Gene 6287 (Tetrahymena)

6287

Species: Tetrahymena
Alias: 58.m00259, 6287, 3719.m00113, PreTt06287, 372, TTHERM_00483530
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: PEK
Subfamily: PEK-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
6287.AA Protein None 1013 None Fasta, JSON
6287.kin_dom Protein Kinase Domain None 834 None Fasta, JSON
6287.NA RNA None 3042 None Fasta, JSON

Protein domain

Protein domains of 6287.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 6287.AA PEK-Unclassified 132-965 88 0.0 2384.12 In-house 1-835 (835) Show / Hide 
Range on Protein: 132-965
Range on HMM: 1-835/835
Sequence Identity: 88% (737 aa)

FIQLQKIGQGGFASVYRVVHKIDDTEYAVKQIHLKIKDIKEDLQKHYEKLIREARYLAQVNHPNVIRYFHSWIEVTEKKKSQKQEEQKRQTLELSSSFAK
|.|.|||||||||.||...||.|..||||||||..||||||||||||||.|.|.||.|||||||.|||.||||||..||.||||||||||||||||||||
FNQVQKIGQGGFAIVYQCCHKFDQMEYAVKQIHVNIKDIKEDLQKHYEKEIMEVRYMAQVNHPNIIRYYHSWIEVEIKKNSQKQEEQKRQTLELSSSFAK

KKKSKDNNNVSPSKKDKKEDKQLAIQSNQANLKQQPANSNNPAGQNQQKVVDSNKGGISQVASVQNKNSDATNIHIQAQTNNQKGKQQQQQQVNQGKQTQ
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
KKKSKDNNNVSPSKKDKKEDKQLAIQSNQANLKQQPANSNNPAGQNQQKVVDSNKGGISQVASVQNKNSDATNIHIQAQTNNQKGKQQQQQQVNQGKQTQ

QIQLNNQDQSDEDNNEDSNTFYFEDEFDNEVVFIEENSKSIKQDESQQENSHSSGNNLNQSNIKSNNDMSDQSPIPNPNVASKQKPSQIKIFNNNSNGNS
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||.|..||..||||..|.|.|||||||||||||||||||||||||
QIQLNNQDQSDEDNNEDSNTFYFEDEFDNEVVFIEENSKSIKQDESQQENSHSSGNNINHYNINDNNDMENQDPFPNPNVASKQKPSQIKIFNNNSNGNS

AEIPNTKKSSKDIKKLSEFSSAMHGNNNEESQENDSQSFNKGQSDFQLVFESYSEKSKSDLKDECKQIAPDNNNQNTSKLVQNKKQDQGEKKNINKCNNN
||||||||||||||||||.||.||.|||||||||||||.|..|||.|..|||||||||||||||||||||||||||||||||||||||||||||||||||
AEIPNTKKSSKDIKKLSEYSSVMHANNNEESQENDSQSYNNNQSDYQSNFESYSEKSKSDLKDECKQIAPDNNNQNTSKLVQNKKQDQGEKKNINKCNNN

NNQNKNQILETKKQEQNANCAINNKNNKNSHDILKNNQISQQTQNNNNNNKNQLQQNQQQNQANSISNTKSYERRKNKSMDYLTIDQKQREFQLDKYDEI
||||||||||||||||||||||||||||.||||..||||.||.|||||||.||||||||||||||||||||||||||||||||||||||||||||||||.
NNQNKNQILETKKQEQNANCAINNKNNKCSHDIGNNNQIIQQCQNNNNNNYNQLQQNQQQNQANSISNTKSYERRKNKSMDYLTIDQKQREFQLDKYDEF

IFYLQTELCHQTLAEYITNRNKKLFSQQQFNQNLSIKNSCANISNNSNIKNQNLCLQSTQSMFNMNESNSFSGQQNSINNNLNQNNLMHPTLTYSNSCNC
|||.|.||||.|.|.||.|||||||||||||||||||||||||.||.||||||||.|||||||||||.||||||||||||||||||||||||||||||||
IFYIQMELCHYTTARYIINRNKKLFSQQQFNQNLSIKNSCANINNNKNIKNQNLCIQSTQSMFNMNETNSFSGQQNSINNNLNQNNLMHPTLTYSNSCNC

SDPFDILTFEYKQQAIAILKEIIKGLYHIHHICKMVHRDLKPHNIFLTDN-MQVKIGDFGLVKKLSKLINPNQKIQYNDHQLYGKKLGNDNSGMKQTSTN
|||||||.||||||...|...|||.||||||.|||||||.||||||...| ||.||||||||||..||||.||||||||||||||||.|.|..|.|...|
SDPFDILIFEYKQQCREITRQIIKALYHIHHQCKMVHRDIKPHNIFVCQNPMQIKIGDFGLVKKIEKLINDNQKIQYNDHQLYGKKLNNNNNNMNQNNNN

NSFSGASTSPSETNSGYHDKLPFYLPKEEITSTCGTATYASPEQLSQKKVRIKAHFQAEFFDHRADIYSLGIIILQLFHPMNTSMELVKTIQNCKKGELP
|.|.||||||||||||||||||||||||||||||||.||.|.||.|||||||||||||.|..||.||||.|||..|.||.|||.||.|||||||||||||
NKFVGASTSPSETNSGYHDKLPFYLPKEEITSTCGTYTYSSNEQESQKKVRIKAHFQADFYNHRTDIYSVGIIFFQMFHQMNTTMERVKTIQNCKKGELP

KHFCAKFPRLAEIIKDSLSNDPQKRPLLSKIEQTL
|||||||||||||||||||||||||||||||||||
KHFCAKFPRLAEIIKDSLSNDPQKRPLLSKIEQTL
Kinase 6287.AA PEK 132-967 27 5e-243 813.65 In-house 1-655 (655) Show / Hide 
Range on Protein: 132-967
Range on HMM: 1-655/655
Sequence Identity: 27% (234 aa)

FIQLQKIGQGGF-ASVYRVVHKIDDTEYAVKQIHLKIKDIK----------EDLQKHYEKLIREARYLAQVNHPNVIRYFHSWIEVTEKKKSQKQEEQKR
|...|..|.|||  .||.| .|.|...||.|.|.|..|..|          ....||.||  ||...||. ||||..||...|||. |.|..|.|.|...
FEEIQCLGKGGFGGQVYKVQNKLDGCYYAIKRIKLNWKQRKQPCITQECMIHKCKKHCEKVLREVKTLARLNHPNIVRYHNAWIEKPEEKWQQQQDEMWQ

QTLELSSSFAKKKKSKDNNNVSPSKKDKKEDKQLAIQSNQANLKQQPANSNNPAGQNQQKVVDSNKGGISQVASVQNKNSDATNIHIQAQTNNQKGKQQQ
.. .......|. ||||.|.. |..|.. .| ..|..||.... .                                                       
LDSSTDWPNGKH-KSKDYNFH-PFEKEW-DD-EEAQESNVMSE-C-------------------------------------------------------

QQQVNQGKQTQQIQLNNQDQSDEDNNEDSNTFYFEDEFDNEVVFIEENSKSIKQDESQQENSHSSGNNLNQSNIKSNNDMSDQSPIPNPNVASKQKPSQI
                                             |......|.......|||||.||...|...|....||.|..||            
---------------------------------------------EDREQKGKKKCWSESNSHSSKNNYEESMEWSCSEHSDSSSFPN------------

KIFNNNSNGNSAEIPNTKKSSKDIKKLSEFSSAMHGNNNEESQENDSQSFNKGQSDFQLVFESYSEKSKSDLKDECKQIAPDNNNQNTSKLVQNKKQDQG
 |.|..| .|. ...|...|...... |...|....|....|..|...|.|.........|...|..|.|. .|..|...|.|.........|....|| 
-IENQFS-INF-GTENENESHISYWSSSVYMSSSWDNPFDSSFSNSCDSTNFNKDEDHSFFSCSSYSSCSTDCDDSKDSSPFNWDGGCDNWEQYEYSDQD

EKKNINKCNNNNNQNKNQILETKKQEQNANCAINNKNNKNSHDILKNNQISQQTQNNNNNNKNQLQQNQQQNQANSISNTKSYERRKNKSMDYLTIDQKQ
.... |.|.......|||. ..............||| ..||.|....|......||.|||||...|.....|                           
DEHEQNDCQSKQCDSKNQSHKKCMEMTWIQDQEDNKN-NCSHHIGSSSQSQEEMENNTNNNKNKFKQMHNTKQ---------------------------

REFQLDKYDEIIFYLQTELCHQTLAEYITNRNKKLFSQQQFNQNLSIKNSCANISNNSNIKNQNLCLQSTQSMFNMNESNSFSGQQNSINNNLNQNNLMH
       |.....|.|.|.|.... ......|. . . .|||.. . .|||.|..||. |.||. |.|||.|| || ... ..                 
-------YQCHYLYIQMEYCEKKTLRDWIDNNG-C-P-VQFNYW-R-RNSCKNHYNNY-IMNQC-CFQSTWSM-NM-RQW-DE-----------------

PTLTYSNSCNCSDPFDILTFEYKQQAIAILKEIIKGLYHIHHICKMVHRDLKPHNIFLTDNMQ-----VKIGDFGLVKKLSKLINPNQKI--QYNDHQLY
               ... |..|.|.  |...|..||..||. . |.||||||.||||... |     ||||||||......|.. .||.  | .| |.|
---------------NNCMFWDKDQCWRIFRQILEGLNYIHSQG-MIHRDLKPSNIFLDCDGQHHQMQVKIGDFGLATNHEMLSQ-SQKNYNQ-QD-QSY

GKKLGNDNSGMKQTSTNNSFSGASTSPSETNSGYHDKLP---FYLPKEEITSTCGTATYASPEQLSQKKVRIKAHFQAEFFDHRADIYSLGIIILQLFHP
.|. .|||. ...|...||..|..|... .|. ||. .|   ||......|...||..|.||||||..      |.|.....|..|.||||||......|
WKYVANDNCQWWNTNQQNSPTGQDTHMW-SNN-YHI-QPTSMFYCEHCHHTGGVGTCLYMSPEQLSGQ------HYQKSHYNHKVDMYSLGIIFFEMWYP

MNTSM-ELVKTIQNCKK------GELP-KHFCAKFPRLAEIIKDSLSNDPQKRPLLSKIEQTLQE
..|.| | |||......      |..| |.|. |.|..|..|.. ||.|||.||  . | |..  
FFTTMMERVKTLTDLRDESIQFPGDFPPKWFDNKYPKQADFIQWMLSHDPQQRPSAQQILQHEFF
Kinase 6287.AA CAMK 137-903 6 1.6e-31 98.27 In-house 1-323 (425) Show / Hide 
Range on Protein: 137-903
Range on HMM: 1-323/425
Sequence Identity: 6% (58 aa)

KIGQGGFASVYRVVHKIDD------------TEYAVKQIHLK---------------IKDIKEDL------QKHYEKLIREARYLAQ-------VNHPNV
..|.|.|. |....|| .             ...|.| |  |               |...|..       .|  ... || . . .       ..|||.
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

IRYFHSWI-------------------------------EVTEKK------------KSQKQEEQKRQTLELSSSFAKKKKSKDNNNVSPSKKDKKEDKQ
|. .. .                                |  .              .... ||  .                                 
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQ---------------------------------

LAIQSNQANLKQQPANSNNPAGQNQQKVVDSNKGGISQVASVQNKNSDATNIHIQAQTNNQKGKQQQQQQVNQGKQTQQIQLNNQDQSDEDNNEDSNTFY
                                                                                                    
----------------------------------------------------------------------------------------------------

FEDEFDNEVVFIEENSKSIKQDESQQENSHSSGNNLNQSNIKSNNDMSDQSPIPNPNVASKQKPSQIKIFNNNSNGNSAEIPNTKKSSKDIKKLSEFSSA
                                                                                                    
----------------------------------------------------------------------------------------------------

MHGNNNEESQENDSQSFNKGQSDFQLVFESYSEKSKSDLKDECKQIAPDNNNQNTSKLVQNKKQDQGEKKNINKCNNNNNQNKNQILETKKQEQNANCAI
                                                                                                    
----------------------------------------------------------------------------------------------------

NNKNNKNSHDILKNNQISQQTQNNNNNNKNQLQQNQQQNQANSISNTKSYERRKNKSMDYLTIDQKQREFQLDKYDEIIFYLQTELCHQTLAEYITNRNK
                                                                                                    
----------------------------------------------------------------------------------------------------

KLFSQQQFNQNLSIKNSCANISNNSNIKNQNLCLQSTQSMFNMNESNSFSGQQNSINNNLNQNNLMHPTLTYSNSCNCSDPFDILTFEYKQ---QAIAIL
                                                                                 |||.  . .    .|  . 
---------------------------------------------------------------------------------FDIV-ERGRFTEREARRYF

KEIIKGLYHIHHICKMVHRDLKPHNIFLTDNM-----------------QVKIGDFGLVKKLSK------------------LINPNQKIQYNDHQLYGK
. |. .. ..|     ||||||| || |.||.                 ..|| |||. .|. .                                    
RQICSAVHYCHSHN-IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQW-----------------

KLGNDNSGMKQTSTNNSFSGASTSPSETNSGYHDKLPFYLPKEEITSTCGTATYAS-PEQLSQKKVRIKAHFQ-----AEFFDHRADIYSLGII
                                    .   . .  .  |||  |.. || |..|.   .   .      .  .  .|. |.|.|
------------------------------------TTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQ--NATDEEKPYYGPKCDMWSCGVI
Kinase 6287.AA TKL 744-965 16 3.6e-25 87.59 In-house 132-364 (364) Show / Hide 
Range on Protein: 744-965
Range on HMM: 132-364/364
Sequence Identity: 16% (47 aa)

QQAIAILKEIIKGLYHIHH-------ICKMVHRDLKPHNIFLTDNMQ--------------VKIGDFGLVKKLSKLINPNQK-------IQYNDHQLYGK
.| . . ..| .|... |         ....|||||..||.. .|..              .||.|||| . .|.  | |         .          
HQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESA----------

KLGNDNSGMKQTSTNNSFSGASTSPSETNSGYHDKLPFYLPKEEITS---------TCGTATYASPEQLSQKKVRIKAH-----FQAEFFDHRADIYSLG
                                           |  .          |||  . .|| | ..    ..      .. . .. ..|.|| |
-------------------------------------------E--HQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFG

IIILQLFH---PMNTSMELVKT---------IQNCKKGELPKHF------------CAKFPRLAEIIKDSLSNDPQKRPLLSKIEQTL
|..  ..    |    ..             ...|.||. |                   |.......|  . ||.|||  ..| ..|
IVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase 6287.AA PEK 132-205 36 1.8e-23 74.18 In-house 1-76 (758) Show / Hide 
Range on Protein: 132-205
Range on HMM: 1-76/758
Sequence Identity: 36% (28 aa)

FIQLQKIGQGGFASVYRVVHKIDDTEYAVKQIHLKI--KDIKEDLQKHYEKLIREARYLAQVNHPNVIRYFHSWIE
|   |..|.||| .|.|.  | |. .||.| | ...          .  ||  ||.| ||  .|.| .|||..| |
FEHIQCLGHGGFGVVFRAKNKVDMNNYAIKRITFPNSNNQSPTNRESAREKVMREVRTLAMLDHHNIVRYFNAWLE
Kinase 6287.AA Pkinase 744-908 18 1.1e-21 77.8 Pfam 108-206 (293) Show / Hide 
Range on Protein: 744-908
Range on HMM: 108-206/293
Sequence Identity: 18% (32 aa)

QQAIAILKEIIKGLYHIHHICKMVHRDLKPHNIFLTDNMQV----KIGDFGLVKKLSKLINPNQKIQYNDHQLYGKKLGNDNSGMKQTSTNNSFSGASTS
.... ....|..||...|  .. .|||||| ||.. .|...    ||.|||| |...                                           
WECKFYMYQILRGLEYCHS-MGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-------------------------------------------

PSETNSGYHDKLPFYLPKEEITSTCGTATYASPEQLSQKKVRIKAHFQAEFFDHRADIYSLGIIILQLF
              | ...  |. |||  |..|| .            ..  ....|..|.|.|. ...
--------------Y-NNS-MTTFCGTPWYMAPEVIR----------GGQYYGPKVDMWSCGCILYEML
Kinase 6287.AA PEK 865-956 35 5.7e-19 58.87 In-house 650-747 (758) Show / Hide 
Range on Protein: 865-956
Range on HMM: 650-747/758
Sequence Identity: 35% (35 aa)

GTATYASPEQLSQKKVRIKAHFQA-----EFFDHRADIYSLGIIILQLFHP-MNTSMELVKTIQNCKKGELPKHFCAKFPRLAEIIKDSLSNDPQKRP
|| .|.||||.. . |     .          .|  ||||||.|   |.||  .| || ..|. . ..| .|| |  | |  .| |.. .| .|  ||
GTHLYMSPEQCHHQSVFGTGTYTNPEQKKTWYNHKVDIYSLGLIFFELIHPGFSTQMERIRTMCDLRNGQWPKWFTQKYPQEYEFIQQMMSMNPDERP
Kinase 6287.AA HRI 132-205 41 2.9e-17 56.8 In-house 1-69 (613) Show / Hide 
Range on Protein: 132-205
Range on HMM: 1-69/613
Sequence Identity: 41% (31 aa)

FIQLQKIGQGGFASVYRVVHKIDDTEYAVKQIHLKIKDIKEDLQKHYEKLIREARYLAQVNHPNVIRYFHSWIE
|.|.  ||.||.  ||.| || |   ||.| |  | |  | ...    |. || . ||  .|.|..||  .|||
FEQKEIIGKGGYGRVYKVRHKLDKQHYAIKKIKIK-KRTKCSCM----KMQREVKVLACLQHHNIVRYHQAWIE
Kinase 6287.AA NEK 132-205 32 5.7e-17 56.65 In-house 1-75 (286) Show / Hide 
Range on Protein: 132-205
Range on HMM: 1-75/286
Sequence Identity: 32% (26 aa)

FIQLQKIGQGGFASVYRVVHKIDDTE-----YAVKQIHLKIKDIKEDLQKHYEKLI-REARYLAQVNHPNVIRYFHSWIE
.  ..||||| | .||.| .|.|  .     |. |.|     ....  .|  ....  |.| |.| .|||...|. |.||
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKI-----NMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIE
Kinase 6287.AA Pkinase 132-205 28 1.1e-15 56.5 Pfam 1-71 (293) Show / Hide 
Range on Protein: 132-205
Range on HMM: 1-71/293
Sequence Identity: 28% (21 aa)

FIQLQKIGQGGFASVYRVVHKIDDTEYAVKQIHLKIKDIKEDLQKHYEKLIREARYLAQVNHPNVIRYFHSWIE
.  ..|||.|.|..||. .|| .  ..|||.| ..  ..|.. ...  .| .|..... .||||..|..... .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR--HEKSWKDQTHRRL-SEIQIMKRLNHPNIVRLYDWFED
Kinase 6287.AA WEE 132-205 26 2.6e-14 44.49 In-house 1-76 (297) Show / Hide 
Range on Protein: 132-205
Range on HMM: 1-76/297
Sequence Identity: 26% (22 aa)

FIQLQKIGQGGFASVYRVVHKIDDTEYAVKQIHLKIKDIKEDLQKHY--EKLIREARYLAQVN-------HPNVIRYFHSWIE
| ..||||.| |..|| ....||   ||.|..  ..      ....   .  .||.. ....        ||...||. .|.|
FQEVQKIGEGSFGEVYKCRCRIDGCIYAIKKSK-QP------FRGYSERKRALREVYAHMVLGQIMDCDHHPHIVRYYSAWEE
Kinase 6287.AA S_TKc 132-971 6 4.8e-14 28.99 SMART 1-231 (231) Show / Hide 
Range on Protein: 132-971
Range on HMM: 1-231/231
Sequence Identity: 6% (59 aa)

FIQLQKIGQGGFASVYRVVHKIDDTEYAVKQIHLKIKDIKEDLQKHYEKLIREARYLAQVNHPNVIRYFHSWIEVTEKKKSQKQEEQKRQTLELSSSFAK
.  |.|||.|.|..||...|| .. ..|.|.|.                                                                   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------------------------------------------------------------------

KKKSKDNNNVSPSKKDKKEDKQLAIQSNQANLKQQPANSNNPAGQNQQKVVDSNKGGISQVASVQNKNSDATNIHIQAQTNNQKGKQQQQQQVNQGKQTQ
                                                                                                    
----------------------------------------------------------------------------------------------------

QIQLNNQDQSDEDNNEDSNTFYFEDEFDNEVVFIEENSKSIKQDESQQENSHSSGNNLNQSNIKSNNDMSDQSPIPNPNVASKQKPSQIKIFNNNSNGNS
                                                                                                    
----------------------------------------------------------------------------------------------------

AEIPNTKKSSKDIKKLSEFSSAMHGNNNEESQENDSQSFNKGQSDFQLVFESYSEKSKSDLKDECKQIAPDNNNQNTSKLVQNKKQDQGEKKNINKCNNN
                                                                                                    
----------------------------------------------------------------------------------------------------

NNQNKNQILETKKQEQNANCAINNKNNKNSHDILKNNQISQQTQNNNNNNKNQLQQNQQQNQANSISNTKSYERRKNKSMDYLTIDQKQREFQLDKYDEI
                                                                                                    
----------------------------------------------------------------------------------------------------

IFYLQTELCHQTLAEYITNRNKKLFSQQQFNQNLSIKNSCANISNNSNIKNQNLCLQSTQSMFNMNESNSFSGQQNSINNNLNQNNLMHPTLTYSNSCNC
                                                                          .. ..      .  || .     .  
--------------------------------------------------------------------------EHIRREIQILKK-HHPNIVKLYDVFQ

SDPFDILTFEYKQQ------------------------AIAILKEIIKGLYHIHHICKMVHRDLKPHNIFLTDNMQVKIGDFGLVKKLSKLINPNQKIQY
.  .  . .||  .                        |  ....|...| ..|   . .|||||| ||.|..  ..||.|||| ..|            
D-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPEHARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE--HIKICDFGLARQL------------

NDHQLYGKKLGNDNSGMKQTSTNNSFSGASTSPSETNSGYHDKLPFYLPKEEITSTCGTATYASPEQLSQKKVRIKAHFQAEFFDH-RADIYSLGIIILQ
                                                     |. |||  | .|| |               ... ..|..|.|.|.  
-----------------------------------------------------TTFCGTPWYMAPEVL--------------GYGKCKCDWWSCGCILYE

LFH---PMNTSMELVKTIQNCKKGELPKHFCAKFPRLAEIIKDSLSNDPQKRPLLSKIEQ---TLQEMEMM
..    |     .. .......            | . ..|.  |  ||.|||   .. |       .. .
MLCGYPPFP---QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 6287.AA WEE 749-797 37 5.3e-14 43.43 In-house 116-184 (297) Show / Hide 
Range on Protein: 749-797
Range on HMM: 116-184/297
Sequence Identity: 37% (26 aa)

ILKEIIKGLYHIHHICKMVHRDLKPHNIFLTDNM--------------------QVKIGDFGLVKKLSK
|| .|..|| |||  | ||| |.|| |||.. .|                      ||||||.|.....
ILVDICQGLHHIHSNCGMVHMDIKPENIFISKKMNCNQIVNNDQQNNNDWWFNMMCKIGDFGHVTDMNS
Kinase 6287.AA PKR 743-795 50 1e-12 41.73 In-house 122-173 (272) Show / Hide 
Range on Protein: 743-795
Range on HMM: 122-173/272
Sequence Identity: 50% (27 aa)

KQQAIAILKEIIKGLYHIHHICKMVHRDLKPHNIFLTDNMQVKIGDFGLVKKL
|  .. .   |.||   | |  |..|||||| |||| |. ..||||||||  |
KVLILDLYEQIVKGVDYI-HSKKLIHRDLKPSNIFLVDERHIKIGDFGLVTAL
Kinase 6287.AA NEK 753-797 43 1e-12 41.49 In-house 123-175 (286) Show / Hide 
Range on Protein: 753-797
Range on HMM: 123-175/286
Sequence Identity: 43% (23 aa)

IIKGLYHIHHIC----KMVHRDLKPHNIFLT-DNMQ---VKIGDFGLVKKLSK
....|...|       | .|||.|| ||||| .|..   |||||||. | |..
MCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNH
Kinase 6287.AA TKL 138-198 15 1.2e-12 41.87 In-house 1-89 (364) Show / Hide 
Range on Protein: 138-198
Range on HMM: 1-89/364
Sequence Identity: 15% (14 aa)

IGQGGFASVYRVVHKIDD--------TEYAVKQIHL--------KIKD------------IKEDLQKHYEKLIREARYLAQVNHPNVIR
||.|||. ||. ...  .        .. |||...         ....            . .....  .....|.. . . .|||...
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQ
Kinase 6287.AA GCN2 859-956 28 1.5e-12 39.86 In-house 409-500 (511) Show / Hide 
Range on Protein: 859-956
Range on HMM: 409-500/511
Sequence Identity: 28% (30 aa)

EITSTCGTATYASPEQLSQKKVRIKAHFQAEFFDHRADIYSL-GIIILQLFHP-MNTSMELVKTIQNCKKGELPKHFCA----KFPRLAEIIKDSLSNDP
..|.  ||. | .|||.                . ..|.||| |||.. ...| . |.|| |... . .. |.|. | .    . .  ...|.  |. ||
HHTGKVGTPFYMCPEQQ------------KSHYNQKVDMYSLGGIIFFEMWYPPFCTQMERVQILKQLRSCEFPQDFDKKVDNHHKDQQDMIRWCLNHDP

QKRP
||||
QKRP
Kinase 6287.AA GCN2 752-809 34 2e-11 35.88 In-house 316-393 (511) Show / Hide 
Range on Protein: 752-809
Range on HMM: 316-393/511
Sequence Identity: 34% (27 aa)

EIIKGLYHIHHICKMVHRDLKPHNIFLTDNMQVKIGDFGLVKK---------------------LSKLINPNQKIQYND
.|. || .||    |.|||||| ||||. . .||||||||..                      .. ... .|. | |.
QILEGLNYIHSQ-GMIHRDLKPSNIFLDCCGNVKIGDFGLATNNKMESQINRKQQKQQQQASSHWAIQNEICQDDQFNQ
Kinase 6287.AA HRI 749-791 53 3.7e-11 34.77 In-house 438-483 (613) Show / Hide 
Range on Protein: 749-791
Range on HMM: 438-483/613
Sequence Identity: 53% (25 aa)

ILKEIIKGLYHIHHICKMVHRDLKPHNIFLTDNMQ----VKIGDFGL
|  .|. |.. ||     ||||.|| |||| |  |    ||||||||
IFQQIVEGMFYIHNMF-IVHRDVKPRNIFLHDPDQGHPQVKIGDFGL
Kinase 6287.AA PEK 749-793 33 9.3e-10 27.5 In-house 447-514 (758) Show / Hide 
Range on Protein: 749-793
Range on HMM: 447-514/758
Sequence Identity: 33% (23 aa)

ILKEIIKGLYHIHHICKMVHRDLKPHNIFLTDNMQ------------------------VKIGDFGLVK
. . |. |.  ||  . | |||||| |||..   |                        .||||||||.
WFHQICEGVNYIHS-KGMIHRDLKPSNIFFSMDSQHHQQSSFSNISSSFEENSDGGHQIIKIGDFGLVT
Kinase 6287.AA HRI 861-930 37 1.8e-09 28.67 In-house 518-576 (613) Show / Hide 
Range on Protein: 861-930
Range on HMM: 518-576/613
Sequence Identity: 37% (26 aa)

TSTCGTATYASPEQLSQKKVRIKAHFQAEFFDHRADIYSLGIIILQLFHPMNTSMELVKTIQNCKKGELP
||  || ||||||||               .| . | ||.|.| . || |  | ||  . .   . | .|
TSRVGTCTYASPEQL-----------DGSQYDNKSDMYSMGVILFELFQPFGTEMERAEVLTGVRTGQIP
Kinase 6287.AA PKR 132-203 29 4.3e-08 24.95 In-house 1-61 (272) Show / Hide 
Range on Protein: 132-203
Range on HMM: 1-61/272
Sequence Identity: 29% (21 aa)

FIQLQKIGQGGFASVYRVVHKIDDTEYAVKQIHLKIKDIKEDLQKHYEKLIREARYLAQVNHPNVIRYFHSW
| .. .|| |||  |..  |.||   |..| .               ||  .| . ||...| |...|   |
FKDIEEIGSGGFGQVFKAKHRIDGKRYVIKRVKYNN-----------EKAEHEVQALAKLDHVNIVHYHSCW
Kinase 6287.AA PKR 861-965 32 1.4e-07 23.04 In-house 181-272 (272) Show / Hide 
Range on Protein: 861-965
Range on HMM: 181-272/272
Sequence Identity: 32% (34 aa)

TSTCGTATYASPEQLSQKKVRIKAHFQAEFFDHRADIYSLGIIILQLFHPMNTSMELVKTIQNCKKGELP-KHFCAKFPRLAEIIKDSLSNDPQKRPLLS
|   ||  | ||||.. .      |.  |      ||| ||.|.  | |   | .| .|  .. ..|..    |  |   |   ..  ||. |. ||  |
TRRKGTLQYMSPEQIFSQ------HYGKEV-----DIYALGLILAELLHVCFTEFEKIKFFEDLRDGDFSNDIFDNKEKTL---LQKLLSKKPKDRPNTS

KIEQTL
 | .||
EILRTL
Kinase 6287.AA GCN2 132-389 18 2e-06 17.95 In-house 1-265 (511) Show / Hide 
Range on Protein: 132-389
Range on HMM: 1-265/511
Sequence Identity: 18% (53 aa)

FIQLQKIGQGGFASVYR-VVHKIDDTEYAVKQIHLKIKDIKEDLQKHYEK--LIREARYLAQVNHPNVIRYFHSWIE-----VTEKKKSQKQEEQKRQTL
|  .. .|.||| .|.  |  . | . ||.| . ...|      .|.. |    ||.  |.  .|..| ||. .|||     ...   .  .. . .   
FEEICCLGKGGFGQVVKNVRNMHDGRYYAIKKWPINWKQ-----RKLPCKHKIMREVKLLCRLHHQHVVRYYQAWIEKCDEPMVTDTNNDDDTNNNYHSD

ELSSSFAKKKKSKDNNNVSPSKKDKKEDKQLAIQSNQANLKQ------QPANSNNPAGQNQQKVVDSNKG----------GISQVASVQNKNSDATNIHI
  | .|. . .. . .| | . .. ||. .    ||. |         .   ..|| .|    .  .  |            |   |      |  .|  
DESECFSGQYEMPKSVNQS-EEMCNKEESMEWSMSNERNNSNWHDNGNFFSEWDNPFDQPFGPKCAFRMGQKRTFDLTDDHYSYCHSDCEFDDDVFDIDW

QAQTNN----------QKGKQQQQQQVNQGKQTQQIQLNNQDQSDEDNNEDSNTFYFEDEFDNEVVFI-EENSKSIKQDESQQENSHSSGNNL
..  ||          .. .||. | ... ....|                      .. .|.|...  |. ... |  ..|....  . .|.
DIESNNVRDMESDDNEWEQEQQNNQSFQPKQEDHQ----------------------NQYYDQEDLNNAESEDQNKKKSQQQDKMCQNQHKNK
Kinase 6287.AA TyrKc 132-965 6 8e-06 -128.74 SMART 1-280 (280) Show / Hide 
Range on Protein: 132-965
Range on HMM: 1-280/280
Sequence Identity: 6% (57 aa)

FIQLQKIGQGGFASVYRVVHKIDDTEYAVKQIHLKIKDIKEDLQKHYEKLIREARYLAQV--NHPNVIRYFHSWIE-------------VTE--------
   ..|.| | |  ||. . |   .. ||| ..              | ..|||| . ..  .|||..| .   ..             |.|        
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA----------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLK

---KKKSQKQEEQKRQTLELSSSFAKKKKSKDNNNVSPSKKDKKEDKQLAIQSNQANLKQQPANSNNPAGQNQQKVVDSNKGGISQVASVQNKNSDATNI
   .|.  |                                                                                           
DYLRKHRPK-------------------------------------------------------------------------------------------

HIQAQTNNQKGKQQQQQQVNQGKQTQQIQLNNQDQSDEDNNEDSNTFYFEDEFDNEVVFIEENSKSIKQDESQQENSHSSGNNLNQSNIKSNNDMSDQSP
                                                                                                    
----------------------------------------------------------------------------------------------------

IPNPNVASKQKPSQIKIFNNNSNGNSAEIPNTKKSSKDIKKLSEFSSAMHGNNNEESQENDSQSFNKGQSDFQLVFESYSEKSKSDLKDECKQIAPDNNN
                                                                                                    
----------------------------------------------------------------------------------------------------

QNTSKLVQNKKQDQGEKKNINKCNNNNNQNKNQILETKKQEQNANCAINNKNNKNSHDILKNNQISQQTQNNNNNNKNQLQQNQQQNQANSISNTKSYER
                                                                                                    
----------------------------------------------------------------------------------------------------

RKNKSMDYLTIDQKQREFQLDKYDEIIFYLQTELCHQTLAEYITNRNKKLFSQQQFNQNLSIKNSCANISNNSNIKNQNLCLQSTQSMFNMNESNSFSGQ
                                                                                                    
----------------------------------------------------------------------------------------------------

QNSINNNLNQNNLMHPTLTYSNSCNCSDPFDILTFEYKQQAIAILKEIIKGLYHIHHICKMVHRDLKPHNIFLTDNMQVKIGDFGLVKKLSKL-INPNQK
                                      .. . .   | .|  ..|.  . .||||   |. ...| .|||.|||| ...     .    
-----------------------------------LCMKDLLSFCWQIACGMEYLHSK-NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQG---

IQYNDHQLYGKKL-GNDN-----------SGMKQTSTNNS------------FSGASTSPSE--------------TNSGYHDKLPFY-LPKEEITSTCG
     .. | ||  .. .           . .. . |  |            |.   . ...                .||  . | . .  . .     
---ESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY--P-MS----

TATYASPEQLSQKKVRIKAHFQAEFFDHRADIYSLGIIILQLFHPMNTSMELVKTIQNCKKGELPKHFCAKFPRLAEIIKDSLSNDPQKRPLLSKIEQTL
                                                                   |    . . .|.|.    || .||  | | . .
-------------------------------------------------------------------FVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase 6287.AA Pkinase_Tyr 765-791 51 0.000156 15.98 Pfam 131-157 (270) Show / Hide 
Range on Protein: 765-791
Range on HMM: 131-157/270
Sequence Identity: 51% (14 aa)

KMVHRDLKPHNIFLTDNMQVKIGDFGL
...||||   |. .|.|..|||.||||
NCIHRDLAARNCLVTENNVVKICDFGL
Kinase 6287.AA Pkinase_Tyr 132-199 26 0.00545 10.75 Pfam 1-69 (270) Show / Hide 
Range on Protein: 132-199
Range on HMM: 1-69/270
Sequence Identity: 26% (19 aa)

FIQLQKIGQGGFASVYRVVHK----IDDTEYAVKQIHLKIKDIKEDLQKHYEKLIREARYLAQV-NHPNVIRY
 . ..|.|.| | .||. . |     .... ||| .     . ..      |...|||. . |  .|||..|.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQN---CREDFMREAKIMKQLGHHPNIVRL
Kinase 6287.AA HRI 634-654 38 0.012629 4.01 In-house 395-415 (613) Show / Hide 
Range on Protein: 634-654
Range on HMM: 395-415/613
Sequence Identity: 38% (8 aa)

YLQTELCHQTLAEYITNRNKK
. | .||  .| . |. |||.
HIQMQLCELSLWDWISERNKR
Kinase 6287.AA WEE 895-907 69 0.288041 0.09 In-house 217-229 (297) Show / Hide 
Range on Protein: 895-907
Range on HMM: 217-229/297
Sequence Identity: 69% (9 aa)

ADIYSLGIIILQL
|||.|||| |. |
ADIFSLGITIYEL