Gene 10831 (Tetrahymena)

10831

Species: Tetrahymena
Alias: 826, PreTt10831, 204.m00060, 10831, TTHERM_01030010
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: NEK

Sequence

Name Sequence Type Origin Length Description Download
10831.AA Protein None 549 None Fasta, JSON
10831.kin_dom Protein Kinase Domain None 258 None Fasta, JSON
10831.NA RNA None 1650 None Fasta, JSON

Protein domain

Protein domains of 10831.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 10831.AA NEK 11-268 44 5.2e-155 521.26 In-house 1-286 (286) Show / Hide 
Range on Protein: 11-268
Range on HMM: 1-286/286
Sequence Identity: 44% (127 aa)

FEILKRLGEGSFGSVYQVKRKSDEKI-----YAMKKVKMMSLSTKEKENAL-NEVRILASIKSDNIISYKEAFYDEKSSTLCIIMEFAT-KGDVLQQ---
.||.| .|.||||.|| |.||||.|.     |..||..|...| |||.||. ||||||...|..||..|...|..|....|||.||..  .||  |.   
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKS

ISEKKKKHSYFEENLIWKYAADMLLGLKSLHDM-----KILHRDLKGANVFIAEDGS----LKLGDLNVSKVQKRD--FAYT-QTGTPYYTSPEVWQNRP
| ..|.|. ||||. ||.. . |.|.|| .||.     ||||||.| .|.|.  ...    .|.||...|||....  .||| |.||||| ||||.||.|
IKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDMAYTTQVGTPYYMSPEVCQNKP

YDSKCDVWSLGCVLYEIVTL--EPPFKGT--SMEDLYKRVLRG-NFSPINLQR-YSSDLQKFIESCLKVEPKMRSSVESLLNHKCI
|..|.|.|||||||||..||  ..||...  .|. ||... .| ...||. .| ||.|||..|...|...|..| |....|.. .|
YNNKSDIWSLGCVLYEMCTLKPKHPFEAWDMNMPSLYMKIMKGPQYPPIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase 10831.AA S_TKc 11-268 28 1.8e-88 301.16 SMART 1-231 (231) Show / Hide 
Range on Protein: 11-268
Range on HMM: 1-231/231
Sequence Identity: 28% (76 aa)

FEILKRLGEGSFGSVYQVKRKSDEKIYAMKKVKMMSLSTKEKENALNEVRILASIKSDNIISYKEAFYDEKSSTLCIIMEFATK--GDVLQQISEKKK--
.|||. .|.|.||.||... |.. .|.|.|..|         |....|..|| . . .||. ....|.|   . |...||..    ||... | ....  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHG

KHSYFEENLIWKYAADMLLGLKSLHDMKILHRDLKGANVFIAEDGSLKLGDLNVSKVQKRDFAYTQTGTPYYTSPEVWQNRPYDS-KCDVWSLGCVLYEI
....| |  ...|.. ....|. .|...|.||||| .|... |   .|..|  ....      .|. |||.| .|||    .|.  |||.||.||.||| 
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEM

VTLEPPFKGTSMEDLYKRVLRGNFSPINLQRYSSDLQKFIESCLKVEPKMRSSVESLLN-------HKCI
.. .|||    |. ..|...            |...  ||. ||...|. | ..  .|.       |  .
LCGYPPFP--QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 10831.AA NEK1 11-268 37 3.4e-85 289.33 In-house 1-276 (276) Show / Hide 
Range on Protein: 11-268
Range on HMM: 1-276/276
Sequence Identity: 37% (105 aa)

FEILKRLGEGSFGSVYQVKRKSDEKIYAMKKVKMMSLSTKEKENALNEVRILASIKSDNIISYKEAFYDEKSSTLCIIMEFATKGDVLQQISEKKKKHSY
....| .|||||| .. ||.|.| . |..|  . |  . ||.|...||| |||  |  ||..|||.|  . .  | |.||..  ||  | | ..| |   
YHYIKQIGEGSFGKAWLVKHKEDGQHYVIKEINVMKMQEKEREESMNEVAILAKMKHPNIVKYKESFEENGCGILYIVMEYCDGGDLMQKINRQKRKGKL

FEENLIWKYAADMLLGLKSLHDMKILHRDLKGANVFIA--EDG---------------SLKLGDLNVSKV--QKRDFAYTQTGTPYYTSPEVWQNRPYDS
| |  |  .   . |.|.  || ||||||.|  |.|    ..|                .||||  ....     ..| |  ||||| ||| .||.||. 
FSEDQIMHWFCQICLALNHIHDRKILHRDIKSQNIFLTISKNGMGSGSGSGSSNDSIPLVKLGDFGIARMLNHTMEYACTCIGTPYYLSPEICQNKPYNN

KCDVWSLGCVLYEIVTLEPPFKGTSMEDLYKRVLRGNFSPINLQRYSSDLQKFIESCLKVEPKMRSSVESLLNHKCI
| |.||||||||| .||  || . ..  |  ....| ..||  ..|| .||  . . .|. |. | || ..|    |
KSDIWSLGCVLYELCTLKHPFEANNWKNLVLKICQGTYPPIP-PHYSYELQSLVSQMFKRNPRHRPSVNQILERPFI
Kinase 10831.AA Pkinase 11-268 26 5.1e-78 270.31 Pfam 1-293 (293) Show / Hide 
Range on Protein: 11-268
Range on HMM: 1-293/293
Sequence Identity: 26% (80 aa)

FEILKRLGEGSFGSVYQVKRKSDEKIYAMKKVKMMSLSTKEKENALN--EVRILASIKSDNIISYKEAFYDEKSSTLCIIMEFATKG----DVLQQIS-E
..|....|.||||.||. ..|...||.|.|..|  . . ........  |..|.......||. ....|.|  .. ....||.. .|    |    || .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYISTW

KKKKHSYFEENLIWKYAADMLLGLKSLHDMKILHRDLKGANVFIAEDGSL----KLGDLNVSK---VQKRDFAYTQTGTPYYTSPEVWQ-NRPYDSKCDV
.... . |.|. . .|.  .| ||. .|.|.|.||||| .|..| ..| .    |..|  ..|     .   ..| .|||.| .||| . ...|..|.|.
RHGCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDM

WSLGCVLYEIVTLEPPFKGT------SMEDLYKRVLRGNFSPINLQRYS-------------------SDLQKFIESCLKVEPKMRSSVESLLNHKCI
||.||.||| .. .|||.|       ..  ...|.... ..    . .|                   .....||..||.. || | . | .|.|. .
WSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 10831.AA STE 11-268 21 8e-71 241.61 In-house 1-359 (359) Show / Hide 
Range on Protein: 11-268
Range on HMM: 1-359/359
Sequence Identity: 21% (79 aa)

FEILKRLGEGSFGSVYQVKRKS---------------DEKIYAMKKVKMMSLST---------------KEKENALNEVRILASIK--SDNIISYKEAFY
.|.....|.|.||.||. ...                  .|.|.|.... . ..               .|... |.|..|.   .  ..||. |  ...
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

DE---KSS--TLCIIMEFATKGDVLQQISEKKKKH----------SYFEENLIWKYAADMLLG-LKSLHDMKILHRDLKGANVFIAEDGSLKLGDLNVSK
.|   ...  .|.|.||.   | . . | .|...           ..|.|..| ... . | | |. ||...| |||.|.||...      || |  |..
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

VQKRD------------------FAYTQTGTPYYTSPEVWQN------RPYDSKCDVWSLGCVLYEIVTLEPPF-KGTSMEDLYKRVLRG----------
    .                    .| .||| . .||| |.       .|| |||.|||||.. | .| .||. ... |. ..     .          
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC

---NFSPINLQ-------------------RYSSDLQKFIESCLKVEPKMRSSVESLLN--HKCI
   . .|   .                   ..|.... ||. ||. .|. | ... ||.  |. |
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 10831.AA NEK4 11-268 35 8.1e-71 241.59 In-house 1-257 (257) Show / Hide 
Range on Protein: 11-268
Range on HMM: 1-257/257
Sequence Identity: 35% (93 aa)

FEILKRLGEGSFGSVYQVKRKSDEKIYAMKKVKMMSLSTKEKENALNEVRILASIKSDNIISYKEAFYDEKSSTLCIIMEFATKGDVLQQISEKKKKHSY
....|  | ||.| |. |. . | | | |||...   | .|.  |. |...|   |  ||..||| .  |    |.|.| |   ||  ..   |..|   
YCHMKVVGKGSYGEVWLVRHRRDKKQYVMKKMFLKNASRRERKAAEHEAQLLSQLKHPNIVEYKESWEIENGQFLYIVMGFCEGGDLYRKL--KQQKNQF

FEENLIWKYAADMLLGLKSLHDMKILHRDLKGANVFIAEDGSLKLGDLNVSKVQK--RDFAYTQTGTPYYTSPEVWQNRPYDSKCDVWSLGCVLYEIVTL
 ||. .        ..|  .|. .|||||||  |.|.     .|.||. .|.|     |.| |  ||||| |||.. ||||| | |.||||| .||..||
LEEYQVVEWFVQIAMALQYMHEKHILHRDLKTQNIFLTKKNIIKIGDFGISRVLNNHCDMAKTMIGTPYYMSPECFGNRPYDYKSDIWSLGCCVYEMITL

EPPFKGTSMEDLYKRVLRGNFSPINLQRYSSDLQKFIESCLKVEPKMRSSVESLLNHKCI
   |    |  |  ... |   |.  . || |||  .   |.  |. | |. ...    |
KHAFDAKDMNSLIYQIIQGQPPPMP-PNYSQDLQNLVYQMLEKQPTKRPSIFDIFQMPYI
Kinase 10831.AA NEK2 11-268 30 1.3e-70 236.97 In-house 1-319 (319) Show / Hide 
Range on Protein: 11-268
Range on HMM: 1-319/319
Sequence Identity: 30% (99 aa)

FEILKRLGEGSFGSVYQVKRKSDEKIYAMKKVKMMSLSTKEKENALNEVRILASIKSDNIISYKEAFYDEKSSTLCIIMEFATKGDVLQQISEKKKKHSY
 |.|. .|.||||... |.|||| || . |  .  ..  ||.    .|. ||   |  ||. |     |...||| |.||.   ||  | |.  .| . |
YEVLYTIGNGSFGRCRKVRRKSDGKILVWKEICYGHMQEKECQMLVSECNILRQLKHPNIVRYYDWIIDRQNSTLYIVMEYCEGGDLSQMIKKCRKERQY

FEENLIWKYAADMLLGLKSLHD---------------------MKILHRDLKGANVFIAEDGS-------------------------------------
.||  ||.  . ... |.  |                        |||||.| ||.|  .|..                                     
MEEEFIWRIMFQLCTALQECHNGVELPTLTTIYDRMKPRIDGKHTILHRDIKPANIFLDYDHNDYNINEQVDGHEEVNSNYYRDHRVNSGKRGSPMDYSQ

--LKLGDLNVSKVQKRD--FAYTQTGTPYYTSPEVWQNRPYDSKCDVWSLGCVLYEIVTLEPPFKGTSMEDLYKRVLRGNFSPINLQRYSSDLQKFIESC
   ||||    .. ..|  || |  ||||| |||. . ..|. | |.||.||..||  .| |||..|.   |   .  | |..|  | ||..|.. | . 
VVVKLGDFGLARMLNHDTSFAHTFVGTPYYMSPEQMHGQKYNEKSDIWSVGCLIYEMCALHPPFQATNQAQLQEKIKQGHFRRIPYQ-YSRHLNEIIHFM

LKVEPKMRSSVESLLNHKCI
..| .. | |.| .| |  |
INVDHYHRPSIEEILQHPQI
Kinase 10831.AA ULK 11-268 25 1.1e-66 227.9 In-house 1-329 (329) Show / Hide 
Range on Protein: 11-268
Range on HMM: 1-329/329
Sequence Identity: 25% (85 aa)

FEILKRLGEGSFGSVYQVK---RKSDEKIYAMKKVKMMSLSTKEKEN-----------ALNEVRILASIK----SDN----IISYKEAFYDEKSSTLCII
... ..||.|||| ||. .   .| | ..  . ..||...... ..|             ||..|.  .|    . |    |. ... |.. ..  . ||
YCLNHCLGKGSFGKVYKGRNKKTK-D-YVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYII

MEFATKGDVLQQISEKKK------KHSYFEENLIWKYAADMLLGLKSLHDMKILHRDLKGANVFIAED------------GSLKLGDLNVSKV-QKR---
||.   ||  | |...||      .. ...|. . ..  . | |.| ||...| |||.| .|. | ..            | ||..|   .|. ..    
MEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNME

-DFAYTQT------GTPYYTSPEVWQNR----PYD-SKCDVWSLGCVLYEIVTLEPPFKGTSMEDLY---KRVLRGN---------FSPINLQR------
 . ..|..      |||.| .|...|..    ||. .|||.|||||..||... .|||..   .|.|   .. |. |           |.. .       
QQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQ

YSSDLQKFIESCLKVEPKMRSSVESLLNHKCI
 |.... .|  .|....| | | | |.||...
ISPECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase 10831.AA Ciliate-E2 11-268 20 2.8e-64 219.54 In-house 1-365 (365) Show / Hide 
Range on Protein: 11-268
Range on HMM: 1-365/365
Sequence Identity: 20% (77 aa)

FEILKRLGEGSFGSVYQVKRKSDEKIY------------------AMKKVKMMSLSTKEKENALNEVRIL----------------ASIKSDNIISYKEA
....| .|.|.|||||..|.... | .                  ..|.. | ... ...|. ..| .|.                 .....||| ..|.
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FYDEKSSTLCIIMEFATKGDVLQQISEKKKKH---------------SYFEENLIW-------KYAADMLLGLKSLHDMK-ILHRDLKGANVFIAEDGSL
|.... ... ..||..  || .. | ..|||.               .|. . ..         |.| ..|.|..||  . |.|||.|  |...     .
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

KLGDLNVSK-VQKR--------------------------------DFAYTQTGTPYYTSPEVWQNRP---------YDSKCDVWSLGCVLYEIVTLEPP
|. |.  || ...                                 . ..|. |||.| .||. .. .         || |||.||||..||| .. .||
KIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP

FKGTSMEDLYKRVLRGNFS-PINL---------------QRYSSDLQKFIES----CLKVEPKMRSS-VESLLNHKCI
|        ..  . .... | .                .  | . . .|      .|...|. | .  | .|||. .
F--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 10831.AA CAMK 16-268 17 5.5e-63 201.51 In-house 1-425 (425) Show / Hide 
Range on Protein: 16-268
Range on HMM: 1-425/425
Sequence Identity: 17% (75 aa)

RLGEGSFGSVYQVKRKSDE------------KIYAMKKVKMMSLS--------------------------TKEKENALNEVRILAS-------IKSDNI
 ||.|||| |. ...|..             . .|.| ..   |.                           | ..| ..|..|. .       ..  ||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

ISYKEAFYD----------EKSST--------LCIIM---EFATKG----DVLQQISEKKKK-----------HSYFEENLIWKYAADMLLGLKSLHDMK
|.  |.. |          |  |.        ....|   |... |    |... | |....           . .|.|    .|   .. ... .|...
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

ILHRDLKGANVFIAED-----------------GSLKLGDLNVSKVQKR-------------------------DFAYTQTGTPYYTS-PEVWQN-----
| |||||  |. . ..                 . .|. |   ... ..                         .  .|. |||.| . ||| .      
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

---------RPYDSKCDVWSLGCVLYEIVTLEPPFKGT-------------SMEDLYKRVLRGNFS-PINLQRYSS---------------------DLQ
         ..|. |||.||.|..||  .. .||| |              ....|......|... |      .|                     . .
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK

KFIESCLKVEPKMRSSVESLLNHKCI
 .| ..|.|.|. | ..|  |||. .
DLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 10831.AA ULK 11-268 25 1.8e-62 213.89 In-house 1-324 (324) Show / Hide 
Range on Protein: 11-268
Range on HMM: 1-324/324
Sequence Identity: 25% (83 aa)

FEILKRLGEGSFG-SVYQVK-RKSD--EKIYAMKKVKMMSLSTKEKE--------NALNEVRILASIK---SDN--IISYKEAFYDEKSSTLCIIMEFAT
... ..||.||||  ||. .  |..   ...| |.. . ... |..|        .  ||..|.  .|   . |  |. ... |..  .  ..||||.  
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

KGDVLQQISEKKK-----KHSYFEENLIWKYAADMLLGLKSLHDMKILHRDLKGANVFIAED------------GSLKLGDLNVSKV-----QKRDFAYT
 ||  | | ..||     .. ...|. . ..  . . |.| ||...| |||.| .|  | ..            | ||..|   .|.     .  .  .|
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQT

QT------GTPYYTSPEVWQNR----PYD-SKCDVWSLGCVLYEIVTLEPPFKGTSMEDLYKR--VLRGN---------FSPINLQ------RYSSDLQK
.       |||.| .|...|..    ||. .|||.|||||..||... ..||..   .|.|..   |  |           ||. .        |.... 
CVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKD

FIESCLKVEPKMRSSVESLLNHKCI
.|  .|....| | | | ..||...
LIRRMLQYDEKDRISWEEIFNHPWF
Kinase 10831.AA Ciliate-E2-Unclassified 11-268 25 2.8e-60 206.6 In-house 1-352 (352) Show / Hide 
Range on Protein: 11-268
Range on HMM: 1-352/352
Sequence Identity: 25% (88 aa)

FEILKRLGEGSFGSVYQVKRKSDEKIYAMKKVK-MMSLSTKEKEN---------ALNEV---------RILAS--IKSDNIISYKEAFYDEKSSTLCIIM
..|.| .|.|.||.||....|.. ..||||  | ... . | ..|         ..|.          .|.    . ..... .|. .....  ...|.|
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVM

EFATKGDVLQQISEKKK------------KHSY-FEENLIW-----KYAADMLLGLKSLHDMK-ILHRDLKGANVFIAEDG---SLKLGDLNVSK-----
|..  || .| |...||            |..  |.|. .      .|.|  |.||..||  . |.|||.|  |... ..|    .|. |.  ||     
EYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQN

------------VQKRDFAYTQTGTPYYT----SPEVWQNRPYD----SKCDVWSLGCVLYEIVTLEPPFKGTSMED----------------LYKRVLR
            . |.. ..|..|||.|     .||| |.  ||     |||.||||..|||... ..||.... |.                ||.  . 
NNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQ

G--NFSPINL----QRYSSDLQKFIE----SCLKVEPKMRSSVESLLNHKCI
.  .|.. .     .. |   . ||.    ..||. |. | . | .|||  .
KNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 10831.AA TyrKc 11-268 21 8.5e-18 65.0 SMART 1-280 (280) Show / Hide 
Range on Protein: 11-268
Range on HMM: 1-280/280
Sequence Identity: 21% (63 aa)

FEILKRLGEGSFGSVYQVKRKSDEKIYAMKKVKMMSLSTKEKENALNEVRILASI--KSDNIISYKEAFYDE-----KSSTLCIIMEFATKGDVLQQISE
 . .| |||| || ||. . |      | |..|  .     .|  ..| ||. ..  . .||.    .  ..      .  |.|.||.. .|| .. . .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

KKKKHSYFEENLIWKYAADMLLGLKSLHDMKILHRDLKGANVFIAEDGSLKLGDLNVSKVQKRD-------FAYTQT---GTP-----YYTSPEVWQNRP
...|   .      ... .   |   ||.... ||||   |. ..|..  | .|   |.  . |         |...   |.        ..||... . 
HRPK---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK

YDSKCDVWSLGCVLYEIVTL-EPPFKG-----TSMEDLYKRVLRGNFSPINLQ-------RYSSDLQKFIESCLKVEPKMRSSVESLLNHKCI
. .| |||| | ...|| |. ..|  |      | ......| .|.  |.          . .... . ...| . .|..| . . .  |.|.
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase 10831.AA Pkinase_Tyr 130-228 28 1.9e-12 42.78 Pfam 127-233 (270) Show / Hide 
Range on Protein: 130-228
Range on HMM: 127-233/270
Sequence Identity: 28% (30 aa)

LHDMKILHRDLKGANVFIAEDGSLKLGDLNVSKVQKRDFAY-TQTG---TPY-YTSPEVWQNRPYDSKCDVWSLGCVLYEIVTLE-PP-FKGTSMEDLYK
|..... ||||   |. ..|..  | .|   ..    |  | ...|    |   ..||..... . .| |||| | ...||.|.   | ..| | |..|.
LESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYE

RV-LRGN
..  .|.
YIYEDGY
Kinase 10831.AA Pkinase_Tyr 11-96 25 2.6e-08 28.79 Pfam 1-93 (270) Show / Hide 
Range on Protein: 11-96
Range on HMM: 1-93/270
Sequence Identity: 25% (24 aa)

FEILKRLGEGSFGSVYQVKRK----SDEKIYAMKKVKMMSLSTKE--KENALNEVRILASI-KSDNIISYKEAFYDEKSS-TLCIIMEFATKGD
 ...| ||||.||.||. . |    ...   | |..|  . . ..  .|  ..|..|. .. . .||...  . .|.. .  ..|.||.. .||
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKE-GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGD