24902

Species: Tetrahymena
Alias: 24902, TTHERM_00390060, 71, PreTt24902, 41.m00309
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: NEK

Sequence

Name Sequence Type Origin Length Description Download
24902.AA Protein None 880 None Fasta, JSON
24902.kin_dom Protein Kinase Domain None 255 None Fasta, JSON
24902.NA RNA None 2643 None Fasta, JSON

Protein domain

Protein domains of 24902.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 24902.AA NEK 4-258 49 2.5e-162 545.58 In-house 1-286 (286) Show / Hide
Range on Protein: 4-258
Range on HMM: 1-286/286
Sequence Identity: 49% (141 aa)

YETVKLIGSGAFGQVYLVKHKREDKM-----YVNKKIKTRDMSQKDRENTE-NEVRLLQKLRHANIVAYKDSYMDRE-QYLNIVMIHCE-GGDMHNR---
|| .| ||.|.||.||.|..|.  |.     || |||..  ||.|...|.  ||||.|..|.| |||.|.||..... ..|.||| .|| |||....   
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKS

IKNQK--GKNFPEDQIQDWLAQMALALFYLHEK-----KILHRDLKTQNIFLKS-GR----VRLGDFGIAKVLDSTRDFANT-CIGTPYYMSPELFKYKP
||.||  ||.|.|.|| ||..||.||| |.|..     ||||||.|.||||| . ..    |..|||||.|||..|.|.|.| ..|||||||||... ||
IKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDMAYTTQVGTPYYMSPEVCQNKP

YSYKSDIWAFGCVLYEMCNL--RHAFDAQ--SLNGLAVKIMNG-TYPPINST--YSKSLRDLIGKMLQLNPKSRPSILDIINTSFV
|..|||||..|||||||| |  .|.|.|.  ....|..|||.| .||||.|.  ||. |..|| .||| .|..|||. .|....|.
YNNKSDIWSLGCVLYEMCTLKPKHPFEAWDMNMPSLYMKIMKGPQYPPIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI

Kinase 24902.AA NEK1 4-258 47 2.8e-125 422.48 In-house 1-276 (276) Show / Hide
Range on Protein: 4-258
Range on HMM: 1-276/276
Sequence Identity: 47% (131 aa)

YETVKLIGSGAFGQVYLVKHKREDKMYVNKKIKTRDMSQKDRENTENEVRLLQKLRHANIVAYKDSYMDREQ-YLNIVMIHCEGGDMHNRIKNQ--KGKN
|.  | ||.|.|| ..||||| . ..|| | |.   |..|.||.  ||| .|.|..| |||.||.|   . .  | |||  |.|||.  .|..|  ||| 
YHYIKQIGEGSFGKAWLVKHKEDGQHYVIKEINVMKMQEKEREESMNEVAILAKMKHPNIVKYKESFEENGCGILYIVMEYCDGGDLMQKINRQKRKGKL

FPEDQIQDWLAQMALALFYLHEKKILHRDLKTQNIFLK---SG---------------RVRLGDFGIAKVLDSTRDFANTCIGTPYYMSPELFKYKPYSY
|.|||| .|  |. ||| . | .||||||.|.|||||    .|                |.|||||||..| .| ..|.|||||||| |||.   |||  
FSEDQIMHWFCQICLALNHIHDRKILHRDIKSQNIFLTISKNGMGSGSGSGSSNDSIPLVKLGDFGIARMLNHTMEYACTCIGTPYYLSPEICQNKPYNN

KSDIWAFGCVLYEMCNLRHAFDAQSLNGLAVKIMNGTYPPINSTYSKSLRDLIGKMLQLNPKSRPSILDIINTSFV
|||||. |||||| | | |.|.|...  |  ||  |||||| ..||. |. |. .|.. ||..|||. .|    |.
KSDIWSLGCVLYELCTLKHPFEANNWKNLVLKICQGTYPPIPPHYSYELQSLVSQMFKRNPRHRPSVNQILERPFI

Kinase 24902.AA NEK4 4-258 48 1.1e-120 407.19 In-house 1-257 (257) Show / Hide
Range on Protein: 4-258
Range on HMM: 1-257/257
Sequence Identity: 48% (125 aa)

YETVKLIGSGAFGQVYLVKHKREDKMYVNKKIKTRDMSQKDRENTENEVRLLQKLRHANIVAYKDSYMDREQ-YLNIVMIHCEGGDMHNRIKNQKGKNFP
|. .| .| | .| |.||.|.|  | || ||.. .  |...|  .| |..|| .|.| ||| ||.|.   .  .| |||  |||||. .. | ||..  .
YCHMKVVGKGSYGEVWLVRHRRDKKQYVMKKMFLKNASRRERKAAEHEAQLLSQLKHPNIVEYKESWEIENGQFLYIVMGFCEGGDLYRKLKQQKNQFLE

EDQIQDWLAQMALALFYLHEKKILHRDLKTQNIFL-KSGRVRLGDFGIAKVLDSTRDFANTCIGTPYYMSPELFKYKPYSYKSDIWAFGCVLYEMCNLRH
| |. .|  | |.|| |.|||.||||||||||||| |   ...|||||..||.   |.| | ||||||||||.|  .|| ||||||. || .|||  |.|
EYQVVEWFVQIAMALQYMHEKHILHRDLKTQNIFLTKKNIIKIGDFGISRVLNNHCDMAKTMIGTPYYMSPECFGNRPYDYKSDIWSLGCCVYEMITLKH

AFDAQSLNGLAVKIMNGTYPPINSTYSKSLRDLIGKMLQLNPKSRPSILDIINTSFV
||||  .| |  .|..|  ||.   ||. | .|. .||.  |. |||| ||.   ..
AFDAKDMNSLIYQIIQGQPPPMPPNYSQDLQNLVYQMLEKQPTKRPSIFDIFQMPYI

Kinase 24902.AA NEK8 4-258 37 1.9e-100 287.48 In-house 1-278 (278) Show / Hide
Range on Protein: 4-258
Range on HMM: 1-278/278
Sequence Identity: 37% (106 aa)

YETVKLIGSGAFGQVYLVKHKRED--KMYVNKKIKTRDMSQKDRENTENEVRLLQKLRHANIVAYKDSYMDREQYLNIVMIHCEGGDMHNRIKNQKG-KN
|| .  .| |||| . |   |  .  .  . | | . .|| | |    ||...| .| |.||..| |. |. .. | |.|  ..||     |  |.. . 
YERIRVVGRGAFGICWLYRRKEDQSHHLVIWKQINMHRMSEKERQMAQNEIQVLSMLQHPNIISYYDHFME-DNTLMIEMEYADGGTLYQMIQHQQNKLF

FPED----------------QIQDWLAQMALALFYLHEKKILHRDLKTQNIFL-KS-GRVRLGDFGIAKVLDSTRDFAN--TCIGTPYYMSPELFKYKPY
..|                 .| . . || .|. ..|.. ||||||||||||. .. . | .|||||.|.. .    .   | .|||||||||. . |||
EEERQLKQVNHCFNIYFNEQMILWYFFQMCSAVHHMHQHNILHRDLKTQNIFMTRHRMVVKIGDFGISKIMNTKYHMQTTKTVVGTPYYMSPEMCEGKPY

SYKSDIWAFGCVLYEMCNLRHAFDAQSLNGLAVKIMNG-TYPPINSTYSKSLRDLIGKMLQLNPKSRPSILDIINTSFV
  |||.|| |||||||| |. ||.|  |  | .||| . .| || . ||. .| |.   ||. |  |||   |     .
NQKSDMWALGCVLYEMCCLKRAFEASNLPALVWKIMQCRAYEPISDHYSNEMRMLVHNCLQQDPEQRPSASQIMAMPLC

Kinase 24902.AA S_TKc 4-258 31 1.5e-92 314.66 SMART 1-231 (231) Show / Hide
Range on Protein: 4-258
Range on HMM: 1-231/231
Sequence Identity: 31% (86 aa)

YETVKLIGSGAFGQVYLVKHKREDKMYVNKKIKTRDMSQKDRENTENEVRLLQKLRHANIVAYKDSYMDREQYLNIVMIHCEG--GDMHNRIKNQKGKN-
|| ...||.||||.||...||. .. .  |.||         |....|...|.| .| ||| ..|.. |  ..| .|| .|.|  ||.. .||.....  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---FPEDQIQDWLAQMALALFYLHEKKILHRDLKTQNIFLKSGRVRLGDFGIAKVLDSTRDFANTCIGTPYYMSPELFKYKPYSY-KSDIWAFGCVLYEM
   ||| ... ...|...|| |.|...|.||||| .||.| . .. ..|||.|..|       .|..|||.||.||..   .|.. |.|.|..||.||||
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEM

CNLRHAFDAQSLNGLAVKIMNGTYPPINSTYSKSLRDLIGKMLQLNPKSRPSILDIIN-------TSFV
.  .  |.   .. .  ||.           |....|.| |.|| .|. ||.. .. .         ..
LCGYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase 24902.AA Pkinase 4-258 27 5.8e-85 293.36 Pfam 1-293 (293) Show / Hide
Range on Protein: 4-258
Range on HMM: 1-293/293
Sequence Identity: 27% (83 aa)

YETVKLIGSGAFGQVYLVKHKREDKMYVNKKIKTRDMSQKDRENTEN--EVRLLQKLRHANIVAYKDSYMDREQYLNIVMIHCEGG----DMHNRIKNQK
|.... ||||.||.||. .|| . |... |.|| |. . . ...  .  |......|.| ||| ..|...| .... .|| .||||    | . .|. ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-KDHIYMVMEYCEGGLYVMDLFDYISTWR

GKNF--PEDQIQDWLAQMALALFYLHEKKILHRDLKTQNIFLK-SGRV----RLGDFGIAKVL-DSTRDFANTCIGTPYYMSPELFK-YKPYSYKSDIWA
...|  .|....... |.. .| |.|...|.||||| .||...  | .    ...|||.||..       ..|  |||.||.||. . ...|..|.|.|.
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

FGCVLYEMCNLRHAFDAQ----SLNGLAVKIMNGTYPPINSTYS-----------------------KSLRDLIGKMLQLNPKSRPSILDIINTSFV
.||.||||.. |  |. .    . .   ..| .  .||. . ..                       ....|.| ..|...||.||.. .| .  ..
CGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF

Kinase 24902.AA NEK-Unclassified 4-258 37 1.9e-79 262.67 In-house 1-258 (258) Show / Hide
Range on Protein: 4-258
Range on HMM: 1-258/258
Sequence Identity: 37% (98 aa)

YETVKLIGSGAFGQVYLVKHKREDKMYVNKKIKTRDMSQKDRENTENEVRLLQKLRHANIVAYKDSYMDREQYLNIVMIHCEGGDMHNRIKNQKGK--NF
|. .  .| |  | ||||.|.   .  | ..|  |    | .    | . .| .|||  || | ||. .  . |      |.||..  ||. . .|   |
YDKITTLGQGGGGAVYLVRHQISKRHLV-QQISKR----KKKKKRQNKIIILSQLRHPHIVTYHDSFFENAK-LFYTQDYCDGGNLDRRIQKHRKKNEPF

PEDQIQDWLAQMALALFYLHEKKILHRDLKTQNIFL-KSGRVRLGDFGIAKVLDSTRDFANTCIGTPYYMSPELFKYKPYSYKSDIWAFGCVLYEMCNLR
 |  |  |  ||  |. | | .||.|||||.||||| ..  | .|||||....| ||| | ||.||. .||||  . .||  .||.|. ||..||||   
DEGRIMQWCIQMIMAVQYIHQRKIIHRDLKPQNIFLTDDDTVSMGDFGISRIMDHTRDKARTCVGTMCWMSPEVCQDQPYNNRSDVWSLGCIIYEMCTCE

HAFDAQSLNGLAVKIMNGTY------PPINSTYSKSLRDLIGKMLQLNPKSRPSILDIINTSFV
 .||....  .  ||  .         |. .|||  | ..|  ||. |.  ||| ..|.   ..
PFFDTHNMGEVYMKIKQDDNRLEEALEPVSKTYSTDLQQVIRFMLRRNFQQRPSATEIVEQDYI

Kinase 24902.AA NEK2 4-258 31 1.1e-73 247.54 In-house 1-319 (319) Show / Hide
Range on Protein: 4-258
Range on HMM: 1-319/319
Sequence Identity: 31% (102 aa)

YETVKLIGSGAFGQVYLVKHKREDKMYVNKKIKTRDMSQKDRENTENEVRLLQKLRHANIVAYKDSYMDREQ-YLNIVMIHCEGGD---MHNRIKNQKGK
||  . ||.| ||... |..|   |  | | |.   |  | .    .|. .|..|.| ||| | |   ||..  | ||| .|||||   |  . .... .
YEVLYTIGNGSFGRCRKVRRKSDGKILVWKEICYGHMQEKECQMLVSECNILRQLKHPNIVRYYDWIIDRQNSTLYIVMEYCEGGDLSQMIKKCRKER-Q

NFPEDQIQDWLAQMALALFYLHE------------------KK---ILHRDLKTQNIFL-KSGR------------------------------------
 ..|  |   ..|. .||   |                   .    |||||.|  ||||   .                                     
YMEEEFIWRIMFQLCTALQECHNGVELPTLTTIYDRMKPRIDGKHTILHRDIKPANIFLDYDHNDYNINEQVDGHEEVNSNYYRDHRVNSGKRGSPMDYS

---VRLGDFGIAKVLDSTRDFANTCIGTPYYMSPELFKYKPYSYKSDIWAFGCVLYEMCNLRHAFDAQSLNGLAVKIMNGTYPPINSTYSKSLRDLIGKM
   | ||||| |..|     || | .|||||||||. .  .|. |||||. ||..|||| |.  | | .   |..|| .| . .| . ||. | ..|  |
QVVVKLGDFGLARMLNHDTSFAHTFVGTPYYMSPEQMHGQKYNEKSDIWSVGCLIYEMCALHPPFQATNQAQLQEKIKQGHFRRIPYQYSRHLNEIIHFM

LQLNPKSRPSILDIINTSFV
. .....||||  |.  ...
INVDHYHRPSIEEILQHPQI

Kinase 24902.AA CAMK 9-258 19 3.7e-73 234.86 In-house 1-425 (425) Show / Hide
Range on Protein: 9-258
Range on HMM: 1-425/425
Sequence Identity: 19% (84 aa)

LIGSGAFGQVYLVKHKRED------------KMYVNKKIKTRDMS--------------------------QKDRENTENEVRLLQK-------LRHANI
 .|.|.||.|.|..||.              . .  | |... ..                          .|||.| ..|.....|       |.| ||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VAYKDSYMDREQ------------------YLNIVM---IHCEGG----DMHNRIKNQKG-------------KNFPEDQIQDWLAQMALALFYLHEKKI
.   . | |...                  .. .||    .|.||    |. ..|. ...             . |.|.. . .  |.. |. |.|...|
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

LHRDLKTQNIFLKS------------------GRVRLGDFGIAKVLDS-----------------------TRDFANTCIGTPYYMS-PELFKY------
 |||||  || | .                  . . . ||| |...|.                       . .  .|. |||.||. ||....      
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

--------KPYSYKSDIWAFGCVLYEMCNLRHAFDAQ-------------SLNGLAVKIMNGTYPPI------------------------NSTYSKSLR
        ..|..|.|.|. |..|| |   .  |..              ... |  |||.| |  .                        . . |.. .
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHH-FVSQECK

DLIGKMLQLNPKSRPSILDIINTSFV
||| |||| .|. |..| .. |  ..
DLIRKMLQVDPEKRMTIEQCLNHPWM

Kinase 24902.AA STE 4-258 22 5.9e-71 242.03 In-house 1-359 (359) Show / Hide
Range on Protein: 4-258
Range on HMM: 1-359/359
Sequence Identity: 22% (83 aa)

YETVKLIGSGAFGQVYLVKHKR---------------EDKMYVNKKIKTRDMSQ---------------KDRENTENEVRLLQKLR--HANIVAYKDSYM
.| .. ||.||||.||. ...                  ...  |... .. ..               ..... ..|.....|..  | ||| | ..|.
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

DR------EQYLNIVMIHCEGGDMHNRIKNQKGKNFP------------EDQIQDWLAQMALA-LFYLHEKKILHRDLKTQNIFLKSGRVRLGDFGIAKV
.       ...|.|.| ...||     ||. .|...|            |.||   . |   . | |||...| |||.| .||.|    | | |||... 
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL----VKLCDFGVCGQ

LDS---------------TRD-FANTCIGTPYYMSPELFKY------KPYSYKSDIWAFGCVLYEMCNLRHAF-DAQSLNGLAVKIMN------------
|..               |..   ||..||| .|.||  .       |.|..|.||| .||.. ||.. .. . | . .  .  ...|            
LTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCI

--GTYPPINS-------------------TYSKSLRDLIGKMLQLNPKSRPSILDIIN--TSFV
  |. ||. .                    .|....| | | || .|. ||.  . ..   .|.
VNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI

Kinase 24902.AA ULK 4-258 26 3.3e-70 239.55 In-house 1-329 (329) Show / Hide
Range on Protein: 4-258
Range on HMM: 1-329/329
Sequence Identity: 26% (88 aa)

YETVKLIGSGAFGQVYLVKHKRE----DKMYVNKKIKTRDMSQKDREN--------TENEVRLLQKLR--------HANIVAYKDSYMDRE-QYLNIVMI
|.  . .|.|.||.||  ..|.     ..... |.|    |.||  |.         .||.....||         | ||| ..| ...    .. |.| 
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

HCEGGDMHNRIKNQKG--------KNFPEDQIQDWLAQMALALFYLHEKKILHRDLKTQNIFLKSG-------------RVRLGDFGIAKVLDST---RD
 |.|||  . ||..|.        |...|....  . | . .. .||...| |||.| ||| .. |             .. ..||| ||..|.     .
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

FANTCI------GTPYYMSPELFKYK----PYS-YKSDIWAFGCVLYEMCNLRHAFDAQSLNGLAVKIMNGT------------YPPIN-------STYS
 . ||       |||.||.|.... .    ||. ||.||| .||..|||   .  | |.  | .  .|..                |..        . |
MMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQIS

KSLRDLIGKMLQLNPKSRPSILDIINTSFV
. ..||| .||| ..| | |. ...|  ..
PECKDLIRRMLQYDEKDRISWEELFNHPWF

Kinase 24902.AA NEK11 4-258 40 2.9e-68 233.1 In-house 1-259 (259) Show / Hide
Range on Protein: 4-258
Range on HMM: 1-259/259
Sequence Identity: 40% (104 aa)

YETVKLIGSGAFGQVYLV---KHKREDKMYVNKKIKTRDMSQKDRENTENEVRLLQKLRHANIVAYKDSYMDREQYLNIVMIHCEGGDMHNRIKNQK--G
|   . .|||.|| ||||   | || . . | | |   ..   .      |  || .| |  || .  |.|. ...  |.   ||| |. .||.  |  |
YVLQQKLGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANVEAQLLSRLHHPAIVRFHASFMEQDNFC-IITEYCEGRDLDYRIQEYKQAG

KNFPEDQIQDWLAQMALALFYLHEKKILHRDLKTQNIFLKSGRVRLGDFGIAKVLDSTRDFANTCIGTPYYMSPELFKYKPYSYKSDIWAFGCVLYEMCN
| ||| || .|  |. |   |.||..||||||| .|||||   ...||||....|    | | |  ||| |||||  | . |  |||||.  |.||||| 
KIFPENQIIEWFIQLLLGVDYMHERRILHRDLKSKNIFLKNNLLKIGDFGVSRLLMGSCDLATTLTGTPHYMSPEALKHQGYDTKSDIWSLACILYEMCC

LRHAFDAQSLNGLAVKIMNGTYPPINSTYSKSLRDLIGKMLQLNPKSRPSILDIINTSFV
. |||   .   . ..|. |  | .   | . |  .. .||  ||  |||  ||.   ..
MDHAFAGSNFLSIVLNIVEGDTPSLPDRYPRELNTIMERMLNKNPSLRPSAIDILKIPYM

Kinase 24902.AA Pkinase_Tyr 4-199 24 6.5e-29 98.54 Pfam 1-210 (270) Show / Hide
Range on Protein: 4-199
Range on HMM: 1-210/270
Sequence Identity: 24% (52 aa)

YETVKLIGSGAFGQVYLVKHK-REDKMYVNKKIKTR--DMSQKD--RENTENEVRLLQKL-RHANIVAYKDSYMDREQY--LNIVMIHCEGGDMHNRIKN
 .  | .|.||||.||. . |  .|.  .   .|.   . ....  ||   .|.... .| .| ||| .    .|...   . ||| ....||...  ..
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

Q--KGKNFPEDQIQDWLAQMALALFYLHEKKILHRDLKTQNIFLK-SGRVRLGDFGIAKVL--DSTR-DFANTCIGTPYYMSPELFKYKPYSYKSDIWAF
.   .....  .. .. .| | .. ||..|.. |||| . |. .. .. |. .||| |. .  |..    .  .      |.|| ..|. .. |||.|.|
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSF

GCVLYEMCNL
| ...|.. .
GVLMWEIFTY

Kinase 24902.AA TyrKc 4-258 20 6.8e-21 76.65 SMART 1-280 (280) Show / Hide
Range on Protein: 4-258
Range on HMM: 1-280/280
Sequence Identity: 20% (61 aa)

YETVKLIGSGAFGQVYLVKHKREDKMYVN---KKIKTRDMSQKDRENTENEVRLLQKL--RHANIVAYKDSYMDRE------QYLNIVMIHCEGGDMHNR
 .  | .|.||||.||. . |      ..   |..|        ||   .| |.. ||  .| |||.     .. .      . | ||| ....|| ...
ITLGKKLGEGAFGEVYKGTWK------IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY

IKNQKGKNFPEDQIQDWLAQMALALFYLHEKKILHRDLKTQNIFLKSGR-VRLGDFGIAKVLDST-------RDFAN----TCI--GTPYYMSPELFKYK
... ..| .. ..  ..  | |    |||.|.. |||| . |. ..... |. .||| .. ...                  .        |.|| ..|.
LRKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYG

PYSYKSDIWAFGCVLYEMCNLRHAFDAQ------SLNGLAVKIMNGTYPPINST--------YSKSLRDLIGKMLQLNPKSRPSILDIINTSFV
 .. |||.|.|| ...|.. .             |   .  ....| ..|.            .. . ... .  . .|..||.  .|   .. 
KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF