Gene 23433 (Tetrahymena)

23433

Species: Tetrahymena
Alias: 23433, 903, TTHERM_00809380, 137.m00127, PreTt23433
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: NEK

Sequence

Name Sequence Type Origin Length Description Download
23433.AA Protein None 1100 None Fasta, JSON
23433.kin_dom Protein Kinase Domain None 257 None Fasta, JSON
23433.NA RNA None 3303 None Fasta, JSON

Protein domain

Protein domains of 23433.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 23433.AA NEK 33-289 45 1.9e-156 526.04 In-house 1-286 (286) Show / Hide 
Range on Protein: 33-289
Range on HMM: 1-286/286
Sequence Identity: 45% (130 aa)

FEVISKLGEGSFSQVFQVKRKSDGMI-----YAMKKVKMGLLKEKEKENAL-NEVRILASLNDEFIVGYKEAFIDEQSQILCVVMEYAA-GGDLQGK---
.|.| |.|.|||..|. |.||||| .     |..||..|| ..||||.||. ||||||..|. . ||.|...||.||.. || ||||.  ||||. |   
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKS

ITANIKSKTMFPESEVWKALIHMSKGLQILHQM-----QILHRDLKCANVFLSLEGV----YKLGDLNVSKVAKKG--LVYT-QTGTPYYASPEVWRDEP
|  . .....|.|...|. .|.|...|. .|..      |||||.|..|.||. ..      |.||...||| ...  . || |.|||||.||||....|
IKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDMAYTTQVGTPYYMSPEVCQNKP

YDVKSDIWSLGCVLYEMCAL--KPPFRAN--DMEGLYKKVQKG-DFERIPKK--YSEDLQRMLTMLLKVNPKDRPSCEQILSNPIV
|. |||||||||||||||.|  |.||.|.  .|..||.|..|| ....||..  ||.|||......|...|..||||.|||..|..
YNNKSDIWSLGCVLYEMCTLKPKHPFEAWDMNMPSLYMKIMKGPQYPPIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase 23433.AA NEK1 33-289 39 4e-88 299.07 In-house 1-276 (276) Show / Hide 
Range on Protein: 33-289
Range on HMM: 1-276/276
Sequence Identity: 39% (110 aa)

FEVISKLGEGSFSQVFQVKRKSDGMIYAMKKVKMGLLKEKEKENALNEVRILASLNDEFIVGYKEAFIDEQSQILCVVMEYAAGGDLQGKITANIKSKTM
...|...|||||  .. ||.|.||  |..|  .    .|||.|...||| ||| .  . ||.|||.|. . . ||  ||||. ||||  || .   .  .
YHYIKQIGEGSFGKAWLVKHKEDGQHYVIKEINVMKMQEKEREESMNEVAILAKMKHPNIVKYKESFEENGCGILYIVMEYCDGGDLMQKINRQKRKGKL

FPESEVWKALIHMSKGLQILHQMQILHRDLKCANVFLS--LEG---------------VYKLGDLNVSKVAKKGLVYTQT--GTPYYASPEVWRDEPYDV
|.| .     . ....|.  |   |||||.|  |.||.    |               . ||||  ....    . | .|  ||||| ||| .   ||. 
FSEDQIMHWFCQICLALNHIHDRKILHRDIKSQNIFLTISKNGMGSGSGSGSSNDSIPLVKLGDFGIARMLNHTMEYACTCIGTPYYLSPEICQNKPYNN

KSDIWSLGCVLYEMCALKPPFRANDMEGLYKKVQKGDFERIPKKYSEDLQRMLTMLLKVNPKDRPSCEQILSNPIV
||||||||||||| |.|| || || .  |  |. .| .  ||. ||..||  .. ..|.||..|||  |||. |..
KSDIWSLGCVLYELCTLKHPFEANNWKNLVLKICQGTYPPIPPHYSYELQSLVSQMFKRNPRHRPSVNQILERPFI
Kinase 23433.AA S_TKc 33-289 28 1.6e-83 284.66 SMART 1-231 (231) Show / Hide 
Range on Protein: 33-289
Range on HMM: 1-231/231
Sequence Identity: 28% (77 aa)

FEVISKLGEGSFSQVFQVKRKSDGMIYAMKKVKMGLLKEKEKENALNEVRILASLNDEFIVGYKEAFIDEQSQILCVVMEYAAG--GDLQGKITANIKSK
.|.. |.|.|.|..|.... |..| |.|.|..|         |....|..|| . . ..|| ....| |   . |..||||. |  |||   |  . . .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHG

TM--FPESEVWKALIHMSKGLQILHQMQILHRDLKCANVFLSLEGVYKLGDLNVSKVAKKGLVYTQTGTPYYASPEVWRDEPYDV-KSDIWSLGCVLYEM
.   ||| .... .  . ..|. .|...|.||||| .|..|.   . |..|  ....      .|. |||.| .|||    .|.  |.|.||.||.||||
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEM

CALKPPFRANDMEGLYKKVQKGDFERIPKKYSEDLQRMLTMLLKVNPKDRPSCEQILS-------NPIV
.. .|||.  .|. ..||.            |...  ..  .|...|..||.. ..|         | .
LCGYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 23433.AA NEK2 33-289 32 4.9e-78 262.34 In-house 1-319 (319) Show / Hide 
Range on Protein: 33-289
Range on HMM: 1-319/319
Sequence Identity: 32% (104 aa)

FEVISKLGEGSFSQVFQVKRKSDGMIYAMKKVKMGLLKEKEKENALNEVRILASLNDEFIVGYKEAFIDEQSQILCVVMEYAAGGDLQGKITANIKSKTM
 ||   .|.||| ..  |.||||| | . |  . | . |||.    .|. ||  |  ..|| |    ||.|.. | .|||| .||||   |.   | .. 
YEVLYTIGNGSFGRCRKVRRKSDGKILVWKEICYGHMQEKECQMLVSECNILRQLKHPNIVRYYDWIIDRQNSTLYIVMEYCEGGDLSQMIKKCRKERQY

FPESEVWKALIHMSKGLQILHQ---------------------MQILHRDLKCANVFLSLEGV-------------------------------------
..|. .|. .  .   ||  |                        |||||.| ||.||. ..                                      
MEEEFIWRIMFQLCTALQECHNGVELPTLTTIYDRMKPRIDGKHTILHRDIKPANIFLDYDHNDYNINEQVDGHEEVNSNYYRDHRVNSGKRGSPMDYSQ

--YKLGDLNVSKVAKKGLVYTQT--GTPYYASPEVWRDEPYDVKSDIWSLGCVLYEMCALKPPFRANDMEGLYKKVQKGDFERIPKKYSEDLQRMLTMLL
   ||||    .. ..   . .|  ||||| |||.  . .|. ||||||.||..||||||.|||.|     |  |...| |.|||  ||..|.   .  .
VVVKLGDFGLARMLNHDTSFAHTFVGTPYYMSPEQMHGQKYNEKSDIWSVGCLIYEMCALHPPFQATNQAQLQEKIKQGHFRRIPYQYSRHLNEIIHFMI

KVNPKDRPSCEQILSNPIV
.|... ||| | || .| .
NVDHYHRPSIEEILQHPQI
Kinase 23433.AA Pkinase 33-289 28 2.3e-67 234.89 Pfam 1-293 (293) Show / Hide 
Range on Protein: 33-289
Range on HMM: 1-293/293
Sequence Identity: 28% (85 aa)

FEVISKLGEGSFSQVFQVKRKSDGMIYAMKKVKMGLLKEKEKENALN--EVRILASLNDEFIVGYKEAFIDEQSQILCVVMEYAAGG----DLQGKITAN
.....|.|.|||..|.. ..|..| |.|.|..|    |.........  |..|...|| ..|| ....| |  .. ...||||. ||    ||   |.. 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYIST-

IKSKTMF--PESEVWKALIHMSKGLQILHQMQILHRDLKCANVFLSLEGVY----KLGDLNVSK---VAKKGLVYTQTGTPYYASPEVWR-DEPYDVKSD
 .... |  .| |. . .  . .||. .|.| |.||||| .|.... .|.     |..|  ..|     ...  .| .|||.|..||| | ...|. |.|
-WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVD

IWSLGCVLYEMCALKPPFRAN------DMEGLYKKVQKGDFERI-PKKYS-------------------EDLQRMLTMLLKVNPKDRPSCEQILSNPIV
.||.||.||||.  .|||.        |.  ..... ......  |...|                   |...  .. .|...||.||..||||  | .
MWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 23433.AA NEK4 33-289 36 4.1e-67 229.27 In-house 1-257 (257) Show / Hide 
Range on Protein: 33-289
Range on HMM: 1-257/257
Sequence Identity: 36% (95 aa)

FEVISKLGEGSFSQVFQVKRKSDGMIYAMKKVKMGLLKEKEKENALNEVRILASLNDEFIVGYKEAFIDEQSQILCVVMEYAAGGDLQGKITANIKSKTM
.. .   | ||.  |. |. . |.  | |||...     .|.  |. |...|  |    || ||| .  |  |.|..|| .  ||||  |     .   .
YCHMKVVGKGSYGEVWLVRHRRDKKQYVMKKMFLKNASRRERKAAEHEAQLLSQLKHPNIVEYKESWEIENGQFLYIVMGFCEGGDLYRKLKQ--QKNQF

FPESEVWKALIHMSKGLQILHQMQILHRDLKCANVFLSLEGVYKLGDLNVSKVAK--KGLVYTQTGTPYYASPEVWRDEPYDVKSDIWSLGCVLYEMCAL
 .|. |    .    .|| .|. .|||||||  |.||    . |.||. .|.|      .  |  ||||| |||..   ||| ||||||||| .|||  |
LEEYQVVEWFVQIAMALQYMHEKHILHRDLKTQNIFLTKKNIIKIGDFGISRVLNNHCDMAKTMIGTPYYMSPECFGNRPYDYKSDIWSLGCCVYEMITL

KPPFRANDMEGLYKKVQKGDFERIPKKYSEDLQRMLTMLLKVNPKDRPSCEQILSNPIV
|  | | ||  |  .. .|    .|..||.||| ..  .|.  |..|||  .|.  | .
KHAFDAKDMNSLIYQIIQGQPPPMPPNYSQDLQNLVYQMLEKQPTKRPSIFDIFQMPYI
Kinase 23433.AA CAMK 38-289 18 7.2e-63 201.13 In-house 1-425 (425) Show / Hide 
Range on Protein: 38-289
Range on HMM: 1-425/425
Sequence Identity: 18% (77 aa)

KLGEGSFSQVFQVKRKSDG------------MIYAMKKVKMGLLK--------------------------EKEKENALNEVRILAS-------LNDEFI
.||.|||..|. ...|...              .|.| ..   ||                          .| ..| ..|..|. .       |. . |
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VGYKEAFIDEQ-----------------SQILCVVM---EYAAGG----DLQGKITAN------------IKSKTMFPESEVWKALIHMSKGLQILHQMQ
.   |.. |..                  . .. ||   ||. ||    ||  .|...            . ..  |.|.|. .    .  ... .|.. 
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIV-ERGRFTEREARRYFRQICSAVHYCHSHN

ILHRDLKCANVFLSLE-----------------GVYKLGDLNVSKVAKKG-------------------------LVYTQTGTPYYAS-PEVWRD-----
| |||||. |. |.                   .  |. |   ... ..|                         . .|. |||.|.. ||| .      
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

---------EPYDVKSDIWSLGCVLYEMCALKPPFRAN-------------DMEGLYKKVQKGDFERIPKK-----------------------YSEDLQ
         ..|. |.|.||.|..|| |   .|||..              ... |..|..||... .|..                        |.. .
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK

RMLTMLLKVNPKDRPSCEQILSNPIV
 ..  .|.|.|..|...||.|. | .
DLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 23433.AA NEK6 33-280 35 2.1e-58 190.71 In-house 1-252 (252) Show / Hide 
Range on Protein: 33-280
Range on HMM: 1-252/252
Sequence Identity: 35% (90 aa)

FEVISKLGEGSFSQVFQVKRKSDGMIYAMKKVKM-GLLKEKEKENALNEVRILASLNDEFIVGYKEAFIDEQSQILCVVMEYAAGGDLQGKITANIKSKT
|..  |.| | || |.. .   |..  |.|||..  .. .| ..  . |. .| .|| . .. | ..||..    | .|.| |  ||.   |    | | 
FQIEKKIGKGQFSEVYRAQCLWDDKHVALKKVQIFEMMDAKARQDCIKEIDLLKQLNHPNVIKYYASFIENNE--LNIVLELADAGDMSRMIKHFKKQKR

MFPESEVWKALIHMSKGLQILHQMQILHRDLKCANVFLSLEGVYKLGDLNVSKV--AKKGLVYTQTGTPYYASPEVWRDEPYDVKSDIWSLGCVLYEMCA
. ||  .||  . ... |. .|.  ..|||.| ||||.  .|. ||||| . .   .|        ||||| |||  ... |  |||||||||.|||| |
LIPERTIWKYFVQLCSALEHMHSKRVMHRDIKPANVFITANGIVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIHENGYNFKSDIWSLGCLLYEMAA

LKPPFRANDME--GLYKKVQKGDFERIP-KKYSEDLQRMLTMLLKVNPKDRPSC
|. ||    |    | ||... |.  .|   |||.|.....| .. .|. ||  
LQSPFYGDKMNLYSLCKKIEQCDYPPLPADHYSEQLRQLVCMCIHPDPEWRPDI
Kinase 23433.AA Ciliate-E2 33-289 22 5.1e-58 197.75 In-house 1-365 (365) Show / Hide 
Range on Protein: 33-289
Range on HMM: 1-365/365
Sequence Identity: 22% (84 aa)

FEVISKLGEGSFSQVFQVKR-----------------------KSDGMIYAMKKV-KMGLLKEKEKENALNEVR----------ILASLNDEFIVGYKEA
...| |.|.|.|..|...|.                       | ...||||| . | ..   | ... ..|..          || .||  .|. ..|.
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FIDEQSQILCVVMEYAAGGDLQGKITAN-IKSKTMFP------ESEVWKALIHMSK---------------GLQILHQMQ-ILHRDLKCANVFLSLEGVY
|.... . .  ||||. ||||.  |  | .|..  ..      | |. .   .  .               .|. ||.   |.|||.|  |...      
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

KLGDLNVSKVAKKG---------------------------------LVYTQTGTPYYASPEVWRDEP---------YDVKSDIWSLGCVLYEMCALKPP
|. |.  || ...                                  ...|. |||.| .||. . ..         || |.||||||..||||.  |||
KIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP

FRANDMEGLYKKVQKGDFE-R----------------IPKKYSEDLQRMLTM----LLKVNPKDRPS-CEQILSNPIV
|        ... ...... .                ..|| |.. . ..      .|...|. |..  |||| .|. 
F--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 23433.AA STE 33-289 23 6.9e-58 198.62 In-house 1-359 (359) Show / Hide 
Range on Protein: 33-289
Range on HMM: 1-359/359
Sequence Identity: 23% (85 aa)

FEVISKLGEGSFSQVFQVKRKS---------------DGMIYAMKKVKMGLLK---------------EKEKENALNEVRILASLN--DEFIVGYKEAFI
.| |.|.|.|.| .|.. ...                 | |.|.|....   .               ..|... |.|..|.  .|   ..|| |  ...
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

DE---QSQ--ILCVVMEYAAGGDLQGKITAN-IKSKTM---------FPESEVWKALIHMSKG-LQILHQMQILHRDLKCANVFLSLEGVYKLGDLNVSK
.|   ...   |...||| .|| |   |  . .. |..         ||||.. . .    || |. ||...| |||.|.||..|      || |  |..
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

-VAK-----------------KGLVYTQTGTPYYASPEVWR------DEPYDVKSDIWSLGCVLYEMCALKPPFRA-NDMEGLYKKVQK-----------
 ...                 ..  .| .||| . .||| .      | .||.|.|||||||.. ||.  |||.   ..|. .. . ..           
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC

---GDFERIPK-------------------KYSEDLQRMLTMLLKVNPKDRPSCEQILS--NPIV
   |.  ..|                    |.|....  .   |. .|..||. .| |.   | .
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 23433.AA Ciliate-E2-Unclassified 33-289 24 6.5e-57 195.39 In-house 1-352 (352) Show / Hide 
Range on Protein: 33-289
Range on HMM: 1-352/352
Sequence Identity: 24% (86 aa)

FEVISKLGEGSFSQVFQVKRKSDG-----------MIYAMKKVKMGLLKEKEKENALNEVR-------------ILASLNDEFIVGYKEAFIDEQSQILC
...| ..|.|.|..|.....|...           .||..|...     .. .....|.               || .....||| . ..| |.|  .. 
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYI-

VVMEYAAGGDLQGKIT-------------ANIKSKTMFPESEVW-----KALIHMSKGLQILHQMQ-ILHRDLKCANVFLSLEG---VYKLGDLNVSK--
 ||||. ||||.  |.              |.|.. .|.| ..      . . .  .||. ||. . |.|||.|. |.... .|     |. |.  ||  
-VMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKY

---------------VAKKGLVYTQTGTPYYA----SPEVWRDEPYD----VKSDIWSLGCVLYEMCALKPPFRANDMEG----------------LYKK
               . |. . .|..|||.|     .||| . . ||     |.||||||..||||.  ..|| .|. |                 ||..
QQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQN

VQKGDFERIP-------KKYSEDLQRMLT----MLLKVNPKDRPSCEQILSNPIV
 ......  .       |. |.  . ...     .||.||. |.. ||||  |. 
IKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 23433.AA ULK 33-289 24 2.4e-56 193.51 In-house 1-329 (329) Show / Hide 
Range on Protein: 33-289
Range on HMM: 1-329/329
Sequence Identity: 24% (80 aa)

FEVISKLGEGSFSQVFQVK---RKSDGMIYAMKKVKMGLLKEKEKEN-----------ALNEVRILASLN----DEF----IVGYKEAFIDEQSQILCVV
.... .||.||| .|.. .   .| |  .  . ..|| ..... ..|             ||..|.  |.     ..    || ... | . ..  .  .
YCLNHCLGKGSFGKVYKGRNKKTK-D-YVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYII

MEYAAGGDLQGKITANIK------SKTMFPESEVWKALIHMSKGLQILHQMQILHRDLKCANVFLSLE------------GVYKLGDLNVSKVAKKG---
|||  ||||.  |  | |       |  ..|.|. . ...   |.. ||...| |||.| .|. ..              ||.|..|   .|.  ..   
MEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNME

--LVYTQT------GTPYYASPEVWR----DEPYD-VKSDIWSLGCVLYEMCALKPPFRANDMEGLY-----KKVQKGDFER-----IPKK---------
  . .|..      |||.| .|...      .||.  |.|||||||..|||   ||||.|.  . .|     | .....  .     .| .         
QQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQ

YSEDLQRMLTMLLKVNPKDRPSCEQILSNPIV
 |....  .  .|....||| | |.....|..
ISPECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase 23433.AA TyrKc 33-287 19 1.7e-16 43.93 SMART 1-280 (280) Show / Hide 
Range on Protein: 33-287
Range on HMM: 1-280/280
Sequence Identity: 19% (57 aa)

FEVISKLGEGSFSQVFQVKRKSDGMIYAMKKVKMGLLKEKEKENALNEVRILASL--NDEFIVGYKEAFIDE-----QSQILCVVMEYAAGGDLQGKITA
 . . ||||| | .|.. . |   .  | |..| .      .|  ..| ||. .|  . . ||    . ...      .. |..||||...|||.  . .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

NIKSKTMFPESEVWKALIHMSKGLQILHQMQILHRDLKCANVFLSLEGVYKLGDLNVSKVAKKG-------LVYTQT---GTP-----YYASPEVWRDEP
. .    .. ..  .  .  ..| . ||.... |||| . |. .. ... | .|   |.  . .        .|...   |.         .||....  
HRPK---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK

YDVKSDIWSLGCVLYEMCAL-KPPFRA-----NDMEGLYKKVQKGDFERIPKK--------YSEDLQRMLTMLLKVNPKDRPSCEQILSNP
.  |||.|| | ...|.. . ..|         . . ....|..|.  ..|.          .... .. ..  . .|.|||. ..| .  
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase 23433.AA Pkinase_Tyr 33-119 26 0.000228 15.42 Pfam 1-94 (270) Show / Hide 
Range on Protein: 33-119
Range on HMM: 1-94/270
Sequence Identity: 26% (25 aa)

FEVISKLGEGSFSQVFQVKRK----SDGMIYAMKKVKMGLLKEKE--KENALNEVRILASL-NDEFIVGYKEAFIDEQSQ-ILCVVMEYAAGGDL
 . . |||||.| .|.. . |    ....  | |..|     ...  .|  ..|..|. .| . . || .  . .|.. .  ...||||...|||
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKE-GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDL
Kinase 23433.AA Pkinase_Tyr 152-230 25 0.000291 15.06 Pfam 127-210 (270) Show / Hide 
Range on Protein: 152-230
Range on HMM: 127-210/270
Sequence Identity: 25% (21 aa)

LHQMQILHRDLKCANVFLSLEGVYKLGDLNVSKVAKKGLVY-TQTG---TPY-YASPEVWRDEPYDVKSDIWSLGCVLYEMCAL
|..... |||| . |. .. ..| | .|   ..   .   | ...|    |    .||....  . .|||.|| | ...|.. .
LESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVLMWEIFTY