Gene 5505 (Tetrahymena)

5505

Species: Tetrahymena
Alias: 3708.m00125, PreTt05505, TTHERM_00440500, 49.m00277, 5505, 433
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-E8

Sequence

Name Sequence Type Origin Length Description Download
5505.AA Protein None 723 None Fasta, JSON
5505.kin_dom Protein Kinase Domain None 101 None Fasta, JSON
5505.NA RNA None 2172 None Fasta, JSON

Protein domain

Protein domains of 5505.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 5505.AA Ciliate-E8 294-398 69 2e-87 273.04 In-house 29-138 (138) Show / Hide 
Range on Protein: 294-398
Range on HMM: 29-138/138
Sequence Identity: 69% (76 aa)

KFKQLNEACIQMLLCHPNIQNIEEVFAVTNNEIVIVQKMQGENLNKLLINKKID-----QEKAMGYIQQIMKAFCYLHSLNIIHSDFKLENVVTVLDDDT
||  |||.|||||.||.|||||..|....||.||||||||||||.|.|..||||     |.|.||||||||.||||||..||||.||||.|......|||
KFDILNEICIQMLVCHRNIQNIYDVYQNENNKIVIVQKMQGENLRKYLKFKKIDGSYICQNKRMGYIQQIMDAFCYLHNNNIIHCDFKLNNILVQRNDDT

KIKIIDFGFS
||||||||||
KIKIIDFGFS
Kinase 5505.AA CAMK 298-411 18 1.4e-18 55.87 In-house 79-281 (425) Show / Hide 
Range on Protein: 298-411
Range on HMM: 79-281/425
Sequence Identity: 18% (38 aa)

LNEACIQML-------LCHPNIQNIEEVFA------------VTNN-------EIVIV----QKMQGE----NLNKLLINK----------------KID
..| .| ..       | |||| .. ||.               ..       ....|      ..|      |   .. .                ...
RREIEIMKKLQGIGNKLDHPNIIKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFT

QEKAMGYIQQIMKAFCYLHSLNIIHSDFKLENVVTVLDDD---------------TKIKIIDFGFSQIKIFNK-------------------------FF
 . |  |..||  |  |.||.||.| | |.||.  . ..|                .||||||||..... ..                         . 
EREARRYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMK

TPLG
|. |
TFCG
Kinase 5505.AA Ciliate-E2 283-433 21 3.1e-18 59.18 In-house 58-283 (365) Show / Hide 
Range on Protein: 283-433
Range on HMM: 58-283/365
Sequence Identity: 21% (51 aa)

NELFQQTTELQKFKQLNEAC--------IQMLLCHPNIQNIEEVFA--VTNNEIVIVQKMQGENLNKLLINK------------KIDQEKAMGYIQQIMK
|...|.  |.. ....|.          |. .| |||| .. |.|    .||   .    || .| ....|.            ... ...  ...|| .
NQIEQIKQEIHIMREINC-FYKKINEKNILEQLNHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQ

---------------AFCYLHSLN-IIHSDFKLENVVTVLDDDTKIKIIDFGFSQIKIFN----------KFFTPLG-----------------------
               |. |||| | ||| | |.||..        |||||||.|..   .          | ..  .                       
GFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTIC

YTKGYEPI----EEK---------YTFESDIFSIG
.| || .      .|         |....||.|.|
GTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLG
Kinase 5505.AA CAMKL 292-398 26 2.7e-15 45.13 In-house 33-176 (297) Show / Hide 
Range on Protein: 292-398
Range on HMM: 33-176/297
Sequence Identity: 26% (39 aa)

LQKFKQLN---------------------EACIQMLLC---HPNIQNIEEVF------AVTNNEIVIVQKMQGEN---LNKLLINK-----KIDQEKAMG
. |.|  |                     |..|...|    ||||  . ||.        | ..|..|    .     |   ....     ... . |  
IDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIET-KKIYLVMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARR

YIQQIMKAFCYLHSLNIIHSDFKLENVVTVLDDDTKIKIIDFGFS
| .||. |  |.||..|.| | |.||.    ... .|||||||||
YFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFS
Kinase 5505.AA HUNK 300-398 33 1.1e-14 43.17 In-house 50-162 (433) Show / Hide 
Range on Protein: 300-398
Range on HMM: 50-162/433
Sequence Identity: 33% (38 aa)

EACIQMLLCHPNIQNIEEVFAVTNNEIVIVQKMQGENLNKLLINKK---IDQEKAMGYIQQIMKAFCYLHSLNIIHSDFKLEN------VVTVLDDDTKI
|| |. .. ||||    ||    ||   .     | .| ...  ||    .   |  || |.  |   .| . ..|.| | ||      .   |||| .|
EAQIMQMMRHPNIVRLYEVMETDNNYYLVMEYCPGGDLMHKVCEKKGGRLEEGVARRYIRQLVSAVHHMHHHGVVHRDLKIENLETYLSLSLLLDDDHNI

K-----IIDFGFS
|     ||||| |
KNYVAFIIDFGLS
Kinase 5505.AA AMPK 343-400 36 2.9e-14 38.83 In-house 94-149 (254) Show / Hide 
Range on Protein: 343-400
Range on HMM: 94-149/254
Sequence Identity: 36% (21 aa)

NKKIDQEKAMGYIQQIMKAFCYLHSLNIIHSDFKLENVVTVLDDDTKIKIIDFGFSQI
..... . |  ..|||  .  |.| ..| | | |.||.   ||.. .||| ||| | .
HGRLQEREACRFFQQIISGVEYCHRHMIVHRDLKPENL--LLDHNKNIKIVDFGLSNM
Kinase 5505.AA Ciliate-E2a 333-433 26 6.2e-14 37.42 In-house 82-203 (275) Show / Hide 
Range on Protein: 333-433
Range on HMM: 82-203/275
Sequence Identity: 26% (32 aa)

QGENLNKLLINKK-IDQE--KAMGYIQQIM-KAFCYLHSLNIIHSDFKLENVVTV-LDDD----TKIKIIDFGFSQIK---IFNKFFTPLGYTKGYEP--
.|  | . ....| ...|  ... ..||.  ... |.|..||.| | |.||.    .. .    ..|||||||...     . .. |.  | | || .  
EGGELYDKIKQCKRFFEEIQEICDIMQQLLWQGLHYMHQRNIMHRDLKPENILFKNCSKNSIQNSDIKIIDFGLATFIDKDEKKYMFQKCG-TPGYVAPE

----IEE----KYTFESDIFSIG
     |.    .|.   |..|.|
VLNNKEVLKHKQYDTKCDMWSCG
Kinase 5505.AA Ciliate-E2-Unclassified 309-433 23 6.4e-14 44.68 In-house 80-257 (352) Show / Hide 
Range on Protein: 309-433
Range on HMM: 80-257/352
Sequence Identity: 23% (43 aa)

HPNIQNIEEVFAVTNNEIVIVQKMQGENLNKLLIN------------------KKIDQEKAM-----GYIQQIMKAFCYLHSLN-IIHSDFKLENVVTVL
||.| . ...|  ..| . . ....| .| . . .                  |... ..|       |. || ....|||. | ||| | |.||.  ..
HPFIVKMFYCFQDKQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENI--LF

DDDT---KIKIIDFGFSQ-----------------IKIFNKFFTPLGYTKGYEP-------IEE-KYT----FESDIFSIG
|..    .|||||||.|                  | ..... |  | | .| |       ... .|     ...||.| |
DNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCG-TPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLG
Kinase 5505.AA NuaK 307-398 34 7.4e-14 32.28 In-house 56-146 (252) Show / Hide 
Range on Protein: 307-398
Range on HMM: 56-146/252
Sequence Identity: 34% (32 aa)

LCHPNIQNIEEVFAVTNNEIVIVQKMQGENLNKLLIN-KKIDQEKAMGYIQQIMKAFCYLHSLNIIHSDFKLENVVTVLDDDTKIKIIDFGFS
| ||.| .| |||   .  ...     | .|   . . |..  . |     ||  |  | |  .|.| | ||||.   ||..  .|| ||| |
LNHPHIIHIYEVFENKDKIVIVMEYASGGELYDYISECKSLPEREARHFFRQIVSAVHYCHKHRICHRDLKLENI--LLDQNCNAKIADFGLS
Kinase 5505.AA Aur 339-398 45 1.7e-13 31.48 In-house 91-149 (257) Show / Hide 
Range on Protein: 339-398
Range on HMM: 91-149/257
Sequence Identity: 45% (28 aa)

KLLINKKIDQEKAMGYIQQIMKAFCYLHSLNIIHSDFKLENVVTVLDD-DTKIKIIDFGFS
. ..||..| ..|  |..||  |. |.|| |||| | | ||.   ||. . .||| ||| |
QKQPNKRFDEQRAAKYMYQICNALDYCHSKNIIHRDIKPENI--LLDQCNGNIKICDFGWS
Kinase 5505.AA Pkinase 298-433 25 1.9e-12 45.07 Pfam 46-199 (293) Show / Hide 
Range on Protein: 298-433
Range on HMM: 46-199/293
Sequence Identity: 25% (40 aa)

LN--EACIQMLLCHPNIQNIEEVFAVTNNEIVIVQKMQGE----NLNKLLI---NKKI--DQEKAMGYIQQIMKAFCYLHSLNIIHSDFKLENVVTVLDD
..  |..|   |.||||  . ..|   ..  ..   ..|      |  ..    ....  . . .  |. || ..  |.|| .||| | |.||.   .|.
RRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENI--LIDN

DTKI----KIIDFGFSQI--KIFNKFFTPLGYTKGY---EPIE--EKYTFESDIFSIG
.  |    ||.|||..       |  .| .  | .|   | |   ..|. ..|..|.|
NGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCG
S_TKc 5505.AA S_TKc 278-534 16 9.6e-11 -19.37 SMART 1-231 (231) Show / Hide 
Range on Protein: 278-534
Range on HMM: 1-231/231
Sequence Identity: 16% (49 aa)

YHLFGN---------ELFQQTT--------ELQKFKQLNEACIQMLLCHPNIQNIEEVFAVTNNEIVIVQKMQG--ENLNKLLINKK-------IDQEKA
|..             . . .         ..   . ..|  | .   |||| .. .||   ..  ..   . |   .| ... ...       ..   |
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HA

MGYIQQIMKAFCYLHSLNIIHSDFKLENVVTVLDDDTKIKIIDFGFSQIKIFNKFFTPLGYTKGY---EPIEEKYTF-ESDIFSIGKSINKIYANNKFYK
  |..|| .|  |.||..||| | | ||.         |||.|||.. .       | .  |  |   | .  .|.. ..|. |.|  .   ..    . 
RFYMYQICCALEYCHSHGIIHRDLKPENILLDE----HIKICDFGLARQL------TTFCGTPWYMAPEVL--GYGKCKCDWWSCGCILYEMLCGYPPFP

SITFSVQQEPENKKTQFIEFQNKYKQFNIIAITQQILLLLDENITPQNQSFVECLADNDIKLFVLKLLSY--EKRISQNQNIE-----IQIQLL
                     . .. |..|                          . . | |. |.| .  |||..  .  .      . . .
---------------------QMQMMFKKIG-------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
TyrKc 5505.AA TyrKc 279-474 16 0.000488 -157.34 SMART 1-280 (280) Show / Hide 
Range on Protein: 279-474
Range on HMM: 1-280/280
Sequence Identity: 16% (46 aa)

HLFGNEL---------------------FQQTTELQKFKQLNEACIQMLL--CHPNIQNIEEVFAVT-------NNEIVIVQKMQGENLNKLLINKK--I
  .| .|                      .  . .. |  ..|| | . |   |||| ..  |               ...  | . .|.. | ...  .
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDA-REDF--MREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKL

DQEKAMGYIQQIMKAFCYLHSLNIIHSDFKLENVVTVLDDDTKIKIIDFGFSQIKIFNK--------FFTPLG--YTKGYEPI---------EEKYTFES
  ..   .  || .   |||| |.|| |    |.   ....  .|| ||| |  .| ..          .. .   .|.  ||         . |.|..|
CMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNC--LVGENHTVKISDFGLS-RDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKS

D----------IFSIGKSINKI-----YANNKFYKSITFSVQQEPENK--------KTQFI----------------EFQNKYKQF
|          ||. |..           |   .. .      ..            .. .                 |.. ...|
DVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF