Gene 7517 (Tetrahymena)
7517
Group:
Other
Family:
Ciliate-E3
Sequence
Protein domains of 7517.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 7517.AA | Ciliate-E3 | 21-108 | 56 | 9.4e-56 | 172.36 | In-house | 1-88 (202) | Show / Hide |
Range on Protein: 21-108 Range on HMM: 1-88/202 Sequence Identity: 56% (50 aa) YTVQVLLGKGSFGRVYKAHDFQNNRIVAIKALIPDYQRDEGVLLNLVKSFQEIQNASSINSEYVVKIYESYLDKDLFVIFIVQEFCSR ||||..||.|.|||||||.|||||..|||||.|...|..|||.....|..||.||...|||..|||....|.|.....||||||.||. YTVQQILGCGQFGRVYKAFDFQNNQDVAIKAIICQNQQNEGVGEQFQKTQQEFQNCQQINSQNVVKCHDQYYDQQNKMIFIVQEYCSN |
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| Kinase | 7517.AA | Ciliate-E3 | 109-178 | 60 | 1.3e-48 | 149.79 | In-house | 128-202 (202) | Show / Hide |
Range on Protein: 109-178 Range on HMM: 128-202/202 Sequence Identity: 60% (45 aa) DIKPENILVDERE---IIKIGDFGEAKQLKKDK--NQTQATGASPIFAAPEVNDKSLISFESDYYSVGAVICIIS ||||.|||||... ||||.||||.|||.|.| ..||..|..|..||||.||...||.||||||||||.| . DIKPDNILVDKNNNQLIIKICDFGESKQLRKNKGHTHTQYQGWTPFYAAPEQNDQQQISKESDYYSVGAVFCQLC |
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| Kinase | 7517.AA | S_TKc | 21-228 | 21 | 2.9e-15 | 46.84 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 21-228
Range on HMM: 1-231/231
Sequence Identity: 21% (57 aa)
YTVQVLLGKGSFGRVYKAHDFQNNRIVAIKALIPDYQRDEGVLLNLVKSFQEIQNASSINSEYVVKIYESYLDKDLFVIFIVQEFCSR------------
|.. ..|||.||.|||... .|||||| . . .||| .. . ...||.|... | ...| |.|.
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKR
-----------------------------------DIKPENILVDEREIIKIGDFGEAKQLKKDKNQTQATGASPIFAAPEVNDKSLISF-ESDYYSVGA
|.||||||.|| |||.||| |.|| .| . |||| .. ..| .|.|
GRHGLRFPFPEHARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGC
VICIISG----LQYKDLQMIQVGVLPDVRNLNNKNLLLLAFNMMSISPNKRAPCSQVLQ----------I
.. . . . .|... . . .. . ... |.|| . ..|| .
ILYEMLCGYPPFP-QMQMMFKKIG--------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
|
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| Kinase | 7517.AA | Ciliate-E2-Unclassified | 108-171 | 28 | 2.9e-15 | 49.41 | In-house | 168-257 (352) | Show / Hide |
Range on Protein: 108-171 Range on HMM: 168-257/352 Sequence Identity: 28% (26 aa) RDIKPENILVDERE---IIKIGDFGEAKQLKKDKNQ---------------TQATGASPIFA----APEVNDKSLIS----FESDYYSVG |||||||||.|. ||| ||| .|..... |. .. . .|.. |||| .. . ...|..|.| RDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLG |
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| Kinase | 7517.AA | CAMK | 108-171 | 21 | 1.6e-14 | 42.48 | In-house | 203-321 (425) | Show / Hide |
Range on Protein: 108-171
Range on HMM: 203-321/425
Sequence Identity: 21% (25 aa)
RDIKPENILVDERE-----------------IIKIGDFGEAKQLKKDKNQTQA-----------------------TGASPIFAA-PEVNDKSL------
||.||||||.|... ||| ||| |.......|... .| ..| ||| ..
RDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQN
--------ISFESDYYSVG
.....| |.|
ATDEEKPYYGPKCDMWSCG
|
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| Kinase | 7517.AA | Ciliate-E1 | 108-168 | 34 | 6.5e-14 | 42.07 | In-house | 133-202 (202) | Show / Hide |
Range on Protein: 108-168 Range on HMM: 133-202/202 Sequence Identity: 34% (24 aa) RDIKPENILVDEREIIKIGDFGEAKQLK-KDKNQTQATGASPIFAAPEV--------NDKSLISFESDYY |||||.|||.. .. .. ||| .|.|| ....|.| .| .. ||. |.. |...|| | RDIKPQNILINNQGNYVYCDFGISKFLKNNQNQQCQYKGYTHYYYPPEQYNCPEQEHNKNQKINYKSDIY |
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| Kinase | 7517.AA | Pkinase | 21-106 | 30 | 1.2e-13 | 49.32 | Pfam | 1-82 (293) | Show / Hide |
Range on Protein: 21-106 Range on HMM: 1-82/293 Sequence Identity: 30% (27 aa) YTVQVLLGKGSFGRVYKAHDFQNNRIVAIKALIPDYQRDEGV--LLNLVKSFQEIQNASSINSEYVVKIYESYLDKDLFVIFIVQEFC |.. .|.||||.|||.|. ...|||.| . . .... ...| .||| ..|....|..|... ||| .|.|.| YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL----SEIQIMKRLNHPNIVRLYDWFEDKDHIY--MVMEYC |
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| Kinase | 7517.AA | Ciliate-E2 | 108-174 | 23 | 1.5e-13 | 42.9 | In-house | 185-286 (365) | Show / Hide |
Range on Protein: 108-174 Range on HMM: 185-286/365 Sequence Identity: 23% (25 aa) RDIKPENILVDEREIIKIGDFGEAKQLKKD----------KNQTQATGA----------------------SPIFAAPEVNDKSL---------ISFESD |||||||||. ||| ||| .|....| |. .. . .| . |||. . ....| RDIKPENILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCD YYSVGAVI ..|.| .. IWSLGVIL |
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| Kinase | 7517.AA | Ciliate-A1 | 108-232 | 21 | 1.8e-13 | 42.16 | In-house | 125-301 (301) | Show / Hide |
Range on Protein: 108-232
Range on HMM: 125-301/301
Sequence Identity: 21% (38 aa)
RDIKPENILVDEREIIKIGDFGEAKQLKKDK------------------NQTQATGASPIFAAPEV---------NDKSLISFESDYYSVGAVICIISG-
||.||.|||. . . .|| |.| ||| . .| | . . .|| . |. || ||.| .|| .
RDLKPQNILIHFDDKWKICDLGMSKQLEQNQDCCDDVNGCSFSKQVNKHYHTCKKGGNLYYMSPEQYQMHYRDQMFIENKIYKQSDMYSLGCIICFLCYK
----------LQYKDLQMIQ--------------VGVLPDVRNLNNKNLLLLAFNMMSISPNKRAPCSQVLQILEQT
. ..|. .. | . . . | |.| ||. || | .|... | .
EDSHPYVGTIVNIFGNNMQNDQSIHFCKSVNAIKKIIFPPMQEPRFEELQNLIFKMMQYEPNNRCSLQQCIDCLYIF
|
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| Kinase | 7517.AA | Ciliate-A1 | 21-106 | 29 | 2.5e-13 | 41.66 | In-house | 1-83 (301) | Show / Hide |
Range on Protein: 21-106 Range on HMM: 1-83/301 Sequence Identity: 29% (26 aa) YTVQVLLGKGSFGRVYKAHDFQNNR-IVAIKALIPDYQRDEGVLLNLVKSFQEIQNASSINSEYVVKIYESYLDKDL--FVIFIVQEFC |.| |..||||| | .| | ||.. ...| .| .. || . ||. .|.| |. ... . ||. |.| YHVVQLIDKGSFGVVMRAYDIQNQKKYLCCKIIICTNFE------QYKNNIQEYRKCKQINHNNVIKNYQQLYYNTNNKECMFIIMEYC |
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| Kinase | 7517.AA | STE | 21-107 | 18 | 5.5e-13 | 42.3 | In-house | 1-120 (359) | Show / Hide |
Range on Protein: 21-107 Range on HMM: 1-120/359 Sequence Identity: 18% (22 aa) YTVQVLLGKGSFGRVYKAHDF------QNNRI---------VAIKALIPDYQRD-----EGVLLN--------LVKSFQEIQNASSIN--SEYVVKIYES .. . .|||.|| |||| . ..... .||| . . .. | . . . .||. . | ....|| | . WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQEN-Q-ELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGC YLDKD-----LFVIFIVQEFCS |.... ..|. |... YFKEGHNHKNDDELWICMEYMD |
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| Kinase | 7517.AA | Pkinase | 108-174 | 37 | 1.2e-12 | 45.77 | Pfam | 132-202 (293) | Show / Hide |
Range on Protein: 108-174 Range on HMM: 132-202/293 Sequence Identity: 37% (28 aa) RDIKPENILVDEREII----KIGDFGEAKQLKKDKNQTQATG--ASPIFAAPEVND-KSLISFESDYYSVGAVI ||.||||||.|.. | ||.||| |||.. |.. .|. .| ..|||| . .. ..| .|.| .. RDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCIL |
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| Kinase | 7517.AA | Ciliate-E2 | 21-107 | 19 | 4.9e-12 | 37.59 | In-house | 1-117 (365) | Show / Hide |
Range on Protein: 21-107 Range on HMM: 1-117/365 Sequence Identity: 19% (23 aa) YTVQVLLGKGSFGRVYKAHDFQNNRIVAIKALIPDYQRDEG-------VLLNLVKSF--QEIQNASSINSEY-----------------------VVKIY | .. ..|.|.|| |||. . .... .||| ..| . . . .|.. ..|.. ....... ..|.| YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQ-QRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMY ESYLDKDLFVIFIVQEFCS |.. .|| |..| |.|. ECFQEKDDNNIYLVMEYCQ |
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| Kinase | 7517.AA | ULK | 108-174 | 23 | 6.9e-12 | 37.87 | In-house | 154-246 (329) | Show / Hide |
Range on Protein: 108-174 Range on HMM: 154-246/329 Sequence Identity: 23% (22 aa) RDIKPENILVDERE------------IIKIGDFGEAKQLKKD---KNQTQATG------ASPIFAAPEVND----KSLIS-FESDYYSVGAVI |||||.|||... ..||.||| ||.. .| ....... .|.. ||.. . . ...| .|.| .. RDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIF |
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| Kinase | 7517.AA | ULK | 21-106 | 25 | 2.6e-11 | 35.85 | In-house | 1-102 (329) | Show / Hide |
Range on Protein: 21-106 Range on HMM: 1-102/329 Sequence Identity: 25% (27 aa) YTVQVLLGKGSFGRVYKAHDFQN----NRIVAIKA-----LIPDYQRDE-GVLLNLVKSFQEIQNASSIN----SEY----VVKIYESYLDKDLFVIFIV | . |||||||.|||. . .. | .||.| .. ... .| ....|.| .||.. .. ... .|| |. . ... |.|. YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLK--NEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYII QEFC .|.| MEYC |
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| Kinase | 7517.AA | ULK | 108-174 | 24 | 3.4e-11 | 36.04 | In-house | 150-242 (324) | Show / Hide |
Range on Protein: 108-174 Range on HMM: 150-242/324 Sequence Identity: 24% (23 aa) RDIKPENILVDERE------------IIKIGDFGEAKQLKKDKNQTQAT----------GASPIFAAPEVND----KSLIS-FESDYYSVGAVI |||||.|||. . ..||.||| ||.. .. . | . | .|.. ||.. . . ...| .|.| .. RDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQTCVNEKRIKG-TPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIF |
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| Kinase | 7517.AA | CDK-Unclassified | 104-131 | 39 | 3.7e-11 | 32.83 | In-house | 141-173 (324) | Show / Hide |
Range on Protein: 104-131 Range on HMM: 141-173/324 Sequence Identity: 39% (13 aa) EFCSRDIKPENILVDERE-----IIKIGDFGEA .. .|||||.||... . ..||.||| | KIMHRDIKPQNIMITNNNSTVSPMLKIADFGQA |
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| Kinase | 7517.AA | ULK | 21-106 | 27 | 2.9e-10 | 32.66 | In-house | 1-99 (324) | Show / Hide |
Range on Protein: 21-106 Range on HMM: 1-99/324 Sequence Identity: 27% (28 aa) YTVQVLLGKGSFG-RVYKAHDFQN---NRIVAIKALI-----PDYQRDE-GVLLNLVKSFQEIQNASSIN---SEY--VVKIYESYLDKDLFVIFIVQEF | . ||||||| |||. . .. | .||.| .....| ....| | .|||. .. ... .|| |. . ... |.|..|. YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLK--NEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEY C | C |
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| Kinase | 7517.AA | CDK-Unclassified | 21-53 | 48 | 1.3e-08 | 24.31 | In-house | 1-33 (324) | Show / Hide |
Range on Protein: 21-53 Range on HMM: 1-33/324 Sequence Identity: 48% (16 aa) YTVQVLLGKGSFGRVYKAHDFQNNRIVAIKALI | | .|.| || |.|| ||| ...|||| .. YRMQCKYGEGTFGCVCKAIDFQTQKHVAIKKIM |
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| Kinase | 7517.AA | STE | 108-175 | 25 | 2.9e-08 | 25.42 | In-house | 176-259 (359) | Show / Hide |
Range on Protein: 108-175 Range on HMM: 176-259/359 Sequence Identity: 25% (23 aa) RDIKPENILVDEREIIKIGDFGEAKQLKK-----------------DKNQTQATGASPIFAAPEVNDK------SLISFESDYYSVGAVIC ||||| |||. .|. ||| ..|| . ... . .| . |||| .. . .. .| .|.| .|. RDIKPANILL-----VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP--WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTII |
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| Kinase | 7517.AA | Ciliate-E2-Unclassified | 21-106 | 19 | 3.8e-08 | 24.36 | In-house | 1-103 (352) | Show / Hide |
Range on Protein: 21-106 Range on HMM: 1-103/352 Sequence Identity: 19% (20 aa) YTVQVLLGKGSFGRVYKAHDFQNNRIV-----AIKALIPDYQRDEGVLLNLVKSFQEIQNA--------------SSINSEYVVKIYESYLDKDLFVIFI |... .|.|.|| |||. . ... . ..|. | . . . . ... . .|..| . .|. ..... | ..| . |.| YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYI VQEFC | |.| VMEYC |
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| Kinase | 7517.AA | Ciliate-E1 | 27-107 | 23 | 8.6e-08 | 21.93 | In-house | 1-80 (202) | Show / Hide |
Range on Protein: 27-107 Range on HMM: 1-80/202 Sequence Identity: 23% (19 aa) LGKGSFGRVYKAHDFQNN-RIVAIKALIPDYQRDEGVLLNLVKSFQEIQNASSINSEYVVKIYESYLDKDLFVIFIVQEFCS .|.|||..|.|| .|| . ||.| ..... .... | ..|.. .. .|...|.. . .... .. |..|.|. IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK--FKKECYIIQIIDYIKIDQNYICIIIFECCC |
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| Kinase | 7517.AA | CAMK | 26-107 | 16 | 1.1e-07 | 20.06 | In-house | 1-143 (425) | Show / Hide |
Range on Protein: 26-107 Range on HMM: 1-143/425 Sequence Identity: 16% (24 aa) LLGKGSFGRVYKAHDFQNN------------RIVAIKA-----LIPDY---------QRDEGVLL--------NLVKSFQEIQNASS-------INSEYV ||.|||| |... . ... . |||| | . ..... .. . ..||. .. .. . . TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI VKIYESYLD-------KDLF-----------VIFIVQ---EFCS .|.|| | | | . ...| |.|| IKLYEVYEDPHYFKNTND-YETSKQVFTKDKHMYMVMEIMEYCS |
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| Kinase | 7517.AA | TyrKc | 21-229 | 14 | 2e-07 | -102.63 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 21-229
Range on HMM: 1-280/280
Sequence Identity: 14% (43 aa)
YTVQVLLGKGSFGRVYKAHDFQNNRIVAIKALIPDYQRDEGVLLNLVKSF-QEIQNASSI--NSEYVVKIYESYLDK-----DLFVIFIVQEFCS-----
| || | ||.|||.. . ||.| | .| .. | .|.. ... . . .|..| ... ..|| |...
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA----------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLK
------------------------------------RDIKPENILVDEREIIKIGDFGEAKQLKKD-------KNQT-----QATGASPIF-AAPEVNDK
||. |.||.|. ..||.||| .. .. | . . .. . || |||. ..
DYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINY
S-----------------LISFESDYYSV-----GAVICIISGLQYKDLQMIQVGVLPDVRNL----NNKNLLLLAFNMMSISPNKRAPCSQVLQIL
. . .. |. . .| .. . .. .. . . . . |..| |.. ...
GKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY---P-MSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
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| Kinase | 7517.AA | Pkinase_Tyr | 21-52 | 36 | 0.001307 | 12.85 | Pfam | 1-36 (270) | Show / Hide |
Range on Protein: 21-52 Range on HMM: 1-36/270 Sequence Identity: 36% (13 aa) YTVQVLLGKGSFGRVYKAHDF----QNNRIVAIKAL | ||.|.||.|||.. . ... ||.| | ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML |
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| Kinase | 7517.AA | Pkinase_Tyr | 114-150 | 35 | 0.004989 | 10.88 | Pfam | 141-179 (270) | Show / Hide |
Range on Protein: 114-150 Range on HMM: 141-179/270 Sequence Identity: 35% (14 aa) NILVDEREIIKIGDFGEAKQL-KKDKN-QTQATGASPIF |.||.| ..||.||| |. . ..| ... | ||. NCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIK |
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| Kinase | 7517.AA | CDK-Unclassified | 209-231 | 30 | 0.010135 | 4.62 | In-house | 302-324 (324) | Show / Hide |
Range on Protein: 209-231 Range on HMM: 302-324/324 Sequence Identity: 30% (7 aa) FNMMSISPNKRAPCSQVLQILEQ |.| . .|..| |...|| .. FQMVMYQPYNRWKCMEILQHPWF |
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