Gene 4647 (Tetrahymena)

4647

Species: Tetrahymena
Alias: PreTt04647, TTHERM_00529780, 4647, 67.m00162, 3684.m00032, 642
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: NEK

Sequence

Name Sequence Type Origin Length Description Download
4647.AA Protein None 949 None Fasta, JSON
4647.kin_dom Protein Kinase Domain None 251 None Fasta, JSON
4647.NA RNA None 2850 None Fasta, JSON

Protein domain

Protein domains of 4647.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 4647.AA NEK 34-284 48 5e-159 534.61 In-house 1-286 (286) Show / Hide 
Range on Protein: 34-284
Range on HMM: 1-286/286
Sequence Identity: 48% (140 aa)

YKRLKLLGEGSFGKAYLVESQSDKSK-----WVIKQISLDAMSPEEKKESY-KEAKILEQLNHPNIVKFKEIYKTK-SGKLCIVMEYAD-GGDLSQK---
|...| .|.|||||.|.|...||...     .|.|.|... ||..||.... .|..||.||.||||||... .  . ...|||||||.. ||||.||   
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKS

IQKQR--GKYFKEEQILDWFTQICLAMKHVHDR----------DLKGQNIFLTSQNI----CKLGDFGIARVLNKTFEKAKT-MVGTPYYLSPEIINSVP
|.||.  |||| ||||.|||.|.|||.|..|||          |.| ||||||..|.     |.|||||..|||.| ..|.| .||||||.|||.... |
IKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDMAYTTQVGTPYYMSPEVCQNKP

YSYKSDVWSIGVVLYEMCCL--RPPFQGE--SLQNLALNIVKG-QYQPIPNI--YSQDLKKLVSNLLQNRPESRYSIQQILGLPFI
|..|||.||.|.||||||.|  ..||...  .. .|...|.|| ||.|||    |||||..|.|..||  ||.|.|..||| .|||
YNNKSDIWSLGCVLYEMCTLKPKHPFEAWDMNMPSLYMKIMKGPQYPPIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase 4647.AA NEK1 34-284 49 7.6e-129 434.35 In-house 1-276 (276) Show / Hide 
Range on Protein: 34-284
Range on HMM: 1-276/276
Sequence Identity: 49% (138 aa)

YKRLKLLGEGSFGKAYLVESQSDKSKWVIKQISLDAMSPEEKKESYKEAKILEQLNHPNIVKFKEIYKTKSGK--LCIVMEYADGGDLSQKIQKQ--RGK
| ..| .||||||||.|| . .| .  ||| |..  |...|. || .|..||. . ||||||.||      |.  | |||||.||||| |||..|  .||
YHYIKQIGEGSFGKAWLVKHKEDGQHYVIKEINVMKMQEKEREESMNEVAILAKMKHPNIVKYKESFEEN-GCGILYIVMEYCDGGDLMQKINRQKRKGK

YFKEEQILDWFTQICLAMKHVHD-----RDLKGQNIFLT--SQN---------------ICKLGDFGIARVLNKTFEKAKTMVGTPYYLSPEIINSVPYS
 | | ||..||.|||||..|.||     ||.| ||||||  .                 . |||||||||.|| | | |.| .||||||||||..  || 
LFSEDQIMHWFCQICLALNHIHDRKILHRDIKSQNIFLTISKNGMGSGSGSGSSNDSIPLVKLGDFGIARMLNHTMEYACTCIGTPYYLSPEICQNKPYN

YKSDVWSIGVVLYEMCCLRPPFQGESLQNLALNIVKGQYQPIPNIYSQDLKKLVSNLLQNRPESRYSIQQILGLPFI
 |||.|| |.|||| | |  ||.. ...|| | |..| | |||. ||..|. ||| ...  |..| |..|||  |||
NKSDIWSLGCVLYELCTLKHPFEANNWKNLVLKICQGTYPPIPPHYSYELQSLVSQMFKRNPRHRPSVNQILERPFI
Kinase 4647.AA NEK4 34-284 45 1.7e-104 353.47 In-house 1-257 (257) Show / Hide 
Range on Protein: 34-284
Range on HMM: 1-257/257
Sequence Identity: 45% (116 aa)

YKRLKLLGEGSFGKAYLVESQSDKSKWVIKQISLDAMSPEEKKESYKEAKILEQLNHPNIVKFKEIYKTKSG-KLCIVMEYADGGDLSQKIQKQRGKYFK
|  .|  | ||.|  .|| .. || ..|.| . |   | .|.|.  .||..| || |||||..|| ..   |  |.||| . .|||| .| ..|...  .
YCHMKVVGKGSYGEVWLVRHRRDKKQYVMKKMFLKNASRRERKAAEHEAQLLSQLKHPNIVEYKESWEIENGQFLYIVMGFCEGGDLYRKLKQQKNQFLE

EEQILDWFTQICLAMKHVHD-----RDLKGQNIFLTSQNICKLGDFGIARVLNKTFEKAKTMVGTPYYLSPEIINSVPYSYKSDVWSIGVVLYEMCCLRP
|.|...|| || .|.   |.     |||| |||||| .|| |.|||||.||||   . ||||.|||||.|||.  . || ||||.||.|  .|||  |. 
EYQVVEWFVQIAMALQYMHEKHILHRDLKTQNIFLTKKNIIKIGDFGISRVLNNHCDMAKTMIGTPYYMSPECFGNRPYDYKSDIWSLGCCVYEMITLKH

PFQGESLQNLALNIVKGQYQPIPNIYSQDLKKLVSNLLQNRPESRYSIQQILGLPFI
 |.   .  |   |..||  |.|  |||||. ||  .|. .|. | || .|.  |.|
AFDAKDMNSLIYQIIQGQPPPMPPNYSQDLQNLVYQMLEKQPTKRPSIFDIFQMPYI
Kinase 4647.AA NEK8 34-284 39 1.5e-101 290.69 In-house 1-278 (278) Show / Hide 
Range on Protein: 34-284
Range on HMM: 1-278/278
Sequence Identity: 39% (110 aa)

YKRLKLLGEGSFGKAYLVESQSDK--SKWVIKQISLDAMSPEEKKESYKEAKILEQLNHPNIVKFKEIYKTKSGKLCIVMEYADGGDLSQKIQKQRGKYF
| |   .| |.|| . |    .|   .. ..||| .  ||..|      |  .|  |.||||.   .    . . | |.||||||| | |.||.|..| |
YERIRVVGRGAFGICWLYRRKEDQSHHLVIWKQINMHRMSEKERQMAQNEIQVLSMLQHPNIISYYDHF-MEDNTLMIEMEYADGGTLYQMIQHQQNKLF

KEE-----------------QILDWFTQICLAMKHVHD-----RDLKGQNIFLTSQ-NICKLGDFGIARVLNKTFEKA--KTMVGTPYYLSPEIINSVPY
 ||                 .||. |.|.|.|  |.|.     |||| ||||.|   .. |.|||||. ..|     .  || ||||||.|||.  ..||
EEERQLKQVNHCFNIYFNEQMILWYFFQMCSAVHHMHQHNILHRDLKTQNIFMTRHRMVVKIGDFGISKIMNTKYHMQTTKTVVGTPYYMSPEMCEGKPY

SYKSDVWSIGVVLYEMCCLRPPFQGESLQNLALNIVKG-QYQPIPNIYSQDLKKLVSNLLQNRPESRYSIQQILGLPFI
  |||.|..| ||||||||.  | .. | .| . |. .  | ||.  || ... ||.|.||  || | |  ||.  | .
NQKSDMWALGCVLYEMCCLKRAFEASNLPALVWKIMQCRAYEPISDHYSNEMRMLVHNCLQQDPEQRPSASQIMAMPLC
Kinase 4647.AA S_TKc 34-284 30 3.6e-88 300.15 SMART 1-231 (231) Show / Hide 
Range on Protein: 34-284
Range on HMM: 1-231/231
Sequence Identity: 30% (83 aa)

YKRLKLLGEGSFGKAYLVESQSDKSKWVIKQISLDAMSPEEKKESYKEAKILEQLNHPNIVKFKEIYKTKSGKLCIVMEYADG--GDLSQKIQKQRG---
|. |...|.|.||| |..   ... .  ||.|.         .  ..| .||.. .||||||..... .  ..|..||||.||  ||| . |.|...   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

-KYFKEEQILDWFTQICLAMKHVHD-----RDLKGQNIFLTSQNICKLGDFGIARVLNKTFEKAKTMVGTPYYLSPEIINSVPYSY-KSDVWSIGVVLYE
 ..| | ..  .. |||.|... |.     |||| .||.|..    |..|||.||.|       .|..|||.|..||..   .|.. |.|.||.|..|||
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYE

MCCLRPPFQGESLQNLALNIVKGQYQPIPNIYSQDLKKLVSNLLQNRPESRYSIQQILG-------LPFI
|.| .|||.    ... .....          |...| .....||  || |... ..|         |..
MLCGYPPFP---QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 4647.AA CAMK 39-284 23 4.6e-82 264.11 In-house 1-425 (425) Show / Hide 
Range on Protein: 39-284
Range on HMM: 1-425/425
Sequence Identity: 23% (100 aa)

LLGEGSFGKAYLVESQSDK------------SKWVIKQISLDAMS--------------------------PEEKKESYKEAKILEQ-------LNHPNI
 ||.||||| .|..  ...             |. || |. . ..                          |. .|. ..| .|. .       |.||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VKFKEIYK------------TKSG-------KLCIVM---EYADGG----DLSQKIQKQRG-------------KYFKEEQILDWFTQICLAMKHVHD--
.|. |.|             | |        ....||   ||..||    || ..|.....             ..|.|..   .| ||| |... |.  
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

---RDLKGQNIFLTSQ-----------------NICKLGDFGIARVLNK-----------------------TFEKAKTMVGTPYYLS-PEIINS-----
   ||||  || |..                  |  |. ||| |.....                       . .| ||..|||.| . ||..|.     
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

---------VPYSYKSDVWSIGVVLYEMCCLRPPFQGE-------------SLQNLALNIVKGQYQPIPNI-----------------------YSQDLK
          .|..|.|.||.||.|| | | .|||.|.             ....|  .| ||.|. .|                          ||. |
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK

KLVSNLLQNRPESRYSIQQILGLPFI
 |....||  || |..|.|.|  |..
DLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 4647.AA Pkinase 34-284 26 9.6e-82 282.68 Pfam 1-293 (293) Show / Hide 
Range on Protein: 34-284
Range on HMM: 1-293/293
Sequence Identity: 26% (78 aa)

YKRLKLLGEGSFGKAYLVESQSDKSKWVIKQISLDAMSPEEKKESYK--EAKILEQLNHPNIVKFKEIYKTKSGKLCIVMEYADGG----DLSQKIQKQR
|.... .|.||||. |.   ...  ....|.|...  .......  .  |..|.  |||||||...... . ......||||..||    ||.  |. .|
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-KDHIYMVMEYCEGGLYVMDLFDYISTWR

GKYF--KEEQILDWFTQICLAMKHVHD-----RDLKGQNIFLTSQNIC----KLGDFGIARVL-NKTFEKAKTMVGTPYYLSPEIIN-SVPYSYKSDVWS
.. |   |... ....||. .... |.     |||| .||.. ... .    |..|||.|... .   . ..| .|||.|..||.|. . .|..|.|.||
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

IGVVLYEMCCLRPPFQGE----SLQNLALNIVKGQYQPIPNIYS-----------------------QDLKKLVSNLLQNRPESRYSIQQILGLPFI
.|..||||.| ||||.|.    .  .    |..  . |..  ..                       ...|......|.  |..|....|||  |..
CGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 4647.AA NEK2 31-284 33 4.6e-72 241.95 In-house 1-319 (319) Show / Hide 
Range on Protein: 31-284
Range on HMM: 1-319/319
Sequence Identity: 33% (109 aa)

YEIYKRLKLLGEGSFGKAYLVESQSDKSKWVIKQISLDAMSPEEKKESYKEAKILEQLNHPNIVKF-KEIYKTKSGKLCIVMEYADGGDLSQKIQKQRG-
||.   |. .|.||||. . |   ||.   | | |  . |   |.     |  || || |||||..   |   ..  | |||||  |||||| |.| |  
YEV---LYTIGNGSFGRCRKVRRKSDGKILVWKEICYGHMQEKECQMLVSECNILRQLKHPNIVRYYDWIIDRQNSTLYIVMEYCEGGDLSQMIKKCRKE

-KYFKEEQILDWFTQICLAMKHVHD--------------------------RDLKGQNIFLTSQNI----------------------------------
 .|. || |.  ..|.|.| . .|                           ||.|  |||| .                                     
RQYMEEEFIWRIMFQLCTALQECHNGVELPTLTTIYDRMKPRIDGKHTILHRDIKPANIFLDYDHNDYNINEQVDGHEEVNSNYYRDHRVNSGKRGSPMD

-----CKLGDFGIARVLNKTFEKAKTMVGTPYYLSPEIINSVPYSYKSDVWSIGVVLYEMCCLRPPFQGESLQNLALNIVKGQYQPIPNIYSQDLKKLVS
      |||||| ||.||.    |.| |||||| ||| ..  .|. |||.||.| ..|||| |.||||. . . |.  | .| ...|| .||..| ....
YSQVVVKLGDFGLARMLNHDTSFAHTFVGTPYYMSPEQMHGQKYNEKSDIWSVGCLIYEMCALHPPFQATNQAQLQEKIKQGHFRRIPYQYSRHLNEIIH

NLLQNRPESRYSIQQILGLPFI
  .   ...| ||  ||. |.|
FMINVDHYHRPSIEEILQHPQI
Kinase 4647.AA ULK 34-284 26 1.5e-69 237.4 In-house 1-324 (324) Show / Hide 
Range on Protein: 34-284
Range on HMM: 1-324/324
Sequence Identity: 26% (86 aa)

YKRLKLLGEGSFG-KAYLVE-SQSD--KSKWVIKQISLDAMSPEEKK-------ESYK-EAKILEQLN---HPN--IVKFKEIYKTKSG-KLCIVMEYAD
|   . ||.|||| | |  .  ...  . .. .|.|... |.  ...       .. | | .|. .|.   |||  |||......|.    ..|.||| .
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

GGDLSQKIQKQRG-------KYFKEEQILDWFTQICLAMKHVHD-----RDLKGQNIFLTS------------QNICKLGDFGIARVLN---KTFEKAKT
||||.| |.|...       |.. |....  | ||| ..|. |.     ||.| ||| ..             ....|..||| |....   .   . .|
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQT

MV------GTPYYLSPEIIN----SVPYS-YKSDVWSIGVVLYEMCCLRPPFQGESLQNLALN--------------IVKGQYQPIP----NIYSQDLKK
.|      |||.| .|.|..      ||. ||.|.||.|...|||   ..||..   ... |.              | . . |. .    .. |...| 
CVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKD

LVSNLLQNRPESRYSIQQILGLPFI
| . .||  .. | |...|.  |..
LIRRMLQYDEKDRISWEEIFNHPWF
Kinase 4647.AA Ciliate-E2 34-284 24 2.6e-68 233.24 In-house 1-365 (365) Show / Hide 
Range on Protein: 34-284
Range on HMM: 1-365/365
Sequence Identity: 24% (92 aa)

YKRLKLLGEGSFGKAYLVESQSDKS------------------KWVIKQISLDAMSPEEKKESYKEAKIL----------------EQLNHPNIVKFKEI
|| .|..|.|.||. |...  ...                   |  ||.. .  |.. ....  .| .|.                ||||||||.|..| 
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

YKT-KSGKLCIVMEYADGGDLSQKIQKQRGK---------YFKEEQILDWFTQICL---------------AMKHVHD------RDLKGQNIFLTSQNIC
... .  .. .||||..|||| . |.... |         ||.|..|.. ..||.                |... |       ||.| .||..     .
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

KLGDFGIAR--------------VLNKTFEK------------------AKTMVGTPYYLSPEIINSVP---------YSYKSDVWSIGVVLYEMCCLRP
|. |||...                ...| |                  ..| .|||.|..|||.|. .         |.||.|.||.||.||||.. .|
KIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKP

PFQGESLQNLALNIVKGQYQ-P----------------IPNIYSQDLKKLVSN----LLQNRPESRYS-IQQILGLPFI
||          .| ..... |                ...  ||. | | ..    .||  || |.. ..|||  |..
PF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 4647.AA ULK 34-284 26 3.3e-68 232.93 In-house 1-329 (329) Show / Hide 
Range on Protein: 34-284
Range on HMM: 1-329/329
Sequence Identity: 26% (87 aa)

YKRLKLLGEGSFGKAYLVE-SQSD---KSKWVIKQISLDAMSPEEKKES--------YKEAKILEQLN--------HPNIVKFKEIYKTKSG-KLCIVME
|   . ||.||||| |  .  ...   . |...|.|... |. ...            .| ||. .|.        ||||||......|.    . |.||
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

YADGGDLSQKIQKQRG--------KYFKEEQILDWFTQICLAMKHVHD-----RDLKGQNIFLTS------------QNICKLGDFGIARVLNKT---FE
| .||||.| |.|...        |.. |....  | ||. ..|. |.     ||.| ||| ..             ....|..||| |.....     .
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

KAKTMV------GTPYYLSPEIIN----SVPYS-YKSDVWSIGVVLYEMCCLRPPFQGESLQNLALNIVKGQ------------YQPIP-------NIYS
 ..|.|      |||.| .|.|..      ||. ||.|.||.|...|||   .|||..   . . |.|..               ||.        .. |
MMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQIS

QDLKKLVSNLLQNRPESRYSIQQILGLPFI
...| | . .||  .. | |.....  |..
PECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase 4647.AA Ciliate-E2-Unclassified 34-284 22 1.9e-65 223.71 In-house 1-352 (352) Show / Hide 
Range on Protein: 34-284
Range on HMM: 1-352/352
Sequence Identity: 22% (80 aa)

YKRLKLLGEGSFGKAYLVESQSDKSKWVIKQISLDAMSPEEKKESY-----KEAKILEQLN-----------------HPNIVKFKEIYK-TKSGKLCIV
|| .| .|.|.||| |...  ..| .  ....  ....   |.  .      |.|......                 ||.... |..|  ..  ...||
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV

MEYADGGDLSQKIQKQRG---------------KYFKEEQIL-----DWFTQICLAMKHVHDR------DLKGQNIFLTSQN---ICKLGDFGIARVLNK
|||..||||.| |.|. .               | | |.|..     ..| ||... .. |        |.| .||......    .|. ||||.. ...
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQ

T---------------FEKAKTMVGTPYYL----SPEIINSVPYS----YKSDVWSIGVVLYEMCCLRPPFQGESLQN----------------LALNIV
                .....|..|||.|.    .||.. .  |.    ||.|.|| ||.||||.  ..||....                   |  || 
NNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIK

KGQYQPIP-------NIYSQDLKKLVS----NLLQNRPESRYSIQQILGLPFI
....|  .        . |.  | ...     .|...|..|....|||  |..
QKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 4647.AA Pkinase_Tyr 34-250 28 5.7e-28 95.36 Pfam 1-238 (270) Show / Hide 
Range on Protein: 34-250
Range on HMM: 1-238/270
Sequence Identity: 28% (69 aa)

YKRLKLLGEGSFG---KAYLV-ESQSDKSKWVIKQISLDAMSPEE--KKESYKEAKILEQL-NHPNIVKFKEIYKTKSGK--LCIVMEYADGGDLSQKIQ
 . .| ||||.||   |...  . ...| .  .| .  .  ..|.  ...  .||||. || .|||||..  .   ...   ..|||||. .|||    .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

KQ--RGKYFKEEQILDWFTQICLAMKHVHD-----RDLKGQNIFLTSQNICKLGDFGIARVL-NKTFE-KAKTMVGTPY-YLSPEIINSVPYSYKSDVWS
|.   .. .. ...|.. .||. .| . ..     |||   |. .|..|..| .||| || . |.    ....    |   ..|| ||   .. ||||||
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWS

IGVVLYEMCCL-RPP-FQGESLQNLALNI-VKGQYQPIP
 ||...|.. . . | ..| | . .   |  .|.  |.|
FGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCP
Kinase 4647.AA TyrKc 34-284 24 1.7e-22 81.98 SMART 1-280 (280) Show / Hide 
Range on Protein: 34-284
Range on HMM: 1-280/280
Sequence Identity: 24% (72 aa)

YKRLKLLGEGSFG---KAYLVESQSDKSKWVIKQISLDAMSPEEKKESYKEAKILEQL--NHPNIVKFKEIYKTKS------GKLCIVMEYADGGDLSQK
 . .| |||| ||   |. .        .  .| .  ||     ... ..||.|. .|  .|||||..  .  ...      . |.|||||...||| . 
ITLGKKLGEGAFGEVYKGTWK------IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY

IQKQRGKYFKEEQILDWFTQICLAMKHVHD-----RDLKGQNIFLTSQNICKLGDFGIARVLNKT----FEKAKTMV----GTP-----YYLSPEIINSV
..| |.| .. .. |.. .||.  | . |.     |||   |. .......| .||| .| .        .|   ..    |.        ..|| ||  
LRKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYG

PYSYKSDVWSIGVVLYEMCCL-RPPFQG-----ESLQNLALNIVKGQYQPIPNI--------YSQDLKKLVSNLLQNRPESRYSIQQILGLPFI
 .. |||||| ||...|.. .  .|  |      | | .  .. .| . |.|           .... .. .   .  ||.| . ..|    ..
KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF