HNHCI--PEKIALNLFVQILVGFKEIQKANLIHRDVKLQNILLK-NDQP----KIADFGLVTQ--QQKDKVDGFAGTPMYMAPEILD-GKNYDQQVDIWS
|. |.  .|. . . . ||| | . . . . ||||.|..|||.. |...    ||.||||  |    ..  ..|.||| |||||..  |. |.. ||.||
HG-CFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNSMTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

LGVLLYAMMFNDFPICEQ----TTYMQLERIKMVCTPEFNFEKAKKSKYQ--------------NIRQETVELLQKMLNIDPSKRITLNQLLELPII
.|..|| |..  .| ...    . . |...|...  |.. |.  ...                 |. .|  ... ..|. ||.||.|  |.|. | .
CGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 26140.AA CAMK 31-282 20 1.9e-63 203.03 In-house 1-425 (425) Show / Hide 
Range on Protein: 31-282
Range on HMM: 1-425/425
Sequence Identity: 20% (86 aa)

QIGQGTFGTVYKCSTY-KG------------YEYAIKQIN------------------------------NIKMKKMMNNELDALKS-------VNSKYV
..|.|.||.|..|     .             ..||| |.                              . |..|.. .|.. .|.       .. . .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VRYYE-------------------VFYDKQDHPCIVL---ELCEGG----TLSDLMKKFHN-------------HCIPEKIALNLFVQILVGFKEIQKAN
.. ||                   || .|..| ..|.   |.|.||     | |  ..  .             ....|. |  .| ||. . . . . |
IKLYEVYEDPHYFKNTNDYETSKQVF-TKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

LIHRDVKLQNILLKND------------------QPKIADFGLVTQQQK-------------------------DKVDGFAGTPMYMA-PEILDGKN---
 .||| |. |||| ..                  . ||.|||. .. ..                         .|   | ||| ||| ||.| ||    
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

-----------YDQQVDIWSLGVLLYAMMFNDFPICEQT------------TYMQLERIKMVCTPEFNFEKAKKSK----------------YQNIRQET
           |....|.||.||.||.|    .|  . .            .. .| .  | .  .|  .. ...                   .. || 
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHH-FVSQEC

VELLQKMLNIDPSKRITLNQLLELPII
  |..|||. ||.||.|. | |. | .
KDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 26140.AA CAMKL 26-278 28 1.4e-59 188.73 In-house 1-293 (297) Show / Hide 
Range on Protein: 26-278
Range on HMM: 1-293/297
Sequence Identity: 28% (85 aa)

YKVVKQIGQGTFGTVYKCST-YK-GYEYAIKQIN--NIK-MKKMMNN--------------ELDALKSVN---SKYVVRYYEVFYDKQ-----DHPCIVL
|...|..|.|.||.|  .      | ..||| |.   |.   .|..|              |   .|..|    . ... |||.....     .. ..|.
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

ELCEGGT--LSDLMKKFHNHC--IPEKIALNLFVQILVGFKEIQKANLIHRDVKLQNILLKNDQ---PKIADFGLVTQQQ------KDKVDGFAGTPMYM
|.|.||   | |  .|  ..   .||. |  .| ||. . . . . . .||| |. |||| ...    ||.|||. ....       .| . | |.| ||
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYM

APEILDG--KNYD-QQVDIWSLGVLLYAMMFNDFPICEQTTYMQLERIKMVCTPEFNFEKAKKSKYQN----IRQETVELLQKMLNIDPSKRITLNQLLE
||||. |  | || ..|||||.||.||||..  .|  ..|   .    .. .. ..  .. .  .| .    .  .   |..|||. .|.||.|. |...
APEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYN-K---QGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMN
Kinase 26140.AA STE 26-282 24 7.8e-59 201.78 In-house 1-359 (359) Show / Hide 
Range on Protein: 26-282
Range on HMM: 1-359/359
Sequence Identity: 24% (91 aa)

YKVVKQIGQGTFGTVYKCSTYK----------------GYEYAIKQIN-------------------NIKMKKMMNNELDALKSVN--SKYVVRYYEVFY
.. ...||.|.||||||.   |                |  .||||.|                   |.. ..   .|.. .|  |  ....|.||  ..
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

DK------QDHPCIVLELCEGGTLSDLMK-KF-----HN------HCIPEKIALNLFVQILVG-FKEIQKANLIHRDVKLQNILLKNDQPKIADFGLVTQ
..       |. .|..|...||.|.|..| |.     .|      |..||..     .||| |  . . . . ||||.| .||||     |..|||. .|
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL----VKLCDFGVCGQ

QQKD------------------KVDGFAGTPMYMAPEILDG------KNYDQQVDIWSLGVLLYAMMFNDFPICE-QTTYMQLERIKM------------
 ...                  | . |.||| .||||....      | || ..|||||| ..  |     | .. . ... .. ...            
LTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCI

--VCTPEFNF-----EKAKKSKYQ--------NIRQETVELLQKMLNIDPSKRITLNQLLE--LPII
     | .       |.  .| |.        .  .|  . ..| |..||.|| | .|||.   | |
VNGPPPPLPDHLSQNEM--IS-YGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 26140.AA NEK 26-209 33 1.6e-52 180.82 In-house 1-215 (286) Show / Hide 
Range on Protein: 26-209
Range on HMM: 1-215/286
Sequence Identity: 33% (72 aa)

YKVVKQIGQGTFGTVYKCSTYK-GYE-----YAIKQINNIKM----KKMMN-NELDALKSVNSKYVVRYYEVFYDKQ-DHPCIVLELCE-GGTLSDL---
|...|.|||| ||.|||.   . | .     |..|.||  .|    |..   ||   ||. .. ..|.||. |...| .. ||| | || ||.|...   
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKS

MKKFH--NHCIPEKIALNLFVQILVGFKEIQKA-----NLIHRDVKLQNILLKNDQ-----PKIADFGLVTQQQKD--KVDG-FAGTPMYMAPEILDGKN
 ||    .. ..|.. .. |.|.. . |.. .      . .||| | ||| | ..       || |||.  .....  .    . ||| ||.||.. .| 
IKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDMAYTTQVGTPYYMSPEVCQNKP

YDQQVDIWSLGVLLY
|.. .||||||..||
YNNKSDIWSLGCVLY
Kinase 26140.AA Ciliate-E2c 26-282 29 1.9e-50 173.95 In-house 1-310 (310) Show / Hide 
Range on Protein: 26-282
Range on HMM: 1-310/310
Sequence Identity: 29% (95 aa)

YKVVKQIGQGTFGTVYKCSTYKGYEYAIKQ--------------------INNIKMKK-MMNNELDALKSVNSKYVVRYYEVFYDKQDHPCIVLELCEGG
.   .  |.|..|.||| . ...| . |..                    ..|.| .|    .|.. .|. |.......|. .  .. |  ...| |.||
IDRNNILGSGSYGKVYKAYYCEDYQNEINNVQMNQLFAIKMTCLKNKDIHMINEKDIKESIIREINMMKHMNHPHIIKFYDAKQTDK-HIYLIMEYCNGG

TLSDLMKKFHNHCIPEKIALNLFVQILVGFKEIQKA-NLIHRDVKLQNILLKNDQPKIADFGLVTQQQKDKVD---GF---AGTPMYMAPEILDGKNYDQ
|| .. .  |.  . ||  | .| ||. .||.. |  | .|||.|  |||..|...||||||.  . | | .    ||   .||||||||.|| ||||. 
TLEQYIY--HKPKPNEKQCLYYFSQIISAFKYLHKEKNIFHRDIKPENILIHNGMIKIADFGFSKICQDDNIQNTQGFNTCCGTPMYMAPQILEGKNYYT

-QVDIWSLGVLLYAMMFNDFPIC-----------------EQTTYMQLERIKMV-------------CTPEFNFEKAKKSKY--QNIRQETVELLQKMLN
   |||||||.|| | .  .|                    |.|  .|. .                 |....|     ..   ||| ||. .|..||| 
EKSDIWSLGVTLYYMLCYKLPWESIQEYDSHNICNHCYPWWQNTMKHLKQHIWEYFNPQASAAGVSPITQNIHF-----PENYEQNISQEVKQLIHKMLQ

IDPSKRITLNQLLELPII
 |..|||  ...  ...|
VDEEKRIDWDEIFNHECI
Kinase 26140.AA MARK 26-211 34 1.9e-50 163.22 In-house 1-199 (262) Show / Hide 
Range on Protein: 26-211
Range on HMM: 1-199/262
Sequence Identity: 34% (68 aa)

YKVVKQIGQGTFGTVYK-CSTYKGYEYAIKQIN----NI-KMKKMMNNELDALKSVNSKYVVRYYEVFY-DKQDH-PCIVLELCEGGTLSDLMKKFHNHC
||..|.||.|....|.. |..  | ..||| ..    |  . .|.   |.. .|... ........|.  |   |  ....|...|| | | .|.. |..
YKMLKTIGHGSYAKVKLACHKHTGRKVAIKIYEKFKLNDPQWMKNVMREIEIMKKLDHPNIIKLFHVIEQDTEQHQIYLIMEYASGGELYDYIKAHPNGR

IPEKIALNLFVQILVGFKEIQKANLIHRDVKLQNILLKND---QPKIADFGLVTQQQKDK-VDGFAGTPMYMAPEILDGKNYD-QQVDIWSLGVLLYAM
..|. |  .| ||. . .   . | .||| |..|||.  .   . ||.|||. .. . ..  . | ||| ||||||. .| || . ||||||||.||.|
LHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDFGFSICIPPGQKLNTFCGTPPYMAPEIFLKKPYDGPKVDIWSLGVVLYFM
Kinase 26140.AA TyrKc 26-280 21 6.4e-15 18.5 SMART 1-280 (280) Show / Hide 
Range on Protein: 26-280
Range on HMM: 1-280/280
Sequence Identity: 21% (62 aa)

YKVVKQIGQGTFGTVYKCSTYKGYEYAIKQINNIKMKKMMNNELDALKSV--NSKYVVRYYEVFYDKQ------DHPCIVLELCEGGTLSDLMKKFHNHC
 .  |..| | ||.|||.  .  .. |.| ... . .... .|.  ....  . . .|| | |  ...      . ..||.|....| | |  .| ... 
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK-

IPEKIALNLFVQILVGFKEIQKANLIHRDVKLQNILLKNDQ-PKIADFGLVTQQQKD-------KVDGFA---GTPM-----YMAPEILDGKNYDQQVDI
.. |  |.  .||  |   . . |.||||    |.|.....  ||.||||      |       ..   .   |. .      |||| .. . .  . |.
LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDV

WSLGVLL----------YAMM----FNDFPICEQTTYM-QLERIKMVCTPEFNFEKAKKSKYQNIRQETVELLQKMLNIDPSKRITLNQLLELP
|| ||..          |  |     ... . |.      ... . .. |   |            .|  .. ..  . ||..| | ... |. 
WSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY-P-MSF--------VCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase 26140.AA Pkinase_Tyr 26-112 25 9.8e-13 43.76 Pfam 1-100 (270) Show / Hide 
Range on Protein: 26-112
Range on HMM: 1-100/270
Sequence Identity: 25% (25 aa)

YKVVKQIGQGTFGTVYKCSTY-----KGYEYAIKQINNIKMKKM-----MNNELDALKSV-NSKYVVRYYEVFYDKQDH--PCIVLELCEGGTLSDLMKK
 .  |..|.| ||.|||.  .     .... |.| ...  |..      . .|.  .|.  . . .||.| | .|....  ..||.|....| | |  .|
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK
Kinase 26140.AA NEK 253-282 43 5.6e-08 24.59 In-house 257-286 (286) Show / Hide 
Range on Protein: 253-282
Range on HMM: 257-286/286
Sequence Identity: 43% (13 aa)

QETVELLQKMLNIDPSKRITLNQLLELPII
|.  .|...||. ||..| . ||.||.|.|
QDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase 26140.AA MARK 258-282 28 0.002466 6.95 In-house 238-262 (262) Show / Hide 
Range on Protein: 258-282
Range on HMM: 238-262/262
Sequence Identity: 28% (7 aa)

LLQKMLNIDPSKRITLNQLLELPII
|.|..|...|..|.|. .... | .
LIQRLLTVNPEERPTIEEIMKHPWM
Kinase 26140.AA Pkinase_Tyr 185-209 50 0.00463 10.99 Pfam 181-205 (270) Show / Hide 
Range on Protein: 185-209
Range on HMM: 181-205/270
Sequence Identity: 50% (13 aa)

MAPE-ILDGKNYDQQVDIWSLGVLLY
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MAPECINYGK-FTTKSDVWSFGVLMW
Kinase 26140.AA Pkinase_Tyr 141-166 51 0.038097 7.89 Pfam 131-157 (270) Show / Hide 
Range on Protein: 141-166
Range on HMM: 131-157/270
Sequence Identity: 51% (14 aa)

NLIHRDVKLQNILLK-NDQPKIADFGL
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NCIHRDLAARNCLVTENNVVKICDFGL