Gene 15435 (Tetrahymena)

15435

Species: Tetrahymena
Alias: 52.m00213, 3811.m00970, PreTt15435, 15435, 242, TTHERM_00449170
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: NEK

Sequence

Name Sequence Type Origin Length Description Download
15435.AA Protein None 1005 None Fasta, JSON
15435.kin_dom Protein Kinase Domain None 256 None Fasta, JSON
15435.NA RNA None 3018 None Fasta, JSON

Protein domain

Protein domains of 15435.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 15435.AA NEK 20-275 48 2.7e-162 545.47 In-house 1-286 (286) Show / Hide 
Range on Protein: 20-275
Range on HMM: 1-286/286
Sequence Identity: 48% (138 aa)

YKRIKLLGEGAFGKAYLVEDLRTHEL-----LVQKQMDMKAMSTEEKRETQ-KEARILQQLNHPNIVKFKDVYTTKK-GKLCIIMEYAD-GGDLAKV---
|..|| .|.|.|||.|.|.. ..        .| |...|. || .||...| .|.|||.||.||||||..| .  .. ..|||.|||.. ||||..    
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKS

VKDAR--GKYLQEKQILDWFTQICLAMKHVHDR-----KIIHRDLKGQNIFLTRNHI----VKLGDFGIARVLSKTVEKAKT-MVGTPYYLSPEIIESKP
 |  .  |||..|.||.|||.|.|||.|..|||     ||.|||.| ||||||.|..    ||.|||||..||..|...|.| .||||||.|||....||
IKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDMAYTTQVGTPYYMSPEVCQNKP

YSFKTDIWSLGVILYELCAL--KPPFNAD--SLHFLALKIVKG-QYSPIPTH--FSKEMKNLVSNLLQVDAIRRPSINDIMKMPII
|..| ||||||..|||.|.|  |.||.|.  ... |..||.|| ||.||| |  .|....||.|..||.|   |||.|.|..||.|
YNNKSDIWSLGCVLYEMCTLKPKHPFEAWDMNMPSLYMKIMKGPQYPPIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase 15435.AA NEK1 20-275 48 6.00000000001e-133 447.98 In-house 1-276 (276) Show / Hide 
Range on Protein: 20-275
Range on HMM: 1-276/276
Sequence Identity: 48% (134 aa)

YKRIKLLGEGAFGKAYLVEDLRTHELLVQKQMDMKAMSTEEKRETQKEARILQQLNHPNIVKFKDVYTTKKGK--LCIIMEYADGGDLAKVVKDA--RGK
| .|| .|||.||||.|| .     ..| |      |. .|. |  .|. ||. . ||||||.|.      |.  | |.|||.|||||..  . .  .||
YHYIKQIGEGSFGKAWLVKHKEDGQHYVIKEINVMKMQEKEREESMNEVAILAKMKHPNIVKYKESF-EENGCGILYIVMEYCDGGDLMQKINRQKRKGK

YLQEKQILDWFTQICLAMKHVHDRKIIHRDLKGQNIFLT--RNH---------------IVKLGDFGIARVLSKTVEKAKTMVGTPYYLSPEIIESKPYS
  .| ||..||.|||||..|.|||||.|||.| ||||||  .|                .||||||||||.|. |.| |.| .||||||||||.. ||| 
LFSEDQIMHWFCQICLALNHIHDRKILHRDIKSQNIFLTISKNGMGSGSGSGSSNDSIPLVKLGDFGIARMLNHTMEYACTCIGTPYYLSPEICQNKPYN

FKTDIWSLGVILYELCALKPPFNADSLHFLALKIVKGQYSPIPTHFSKEMKNLVSNLLQVDAIRRPSINDIMKMPII
 |.||||||..|||||.|| ||.| ... | |||..| |.||| |.|.| ..||| ......  |||.|.| . |.|
NKSDIWSLGCVLYELCTLKHPFEANNWKNLVLKICQGTYPPIPPHYSYELQSLVSQMFKRNPRHRPSVNQILERPFI
Kinase 15435.AA NEK8 20-275 42 1.4e-111 319.84 In-house 1-278 (278) Show / Hide 
Range on Protein: 20-275
Range on HMM: 1-278/278
Sequence Identity: 42% (118 aa)

YKRIKLLGEGAFGKAYL---VEDLRTHELLVQKQMDMKAMSTEEKRETQKEARILQQLNHPNIVKFKDVYTTKKGKLCIIMEYADGGDLAKVVKDARG-K
| ||  .| |||| . |    ||   | | . || .|  || .| .  | | ..|  |.||||.   |    . . | | ||||||| |.    . .. .
YERIRVVGRGAFGICWLYRRKEDQ-SHHLVIWKQINMHRMSEKERQMAQNEIQVLSMLQHPNIISYYDHF-MEDNTLMIEMEYADGGTLYQMIQHQQNKL

YLQEK----------------QILDWFTQICLAMKHVHDRKIIHRDLKGQNIFLTRN-HIVKLGDFGIARVLSKTVEKA--KTMVGTPYYLSPEIIESKP
 . |.                .||. |.|.|.|  |.|.  | ||||| ||||.||   .||.|||||. ...     .  || ||||||.|||. |.||
FEEERQLKQVNHCFNIYFNEQMILWYFFQMCSAVHHMHQHNILHRDLKTQNIFMTRHRMVVKIGDFGISKIMNTKYHMQTTKTVVGTPYYMSPEMCEGKP

YSFKTDIWSLGVILYELCALKPPFNADSLHFLALKIVKG-QYSPIPTHFSKEMKNLVSNLLQVDAIRRPSINDIMKMPII
| .| |.|.|| .|||.| ||  | |. |  | .||. .  | ||. | |.||. ||.|.||.|. .|||   ||.|| .
YNQKSDMWALGCVLYEMCCLKRAFEASNLPALVWKIMQCRAYEPISDHYSNEMRMLVHNCLQQDPEQRPSASQIMAMPLC
Kinase 15435.AA NEK4 20-275 43 2.8e-105 356.08 In-house 1-257 (257) Show / Hide 
Range on Protein: 20-275
Range on HMM: 1-257/257
Sequence Identity: 43% (112 aa)

YKRIKLLGEGAFGKAYLVEDLRTHELLVQKQMDMKAMSTEEKRETQKEARILQQLNHPNIVKFKDVYTTKKG-KLCIIMEYADGGDLAKVVKDARGKYLQ
|  .|  | | .|  .||   |     | | |..|  | .|.... .||..| || |||||..|. .    |  |.|.| . .|||| .  |  ... |.
YCHMKVVGKGSYGEVWLVRHRRDKKQYVMKKMFLKNASRRERKAAEHEAQLLSQLKHPNIVEYKESWEIENGQFLYIVMGFCEGGDLYRKLKQQKNQFLE

EKQILDWFTQICLAMKHVHDRKIIHRDLKGQNIFLTRNHIVKLGDFGIARVLSKTVEKAKTMVGTPYYLSPEIIESKPYSFKTDIWSLGVILYELCALKP
|.|...|| || .|.   |...|.||||| ||||||.  |.|.|||||.|||    . ||||.|||||.|||.  ..|| .| ||||||  .||.  || 
EYQVVEWFVQIAMALQYMHEKHILHRDLKTQNIFLTKKNIIKIGDFGISRVLNNHCDMAKTMIGTPYYMSPECFGNRPYDYKSDIWSLGCCVYEMITLKH

PFNADSLHFLALKIVKGQYSPIPTHFSKEMKNLVSNLLQVDAIRRPSINDIMKMPII
 |.|  .  |  .|..||  |.|  .|....|||  .|.    .|||| ||..|| |
AFDAKDMNSLIYQIIQGQPPPMPPNYSQDLQNLVYQMLEKQPTKRPSIFDIFQMPYI
Kinase 15435.AA S_TKc 20-275 31 6.3e-100 339.19 SMART 1-231 (231) Show / Hide 
Range on Protein: 20-275
Range on HMM: 1-231/231
Sequence Identity: 31% (84 aa)

YKRIKLLGEGAFGKAYLVEDLRTHELLVQKQMDMKAMSTEEKRETQKEARILQQLNHPNIVKFKDVYTTKKGKLCIIMEYADG--GDLAKVVKDARG---
|. ....|.||||| |.. . .|...   |...         . ...| .||.. .||||||..||. .  ..|...|||.||  ||| .. |. ..   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

-KYLQEKQILDWFTQICLAMKHVHDRKIIHRDLKGQNIFLTRNHIVKLGDFGIARVLSKTVEKAKTMVGTPYYLSPEIIESKPYSF-KTDIWSLGVILYE
 ... | ..  .. |||.|... |...||||||| .||.|..   .|..|||.||.|       .|..|||.|..||..   .|.. | |.||.|.||||
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYE

LCALKPPFNADSLHFLALKIVKGQYSPIPTHFSKEMKNLVSNLLQVDAIRRPSINDIMK-------MPII
... .|||     ... .|...          |.|.|......||.|  .||.. ....       .| .
MLCGYPPFP---QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 15435.AA Pkinase 20-275 25 4.6e-84 290.39 Pfam 1-293 (293) Show / Hide 
Range on Protein: 20-275
Range on HMM: 1-293/293
Sequence Identity: 25% (76 aa)

YKRIKLLGEGAFGKAYLVEDLRTHELLVQKQMDMKAMSTEEKRETQK--EARILQQLNHPNIVKFKDVYTTKKGKLCIIMEYADGG----DLAKVVKDAR
|.... .|.|.||. |.  .  | .. . |... .  . .....  .  |..|.. |||||||...|.... |......|||..||    ||. ...  |
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-KDHIYMVMEYCEGGLYVMDLFDYISTWR

GKYL--QEKQILDWFTQICLAMKHVHDRKIIHRDLKGQNIFLTRNHIV----KLGDFGIARVL-SKTVEKAKTMVGTPYYLSPEIIE-SKPYSFKTDIWS
.. .  .|... ....||. .... |...||||||| .||.. .|  .    |..|||.|...     . ..| .|||.|..||.|  ...|. | |.||
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

LGVILYELCALKPPFNAD------SLHFLALKIVKGQYSPIPTHFS--------------------KEMKNLVSNLLQVDAIRRPSINDIMKMPII
.|.||||..  .|||  .      .  ..  .| .....      .                    .|.| .....|..|  .||.. .|.. | .
CGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 15435.AA CAMK 25-275 22 5.1e-82 263.96 In-house 1-425 (425) Show / Hide 
Range on Protein: 25-275
Range on HMM: 1-425/425
Sequence Identity: 22% (94 aa)

LLGEGAFGKAYLVEDLRTH------------ELLVQKQMDMKAMS-------------------------TEEKRE-TQKEARILQQ-------LNHPNI
 ||.|.||| .|... .|             .    | .| | ..                         ....|.  ..| .|...       |.||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VKFKDVYT------------TKKG-------KLCIIM---EYADGG----DLAKVVKDARG-------------KYLQEKQILDWFTQICLAMKHVHDRK
.|. .||             | .        .....|   ||..||    ||   ... ..             ....|..   .| ||| |... |...
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

IIHRDLKGQNIFLTRNH-----------------IVKLGDFGIARVLSKTV-----------------------EKAKTMVGTPYYLS-PEIIES-----
|.|||||  || |. |.                  .|. ||| |... .                         .| ||..|||.| . ||....     
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

---------KPYSFKTDIWSLGVILYELCALKPPFNAD-------------SLHFLALKIVKGQYSPIPTHFSK-----------------------EMK
         ..|..|.|.||.||||| .   .|||..|             ... |  || ||.|. .| .||.                       | |
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK

NLVSNLLQVDAIRRPSINDIMKMPII
.|....||||  .|..| .... | .
DLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 15435.AA ULK 20-275 29 5.9e-80 271.95 In-house 1-329 (329) Show / Hide 
Range on Protein: 20-275
Range on HMM: 1-329/329
Sequence Identity: 29% (96 aa)

YKRIKLLGEGAFGKAYLVEDLRTH----ELLVQKQMDMKAMSTEEKRE--------TQKEARILQQLN--------HPNIVKFKDVYTTKKG-KLCIIME
|  .. ||.|.||| |  .. .|.    |. . |..| . |. ...           ..| .|...|.        ||||||..|.. |..   . ||||
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

YADGGDLAKVVKDARG--------KYLQEKQILDWFTQICLAMKHVHDRKIIHRDLKGQNIFLTRNH------------IVKLGDFGIARVLSKT---VE
| .|||| .  |  ..        |.| |....  | ||. ..|. |...|||||.| ||| .. .             ..|..||| |.....     .
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

KAKTMV------GTPYYLSPEIIE----SKPYS-FKTDIWSLGVILYELCALKPPFNADSLHFLALKIVKG---QYSPIP----------------THFS
 ..|.|      |||.| .|.|..     |||. .|.||||||.|.||.   ||||.|     . |.|..    ...|.|                 ..|
MMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQIS

KEMKNLVSNLLQVDAIRRPSINDIMKMPII
.|.|.| . .||.|   | |. .. ..|..
PECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase 15435.AA ULK 20-275 29 4.7e-79 268.94 In-house 1-324 (324) Show / Hide 
Range on Protein: 20-275
Range on HMM: 1-324/324
Sequence Identity: 29% (95 aa)

YKRIKLLGEGAFG-KAYLVEDLRTH---ELLVQKQMDMKAMSTEEKR--------ETQKEARILQQLN---HPN--IVKFKDVYTTKKG-KLCIIMEYAD
|  .. ||.|.|| | |  .. .|.   ..   |..|.| |.  ...          ..| .|...|.   |||  |||..|.. |.    ..||||| .
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

GGDLAKVVKDARG-------KYLQEKQILDWFTQICLAMKHVHDRKIIHRDLKGQNIFLTRNH------------IVKLGDFGIARVLS---KTVEKAKT
|||| .  |  ..       |.| |....  | ||| ..|. |...|||||.| ||| .. .             ..|..||| |...    .   . .|
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQT

MV------GTPYYLSPEIIE----SKPYS-FKTDIWSLGVILYELCALKPPFNADSLHFLA-------------LKIVKGQYSPIP-----THFSKEMKN
.|      |||.| .|.|..     |||. .|.||||||.|.||.   |.||...    .              . ..| |  ..|      ..|.|.|.
CVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKD

LVSNLLQVDAIRRPSINDIMKMPII
| . .||.|   | |. .| ..|..
LIRRMLQYDEKDRISWEEIFNHPWF
Kinase 15435.AA NEK2 20-275 31 2.5e-77 259.93 In-house 1-319 (319) Show / Hide 
Range on Protein: 20-275
Range on HMM: 1-319/319
Sequence Identity: 31% (102 aa)

YKRIKLLGEGAFGKAYLVEDLRTHELLVQKQMDMKAMSTEEKRETQKEARILQQLNHPNIVKF--KDVYTTKKGKLCIIMEYADGGDLAKVVKDARG--K
|   . .|.| ||. . | .  . ..|| | ..   |   |.     |  ||.|| |||||..  ...  ...  | |.|||  ||||. ..| .|   .
YEVLYTIGNGSFGRCRKVRRKSDGKILVWKEICYGHMQEKECQMLVSECNILRQLKHPNIVRYYDWIIDRQNS-TLYIVMEYCEGGDLSQMIKKCRKERQ

YLQEKQILDWFTQICLAMKHVHD---------------------RKIIHRDLKGQNIFLTRNHI------------------------------------
|. |. |.  ..|.|.| . .|                      . |.|||.|  ||||  .|                                     
YMEEEFIWRIMFQLCTALQECHNGVELPTLTTIYDRMKPRIDGKHTILHRDIKPANIFLDYDHNDYNINEQVDGHEEVNSNYYRDHRVNSGKRGSPMDYS

---VKLGDFGIARVLSKTVEKAKTMVGTPYYLSPEIIESKPYSFKTDIWSLGVILYELCALKPPFNADSLHFLALKIVKGQYSPIPTHFSKEMKNLVSNL
   ||||||| ||.| .    |.| |||||| ||| ..  .|. | ||||.| ..||.|||.||| | .   |. || .| ...||   |..   ...  
QVVVKLGDFGLARMLNHDTSFAHTFVGTPYYMSPEQMHGQKYNEKSDIWSVGCLIYEMCALHPPFQATNQAQLQEKIKQGHFRRIPYQYSRHLNEIIHFM

LQVDAIRRPSINDIMKMPII
. ||   ||||. |.. | |
INVDHYHRPSIEEILQHPQI
Kinase 15435.AA Ciliate-E2 20-275 24 4.1e-75 255.86 In-house 1-365 (365) Show / Hide 
Range on Protein: 20-275
Range on HMM: 1-365/365
Sequence Identity: 24% (92 aa)

YKRIKLLGEGAFGKAYLVEDLRTHELL------------------VQKQMDMKAMSTEEKRETQKEARILQ----------------QLNHPNIVKFKDV
|| ||..|.|.||. |.... .. ..                    .|.  || |.  ..... .| .|..                |||||||.|....
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

YTT-KKGKLCIIMEYADGGDLAKVVKDARGK---------YLQEKQILDWFTQICL---------------AMKHVHDRK-IIHRDLKGQNIFLTRNHIV
. . .. .. ..|||..|||| .  |. . |         |. ||.|.. ..||.                |... | .. |||||.| .||..     .
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

KLGDFGIAR------------VLSKTVEKAK--------------------TMVGTPYYLSPEIIESKP---------YSFKTDIWSLGVILYELCALKP
|. |||...            ...|     |                    | .|||.|..|||...|.         |..| |||||||||||..  ||
KIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKP

PFNADSLHFLALKIVKGQYSPIP------------------THFSKEMKNLVSN----LLQVDAIRRPS-INDIMKMPII
||         ... | .   .|                   . |.|.|.| ..    .||.|   |.. ...|.. |..
PF---------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 15435.AA STE 20-275 26 3.5e-73 249.42 In-house 1-359 (359) Show / Hide 
Range on Protein: 20-275
Range on HMM: 1-359/359
Sequence Identity: 26% (97 aa)

YKRIKLLGEGAFGKAYLVEDLR---------------THELLVQKQMDMKAMST---------------EEKRETQKEARILQQLN--HPNIVKFKDVYT
...|. .|.||||. |.  .                 |.|.   |||...  ..               ||. . .|| .|....|  ||||||. . | 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

TK------KGKLCIIMEYADGGDLAKVVKDARGKYLQ------------EKQILDWFTQICLA-MKHVHDRKIIHRDLKGQNIFLTRNHIVKLGDFGIAR
 .      ...|.|.||| ||| | ...|   |.  .            |.||     ||. . ... |. .|||||.|..||.|     ||| |||.. 
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

VLSK----------------TVEKAKTMVGTPYYLSPEIIES------KPYSFKTDIWSLGVILYELCALKPPF---NADSLHFLAL------------K
 |..                ...| .|.|||| . .||.|.       |.|..| ||||||  . |..  |||.   .  .  |...            .
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC

IVKGQYSPIPT-------------------HFSKEMKNLVSNLLQVDAIRRPSINDIMK--MPII
||.|.  |.|.                   ..|.|.|. ... || |   ||. .. .|   | |
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 15435.AA TyrKc 20-273 26 4.3e-36 127.16 SMART 1-280 (280) Show / Hide 
Range on Protein: 20-273
Range on HMM: 1-280/280
Sequence Identity: 26% (77 aa)

YKRIKLLGEGAFG---KAYLVEDLRTHELLVQKQMDMKAMSTEEKRETQKEARILQQL--NHPNIVKFKDVYTTKK------GKLCIIMEYADGGDLAKV
 . .| |||||||   |. .       .    | .   |     ...  .||||. .|  .|||||..  | |...      . |.|.|||...||| . 
ITLGKKLGEGAFGEVYKGTWK------IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY

VKDARGKYLQEKQILDWFTQICLAMKHVHDRKIIHRDLKGQNIFLTRNHIVKLGDFGIARVLSKT----VEKAKTMV----GTP-----YYLSPEIIESK
 .. |.| |. |. |.. .||.  | . |....|||||   |. ...||.|| .||| .| .       ..|   ..    |.        ..|| |  .
LRKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYG

PYSFKTDIWSLGVILYELCAL-KPPFNA-----DSLHFLALKIVKGQYSPIPTH--------FSKEMKNLVSNLLQVDAIRRPSINDIMKMP
 ...|.|.|| || ..|.. . ..|         |   .  .. .| . |.| .         ..|| .. .   . |.  ||. ..| .  
KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase 15435.AA Pkinase_Tyr 66-216 31 2.9e-33 113.28 Pfam 52-210 (270) Show / Hide 
Range on Protein: 66-216
Range on HMM: 52-210/270
Sequence Identity: 31% (50 aa)

KEARILQQL-NHPNIVKFKDVYTTKKGK--LCIIMEYADGGDLAKVVKDA--RGKYLQEKQILDWFTQICLAMKHVHDRKIIHRDLKGQNIFLTRNHIVK
.||.|. || .|||||..  | | ...   ..|.|||. .||| .  ..    .. |  |..|.. .||. .| . .....|||||   |. .|.|..||
REAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVK

LGDFGIARVL-----SKTVEKAKTMVGTPYYLSPEIIESKPYSFKTDIWSLGVILYELCAL
 .||| || .       .. . ....  . . .|| |  . .. |.|.|| || ..|.. .
ICDFGLARDIYNDDYY-YRKRGGGKLPIKWM-APECINYGKFTTKSDVWSFGVLMWEIFTY
Kinase 15435.AA Pkinase_Tyr 20-33 57 0.107808 6.36 Pfam 1-14 (270) Show / Hide 
Range on Protein: 20-33
Range on HMM: 1-14/270
Sequence Identity: 57% (8 aa)

YKRIKLLGEGAFGK
 . .| |||||||.
ITFGKKLGEGAFGE