13547

Species: Tetrahymena
Alias: 13547, 3833.m00745, 45.m00192, TTHERM_00415780, PreTt13547, 101
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: NEK

Sequence

Name Sequence Type Origin Length Description Download
13547.AA Protein None 847 None Fasta, JSON
13547.kin_dom Protein Kinase Domain None 253 None Fasta, JSON
13547.NA RNA None 2544 None Fasta, JSON

Protein domain

Protein domains of 13547.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
REC 13547.AA REC 9-124 19 4.1e-23 84.03 SMART 1-150 (150) Show / Hide
Range on Protein: 9-124
Range on HMM: 1-150/150
Sequence Identity: 19% (31 aa)

IHVLVAEDD----NFQRLALI------DILTLCDYQ--------VTAVENGR-------LARDELLKAD-----------SNIDIVLLDLYMP-------
...|...||      .| .|       ..|.  .|.        |... .|.        | . | . .           ...|....|. ||       
MRILIVDDDPAMAPVIREMLRNYTVIQRLLEKEGYENKMWMVEVVDEA-DGETLMNEIWEALELLQEHRDKKEDATTDQSEPPDLIIMDIMMPGDPFEDG

EMDGIELLLLMQEHEHLKRIPVIMMSFDNEQERVAYCIANGAKDYLVKPLRIQNVKGLA
.||||||.  ..        |.||..  .. | .  ... || ||..|| ... .    
GMDGIELCRRIR--------PIIMLTAHDDEEDRVRALEAGADDYITKPFDPEELLARI

Response_reg 13547.AA Response_reg 11-125 25 4.5e-22 81.64 Pfam 1-115 (115) Show / Hide
Range on Protein: 11-125
Range on HMM: 1-115/115
Sequence Identity: 25% (30 aa)

VLVAEDDNFQRLALIDILT-LCDY-QVTAVENGRLARDELLKADSNIDIVLLDLYMPEMDGIELLLLM-QEHEHLKRIPVIMMSFDNEQERVAYCIANGA
||...|.  .| .|  ||.   .|  |.....|. | . . . .  .|....|. ||.|||.||.  . ..|.    .|.||..  .. . .  ..  ||
VLIVDDHPLMREGLRQILEQKEGYEVVAEADDGEEALEWWQEHH--PDLIIMDINMPGMDGLELCRRIRRQHP-HPQTPIIMCTAHGDEDDAVEALQAGA

KDYLVKPLRIQNVKGLAK
 ||..||  ..  .  ..
NDYITKPFDPDELHAAIR

Kinase 13547.AA NEK 146-401 41 1.5e-144 486.49 In-house 1-286 (286) Show / Hide
Range on Protein: 146-401
Range on HMM: 1-286/286
Sequence Identity: 41% (120 aa)

YKVIRMIGQGAGGSVELVQKRSDGQL-----FALKTISMKFMDDQQKKMAQ-QEITLLKVLVAPSIIRYYESFVEND--SIHIIMEYAK-EGALSDK---
|..|..||||. |.| .|...|||.      ...| |.|. |....|..|| .|. .|| |  | |..||.||.|..  ...|.|||.  .| |..|   
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKS

ITEHKQKGIPIDEETVLYFTAQIIISVLFMHSK-----NILHRDIKTQNLFLTKENI----VKLGDFGISKELG-TNANAKT-LVGTPYFMSPEVCSGEN
| ..|||| ...||... . .|... . .||..     .|||||||.||.||||.|.    ||.|||||||.|. |.  |.| .|||||.||||||... 
IKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDMAYTTQVGTPYYMSPEVCQNKP

YGQKADIWAIGCTLYEMVML--KRPFDND--NLNILFNKIRFE-APPPLHEN--TSTEIRMLITFMLQKDPVKRPSVWDLAKIPII
|..|.|||..|| ||||..|  |.||. .  |.. |..||. .  .||....   |.. ..||..|||||| .|||.... . |.|
YNNKSDIWSLGCVLYEMCTLKPKHPFEAWDMNMPSLYMKIMKGPQYPPIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI

Kinase 13547.AA NEK8 146-401 40 9.20000000001e-108 308.75 In-house 1-278 (278) Show / Hide
Range on Protein: 146-401
Range on HMM: 1-278/278
Sequence Identity: 40% (114 aa)

YKVIRMIGQGAGGSVELVQKRSDG--QLFALKTISMKFMDDQQKKMAQQEITLLKVLVAPSIIRYYESFVENDSIHIIMEYAKEGALSDKITEHKQKGIP
|  || .|.|| |.. |  ...|.  .|  .| | |  |.  .  ||| || .|. |  | || ||..| |. .  | ||||  | | ..|   .|... 
YERIRVVGRGAFGICWLYRRKEDQSHHLVIWKQINMHRMSEKERQMAQNEIQVLSMLQHPNIISYYDHFMEDNTLMIEMEYADGGTLYQMI--QHQQNKL

IDEET-----------------VLYFTAQIIISVLFMHSKNILHRDIKTQNLFLTKE-NIVKLGDFGISKELGTNANAKT---LVGTPYFMSPEVCSGEN
  ||.                 .| .  |. . | .||..||||||.|||| |.|.  ..||.|||||||...|   . |   .||||| |||| |.|  
FEEERQLKQVNHCFNIYFNEQMILWYFFQMCSAVHHMHQHNILHRDLKTQNIFMTRHRMVVKIGDFGISKIMNTKYHMQTTKTVVGTPYYMSPEMCEGKP

YGQKADIWAIGCTLYEMVMLKRPFDNDNLNILFNKIRF-EAPPPLHENTSTEIRMLITFMLQKDPVKRPSVWDLAKIPII
| || |.||.|| ||||  ||| |. .||  | .||    |  |. .  | | |||..  ||.|| .|||.  . . | .
YNQKSDMWALGCVLYEMCCLKRAFEASNLPALVWKIMQCRAYEPISDHYSNEMRMLVHNCLQQDPEQRPSASQIMAMPLC

Kinase 13547.AA S_TKc 146-401 30 9.2e-87 295.46 SMART 1-231 (231) Show / Hide
Range on Protein: 146-401
Range on HMM: 1-231/231
Sequence Identity: 30% (83 aa)

YKVIRMIGQGAGGSVELVQKRSDGQLFALKTISMKFMDDQQKKMAQQEITLLKVLVAPSIIRYYESFVENDSIHIIMEYAKE--GALSDKITEHKQKG--
|...| ||.|| |.| .......|...|.| |.         .....|| .||    | |...|..|.. |.....|||.    | | | | ... .|  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

IPIDEETVLYFTAQIIISVLFMHSKNILHRDIKTQNLFLTKENIVKLGDFGISKELGTNANAKTLVGTPYFMSPEVCSGENYGQ-KADIWAIGCTLYEMV
 |..| .. ....||.  . ..||..|.|||.| .|..|..   .|..|||....|      .|..|||..|.|||.    ||  |.|.|..||.||||.
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEML

MLKRPFDNDNLNILFNKIRFEAPPPLHENTSTEIRMLITFMLQKDPVKRPSVWDLAK-------IPII
  . ||.  ... .|.||.           | | . .|  .||||| |||.. .. .        | .
CGYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase 13547.AA NEK1 146-401 37 5.8e-84 285.26 In-house 1-276 (276) Show / Hide
Range on Protein: 146-401
Range on HMM: 1-276/276
Sequence Identity: 37% (103 aa)

YKVIRMIGQGAGGSVELVQKRSDGQLFALKTISMKFMDDQQKKMAQQEITLLKVLVAPSIIRYYESFVENDS--IHIIMEYAKEGALSDKITEHKQKGIP
| .|..||.|. | . ||....|||....| |.   | .. .  .  |  .|...  | |..|.|||.|| .    |.|||.  | |  || . | || .
YHYIKQIGEGSFGKAWLVKHKEDGQHYVIKEINVMKMQEKEREESMNEVAILAKMKHPNIVKYKESFEENGCGILYIVMEYCDGGDLMQKINRQKRKGKL

IDEETVLYFTAQIIISVLFMHSKNILHRDIKTQNLFLT--KEN---------------IVKLGDFGISKEL-GTNANAKTLVGTPYFMSPEVCSGENYGQ
. | . . .  || . . ..|...|||||||.||.|||  |                 .||||||||.. |  | . |.| .||||  ||| |    | .
FSEDQIMHWFCQICLALNHIHDRKILHRDIKSQNIFLTISKNGMGSGSGSGSSNDSIPLVKLGDFGIARMLNHTMEYACTCIGTPYYLSPEICQNKPYNN

KADIWAIGCTLYEMVMLKRPFDNDNLNILFNKIRFEAPPPLHENTSTEIRMLITFMLQKDPVKRPSVWDLAKIPII
| |||. || ||| . ||.||.  |.  | .||     ||.    |.|.. |.. |....|  |||| .. . |.|
KSDIWSLGCVLYELCTLKHPFEANNWKNLVLKICQGTYPPIPPHYSYELQSLVSQMFKRNPRHRPSVNQILERPFI

Kinase 13547.AA NEK4 146-401 40 1e-80 274.48 In-house 1-257 (257) Show / Hide
Range on Protein: 146-401
Range on HMM: 1-257/257
Sequence Identity: 40% (104 aa)

YKVIRMIGQGAGGSVELVQKRSDGQLFALKTISMKFMDDQQKKMAQQEITLLKVLVAPSIIRYYESFVENDS--IHIIMEYAKEGALSDKITEHKQKGIP
|  .. .|.|  | | ||..| |.  . .| . .|  . ...| | .|. ||  |  | |. | ||.   .     |.| .   | |  |    .||.  
YCHMKVVGKGSYGEVWLVRHRRDKKQYVMKKMFLKNASRRERKAAEHEAQLLSQLKHPNIVEYKESWEIENGQFLYIVMGFCEGGDLYRKL--KQQKNQF

IDEETVLYFTAQIIISVLFMHSKNILHRDIKTQNLFLTKENIVKLGDFGISKELG-TNANAKTLVGTPYFMSPEVCSGENYGQKADIWAIGCTLYEMVML
..|. |.    || .  ..|| |.||||| ||||.|||| ||.|.||||||. |      |||..||||.||||. .   |  | |||..|| .|||. |
LEEYQVVEWFVQIAMALQYMHEKHILHRDLKTQNIFLTKKNIIKIGDFGISRVLNNHCDMAKTMIGTPYYMSPECFGNRPYDYKSDIWSLGCCVYEMITL

KRPFDNDNLNILFNKIRFEAPPPLHENTSTEIRMLITFMLQKDPVKRPSVWDLAKIPII
|  ||  ..| |  .|    |||.  | |...  |.  ||.| | ||||. |. . | |
KHAFDAKDMNSLIYQIIQGQPPPMPPNYSQDLQNLVYQMLEKQPTKRPSIFDIFQMPYI

Kinase 13547.AA Pkinase 146-391 27 7.8e-71 246.43 Pfam 1-283 (293) Show / Hide
Range on Protein: 146-391
Range on HMM: 1-283/293
Sequence Identity: 27% (79 aa)

YKVIRMIGQGAGGSVELVQKRSDGQLFALKTISMKFMDDQQKKMAQQ--EITLLKVLVAPSIIRYYESFVENDSIHIIMEYAKEG----ALSDKITEHKQ
|...| ||.|. |.| . .....|...|.|.|. .  ...... .    || ..| |  | |.|.|..| ..|.|...|||.  |     |.| |.   .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST--W

KGIPI--DEETVLYFTAQIIISVLFMHSKNILHRDIKTQNLFLTKENIV----KLGDFGISKE--LGTNANAKTLVGTPYFMSPEVCS-GENYGQKADIW
.. ..  .|...  .  ||.  . ..||..|.|||.| .|... ... .    |..|||..|   .  |  ..|..|||..|.|||.  |. ||.|.|.|
RHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMW

AIGCTLYEMVMLKRPFDND------NLNILFNKIRFEAPPPLHENTS---------------------TEIRMLITFMLQKDPVKRPS
..||.||||.  . ||...      . . ....|. ..|.. .. ..                      | . .|. .|.||| |||.
SCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIM-GPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT

Kinase 13547.AA Ciliate-E2 146-401 25 6.1e-69 235.36 In-house 1-365 (365) Show / Hide
Range on Protein: 146-401
Range on HMM: 1-365/365
Sequence Identity: 25% (96 aa)

YKVIRMIGQGAGGSVELVQKRSDGQLF------------------ALKTISMKFMDDQQKKMAQQEITLLKVLV----------------APSIIRYYES
||.|..||||. ||| ..........|                  . | . || |  .|...  ||| ... .                  | ||..||.
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FV--ENDSIHIIMEYAKEGALSDKITEHKQKG---IP----IDEETVLYFTAQII---------------ISVLFMHSKN-ILHRDIKTQNLFLTKENIV
|    ...| ..|||.. | | | | ..|.|    |.    ..|. ..|...||.                 . ..|||| |.||||| .|...     .
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

KLGDFGISKELGTN--------------------------------ANAKTLVGTPYFMSPEVCSGEN---------YGQKADIWAIGCTLYEMVMLKRP
|. |||.||.. ..                                  ..|..|||..|.||. .|..         |. |.|||..|..||||.. |.|
KIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP

FDNDNLNILFNKIRFEAPPP------------LHENTSTEIRMLITF----MLQKDPVKRPS-VWDLAKIPII
|     .|. .||.|  | .             ... | |   ||      |||||| ||..  ... . |..
F---QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF

Kinase 13547.AA STE 146-401 25 2.7e-67 229.9 In-house 1-359 (359) Show / Hide
Range on Protein: 146-401
Range on HMM: 1-359/359
Sequence Identity: 25% (92 aa)

YKVIRMIGQGAGGSVELVQKRS---------------DGQLFALKTISMKFMD---------------DQQKKMAQQEITLLKVLV--APSIIRYYESFV
.. |..||.||.|.| .  ..                 |...| | ....  .               .....  ..|| ..| .    | |..|| ...
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

EN-------DSIHIIMEYAKEGALSDKITEHKQKGIPID----------EETVLYFTAQIIIS-VLFMHSKNILHRDIKTQNLFLTKENIVKLGDFGISK
 .       |...|.|||   | |.| | . . .| | .          |. . |.. ||.     . ||..| ||||| .| .|     ||| |||...
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

ELG----------------TNA-NAKTLVGTPYFMSPEVCSGEN------YGQKADIWAIGCTLYEMVMLKRPF-DNDNLNILFNKIRF-----------
 |                 |.. . .|.|||| .|.||| ....      |. |.||| .|||. ||.  | |. |  ..  .|....            
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC

---EAPPPLHENTS-------------------TEIRMLITFMLQKDPVKRPSVWDLAK--IPII
   . |||| ...|                    | .  |   ||||| |||.. .| |   | |
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI

Kinase 13547.AA Ciliate-E2-Unclassified 146-401 23 2e-65 223.65 In-house 1-352 (352) Show / Hide
Range on Protein: 146-401
Range on HMM: 1-352/352
Sequence Identity: 23% (84 aa)

YKVIRMIGQGAGGSVELVQKRSDGQLFALKTISMKFMDDQQKKMA-----QQEITLLKV----------------LVAPSIIRYYESFVENDS--IHIIM
||.|. ||||. |.| ..|.....|..|.|... . ...|...|      ...... .                 |  |....... ....|   | |.|
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVM

EYAKEGALSDKIT-------------EHKQKGIPIDEETVL-----YFTAQIIISVLFMHSKN-ILHRDIKTQNLFLTKEN---IVKLGDFGISKELGTN
||.. | |.. |.             ......  ..|. ..     ...|||.    ..|.|| |.||||| .|.......    .|. ||||||....|
EYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQN

----------------ANAKTLVGTPYFM----SPEVCSGENYG----QKADIWAIGCTLYEMVMLKRPFDNDNLNI----------------LFNKI-R
                 ...| .|||..|    .|||  |.||.     |.|||. |. ||||.. ..||.  | ..                |...|  
NNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQ

FEAPPPLHEN------TSTEIRMLIT----FMLQKDPVKRPSVWDLAKIPII
 .   | ...       | |   .|.     ||.|.| ||.. ... . |..
KNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF

Kinase 13547.AA CAMK 151-392 21 7.3e-64 204.39 In-house 1-416 (425) Show / Hide
Range on Protein: 151-392
Range on HMM: 1-416/425
Sequence Identity: 21% (90 aa)

MIGQGAGGSVELVQKRSDG------------QLFALKTISMKFMD--------------------------DQQKKMAQQEITLLKVLV-------APSI
 .|.|. | | |.. ....            | .| | |. | ..                          .. .|. ..|| ..| |         | |
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

IRYYESFVE-------------------NDSIHIIM---EYAKEGAL----SDKITEHKQKG-----------IPIDEETVLYFTAQIIISVLFMHSKNI
|. || .                     .. ....|   ||.  | |     |.|.||...|             ..|. . ..  ||.  | ..||.||
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

LHRDIKTQNLFLTKE-----------------NIVKLGDFGISKELGT------------------------NANAKTLVGTPYFMS-PEVCSGEN----
 |||.|  |. |..                  | .|. ||| ....                          .   || .|||..|. ||| .|.     
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

----------YGQKADIWAIGCTLYEMVMLKRPFDND-------------NLNILFNKIR---FE-APPP--------------------LHENTSTEIR
          ||.|.|.|..|. || |.  . ||. |             |.. || ||.   ..  ||.                     | . |.| .
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHH-FVSQECK

MLITFMLQKDPVKRPSV
 ||  |||.|| ||...
DLIRKMLQVDPEKRMTI

Kinase 13547.AA NEK-Unclassified 146-401 34 1.5e-60 199.09 In-house 1-258 (258) Show / Hide
Range on Protein: 146-401
Range on HMM: 1-258/258
Sequence Identity: 34% (91 aa)

YKVIRMIGQGAGGSVELVQKRSDGQLFALKTISMKFMDDQQKKMAQQEITLLKVLVAPSIIRYYESFVENDSIHIIMEYAKEGALSDKITEHKQKGIPID
|  |  .||| || | ||      .    . || .    ..||  |  | .|  |  | |. | .|| ||  .    .|   | |  .|  |  |  |.|
YDKITTLGQGGGGAVYLVRHQI-SKRHLVQQISKR----KKKKKRQNKIIILSQLRHPHIVTYHDSFFENAKLFYTQDYCDGGNLDRRIQKHRKKNEPFD

EETVLYFTAQIIISVLFMHSKNILHRDIKTQNLFLTKENIVKLGDFGISKELG-TNANAKTLVGTPYFMSPEVCSGENYGQKADIWAIGCTLYEMVMLKR
|  .     |.|  | . |.. |.||| |.|| |||.. .| .||||||. .  |   |.| |||. .||||||    |  . |.|. || .|||     
EGRIMQWCIQMIMAVQYIHQRKIIHRDLKPQNIFLTDDDTVSMGDFGISRIMDHTRDKARTCVGTMCWMSPEVCQDQPYNNRSDVWSLGCIIYEMCTCEP

PFDNDNLNILFNKIRFEAP------PPLHENTSTEIRMLITFMLQKDPVKRPSVWDLAKIPII
 ||  |.  .. ||  .         |     ||    .|.|||.... .|||  ..   . |
FFDTHNMGEVYMKIKQDDNRLEEALEPVSKTYSTDLQQVIRFMLRRNFQQRPSATEIVEQDYI

Kinase 13547.AA ULK 146-401 25 1.7e-56 193.98 In-house 1-324 (324) Show / Hide
Range on Protein: 146-401
Range on HMM: 1-324/324
Sequence Identity: 25% (85 aa)

YKVIRMIGQGAGG-SVELVQ-KRSD--GQLFALKTISMKFMDDQQKK--------MAQQEITLLKVLV------APSIIRYYESFVENDS--IHIIMEYA
| .....|.|. |  |     |...  .|..| | |..| | .....        . ..|| ..| |          |...|. | . ..  | ||||| 
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNH-HIVKLYDWFETSNHNNIYIIMEYC

KEGALSDKITEHKQ-----KGIPIDEETVLYFTAQIIISVLFMHSKNILHRDIKTQNLFLTKEN------------IVKLGDFGISKELGTN----ANAK
  | |.. | ..|      ..  . |. .. |  ||.    ..|..|| ||||| ||. ... .            ..|..||| .| .  |       .
NGGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQ

TLV------GTPYFMSPEVCS----GENYG-QKADIWAIGCTLYEMVMLKRPFDNDNLNILF-------------------NKIRFEAPPPLHENTSTEI
|.|      |||..|.|.. .    ...|.  |.||| .|| .|||.  | || ..  | ..                   ..|.|  ||    . | |.
TCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPP-KDPKISPEC

RMLITFMLQKDPVKRPSVWDLAKIPII
. ||  |||.|. .| |  .. ..|..
KDLIRRMLQYDEKDRISWEEIFNHPWF

Kinase 13547.AA TyrKc 146-401 19 6.4e-15 18.5 SMART 1-280 (280) Show / Hide
Range on Protein: 146-401
Range on HMM: 1-280/280
Sequence Identity: 19% (57 aa)

YKVIRMIGQGAGGSVELVQKRSDGQLFALKTISMKFMDDQQKKMAQQEITLLKVL--VAPSIIRYYESFVEN-------DSIHIIMEYAKEGALSDKITE
 . ....| || | | . . .   .  | |..         ...  .|. ... |    | |.| |   ..        . . |.|||.. |.| | . .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

HKQKGIPIDEETVLYFTAQIIISVLFMHSKNILHRDIKTQNLFLTKENIVKLGDFGISKELGTN----ANAKTLV-----GTP-----YFMSPEVCSGEN
|. |   .  .. |.|  ||     . ||||. |||. . |  ......|| .||| |....      .. .. .     |.        |.||.     
HRPK---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK

YGQKADIWAIGCTLYEMVML-KRPFDN------DNLNILFNKIRFEAPPPLHEN-------TSTEIRMLITFMLQKDPVKRPSVWDLAKIPII
.  | |.|. | ...|.  . . |  .      .|  .. .  . . .|. ...        ..|. ....   . || .||. ...  . ..
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF

Kinase 13547.AA Pkinase_Tyr 146-342 24 2.7e-11 38.9 Pfam 1-210 (270) Show / Hide
Range on Protein: 146-342
Range on HMM: 1-210/270
Sequence Identity: 24% (52 aa)

YKVIRMIGQGAGGSVELVQKR----SDGQLFALKTISMKFMDDQ--QKKMAQQEITLLKVL-VAPSIIRYYESFV-ENDS--IHIIMEYAKEGALSDKIT
 . ....|.|| |.| .   .    ....  | |..  . |..|  .... . |. ..| |   | |.|.|   . . ..  | |.|||.. | | |   
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMR-EAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

EHKQKGIPIDEETVLYFTAQIIISVLFMHSKNILHRDIKTQNLFLTKENIVKLGDFGISKELGTNANAKTLVGT----PYF-MSPEVCSGENYGQKADIW
.|.  . |.. .. | . .||     . .|||. |||. . |  .|..|.|| .||| .. .    .  . ...    | . |.||. .   .  | |.|
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYY-YRKRGGGKLPIKWMAPECINYGKFTTKSDVW

AIGCTLYEMVML
. | ...|.. .
SFGVLMWEIFTY

DEP 13547.AA DEP 467-542 15 0.000474 14.98 SMART 1-90 (90) Show / Hide
Range on Protein: 467-542
Range on HMM: 1-90/90
Sequence Identity: 15% (14 aa)

LSSALSPYDQKISMFKVERNVINGKQLFQWIQQYYT------------NYNTSQVVEMLNELVEKKYLHHIA--GPLHQSDP-NSLYRFQF
... .    .. ...|. .|.  |..| .|. .                 . .. | . . ... .|.||.   . .. .|  ...|||| 
PETGVKMD-DHRWHMKTYPNCFTGSELVDWLMDHFEGQSNFCPTCTTFIHDREEAVHICQAMLDHGYIHHVNDWHKHTFQDDWQCYYRFQD

DEP 13547.AA DEP 485-540 19 0.000855 17.5 Pfam 15-75 (75) Show / Hide
Range on Protein: 485-540
Range on HMM: 15-75/75
Sequence Identity: 19% (12 aa)

RNVINGKQLFQWIQ-QYYT--NYNTSQVVEMLNELVEKKYLHHIAGPLH-QSDP-NSLYRF
.|.  |... .|.. .  .  . . .. |.. ..|....|.||. .  .  .|  ...|||
PNCFTGSEAVDWLMNDCCEDFIIDREEAVHLGQDLMDHGYIHHVQDHHRGFQDSDHYFYRF

DUF547 13547.AA DUF547 666-719 34 1.4e-05 21.46 Pfam 51-112 (155) Show / Hide
Range on Protein: 666-719
Range on HMM: 51-112/155
Sequence Identity: 34% (22 aa)

PFFSKSQDEFYYTIGNLQFTLDDIKHGIIRGNKTQ----------KLSSFKPFADNDSRKQFVL
.||..  .   ||.|.  ..|||| |||.|.|. .             .||||   | || ..|
WFFFGPWNKAFYTVGGHKYSLDDIEHGILRPNRPHHRQWWKTLFSPHWKFKPFER-DWRK-YAL