Gene 5506 (Tetrahymena)
5506
Group:
Other
Family:
Ciliate-E8
Sequence
Protein domains of 5506.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 5506.AA | Ciliate-E8 | 363-450 | 42 | 3.9e-33 | 100.81 | In-house | 35-130 (138) | Show / Hide |
Range on Protein: 363-450 Range on HMM: 35-130/138 Sequence Identity: 42% (41 aa) EACLAQLIDSRYFLKISNAFINNENRVVNVYAKQGVDLSK-LNFKEID-----ELQKIFYIQQILDAISILHKNNIAHSDIKLNNILLKR--DLNI |.| |. | ..| . . | |..| | .|| | | | ||.|| ......|||||.||...||.|||.|.|.||||||..| |..| EICIQMLVCHRNIQNIYDVYQNENNKIVIVQKMQGENLRKYLKFKKIDGSYICQNKRMGYIQQIMDAFCYLHNNNIIHCDFKLNNILVQRNDDTKI |
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| Kinase | 5506.AA | Ciliate-E2-Unclassified | 400-478 | 27 | 3.8e-09 | 27.9 | In-house | 112-214 (352) | Show / Hide |
Range on Protein: 400-478 Range on HMM: 112-214/352 Sequence Identity: 27% (29 aa) LSKLNF---------------KEIDELQKI-----FYIQQILDAISILHKNN-IAHSDIKLNNILLKRDLN--ISSIILFTIFYKAQGFNQYSPEEQ--K ..| .. |...| | . ||. |||.... ||..| | | |||..|||.. . . || | |..| | .|.. ..| | IKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCD-TNQQQK QNQN .... MQIW |
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| S_TKc | 5506.AA | S_TKc | 322-536 | 15 | 1.9e-08 | -53.1 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 322-536 Range on HMM: 1-231/231 Sequence Identity: 15% (39 aa) FQELQEFQTTHFSKLQKGVYNG--EEYILKQSLDEQQDNKLKYEACLAQLIDSRYFLKISNAFINNENRVVNVYAKQGV---DLSKLNFKE--------I .. |.. |.| |.. .. ... .|. .... | . . . . |. .| . ... | . || .. | . YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----EHIRREIQILKK-HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF DELQKIFYIQQILDAISILHKNNIAHSDIKLNNILLKR-----DLNISSIILFTIFYKAQGFNQYSPEEQKQNQNCTL-RSDIYSL-------------- .| . ||..||..|. .|...| | |.| |||| . | .. .. . .|| . ..|..|. PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDEHIKICDFGLARQL----TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYEMLCGYPPF --AQLIKEILGNNYAPKQLQNLIKKMEEKKQFERCKIDYVQF---RFRLHAFI |.. ...| .... ..|.|. .| .| . . ..| .. PQMQMMFKKIG----SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | 5506.AA | NuaK | 410-450 | 41 | 3.1e-08 | 17.2 | In-house | 100-138 (252) | Show / Hide |
Range on Protein: 410-450 Range on HMM: 100-138/252 Sequence Identity: 41% (17 aa) ELQKIFYIQQILDAISILHKNNIAHSDIKLNNILLKRDLNI | ...| || |. ||..|.| | || |||| . |. EARHFF--RQIVSAVHYCHKHRICHRDLKLENILLDQNCNA |
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| Kinase | 5506.AA | Ciliate-E2 | 406-488 | 19 | 3.4e-08 | 24.22 | In-house | 140-282 (365) | Show / Hide |
Range on Protein: 406-488
Range on HMM: 140-282/365
Sequence Identity: 19% (29 aa)
KEIDELQKIFYIQQILD---------------AISILHKNN-IAHSDIKLNNILLKRDLNISSIILFTIFYKAQGFNQ----------------------
| ..| . .....|||. |. ||..| | | |||..|||. || | . |.. .||
KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPG
-------------------YSPEEQKQNQN---------CTLRSDIYSL
| . | .... . .||.||
YMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSL
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| Kinase | 5506.AA | C2 | 419-447 | 44 | 3.8e-08 | 24.06 | In-house | 130-158 (245) | Show / Hide |
Range on Protein: 419-447 Range on HMM: 130-158/245 Sequence Identity: 44% (13 aa) QILDAISILHKNNIAHSDIKLNNILLKRD |..|.|. ||...| | |||..|.|. | QMMDSINYLHRFDIVHRDIKPSNFLYQFD |
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| Kinase | 5506.AA | Ciliate-C1 | 415-450 | 41 | 5.7e-08 | 16.2 | In-house | 133-168 (328) | Show / Hide |
Range on Protein: 415-450 Range on HMM: 133-168/328 Sequence Identity: 41% (15 aa) FYIQQILDAISILHKNNIAHSDIKLNNILLKRDLNI .| | ..| .| |||.| |.|. |||| . |. YYFHQLINVIQYIHQNNICHRDLKPENILLDENFNL |
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| Kinase | 5506.AA | Trio | 414-448 | 34 | 7.5e-08 | 15.53 | In-house | 98-132 (258) | Show / Hide |
Range on Protein: 414-448 Range on HMM: 98-132/258 Sequence Identity: 34% (12 aa) IFYIQQILDAISILHKNNIAHSDIKLNNILLKRDL ..|..|.| |. || . |.| ||| |... .. KTYMWQMLEAVHYLHNCHILHLDIKPENMMMWHYN |
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| Kinase | 5506.AA | CAMK | 415-450 | 30 | 8e-08 | 20.53 | In-house | 183-235 (425) | Show / Hide |
Range on Protein: 415-450 Range on HMM: 183-235/425 Sequence Identity: 30% (16 aa) FYIQQILDAISILHKNNIAHSDIKLNNILLKRD-----------------LNI .|..||..|. .|..||.| |.|. |||| . || RYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNI |
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| Kinase | 5506.AA | CAMKL | 415-444 | 46 | 8.8e-08 | 20.75 | In-house | 131-160 (297) | Show / Hide |
Range on Protein: 415-444 Range on HMM: 131-160/297 Sequence Identity: 46% (14 aa) FYIQQILDAISILHKNNIAHSDIKLNNILL .| .||..|.. .|...|.| |||. |||| RYFRQIVSAVNYCHSHGIVHRDIKPENILL |
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| Kinase | 5506.AA | AMPK | 416-450 | 37 | 9.1e-08 | 19.2 | In-house | 105-139 (254) | Show / Hide |
Range on Protein: 416-450 Range on HMM: 105-139/254 Sequence Identity: 37% (13 aa) YIQQILDAISILHKNNIAHSDIKLNNILLKRDLNI ..|||. ... .|...|.| | |. |.|| . || FFQQIISGVEYCHRHMIVHRDLKPENLLLDHNKNI |
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| Kinase | 5506.AA | Pkinase | 406-454 | 29 | 3e-06 | 23.35 | Pfam | 101-151 (293) | Show / Hide |
Range on Protein: 406-454 Range on HMM: 101-151/293 Sequence Identity: 29% (15 aa) KEI--DELQKIFYIQQILDAISILHKNNIAHSDIKLNNILLKRDLNISSII . . .| . .||. ||| .. .|...| | |.|. |||.... .|.... GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACV |
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| Asp | 5506.AA | Asp | 757-789 | 45 | 2.138952 | 1.91 | Pfam | 1-35 (348) | Show / Hide |
Range on Protein: 757-789 Range on HMM: 1-35/348 Sequence Identity: 45% (16 aa) WYTGTISIGKGKKNLKVILSTGTSQLMIP--SKNC | |||||| .....||. || | | .| |..| QYYGTISIGTPPQKFTVIFDTGSSDLWVPDSSVYC |
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| Asp | 5506.AA | Asp | 886-919 | 36 | 3.6e-05 | 18.3 | Pfam | 145-180 (348) | Show / Hide |
Range on Protein: 886-919 Range on HMM: 145-180/348 Sequence Identity: 36% (14 aa) LYKKGLIKENMFSLYLGFKNDD----SQLTLGGIDPQK ... |||....||.||. .|| .....||.||.| MMSQGLIDQPAFSVYLN--RDDHAGGGEIIFGGVDPSK |
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| Asp | 5506.AA | Asp | 1300-1333 | 36 | 7.3e-05 | 17.23 | Pfam | 145-180 (348) | Show / Hide |
Range on Protein: 1300-1333 Range on HMM: 145-180/348 Sequence Identity: 36% (14 aa) LYKKGLIKEDMFSLYLGFKNDD----SQLTLGGIDPQK ... |||....||.||. .|| .....||.||.| MMSQGLIDQPAFSVYLN--RDDHAGGGEIIFGGVDPSK |
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