18358b

Species: Tetrahymena
Alias: 1051, 186.m00074, 18358b
External Links:
Annotation:

Classification

Group: Other
Family: PLK
Subfamily: PLK-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
18358b.AA Protein None 610 None Fasta, JSON
18358b.kin_dom Protein Kinase Domain None 249 None Fasta, JSON
18358b.NA RNA None 1830 None Fasta, JSON

Protein domain

Protein domains of 18358b.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 18358b.AA PLK-Unclassified 1-249 67 3.2e-195 654.84 In-house 9-264 (264) Show / Hide
Range on Protein: 1-249
Range on HMM: 9-264/264
Sequence Identity: 67% (172 aa)

KGGFAKCYEFTNLERKQVLAAKVIPKSSLTKSRARQKLMSEIRIHKSLNHRNIVKFQHFFEDQENVYILLEMCTNQTMNELIRRR-------KRLTELEV
||||||||...|.|.|...|||.||||||||.||||||.|||.|||||.|.|||||.|.|||.||||||||.|.|.|..|.|.||       |||||.||
KGGFAKCYQVKNIETKKIYAAKIIPKSSLTKNRARQKLISEIKIHKSLHHKNIVKFEHCFEDHENVYILLEYCPNGTLMEYIKRRNFQLFEKKRLTEYEV

QCYLLQILYSIKYLHDNRVIHRDLKLGNLFLSDKMEIKLGDFGLATKLEYDGERKRTICGTPNYIAPEILEAKETGHSYEVDVWSFGVIAYTLLIGKPPF
.||..||....||||.||.|||||||||.||.|.||.|..|||||||||.|||.|.||||||||||||||..|..|||||||.||||.|.||||||||||
KCYTYQIVQALKYLHQNRIIHRDLKLGNIFLNDNMEVKICDFGLATKLENDGEKKKTICGTPNYIAPEILDGKHQGHSYEVDCWSFGCILYTLLIGKPPF

ETNDVKSTYKKIRTNEYSFPEQIQISSAAKNMIKKILTTDPSKRPTINELFNDDFF
||.|||.|||||..|.|||||...||..||..|..||...|..||||.......|.
ETKDVKQTYKKIKCNQYSFPEPCHISDNAKDLIQHILNWNPDQRPTIDQIMMHPFY

Kinase 18358b.AA PLK 1-249 62 3e-189 621.3 In-house 9-258 (258) Show / Hide
Range on Protein: 1-249
Range on HMM: 9-258/258
Sequence Identity: 62% (156 aa)

KGGFAKCYEFTNLERKQVLAAKVIPKSSLTKSRARQKLMSEIRIHKSLNHRNIVKFQHFFEDQENVYILLEMCTNQTMNELIRRR-KRLTELEVQCYLLQ
|||||||||.|... |||.|.||.|||...|...|.|...||.||..|.|.|||||.|||||.|||||.||.|.|........|| ||||| ||..|..|
KGGFAKCYEMTDIHTKQVYAIKVVPKSLMQKPHQREKMKQEIEIHRQLHHPNIVKFHHFFEDHENVYIVLEYCHNRSLMHYHKRRAKRLTEPEVRYYMYQ

ILYSIKYLHDNRVIHRDLKLGNLFLSDKMEIKLGDFGLATKLEYDGERKRTICGTPNYIAPEILEAKETGHSYEVDVWSFGVIAYTLLIGKPPFETNDVK
|  ..||||..|.||||||||||||.|.|..|.|||||||.||||||||.|.||||||||||.|.....|||||||.||.|.| ||||||||||||.|||
IVQGLKYLHQHRIIHRDLKLGNLFLNDNMHVKIGDFGLATRLEYDGERKKTMCGTPNYIAPEVLDGNKQGHSYEVDCWSLGCIMYTLLIGKPPFETKDVK

STYKKIRTNEYSFPEQIQISSAAKNMIKKILTTDPSKRPTINELFNDDFF
.|||.|. |.|||||...|| .||..|.|.| ..|..||||.......||
ETYKRIKHNHYSFPEHCPISDEAKDLIQKMLNWNPDERPTIDQILQHPFF

Kinase 18358b.AA PLK1 1-249 57 2.5e-128 424.08 In-house 9-253 (253) Show / Hide
Range on Protein: 1-249
Range on HMM: 9-253/253
Sequence Identity: 57% (142 aa)

KGGFAKCYEFTNLERKQVLAAKVIPKSSLTKSRARQKLMSEIRIHKSLNHRNIVKFQHFFEDQENVYILLEMCTNQTMNELIRRRKRLTELEVQCYLLQI
|||||.|||... . |.|.|.||.||| | |. .|.|.  ||.||..|.||.|||| |||||..||||.||.|  . . || .||| .|| |   |. ||
KGGFAHCYEIRDKDTKEVFAGKVVPKSLLIKQHQRDKMTQEIQIHRQLHHRHIVKFHHFFEDKQNVYIVLELCRRRSLMELHKRRKAITEPECRYYMYQI

LYSIKYLHDNRVIHRDLKLGNLFLSDKMEIKLGDFGLATKLEYDGERKRTICGTPNYIAPEILEAKETGHSYEVDVWSFGVIAYTLLIGKPPFETNDVKS
. ...|||.|..|||||||||||| |....|.||||||||.|||||||.|.||||||||||.|.  ..|||.|||.|| | | |.||.|.|||||. .| 
VEGCQYLHNNKIIHRDLKLGNLFLNDHLQVKIGDFGLATKCEYDGERKKTLCGTPNYIAPEVLN--KKGHSFEVDIWSIGCIMYILLFGQPPFETKCLKE

TYKKIRTNEYSFPEQIQISSAAKNMIKKILTTDPSKRPTINELFNDDFF
||..|. |||. |.  .|| .|...|.|.| .||..||||... ||.||
TYSRIKKNEYRIPS--HISQPAAQLIRKMLDPDPTRRPTIEQVLNDEFF

Kinase 18358b.AA PLK2 1-249 47 6.5e-124 401.0 In-house 9-257 (257) Show / Hide
Range on Protein: 1-249
Range on HMM: 9-257/257
Sequence Identity: 47% (121 aa)

KGGFAKCYEFTNLERKQVLAAKVIPKSSLTKSRARQKLMSEIRIHKSLNHRNIVKFQHFFEDQENVYILLEMCTN----QTMNELIRRRKRLTELEVQCY
|||||.||| | ..   | |.|..|.|   | . | |   || .|  | ||.||.| |.|||..|.||||| |      . |      |. ||| ||  |
KGGFARCYEMTDMDTHYVYAVKIVPHSRVAKPHQREKMEREIELHRQLRHRHIVQFHHHFEDRDNIYILLEYCSRQVPLKSMAHMWKVRHHLTEPEVRYY

LLQILYSIKYLHDNRVIHRDLKLGNLFLSDKMEIKLGDFGLATKLEYDGERKRTICGTPNYIAPEILEAKETGHSYEVDVWSFGVIAYTLLIGKPPFETN
..||.  ..|||. ..|||||||||.|. | ||.| |||||| .||  ....||.||||||||||.|  .  ||| | |.|. | | ||.|.| ||||| 
MRQIVSGLRYLHQQCIIHRDLKLGNFFINDNMEVKIGDFGLAARLEPEEHCHRTMCGTPNYIAPEVLNRQ--GHSCESDIWALGCIMYTMLCGRPPFETA

DVKSTYKKIRTNEYSFPEQIQISSAAKNMIKKILTTDPSKRPTINELFNDDFF
. | ||. || | | .|.    |  |. .| ..|  ||  || . ..  .|||
NLKETYRCIRHNHYHMPT--HLSPPARHLIARMLSPDPEDRPSLDHIIRHDFF

Kinase 18358b.AA CAMK 1-249 21 2.3e-90 291.32 In-house 4-425 (425) Show / Hide
Range on Protein: 1-249
Range on HMM: 4-425/425
Sequence Identity: 21% (91 aa)

KGGFAKCYEFTNLERK------------QVLAAKVIPKSSLTK-------------------------SRARQKLMSEIRIHKS-------LNHRNIVKF
.|.|.| .. .. . .            |  |.|.|.|. |..                          . |.....||.|.|.       |.|.||.|.
RGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNIIKL

QHFFED-------------------QENVYILL---EMCTNQ----TMNELIRRR---------------KRLTELEVQCYLLQILYSIKYLHDNRVIHR
 ...||                   ....|. .   |.|..      . . |...               .|.|| |.. |  ||.  ..|.|.. ..||
YEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNIVHR

DLKLGNLFLSDKM-----------------EIKLGDFGLATKLEY-----------------------DGERKRTICGTPNYIA-PEILEAK--------
|||. |. |.|..                  ||. |||.|.|..                        .|.  .| |||| |.| ||.|. |        
DLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQNA

----ETGHSYEVDVWSFGVIAYTLLIGKPPFETN-------------DVKSTYKKIRTNEYSFPE--------------QIQISSA--------AKNMIK
    ........|.|| ||| |..| |.|||.               . . ...||.. .|.||.                 ||          .|..|.
TDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKDLIR

KILTTDPSKRPTINELFNDDFF
|.|..||.||.|| .  |. ..
KMLQVDPEKRMTIEQCLNHPWM

Kinase 18358b.AA S_TKc 1-249 32 5.2e-88 299.6 SMART 9-231 (231) Show / Hide
Range on Protein: 1-249
Range on HMM: 9-231/231
Sequence Identity: 32% (86 aa)

KGGFAKCYEFTNLERKQVLAAKVIPKSSLTKSRARQKLMSEIRIHKSLNHRNIVKFQHFFEDQENVYILLEMCTN--QTMNELIRRRKR------LTELE
||.|.|.|  .. . ... | |.|.          .....||.|.|. .| ||||.  .|.| ...|. .|.| .   .. ..|..|.|      ..| .
KGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-H

VQCYLLQILYSIKYLHDNRVIHRDLKLGNLFLSDKMEIKLGDFGLATKLEYDGERKRTICGTPNYIAPEILEAKETGHSY-EVDVWSFGVIAYTLLIGKP
...|. ||.  ..|.|....||||||  |..|..  .||..|||||..|       .|.||||.|.|||.|     |... ..|.||.|.| | .| |.|
ARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL-----GYGKCKCDWWSCGCILYEMLCGYP

PFETNDVKSTYKKIRTNEYSFPEQIQISSAAKNMIKKILTTDPSKRPTINELFN-------DDFF
||.  ... ..|||.            |. ||..|.|.|. ||.||||. |...       . .|
PFP--QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase 18358b.AA Pkinase 1-249 29 1.7e-85 295.16 Pfam 9-293 (293) Show / Hide
Range on Protein: 1-249
Range on HMM: 9-293/293
Sequence Identity: 29% (84 aa)

KGGFAKCYEFTNLERKQVLAAKVIPKSSLTKSRARQKLM-SEIRIHKSLNHRNIVKFQHFFEDQENVYILLEMCTNQ----TMNELIR--RRKRL--TEL
.|.|...|. ..    .. | |.|.|..  ..  ....  |||.|.|.||| |||.. ..|||  ..|. .| | .        ..|.  |....  .| 
SGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEW

EVQCYLLQILYSIKYLHDNRVIHRDLKLGNLFLSDKMEI----KLGDFGLATKL-EYDGERKRTICGTPNYIAPEILEAKETGHSYEVDVWSFGVIAYTL
|...|..|||  ..|.|....||||||. |........|    |..||||| .. .  ..   |.||||.|.|||..  . ......||.||.|.| | .
ECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIR-GGQYYGPKVDMWSCGCILYEM

LIGKPPFETN------DVKSTYKKIRTNEYSFPEQIQIS-------------------SAAKNMIKKILTTDPSKRPTINELFNDDFF
| |.|||         | .  ...|.  ...|...  .|                   ...|  ||..|. ||.||||. .......|
LCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF

Kinase 18358b.AA CAMKL 1-249 28 1.7e-84 269.57 In-house 9-297 (297) Show / Hide
Range on Protein: 1-249
Range on HMM: 9-297/297
Sequence Identity: 28% (82 aa)

KGGFAKCYEFTN-LERKQVLAAKVIPKSSLTKSRARQK------------LMSEIRIHKSLN---HRNIVKFQHFFEDQEN------VYILLEMCTNQT-
||.|.|    |. .  ..  | |.| |. ...    .|            .  ||.|.|.||   | ||.|. . .|..|.      .|. .| | .   
KGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVMEYCSGGEM

-MNELIRRR----KRLTELEVQCYLLQILYSIKYLHDNRVIHRDLKLGNLFLSDKM--EIKLGDFGLATKLE-Y---DGERKRTICGTPNYIAPEILEA-
 . . |...    .|..| | . |  ||.  ..|.|.....|||.|. |. |....   ||. |||.... . .   .|.  .| ||.|.| ||||..  
DLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYMAPEIFQGN

KETGHSYEVDVWSFGVIAYTLLIGKPPFETN--------DVKSTYKKIRTNEYSFPEQIQISSAAKNMIKKILTTDPSKRPTINELFNDDFF
..  . ..||.|| ||| |... |. ||.          ..   |.||..  | .|  ...|  ....|.|.|...|.||||| .. |. ..
NKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM

Kinase 18358b.AA ULK 1-249 29 9.3e-71 241.38 In-house 9-329 (329) Show / Hide
Range on Protein: 1-249
Range on HMM: 9-329/329
Sequence Identity: 29% (94 aa)

KGGFAKCYEFTNLERK----QVLAAKVIPKSSLTKSR-------ARQKLMSEIRIHKSLN--------HRNIVKFQHFFEDQ--ENVYILLEMCTNQTMN
|| |.| |. .| ..|    .. |.|.|.|... ..        . | |..||.| | |.        | ||||. ..||..   |.|| .| |   .  
KGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIMEYCNGGDLE

ELIRRR----------KRLTELEVQCYLLQILYSIKYLHDNRVIHRDLKLGNLFLSDK------------MEIKLGDFGLATKLEYDG-----ERKRT--
..| ..          |||.| |.. .. |||   |.||....||||.|. |  ....            . .|..|||.| ....|.     .   .  
QYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQMMMTCVNE

--ICGTPNYIAPEILEAK--ETGHS-YEVDVWSFGVIAYTLLIGKPPFETNDVKSTY-----KK----------IRTNEYSFP---EQIQISSAAKNMIK
  .|||| | ||.||. .  .  .. |..|.||.|.| | .| |||||...   ..|     |           |...   ||   ...|||.  |. |.
KRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISPECKDLIR

KILTTDPSKRPTINELFNDDFF
. |. |...| .. ||||  .|
RMLQYDEKDRISWEELFNHPWF

Kinase 18358b.AA Ciliate-E2 1-249 25 6.7e-69 235.22 In-house 9-365 (365) Show / Hide
Range on Protein: 1-249
Range on HMM: 9-365/365
Sequence Identity: 25% (94 aa)

KGGFAKCYEFTN-LERKQV----------------------LAAKVIPKSSLTKSRARQKLMSEIR----------IHKSLNHRNIVKFQHFFE--DQEN
.|.|.. |. .. ...||.                       | |.. |. .      ...| ||.          | ..||| ||.|.  .|.  |..|
QGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYECFQEKDDNN

VYILLEMCTNQTMNELIRRR-----------KRLTELEVQCYLLQILY---------------SIKYLHDNR-VIHRDLKLGNLFLSDKMEIKLGDFGLA
.|. .| |  ... ..|. .           |..|| |.. .  |||.                ..||| .  .||||.|. |...     ||. ||||.
IYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----IKIIDFGLS

TKLEYD-------GERK------------------------RTICGTPNYIAPEILEAKE-------TGHSYEVDVWSFGVIAYTLLIGKPPFETNDVKS
.|.  |        ..|                        .||||||.| |||||. |.       .|..|..|.||.||| | .| |||||       
KKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF-------

TYKKIRTNEYSFPEQ----------------IQISSAAKNMIKK----ILTTDPSKRPT-INELFNDDFF
 ...|  ....||..                 ..|  .|..|||    .|  ||.||.| .....|  .|
-QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF

Kinase 18358b.AA ULK 1-249 28 3.1e-68 233.02 In-house 9-324 (324) Show / Hide
Range on Protein: 1-249
Range on HMM: 9-324/324
Sequence Identity: 28% (89 aa)

KGGFA-KCYEFTNLER---KQVLAAKVIPKSSLTKSRAR-------QKLMSEIRIHKSLN---HRN--IVKFQHFFEDQ--ENVYILLEMCTNQTMNELI
|| |. | |. .| .    .|. |.|.|.|... |.  .       |.|..||.| | |.   | |  |||. ..||..   |.|| .| |   .  ..|
KGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCNGGDLEQYI

RRR---------KRLTELEVQCYLLQILYSIKYLHDNRVIHRDLKLGNLFLSDK------------MEIKLGDFGLATKLEYDG---ERKRTIC------
 ..         |||.| |.. .. ||.   |.||.. .||||.|. |. ....              .|..|||.| ......       |..      
KKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQTCVNEKRIK

GTPNYIAPEILEAK--ETGHS-YEVDVWSFGVIAYTLLIGKPPFETNDVKSTYKK--------------IRTNEYSFP---EQIQISSAAKNMIKKILTT
||| | ||.||. .  .  .. |..|.||.|.| | .| ||.||...   ..|..              |...   ||   ....||.  |. |.. |. 
GTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKDLIRRMLQY

DPSKRPTINELFNDDFF
|...| .. |.||  .|
DEKDRISWEEIFNHPWF

Kinase 18358b.AA SAK 1-249 40 3.8e-68 231.12 In-house 9-254 (254) Show / Hide
Range on Protein: 1-249
Range on HMM: 9-254/254
Sequence Identity: 40% (102 aa)

KGGFAKCYEFTNLERKQVLAAKVIPKSSLTKSRARQKLMSEIRIHKSLNHRNIVKFQHFFEDQENVYILLEMCTNQTMNELIRRRKR-LTELEVQCYLLQ
|||||  |    ..  |  | |.| |  . |.   |.   |..||  | |  |..   .|||.  ||. |||| |  |.  ...| |  || | . .. |
KGGFACVYRAKCIHTHQEVAIKMIDKKLMQKTGMVQRVRNEVEIHCQLKHPSILELYNYFEDNNYVYLVLEMCHNGEMHRYMKHRMRPFTEEEARHFMHQ

ILYSIKYLHDNRVIHRDLKLGNLFLSDKMEIKLGDFGLATKLEYDGERKRTICGTPNYIAPEILEAKETGHSYEVDVWSFGVIAYTLLIGKPPFETNDVK
|.  . |||   ..|||| | |. |. .|..|. ||||||.|.   |.  |.|||||||.|||  |  | |  . |||| | . ||||||.|||.|. ||
IVIGMLYLHSHGIMHRDLTLSNILLTRDMHCKIADFGLATQLKMPHEKHYTMCGTPNYISPEI--ATRTAHGLQSDVWSLGCMLYTLLIGRPPFDTDAVK

STYKKIRTNEYSFPEQIQISSAAKNMIKKILTTDPSKRPTINELFNDDFF
.|  |.   ||  |    .|  |. .|.|.|  .|  | |..      | 
NTLNKVMMAEYIMP--AHLSMEAQDLIHKMLRKNPHERITLSTVLCHPFM

Kinase 18358b.AA Pkinase_Tyr 30-181 28 1.1e-16 57.07 Pfam 40-202 (270) Show / Hide
Range on Protein: 30-181
Range on HMM: 40-202/270
Sequence Identity: 28% (48 aa)

TKSRA--RQKLMSEIRIHKSL-NHRNIVKFQHFFE-DQEN--VYILLEMCTNQTMNELIRR----RKRLTELEVQCYLLQILYSIKYLHDNRVIHRDLKL
. ...  |...|.|..| |.| .| |||..      ..|   .|| .| . .  . .  |.    ...||  .  .. .||     ||.... |||||  
AMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAA

GNLFLSDKMEIKLGDFGLATKLEYDGE---RKRTICGTP-NYIAPEILEAKETGHSYEVDVWSFGV
 |  ..... .| .|||||  . |. .   |||. .  |    ||| .  ..   . . |||||||
RNCLVTENNVVKICDFGLARDI-YNDDYYYRKRGGGKLPIKWMAPECINYGK--FTTKSDVWSFGV

Kinase 18358b.AA TyrKc 13-248 20 8.4e-16 32.77 SMART 1-280 (280) Show / Hide
Range on Protein: 13-248
Range on HMM: 1-280/280
Sequence Identity: 20% (61 aa)

LERKQVL-----------------AAKVIPKSSLTKSRARQKLMSEIRIHKSL--NHRNIVKFQHFFEDQ-------ENVYILLEMCTNQTMNELIRRRK
.. ...|                 | |.. ...      |. .|.|.|| ..|  .| |||..     .|       | ..|..| . .   .. .|...
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

R-LTELEVQCYLLQILYSIKYLHDNRVIHRDLKLGNLFLSDKMEIKLGDFGLATKLEYD---GERKRTIC-----GTP-----NYIAPEILEAKETGHSY
. |.  .   . .||     |||....|||||   |  ....  .| .||||. ... |   ||.| ..      |.         ||| .  ..   . 
PKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI--NYGKFTT

EVDVWSFGVIAY---TLLIGKPPFET-----NDVKSTYKKIRTNEYSFPEQI-------QISSAAKNMIKKILTTDPSKRPTINELFNDDF
. |||||||  .   |.  |..| .       . .  ...... ..  . .          ...  ...|.    ||..||| .|.  ..|
KSDVWSFGVCMWEIFTY--GQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI-HECF

POLO_box 18358b.AA POLO_box 427-495 41 8.4e-25 93.52 Pfam 1-74 (74) Show / Hide
Range on Protein: 427-495
Range on HMM: 1-74/74
Sequence Identity: 41% (31 aa)

YSSKYGLGYLLNNGQAGVF-FNDSTKIILNPKTE-QFDYIE--RNSSSKQDFGAEYTLK-DYPESLQKKLTLLQ
|..|||..|.|.||  .|. |||.|||||.|...  ..||.  .|  ....   ...   .|||.||||||.|.
YRTKYGIMYQLSNGTVQVNFFNDHTKIILCPNMKYAVTYIDHDPNWQRQTYPLSTILEHGCYPEDLQKKLTYLK

POLO_box 18358b.AA POLO_box 533-600 43 1.4e-25 96.07 Pfam 1-74 (74) Show / Hide
Range on Protein: 533-600
Range on HMM: 1-74/74
Sequence Identity: 43% (32 aa)

LRTKNAILFRLSNKVVQVI-FQDSSEIILSSELR-AVTYVN--RKKQRETFPLSTAMES--QNKEMSKRLTYTK
.||| .| ..|||. |||  | |...|||... . |||| .  ...|| |.||||..|.   .... |.|||.|
YRTKYGIMYQLSNGTVQVNFFNDHTKIILCPNMKYAVTYIDHDPNWQRQTYPLSTILEHGCYPEDLQKKLTYLK