Gene 2469 (Tetrahymena)

2469

Species: Tetrahymena
Alias: 824, PreTt02469, TTHERM_00245740, 2469, 21.m00300
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: NEK

Sequence

Name Sequence Type Origin Length Description Download
2469.AA Protein None 543 None Fasta, JSON
2469.kin_dom Protein Kinase Domain None 257 None Fasta, JSON
2469.NA RNA None 1632 None Fasta, JSON

Protein domain

Protein domains of 2469.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 2469.AA NEK 6-262 42 3.5e-152 511.88 In-house 1-286 (286) Show / Hide 
Range on Protein: 6-262
Range on HMM: 1-286/286
Sequence Identity: 42% (122 aa)

FVNLQKIGEGSYSSVHKVRRISDNQE-----YALKKVKLSGLSEKEKDNAL-NEIRILASIAHPNMIAYKDAFFDESSHSLCIVMELAV-NGDLSKK---
.  ..|||.||...|.||||.||...     |..||......|||||.||. ||.|||... ||| ..|.|.|..| ...|||||| .  .|||..|   
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKS

IDSAKKRNSFVPEEEIWTVALHMLRGLKAMHSK-----KILHRDLKCANVFISKQDE----YKIGDLNVSKVAKRG--LVYT-QTGTPYYASPEVWRDEP
|   |... . .||.|| .  .|. .|| ||..     ||||||.|..|.|..|..      ||||...||| ...  . || |.|||||.||||....|
IKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDMAYTTQVGTPYYMSPEVCQNKP

YDSSSDIWSFGCILYELAAL--NPPFRAK--DMEGLYKKVQKG-IFERIPQR--YSNDLQKFIALCLQVSSVQRPSVTQLLNNVLL
|.. |||||.||.|||...|  ..||.|.  .|..||.|..||  ...||..  ||.|||..| ..||..  ||||..|.|.. ..
YNNKSDIWSLGCVLYEMCTLKPKHPFEAWDMNMPSLYMKIMKGPQYPPIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase 2469.AA S_TKc 6-262 28 6.9e-80 272.63 SMART 1-231 (231) Show / Hide 
Range on Protein: 6-262
Range on HMM: 1-231/231
Sequence Identity: 28% (77 aa)

FVNLQKIGEGSYSSVHKVRRISDNQEYALKKVKLSGLSEKEKDNALNEIRILASIAHPNMIAYKDAFFDESSHSLCIVMELAVN--GDLSKKIDSAKKRN
.  |.|||.|....|.|.| .......|.|..|         .....||.|| .  ||| . ..|.| |   ..|..|||.. .  ||| . |.. ... 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHG

SF--VPEEEIWTVALHMLRGLKAMHSKKILHRDLKCANVFISKQDEYKIGDLNVSKVAKRGLVYTQTGTPYYASPEVWRDEPYDS-SSDIWSFGCILYEL
     || ... ..  ....|. .||..|.||||| .|.....  . ||.|  ....      .|. |||.| .|||    .|.  ..|.||.||||||.
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEM

AALNPPFRAKDMEGLYKKVQKGIFERIPQRYSNDLQKFIALCLQVSSVQRPSVTQLLN-------NVLL
..  |||.  .|. ..||.            | ..  ||  |||.   .||.. ..|.          .
LCGYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 2469.AA NEK1 6-262 34 4.7e-77 262.31 In-house 1-276 (276) Show / Hide 
Range on Protein: 6-262
Range on HMM: 1-276/276
Sequence Identity: 34% (94 aa)

FVNLQKIGEGSYSSVHKVRRISDNQEYALKKVKLSGLSEKEKDNALNEIRILASIAHPNMIAYKDAFFDESSHSLCIVMELAVNGDLSKKIDSAKKRNSF
.. ...|||||.  . .|.. .|.|.|..|  ...  .|||. ...||  |||   ||| ..||..|. . .  | |||| . .||| .||  .| ..  
YHYIKQIGEGSFGKAWLVKHKEDGQHYVIKEINVMKMQEKEREESMNEVAILAKMKHPNIVKYKESFEENGCGILYIVMEYCDGGDLMQKINRQKRKGKL

VPEEEIWTVALHMLRGLKAMHSKKILHRDLKCANVFIS--KQD---------------EYKIGDLNVSKVAKRGLVYTQT--GTPYYASPEVWRDEPYDS
 .| .|      .  .|. .|..||||||.|  |.| .  | .                 |.||  ....    . | .|  ||||| ||| .   ||. 
FSEDQIMHWFCQICLALNHIHDRKILHRDIKSQNIFLTISKNGMGSGSGSGSSNDSIPLVKLGDFGIARMLNHTMEYACTCIGTPYYLSPEICQNKPYNN

SSDIWSFGCILYELAALNPPFRAKDMEGLYKKVQKGIFERIPQRYSNDLQKFIALCLQVSSVQRPSVTQLLNNVLL
 ||||| ||.|||| .|  || |. .  |  |. .| .  ||..||..||  ..  ....   ||||.|.|  . .
KSDIWSLGCVLYELCTLKHPFEANNWKNLVLKICQGTYPPIPPHYSYELQSLVSQMFKRNPRHRPSVNQILERPFI
Kinase 2469.AA Pkinase 6-262 26 9.1e-74 256.18 Pfam 1-293 (293) Show / Hide 
Range on Protein: 6-262
Range on HMM: 1-293/293
Sequence Identity: 26% (79 aa)

FVNLQKIGEGSYSSVHKVRRISDNQEYALKKVKLSGLSEKEKDNALN--EIRILASIAHPNMIAYKDAFFDESSHSLCIVMELAVNG----DLSKKID-S
.. ..|||.||...| | .........|.|..|... ..... ....  ||.|.... ||| . ..|.| |  . ....|||.. .|    ||.  |  .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYISTW

AKKRNSFVPEEEIWTVALHMLRGLKAMHSKKILHRDLKCANVFISKQDEY----KIGDLNVSK---VAKRGLVYTQTGTPYYASPEVWR-DEPYDSSSDI
.... .  .|.|.  ... .||||. .||..|.||||| .|..|.....     ||.|  ..|     . .  .| .|||.|..||| | ...|....|.
RHGCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDM

WSFGCILYELAALNPPFRAK------DMEGLYKKVQKGIFERI-PQRYS-------------------NDLQKFIALCLQVSSVQRPSVTQLLNNVLL
||.||||||..  .|||. .      |.  ..... ......  |. .|                    ....||  ||..   .||. .|.|.   .
WSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 2469.AA NEK2 9-262 29 3.4e-69 232.12 In-house 4-319 (319) Show / Hide 
Range on Protein: 9-262
Range on HMM: 4-319/319
Sequence Identity: 29% (94 aa)

LQKIGEGSYSSVHKVRRISDNQEYALKKVKLSGLSEKEKDNALNEIRILASIAHPNMIAYKDAFFDESSHSLCIVMELAVNGDLSKKIDSAKKRNSFVPE
|. ||.||. .. ||||.||    . |  .   . |||..   .|. ||    ||| . | |  .|. . .| ||||    ||||  |  ..|   . .|
LYTIGNGSFGRCRKVRRKSDGKILVWKEICYGHMQEKECQMLVSECNILRQLKHPNIVRYYDWIIDRQNSTLYIVMEYCEGGDLSQMIKKCRKERQYMEE

EEIWTVALHMLRGLKAMHS------------------KK---ILHRDLKCANVFISKQDE---------------------------------------Y
| || . . ... |.  |                   .    |||||.| ||.| .  .                                         
EFIWRIMFQLCTALQECHNGVELPTLTTIYDRMKPRIDGKHTILHRDIKPANIFLDYDHNDYNINEQVDGHEEVNSNYYRDHRVNSGKRGSPMDYSQVVV

KIGDLNVSKVAKRGLVYTQT--GTPYYASPEVWRDEPYDSSSDIWSFGCILYELAALNPPFRAKDMEGLYKKVQKGIFERIPQRYSNDLQKFIALCLQVS
| ||    .. ..   . .|  ||||| |||.  . .|.  ||||| ||..||..|| |||.|.    |  |...| |.||| .|| .|.. |.. . | 
KLGDFGLARMLNHDTSFAHTFVGTPYYMSPEQMHGQKYNEKSDIWSVGCLIYEMCALHPPFQATNQAQLQEKIKQGHFRRIPYQYSRHLNEIIHFMINVD

SVQRPSVTQLLNNVLL
  .|||.  .| . ..
HYHRPSIEEILQHPQI
Kinase 2469.AA STE 6-262 21 1.2e-62 214.49 In-house 1-359 (359) Show / Hide 
Range on Protein: 6-262
Range on HMM: 1-359/359
Sequence Identity: 21% (80 aa)

FVNLQKIGEGSYSSVHKVRRI------SDNQE---------YALKKVKLSGLS---------------EKEKDNALNEIRILASIA--HPNMIAYKDAFF
. ...|||.|.. .|.| ...      . ...         .| |...|.  .               ..|... |.||.|.      ||| . | ...|
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

DES-----SHSLCIVMELAVNGDLSKKID---SAKKRNS-------FVPEEEIWTVALHMLRG-LKAMHSKKILHRDLKCANVFISKQDEYKIGDLNVSK
.|.      ..|.|.||.  .| |.. |.   . .|...       ..||..| ...   |.| |.  ||..| |||.|.||...      |. |  |..
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

-VAK----------------RGLVY-TQTGTPYYASPEVWR------DEPYDSSSDIWSFGCILYELAALNPPFRA-KDMEGLYKKVQK-----------
 ...                ..    | .||| . .||| .      | .|| ..||||.|| . |.|  .||.   ..|. .. . ..           
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC

---GIFERIPQ-------------------RYSNDLQKFIALCLQVSSVQRPSVTQLLN--NVLL
   |   ..|.                   ..| ... ||..|||    .||...|||.     .
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 2469.AA NEK4 6-262 36 1.2e-62 214.44 In-house 1-257 (257) Show / Hide 
Range on Protein: 6-262
Range on HMM: 1-257/257
Sequence Identity: 36% (96 aa)

FVNLQKIGEGSYSSVHKVRRISDNQEYALKKVKLSGLSEKEKDNALNEIRILASIAHPNMIAYKDAFFDESSHSLCIVMELAVNGDLSKKIDSAKKRNSF
.  .. .| |||  |  ||   |   | .||..|   | .|.  |. |...|    ||| . ||. .  |    |.|||     ||| .|    ...| |
YCHMKVVGKGSYGEVWLVRHRRDKKQYVMKKMFLKNASRRERKAAEHEAQLLSQLKHPNIVEYKESWEIENGQFLYIVMGFCEGGDLYRKL--KQQKNQF

VPEEEI--WTVALHMLRGLKAMHSKKILHRDLKCANVFISKQDEYKIGDLNVSKVAK--RGLVYTQTGTPYYASPEVWRDEPYDSSSDIWSFGCILYELA
..|. .  | |   |  .|  || |.|||||||  |.|. |.   ||||. .|.|      .  |  ||||| |||..   |||  ||||| || .||..
LEEYQVVEWFVQIAM--ALQYMHEKHILHRDLKTQNIFLTKKNIIKIGDFGISRVLNNHCDMAKTMIGTPYYMSPECFGNRPYDYKSDIWSLGCCVYEMI

ALNPPFRAKDMEGLYKKVQKGIFERIPQRYSNDLQKFIALCLQVSSVQRPSVTQLLNNVLL
 |   | ||||  |  .. .|    .|. || |||  .   |.    .|||. ...    .
TLKHAFDAKDMNSLIYQIIQGQPPPMPPNYSQDLQNLVYQMLEKQPTKRPSIFDIFQMPYI
Kinase 2469.AA CAMK 11-262 17 1.2e-62 200.36 In-house 1-425 (425) Show / Hide 
Range on Protein: 11-262
Range on HMM: 1-425/425
Sequence Identity: 17% (74 aa)

KIGEGSYSSVHKVRRISDN------------QEYALKKVKLSGLS--------------------------EKEKDNALNEIRILASIA-------HPNM
..|.||.. |.........            |..| | .. . |.                          .| ..| ..||.|. ..        ||| 
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

IAYKDAFFD-----------ESSH-------SLCIVM---ELAVNG----DLSKKIDSAKKRN-----------SFVPEEEIWTVALHMLRGLKAMHSKK
|   ... |             |.        ...||   |.. .|    ||  .| . ...              ..|.|  ..   .. ... .||..
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

ILHRDLKCANVFISKQD-----------------EYKIGDLNVSKVAKRG-------------------------LVYTQTGTPYYAS-PEVWRD-----
| |||||. |. ... .                   || |   ... ..|                         . .|. |||.|.. ||| .      
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

---------EPYDSSSDIWSFGCILYELAALNPPFRAK-------------DMEGLYKKVQKGIFERIPQRYSN-----------------------DLQ
         ..|. ..|.|| |.||| .    |||...             ... |..|..|| .. .|   |.                       . .
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK

KFIALCLQVSSVQRPSVTQLLNNVLL
 .|  .|||   .|....| ||   .
DLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 2469.AA NEK6 6-253 36 2.3e-59 193.96 In-house 1-252 (252) Show / Hide 
Range on Protein: 6-253
Range on HMM: 1-252/252
Sequence Identity: 36% (93 aa)

FVNLQKIGEGSYSSVHKVRRISDNQEYALKKVKLSGL-SEKEKDNALNEIRILASIAHPNMIAYKDAFFDESSHSLCIVMELAVNGDLSKKIDSAKKRNS
|   .||| | .| |.. . . |... |||||..  .  .| ..  . || .| .. |||.| | ..| ..    | ||.|||  ||.|. |   ||   
FQIEKKIGKGQFSEVYRAQCLWDDKHVALKKVQIFEMMDAKARQDCIKEIDLLKQLNHPNVIKYYASFIEN--NELNIVLELADAGDMSRMIKHFKKQKR

FVPEEEIWTVALHMLRGLKAMHSKKILHRDLKCANVFISKQDEYKIGDLNVSKV--AKRGLVYTQTGTPYYASPEVWRDEPYDSSSDIWSFGCILYELAA
 .||  ||     . . |. ||||...|||.| |||||  .   |.||| . .   .|        ||||| |||  ... |   ||||| ||.|||.||
LIPERTIWKYFVQLCSALEHMHSKRVMHRDIKPANVFITANGIVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIHENGYNFKSDIWSLGCLLYEMAA

LNPPFRAKDME--GLYKKVQKGIFERIP-QRYSNDLQKFIALCLQVSSVQRPSV
|  ||    |    | ||...  .  .| . ||..|.. ...|.. .. .|| .
LQSPFYGDKMNLYSLCKKIEQCDYPPLPADHYSEQLRQLVCMCIHPDPEWRPDI
Kinase 2469.AA Ciliate-E2 6-262 20 3.1e-56 191.54 In-house 1-365 (365) Show / Hide 
Range on Protein: 6-262
Range on HMM: 1-365/365
Sequence Identity: 20% (77 aa)

FVNLQKIGEGSYSSVHKVRRISD-----------------------NQEYALKKVKLSGLSEKEK-DNALNEIR----------ILASIAHPNMIAYKDA
.  ..|||.|...|| |......                       ...||.| .| ... .... .. ..||.          || .. ||| | ....
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FFDESSHSLCIVMELAVNGDLSKKIDSAKKRNSFVPE-------EEIWTVALHMLR---------------GLKAMHSKK-ILHRDLKCANVFISKQDEY
| ... ... .|||..  ||| . | . ||   . .|       .|| ..  . |.               .|. .|||. |.|||.|  |...      
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

KIGDLNVSK---------------------------------VAKRGLVYTQTGTPYYASPEVWRDEP---------YDSSSDIWSFGCILYELAALNPP
|| |.  ||                                 . .  ...|. |||.| .||. . ..         || ..||||.|.||||.   .||
KIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP

FRAKDMEGLYKKVQKGIFE-R----------------IPQRYSNDLQKFIAL----CLQVSSVQRPS-VTQLLNNVLL
|        ... ... .. .                ...  |.. . .|      .||.   .|..   |.||.  .
F--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 2469.AA ULK 6-262 23 1.9e-53 183.88 In-house 1-329 (329) Show / Hide 
Range on Protein: 6-262
Range on HMM: 1-329/329
Sequence Identity: 23% (77 aa)

FVNLQKIGEGSYSSVHKVR-RISD---NQEYALKKVKLSGLSEKEKDNA--------LNEIRILASIA--------HPNMIAYKDAFFDESSHSLCIVME
..  ...|.||.  |.| |  ...   |. .| |.. .. ...|....          |||.|.  .         ||| . ..| | .  .  . |.||
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

LAVNGDLSKKIDSAKK------RNSFVPEEEIWTVALHMLRGLKAMHSKKILHRDLKCANVFISKQD------------EYKIGDLNVSKVAKRG-----
.   |||.. |   ||      .. . .|.|.  .  . | |.|..|...| |||.| .|. |.. .             .||.|   .|.   .     
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

LVYTQT------GTPYYASPEVWR----DEPYDSS-SDIWSFGCILYELAALNPPFRAKDMEGLY-----KKVQKG---------IFERIP-----QRYS
. .|..      |||.| .|...      .||... .||||.|||.||.    |||.|   . .|     | ....         .  ..|     .  |
MMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQIS

NDLQKFIALCLQVSSVQRPSVTQLLNNVLL
.... .|  .||.   .| | ..|.|. ..
PECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase 2469.AA ULK 6-262 23 3.9e-53 182.86 In-house 1-324 (324) Show / Hide 
Range on Protein: 6-262
Range on HMM: 1-324/324
Sequence Identity: 23% (76 aa)

FVNLQKIGEGSYS-SVHKVR-RISD--NQEYALKKVKLSGLSEKEKD--------NALNEIRILASIA---HPN--MIAYKDAFFDESSHSLCIVMELAV
..  ...|.||.   |.| |  ...  || .| |.. ......|...        .  |||.|.  .    |||   . ..| | .  .  ..|.||.  
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

NGDLSKKIDSAKK-----RNSFVPEEEIWTVALHMLRGLKAMHSKKILHRDLKCANVFISKQD------------EYKIGDLNVSKVAKRG-----LVYT
 |||.. |   ||     .. . .|.|.  .  . . |.|..|...| |||.| .|  |.. .             .||.|   .|.   .     . .|
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQT

QT------GTPYYASPEVWR----DEPYDSS-SDIWSFGCILYELAALNPPFRAKDMEGLY----KKVQKG------IFE---RIP-----QRYSNDLQK
.       |||.| .|...      .||... .||||.|||.||.    .||..   . .|    | ...|      |     ..|     .  |.... 
CVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKD

FIALCLQVSSVQRPSVTQLLNNVLL
.|  .||.   .| | ....|. ..
LIRRMLQYDEKDRISWEEIFNHPWF
Kinase 2469.AA TyrKc 6-260 18 3.1e-17 55.86 SMART 1-280 (280) Show / Hide 
Range on Protein: 6-260
Range on HMM: 1-280/280
Sequence Identity: 18% (54 aa)

FVNLQKIGEGSYSSVHKVRRISDNQEYALKKVKLSGLSEKEKDNALNEIRILASI--AHPNMIAYKDAFFDE-----SSHSLCIVMELAVNGDLSKKIDS
 . ..|.||| .  |.| . .   .. | |..| .      .   ..|.||. ..   ||| ..   .  ..     ... |.||||.. .||| . . .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

AKKRNSFVPEEEIWTVALHMLRGLKAMHSKKILHRDLKCANVFISKQDEYKIGDLNVSKVAKRG-------LVYTQT---GTP-----YYASPEVWRDEP
 ...   .. ..    ..   .|    |||.. |||| . |. ....   ||.|   |.  . .        .|...   |.         .||....  
HRPK---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK

YDSSSDIWSFGCILYELAAL-NPPFRA-----KDMEGLYKKVQKGIFERIPQR--------YSNDLQKFIALCLQVSSVQRPSVTQLLNNV
. . ||.||||  ..|.  .  .|        .. . ....|..|   ..|.          . .. . .  | .    .||. ...    
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase 2469.AA Pkinase_Tyr 6-92 23 2e-06 22.23 Pfam 1-94 (270) Show / Hide 
Range on Protein: 6-92
Range on HMM: 1-94/270
Sequence Identity: 23% (22 aa)

FVNLQKIGEGSYSSVHKVRRI----SDNQEYALKKVKLSGLSEKE--KDNALNEIRILASI-AHPNMIAYKDAFFDESSH-SLCIVMELAVNGDL
 . ..|.|||.. .|.| .      ..... | |..   | ....  ..  ..|..|. ..  ||| . .  .  |.. . ...||||.. .|||
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDL
Kinase 2469.AA Pkinase_Tyr 175-200 34 0.021668 8.72 Pfam 182-207 (270) Show / Hide 
Range on Protein: 175-200
Range on HMM: 182-207/270
Sequence Identity: 34% (9 aa)

SPEVWRDEPYDSSSDIWSFGCILYEL
.||....  . . ||.||||  ..|.
APECINYGKFTTKSDVWSFGVLMWEI
Kinase 2469.AA Pkinase_Tyr 126-152 37 0.936672 3.18 Pfam 128-154 (270) Show / Hide 
Range on Protein: 126-152
Range on HMM: 128-154/270
Sequence Identity: 37% (10 aa)

HSKKILHRDLKCANVFISKQDEYKIGD
.||.. |||| . |. ....   ||.|
ESKNCIHRDLAARNCLVTENNVVKICD