Gene 11313 (Tetrahymena)
11313
Sequence
Protein domains of 11313.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 11313.AA | Other-Unique | 107-323 | 10 | 2.8e-27 | 89.81 | In-house | 1-249 (249) | Show / Hide |
Range on Protein: 107-323 Range on HMM: 1-249/249 Sequence Identity: 10% (28 aa) IHTLGEGKLTGSCKVIDLVSGQELCVKLIYIKGISEEN-------------------------------LKNMVQMIQKISSINSPYLTNIVNSAYNNDK |...|.|. . ..|... .......|....| .... .... .||..|..... ... ... . ... IKDIGKGTYGRVYKQHHNKKKKYCAKKTKHHKI-HCMDMDNNKREQIYHYQIIHCIFYWTMNHCHLCFCYEHCPNMIFYIMYPWY--HHHCECQCQCEHW SHFVIVSEFMRGGNLQDEIIKHVNEKKVILEDDIWNYIFQD----------KKQIKIGDVGIKQFLDIEKQQQFNGCPYSMSPEGFRGRFTKKSDIWSLG ....... ... . .| ...| ........... ... ..||| | ... . .... ..| .|....... ....|.|....| MNCCHMIHNLHHLHNNNHIHCDINPNNIWINQNNIHMCHNCGHNIPTIIIEHQHIKIMDFNNN-N-MMYFAPEF-SCRWCSPETFDYWPLGEKIDQYHFG CIIYEVAAQTPPFWSNDLEDLKRKVDNTRYSKIINISKHFTYLIESILNPNMKLRPEL |. ... |...|...|. ... . .. .. | |... .. . .||.... ... CYHFHMNCQHWIFHYHDV-QHWPPHESPKDI-HILICQCECCHQCM-VNPYQNPNCFY |
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| Kinase | 11313.AA | NEK2 | 239-332 | 36 | 7.7e-17 | 53.13 | In-house | 224-319 (319) | Show / Hide |
Range on Protein: 239-332 Range on HMM: 224-319/319 Sequence Identity: 36% (35 aa) FNGCPYSMSPEGFRGR-FTKKSDIWSLGCIIYEVAAQTPPFWSNDLEDLKRKVDNTRYSKIINI-SKHFTYLIESILNPNMKLRPELKNILKYSTQ | | || |||| |. ||||||.||.||| .| ||| | |. . ... | . |.| .| . .| . . || ||... FVGTPYYMSPEQMHGQKYNEKSDIWSVGCLIYEMCALHPPFQATNQAQLQEKIKQGHFRRIPYQYSRHLNEIIHFMINVDHYHRPSIEEILQHPQI |
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| Kinase | 11313.AA | PLK1 | 195-332 | 26 | 2.3e-16 | 50.07 | In-house | 112-253 (253) | Show / Hide |
Range on Protein: 195-332 Range on HMM: 112-253/253 Sequence Identity: 26% (37 aa) IKHVNEKKVILED-DIWNYIFQDKKQIKIGDVGIKQFLDIE--KQQQFNGCPYSMSPEGFRGR-FTKKSDIWSLGCIIYEVAAQTPPFWSNDLEDLKRKV .... ..|.| | . | ..|. |.|||| |. ... . ... | | . || . . ||||.|||.| . ||| .. |.. .. CQYLHNNKIIHRDLKLGNLFLNDHLQVKIGDFGLATKCEYDGERKKTLCGTPNYIAPEVLNKKGHSFEVDIWSIGCIMYILLFGQPPFETKCLKETYSRI DNTRYSKIINISKHFTYLIESILNPNMKLRPELKNILKYSTQ . |. .||. ||...|.|. . ||. ...|. KKNEYRIPSHISQPAAQLIRKMLDPDPTRRPTIEQVLNDEFF |
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| Kinase | 11313.AA | NEK | 258-332 | 30 | 2e-15 | 51.16 | In-house | 204-286 (286) | Show / Hide |
Range on Protein: 258-332 Range on HMM: 204-286/286 Sequence Identity: 30% (25 aa) KSDIWSLGCIIYEVAAQ--TPPFWSN--DLEDLKRKVDNT-RYSKII-N--ISKHFTYLIESILNPNMKLRPELKNILKYSTQ |||||||||..|| ... .|| .. ... | |. . |..| . |. ||.. |... ..|| . ||. . KSDIWSLGCVLYEMCTLKPKHPFEAWDMNMPSLYMKIMKGPQYPPIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI |
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| Kinase | 11313.AA | Ciliate-E2-Unclassified | 213-328 | 21 | 1e-14 | 47.52 | In-house | 176-348 (352) | Show / Hide |
Range on Protein: 213-328 Range on HMM: 176-348/352 Sequence Identity: 21% (38 aa) IFQDKK---QIKIGDVGI-----------------KQFLDIEKQQQFNGCPYSM----SPEGFRG-RFT----KKSDIWSLGCIIYEVAAQTPPFWSNDL .|.... .||| | || .|... .....| | |. | .|| ..| .|.||||||.|.|| ...|| .|. LFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNC ED----------------LKRKV-DN-TRYSKIIN------ISKHFTYLIE----SILNPNMKLRPELKNILK |. |... .. . ..| . .|.. .|. ..|. |.. |. .. ||. EQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILN |
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| Kinase | 11313.AA | CAMK | 215-328 | 17 | 2.7e-14 | 41.76 | In-house | 230-421 (425) | Show / Hide |
Range on Protein: 215-328 Range on HMM: 230-421/425 Sequence Identity: 17% (34 aa) QDKKQIKIGDVGIKQFLDI-------------------------EKQQQFNGCPYSMS-PEGFRGR---------------FTKKSDIWSLGCIIYEVAA ... .||| | | ...| .| . | |.|. |. || ..| ..|.|.||.|.| | WNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLC QTPPFWSN-------------DLEDLKRKVDNTRYSKIIN----------------ISKH--------FTYLIESILNPNMKLRPELKNILK .|||.. ....|..|. . .|. . ||. || ..|... . |. .. .|. GYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLN |
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| S_TKc | 11313.AA | S_TKc | 104-330 | 21 | 3.2e-14 | 31.67 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 104-330 Range on HMM: 1-231/231 Sequence Identity: 21% (56 aa) YRYIHTLGEGKLTGSCKVIDLVSGQELCVKLIYIKGISEENLKNMVQMIQKISSINSPYLTNIVNSAYNNDKSHFVIVSEFMRG--GNLQDEIIKHVNEK |. . ..|.| .|... .|.. .| | |.... .|. .| . |.. .. . .. .|. .| |.. | |.| | | |. .. YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK----HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHG --KVILEDDIWNYIFQ-------------------------DKKQIKIGDVGIKQFLDIEKQQQFNGCPYSMSPEGFRGRFTK-KSDIWSLGCIIYEVAA ... | ... |. | |. .|||.| |. .| | | |. |.|| . ..| |.|.||.|||.|| .. LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-HIKICDFGLARQL-----TTFCGTPWYMAPEVL--GYGKCKCDWWSCGCILYEMLC QTPPFWSNDLEDLKRKVDNTRYSKIINISKHFTYLIESILNPNMKLRPELKNILK---------YS |||. ... . .|. |. . .|. .|. . . || .|. . GYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | 11313.AA | NEK4 | 220-272 | 50 | 2.7e-12 | 40.61 | In-house | 141-196 (257) | Show / Hide |
Range on Protein: 220-272 Range on HMM: 141-196/257 Sequence Identity: 50% (28 aa) IKIGDVGIKQFLD--IEKQQQFNGCPYSMSPEGFRGR-FTKKSDIWSLGCIIYEVA ||||| || |. . . | || |||| | | . ||||||||| .|| . IKIGDFGISRVLNNHCDMAKTMIGTPYYMSPECFGNRPYDYKSDIWSLGCCVYEMI |
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| Kinase | 11313.AA | Pkinase | 256-329 | 21 | 9e-12 | 42.7 | Pfam | 190-290 (293) | Show / Hide |
Range on Protein: 256-329 Range on HMM: 190-290/293 Sequence Identity: 21% (22 aa) TKKSDIWSLGCIIYEVAAQTPPFWSN----DLEDLKRKVDNTRY-------SKIINIS-----------------KHFTYLIESILNPNMKLRPELKNIL ..|.|.||.|||.||.. |||.. . | . ....... .. ..|| . . .|...|....| || . || GPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQIL KY . QH |
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| Kinase | 11313.AA | ULK | 215-303 | 22 | 9.9e-12 | 37.31 | In-house | 177-300 (329) | Show / Hide |
Range on Protein: 215-303
Range on HMM: 177-300/329
Sequence Identity: 22% (28 aa)
QDKKQIKIGDVGIKQFLDIE-----KQQQFN------GCPYSMSPEGFRGR-----FT-KKSDIWSLGCIIYEVAAQTPPFWSNDLEDLK-----RKVDN
. . ..||.| | ...| . . . | |. |.|. . |. .. .|.||||||||.|| ||| .. .|.. . ..|
P-NGVLKIADFGFAKHVDNDNMEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINN
------------TRYS---KIINISK
... ....||.
PPPWPQQIKKQPLQFPKDGNDPQISP
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| Kinase | 11313.AA | Ciliate-E2 | 213-328 | 19 | 1.1e-11 | 36.36 | In-house | 193-361 (365) | Show / Hide |
Range on Protein: 213-328 Range on HMM: 193-361/365 Sequence Identity: 19% (35 aa) IFQDKKQIKIGDVGIKQFLDIE----------KQQQFNG------------------------CPYSMSPEGFRGR----------FTKKSDIWSLGCII .| ||| | |. ...|.. | .| . |. |.|| ..| ..|.||||||.|. LF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVIL YEVAAQTPPFWSNDLEDLKRKVDNTRYS----------------KIINISKHFTYLIES----ILNPNMKLRPE-LKNILK || ||| . | . ... . ..|. || .|. . . |. . ||. YEMLFGKPPF------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILN |
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| Kinase | 11313.AA | NEK6 | 220-323 | 32 | 1.1e-11 | 34.48 | In-house | 142-252 (252) | Show / Hide |
Range on Protein: 220-323 Range on HMM: 142-252/252 Sequence Identity: 32% (36 aa) IKIGDVGIKQFLDIEKQQQFN--GCPYSMSPEGFRGR-FTKKSDIWSLGCIIYEVAAQTPPFWSN--DLEDLKRKVDNTRYSKIIN--ISKHFTYLIESI .|.||.|. | . | || |||| . . |||||||||..||.|| ||. | | .|... | . |.. |. . VKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIHENGYNFKSDIWSLGCLLYEMAALQSPFYGDKMNLYSLCKKIEQCDYPPLPADHYSEQLRQLVCMC LNPNMKLRPEL ..|. ..||.. IHPDPEWRPDI |
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| Kinase | 11313.AA | TyrKc | 104-330 | 13 | 2e-08 | -86.36 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 104-330 Range on HMM: 1-280/280 Sequence Identity: 13% (41 aa) YRYIHTLGEG--------KLTGSCKVIDLVSGQELCVKLIYIKGISEENLKNMVQMIQKISSI--NSPYLTNIVNSAYNN-----DKSHFVIVSEFMRGG . ...|||| ... .| . |. .. . . .. ... . | . ... . || |.| .| ITLGKKLGEGAFGEVYKGTWK----------------IQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHG NLQDEIIKHVNEKKVILEDDIWNYIFQ--------------------------DKKQIKIGDVGIKQFLDIE-------KQQQF----NG---CPYS-MS .|.| . || .. . .| .. .| .....||.| | ... . . .| |. |. DLKDYLRKHRPK---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMA PEGF-RGRFTKKSDIWSLGCIIYEVAAQTPPFWSN------DLEDLKRKVDNTRYSKIINI---------SKHFTYLIESILNPNMKLRPELKNILKYS || . |.|| |||.|| | ..|. . ... . ... ..|.. .. .. .. .... . . . || ..| .. PECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF |
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| Kinase | 11313.AA | Ciliate-E2 | 132-204 | 16 | 1.2e-05 | 15.39 | In-house | 47-148 (365) | Show / Hide |
Range on Protein: 132-204 Range on HMM: 47-148/365 Sequence Identity: 16% (17 aa) VKLIYIKGISE---ENLKNMVQMIQKIS-------------SINSPYLTNIVNSAYNNDKSHFVIVSEFMRGGNLQDEIIKH-------------VNEKK .|....| ... |..|.. .....| ..|.|.. ... . ...|.... .| |. ||.|.| |... .||. IKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKE VI .. IK |
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| Kinase | 11313.AA | Ciliate-E2-Unclassified | 104-207 | 14 | 0.000108 | 12.23 | In-house | 1-137 (352) | Show / Hide |
Range on Protein: 104-207 Range on HMM: 1-137/352 Sequence Identity: 14% (20 aa) YRYIHTLGEGKLTGSCKVIDLVSGQEL------CVKLIYIKGISEENLKNMVQMIQKISSINSPYLTN------------------IVNSAYNNDKSHFV |. |...|.| .|... . .. ... || . . ... .... .. . .... | . .. . .|| .. YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKK-YHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIY IVSEFMRGGNLQDEIIK------------HVNEKKVILED || |...||.|.. | | | .... |... IVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTE |
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| Kinase | 11313.AA | Pkinase | 104-192 | 18 | 0.019582 | 9.69 | Pfam | 1-93 (293) | Show / Hide |
Range on Protein: 104-192 Range on HMM: 1-93/293 Sequence Identity: 18% (18 aa) YRYIHTLGEGKLTGSCKVIDLVSGQELCVKLIYIKGISEENLKN-----MVQMIQKISSINSPYLTNIVNSAYNNDKSHFVIVSEFMRGG----NLQD |. . ..|.| .| .. .|.. .|| | ...... ... .|. .... .|. . . .. |.| .| |...|| | | YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLN---HPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFD |
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| Kinase | 11313.AA | CAMK | 109-203 | 12 | 0.029055 | 2.29 | In-house | 1-181 (425) | Show / Hide |
Range on Protein: 109-203 Range on HMM: 1-181/425 Sequence Identity: 12% (22 aa) TLGEGKLTGSCKVIDLVSG------------QELCVKLIYIKGIS-----------------------------EENLKNMVQMIQKISS----INSPYL |||.| ..|. .. |. .| | | .. ..|... ... .|... .. | . TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI TNIVNSAYNND-----------------KSHFVIVS---EFMRGG----NLQDEIIKH-----------------VNEKKV .. ... ..|...| |.. || | | |..| ..|. . IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREA |
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