Gene 8829 (Tetrahymena)

8829

Species: Tetrahymena
Alias: PreTt08829, 8829, TTHERM_00191790, 552, 3697.m00251, 15.m00540
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: PLK
Subfamily: PLK-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
8829.AA Protein None 674 None Fasta, JSON
8829.kin_dom Protein Kinase Domain None 256 None Fasta, JSON
8829.NA RNA None 2025 None Fasta, JSON

Protein domain

Protein domains of 8829.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 8829.AA PLK-Unclassified 30-285 71 6.1e-204 683.81 In-house 1-264 (264) Show / Hide 
Range on Protein: 30-285
Range on HMM: 1-264/264
Sequence Identity: 71% (188 aa)

YLRGKLLGKGGFAKCYEVTNLETKKIIAAKIIPKQTLTKNRARQKLISEIKIHKSLNHQHVVAFEHVFEDHENVYILLELCTNHTLNELIKRR-------
| ||..||||||||||.|.|.|||||.|||||||..||||||||||||||||||||.|...| |||.||||||||||||.|.|.||.|.||||       
YHRGHFLGKGGFAKCYQVKNIETKKIYAAKIIPKSSLTKNRARQKLISEIKIHKSLHHKNIVKFEHCFEDHENVYILLEYCPNGTLMEYIKRRNFQLFEK

KRLTELEVQCYVVQIVNALKYLHSHKVIHRDLKLGNLFLNEKMEIKLGDFGLATKLEFDGEKKHTICGTPNYIAPEILDGKT-GHSYQVDIWSLGVIIYT
|||||.||.||..|||.||||||....|||||||||.|||..||.|..|||||||||.|||||.|||||||||||||||||. ||||.||.||.|.|.||
KRLTEYEVKCYTYQIVQALKYLHQNRIIHRDLKLGNIFLNDNMEVKICDFGLATKLENDGEKKKTICGTPNYIAPEILDGKHQGHSYEVDCWSFGCILYT

LLIGKPPFETPDVKTTYKKIRNISYGFPENVPISDQARGLITRILNIDPQRRPTLDEIMSSSFL
||||||||||.|||.|||||.. .| |||...|||.|. ||..|||..|..|||.|.||...|.
LLIGKPPFETKDVKQTYKKIKCNQYSFPEPCHISDNAKDLIQHILNWNPDQRPTIDQIMMHPFY
Kinase 8829.AA PLK 30-285 61 3.4e-194 637.64 In-house 1-258 (258) Show / Hide 
Range on Protein: 30-285
Range on HMM: 1-258/258
Sequence Identity: 61% (159 aa)

YLRGKLLGKGGFAKCYEVTNLETKKIIAAKIIPKQTLTKNRARQKLISEIKIHKSLNHQHVVAFEHVFEDHENVYILLELCTNHTLNELIKRR-KRLTEL
| ||..|||||||||||.|...||...|.|..||....|...|.|...||.||..|.|...|.|.|.|||||||||.||.|.|..|....||| ||||| 
YERGHFLGKGGFAKCYEMTDIHTKQVYAIKVVPKSLMQKPHQREKMKQEIEIHRQLHHPNIVKFHHFFEDHENVYIVLEYCHNRSLMHYHKRRAKRLTEP

EVQCYVVQIVNALKYLHSHKVIHRDLKLGNLFLNEKMEIKLGDFGLATKLEFDGEKKHTICGTPNYIAPEILDGKT-GHSYQVDIWSLGVIIYTLLIGKP
||..|..|||..|||||.|..|||||||||||||..|..|.|||||||.||.|||.|.|.||||||||||.|||.  ||||.||.||||.|.||||||||
EVRYYMYQIVQGLKYLHQHRIIHRDLKLGNLFLNDNMHVKIGDFGLATRLEYDGERKKTMCGTPNYIAPEVLDGNKQGHSYEVDCWSLGCIMYTLLIGKP

PFETPDVKTTYKKIRNISYGFPENVPISDQARGLITRILNIDPQRRPTLDEIMSSSFL
|||| |||.|||.|..  | |||..||||.|. ||...|| .|..|||.|.|..  |.
PFETKDVKETYKRIKHNHYSFPEHCPISDEAKDLIQKMLNWNPDERPTIDQILQHPFF
Kinase 8829.AA PLK2 30-285 50 3.8e-132 427.95 In-house 1-257 (257) Show / Hide 
Range on Protein: 30-285
Range on HMM: 1-257/257
Sequence Identity: 50% (132 aa)

YLRGKLLGKGGFAKCYEVTNLETKKIIAAKIIPKQTLTKNRARQKLISEIKIHKSLNHQHVVAFEHVFEDHENVYILLELCTN----HTLNELIKRRKRL
|.|||||||||||.||| | ..| .. |.||.|.    | . | |   || .|  | | |.|.| | ||| .|.|||||.|        .    | |. |
YCRGKLLGKGGFARCYEMTDMDTHYVYAVKIVPHSRVAKPHQREKMEREIELHRQLRHRHIVQFHHHFEDRDNIYILLEYCSRQVPLKSMAHMWKVRHHL

TELEVQCYVVQIVNALKYLHSHKVIHRDLKLGNLFLNEKMEIKLGDFGLATKLEFDGEKKHTICGTPNYIAPEILDGKTGHSYQVDIWSLGVIIYTLLIG
|| ||  |  |||  |.|||....|||||||||.|.|. ||.| |||||| .||. .. . |.||||||||||.| .. |||   |||.|| | ||.|.|
TEPEVRYYMRQIVSGLRYLHQQCIIHRDLKLGNFFINDNMEVKIGDFGLAARLEPEEHCHRTMCGTPNYIAPEVL-NRQGHSCESDIWALGCIMYTMLCG

KPPFETPDVKTTYKKIRNISYGFPENVPISDQARGLITRILNIDPQRRPTLDEIMSSSFL
 ||||| . | ||. ||   | .|.    |  || || |.|  ||. || ||.|.   | 
RPPFETANLKETYRCIRHNHYHMPTH--LSPPARHLIARMLSPDPEDRPSLDHIIRHDFF
Kinase 8829.AA PLK1 30-285 54 4.90000000001e-129 426.42 In-house 1-253 (253) Show / Hide 
Range on Protein: 30-285
Range on HMM: 1-253/253
Sequence Identity: 54% (139 aa)

YLRGKLLGKGGFAKCYEVTNLETKKIIAAKIIPKQTLTKNRARQKLISEIKIHKSLNHQHVVAFEHVFEDHENVYILLELCTNHTLNELIKRRKRLTELE
| .|. |||||||.|||... .||...|.|..||. | |. .|.|.  ||.||..|.|.|.| | | |||..||||.||||  . | || |||| .|| |
YEKGRFLGKGGFAHCYEIRDKDTKEVFAGKVVPKSLLIKQHQRDKMTQEIQIHRQLHHRHIVKFHHFFEDKQNVYIVLELCRRRSLMELHKRRKAITEPE

VQCYVVQIVNALKYLHSHKVIHRDLKLGNLFLNEKMEIKLGDFGLATKLEFDGEKKHTICGTPNYIAPEILDGKTGHSYQVDIWSLGVIIYTLLIGKPPF
   |. |||.. .|||  |.|||||||||||||.....|.||||||||.|.|||.|.|.||||||||||.|  |.|||. |||||.| |.|.||.|.|||
CRYYMYQIVEGCQYLHNNKIIHRDLKLGNLFLNDHLQVKIGDFGLATKCEYDGERKKTLCGTPNYIAPEVLN-KKGHSFEVDIWSIGCIMYILLFGQPPF

ETPDVKTTYKKIRNISYGFPENVPISDQARGLITRILNIDPQRRPTLDEIMSSSFL
||  .| ||..|..  |  |..  ||  |. || ..|. ||.|||| .....  |.
ETKCLKETYSRIKKNEYRIPSH--ISQPAAQLIRKMLDPDPTRRPTIEQVLNDEFF
Kinase 8829.AA S_TKc 30-285 33 8e-102 345.49 SMART 1-231 (231) Show / Hide 
Range on Protein: 30-285
Range on HMM: 1-231/231
Sequence Identity: 33% (92 aa)

YLRGKLLGKGGFAKCYEVTNLETKKIIAAKIIPKQTLTKNRARQKLISEIKIHKSLNHQHVVAFEHVFEDHENVYILLELCTN--HTLNELIKRRKR---
|  ....|||.|.|.| ... .|..| | |||.          .....||.|.|. .| ..| .  ||.| ...|. .|.| .   .| ..||.|.|   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---LTELEVQCYVVQIVNALKYLHSHKVIHRDLKLGNLFLNEKMEIKLGDFGLATKLEFDGEKKHTICGTPNYIAPEILDGKTGHSY-QVDIWSLGVIIY
   ..| ....|. ||..||.|.|||..||||||  |..|.|  .||..|||||..|       .|.||||.|.|||.|    |...  .|.||.|.|.|
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILY

TLLIGKPPFETPDVKTTYKKIRNISYGFPENVPISDQARGLITRILNIDPQRRPTLDEIMS-------SSFL
 .| |.|||.  ......|||.            |..|. .| ..|. ||..|||  |..          ..
EMLCGYPPFP--QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 8829.AA CAMK 35-285 22 1.8e-100 324.51 In-house 1-425 (425) Show / Hide 
Range on Protein: 35-285
Range on HMM: 1-425/425
Sequence Identity: 22% (95 aa)

LLGKGGFAKCYEVTNLETK------------KIIAAKIIPKQTLTK-------------------------NRARQKLISEIKIHKS-------LNHQHV
 ||.|.|.| ..... .|.            .  |.|||.|. |..                          . |... .||.|.|.       |.| ..
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VAFEHVFEDHEN-------------------VYILL---ELCTNH----TLNELIKRR---------------KRLTELEVQCYVVQIVNALKYLHSHKV
. . .|.||...                   .|. .   |.|..      | . |...               .|.|| |.. |. ||. |..|.|||..
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

IHRDLKLGNLFLNEKM-----------------EIKLGDFGLATKLEF-----------------------DGEKKHTICGTPNYIA-PEILDG------
.|||||. |. |....                  ||. |||.|.|..                        .|.| .| |||| |.| ||.| |      
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

-------KTGHSYQVDIWSLGVIIYTLLIGKPPFETP-------------DVKTTYKKIRNISYGFPENV--P------------ISDQ--------ARG
       |.......|.||.||| |..| |.|||. .             . . ...||..  | ||.    |            |||.        .. 
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

LITRILNIDPQRRPTLDEIMSSSFL
|| ..|. ||..|.|......  ..
LIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 8829.AA AGC 30-285 22 7.4e-100 258.24 In-house 1-395 (395) Show / Hide 
Range on Protein: 30-285
Range on HMM: 1-395/395
Sequence Identity: 22% (89 aa)

YLRGKLLGKGGFAKCYEVTNL------ETKKIIAAKIIPKQT-LTKNR--ARQKLISE------------IKIHKSLN----------HQHVVA-FEHVF
.   |..|||.| |.| |          |.|. | |.. |..   ...    .. ..|             .| . .|          |. .|    . |
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

EDHEN--VYILLELCT----------N-HTLNELIK--RRKRLTELEVQCYVVQ-------IVNALKYLHS-HKVIHRD-LKLGNLFLNEKMEIKLGDFG
.| ..  .|...|..              ..  | .  ...|..| ... |  .       || || |||| ...|||| ||. |. |.|.  ||| |||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

LATKLEFDG--------------------------------------------------EKKHTICG--TPNYIAPEILDGKTGHSYQVDIWS--LGVII
|....  ||                                                  .. .|.||  ||.|.|||||     .....|.||  ||...
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL-----YGKACDWWSFGLGCLM

YTLLIGKPPFETP----------DVKTTYKKIR------NISYGFPEN--------VPISDQARGLITRILNIDPQRRPT----------LDEIMSSSFL
| .|.|.|||             . . ...||.      |    || .        . .|..|. ||.. |. || .|..           .||..  . 
YEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase 8829.AA CAMKL 30-285 31 4.7e-94 300.54 In-house 1-297 (297) Show / Hide 
Range on Protein: 30-285
Range on HMM: 1-297/297
Sequence Identity: 31% (94 aa)

YLRGKLLGKGGFAKCYEVTN-LETKKIIAAKIIPKQTLTKNRARQK------------LISEIKIHKSLN---HQHVVAFEHVFEDHEN------VYILL
|  || ||||.|.|    |. . |..  | ||| |. ....   .|            .  ||.|.|.||   |.... . .|.|. |.      .|. .
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

ELCTNHT--LNELIKRR----KRLTELEVQCYVVQIVNALKYLHSHKVIHRDLKLGNLFLNEKM--EIKLGDFGLATKLE-F---DGEKKHTICGTPNYI
|.| .    | . |...    .|..| | . |  ||| |..|.|||...|||.|. |. | |..   ||. |||.... .     .|.| .| ||.|.| 
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYM

APEILDG--KTGHSYQVDIWSLGVIIYTLLIGKPPFETP-------DVKTTYKKIRNISYGFP-ENVPISDQARGLITRILNIDPQRRPTLDEIMSSSFL
||||. |  |  . ..|||||.||| |... |. ||. .       | . ..... ..  ..|   . .| ..| || ..|. .| .|||...||.  ..
APEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM
Kinase 8829.AA Pkinase 30-285 30 8.6e-94 322.69 Pfam 1-293 (293) Show / Hide 
Range on Protein: 30-285
Range on HMM: 1-293/293
Sequence Identity: 30% (89 aa)

YLRGKLLGKGGFAKCYEVTNLETKKIIAAKIIPKQTLTKNRARQKLI-SEIKIHKSLNHQHVVAFEHVFEDHENVYILLELCTNH----TLNELIK--RR
| .|. .|.|.|...|. ..  | || | |||.|..  ..  ....  |||.|.|.||| ..| . ..|||. ..|. .|.| .      | ..|.  |.
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

KRL--TELEVQCYVVQIVNALKYLHSHKVIHRDLKLGNLFLNEKMEI----KLGDFGLATKL-EFDGEKKHTICGTPNYIAPEILDGKTGHSYQVDIWSL
...  .| |...|. ||. .|.|.||...||||||. |........|    |..||||| .. .  ..  .|.||||.|.|||.. | ..... ||.||.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GVIIYTLLIGKPPFETP------DVKTTYKKIRNISYGFPENVPIS-------------------DQARGLITRILNIDPQRRPTLDEIMSSSFL
|.|.| .| |.|||         | .  ...|.   . |..  ..|                   . .. .|...|. ||..||| ..|. . ..
GCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 8829.AA MARK 30-285 35 1.7e-81 266.2 In-house 1-262 (262) Show / Hide 
Range on Protein: 30-285
Range on HMM: 1-262/262
Sequence Identity: 35% (95 aa)

YLRGKLLGKGGFAKCYEVTNLETKKIIAAKIIPKQTLTKNRARQKLISEIKIHKSLNHQHVVAFEHVFE--DHEN-VYILLELCTNHTLNELIKRR--KR
|  .| .|.|..|| . .... |..  | ||..|. |... ..... .||.|.|.|.| ... . ||.|  . .. .|. .|.. .. | . || .   |
YKMLKTIGHGSYAKVKLACHKHTGRKVAIKIYEKFKLNDPQWMKNVMREIEIMKKLDHPNIIKLFHVIEQDTEQHQIYLIMEYASGGELYDYIKAHPNGR

LTELEVQCYVVQIVNALKYLHSHKVIHRDLKLGNLFLNEKM--EIKLGDFGLATKLEFDGEKKHTICGTPNYIAPEILDGKTGHSYQVDIWSLGVIIYTL
|.| |   .  ||| |..|.||. ..|||.|. |. . |..   ||. |||.... .  |.|  | |||| | ||||. .|    . ||||||||. |..
LHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDFGFSICIPP-GQKLNTFCGTPPYMAPEIFLKKPYDGPKVDIWSLGVVLYFM

LIGKPPFE--TPDVKTTYKKIRNISYGFPENVPISDQARGLITRILNIDPQRRPTLDEIMSSSFL
. |. ||.  | | |. ||||.. .| .| .  .|...| || |.|...| .|||..|||. ...
VCGYFPFDGDTQDYKELYKKILRGKYDIPCH--VSKECRNLIQRLLTVNPEERPTIEEIMKHPWM
Kinase 8829.AA ULK 30-285 29 1.3e-78 267.47 In-house 1-329 (329) Show / Hide 
Range on Protein: 30-285
Range on HMM: 1-329/329
Sequence Identity: 29% (98 aa)

YLRGKLLGKGGFAKCYEVTNLETK----KIIAAKIIPKQTLTKNR-------ARQKLISEIKIHKSLN--------HQHVVAFEHVFEDH--ENVYILLE
|   . |||| |.| |. .| .||    ...|.|.|.||.. ..        . | |..|||| | |.        |...| . ..||.    |.|| .|
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

LCTNHTLNELIKRR----------KRLTELEVQCYVVQIVNALKYLHSHKVIHRDLKLGNLFLNEK------------MEIKLGDFGLATKLEFDG----
.|   .| ..||..          |||.| |.. .  ||.|..|.||.|..||||.|. |  ....            . .|..|||.| ... |.    
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

-EKKHT----ICGTPNYIAPEILD---GKTGHS-YQVDIWSLGVIIYTLLIGKPPFETPDVKTTY-----KK----------IRNISYGFP---ENVPIS
 ..  .    .|||| | ||.||    ..  .. | .||||||.|.| .| |||||...   ..|     |           |...   ||   ....||
MMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQIS

DQARGLITRILNIDPQRRPTLDEIMSSSFL
.. . || | | .|.  | . .|. .  ..
PECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase 8829.AA ULK 30-285 29 2.2e-78 266.74 In-house 1-324 (324) Show / Hide 
Range on Protein: 30-285
Range on HMM: 1-324/324
Sequence Identity: 29% (95 aa)

YLRGKLLGKGGFA-KCYEVTNLET---KKIIAAKIIPKQTLTKNRAR-------QKLISEIKIHKSLN---HQH--VVAFEHVFEDH--ENVYILLELCT
|   . |||| |. | |. .| .|   ....|.|.|.|. . |.  .       |.|..||.| | |.   |..  .| . ..||.    |.|| .|.| 
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

NHTLNELIKRR---------KRLTELEVQCYVVQIVNALKYLHSHKVIHRDLKLGNLFLNEK------------MEIKLGDFGLATKLEFDG---EKKHT
  .| ..||..         |||.| |.. .  ||.|..|.||.|..||||.|. |. ....              .|..|||.| ... ..    . .|
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQT

IC------GTPNYIAPEILD---GKTGHS-YQVDIWSLGVIIYTLLIGKPPFETPDVKTTYKK--------------IRNISYGFP---ENVPISDQARG
..      ||| | ||.||    ..  .. | .||||||.|.| .| ||.||...   ..|..              |.|    ||   ....||.. . 
CVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKD

LITRILNIDPQRRPTLDEIMSSSFL
|| | | .|.  | . .|| .  ..
LIRRMLQYDEKDRISWEEIFNHPWF
Kinase 8829.AA Pkinase_Tyr 30-217 29 7e-19 64.57 Pfam 1-202 (270) Show / Hide 
Range on Protein: 30-217
Range on HMM: 1-202/270
Sequence Identity: 29% (61 aa)

YLRGKLLGKGGFAKCYEVTNL----ETKKIIAAKIIPKQTLTKNRA--RQKLISEIKIHKSL-NHQHVVAFEHVFE-DHEN--VYILLELCTNHTLNELI
   || ||.| | . |. |      .||   | |.. |.  .  ..  |.....|.|| |.| .|...| .  |   . |   .|| .|.. .  | .  
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KE-GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL

KR----RKRLTELEVQCYVVQIVNALKYLHSHKVIHRDLKLGNLFLNEKMEIKLGDFGLATKL-------EFDGEKKHTICGTPNYIAPE-ILDGKTGHS
..    ...||  .  .. .|| ... ||.|.. |||||   |  ..|.. .| .|||||  .          |. |  |  .    ||| | .||   .
RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWM----APECINYGK--FT

YQVDIWSLGV
 . |.|| ||
TKSDVWSFGV
Kinase 8829.AA TyrKc 30-285 21 8.6e-17 48.78 SMART 1-280 (280) Show / Hide 
Range on Protein: 30-285
Range on HMM: 1-280/280
Sequence Identity: 21% (65 aa)

YLRGKLLGKGGFAKCYEVTNLETKKIIAAKIIPKQTLTKNRARQKLISEIKIHKSL--NHQHVVAFEHVFEDH-------ENVYILLELCTNHTLNELIK
   || || | | . |. |        | | . . .      |. ...|..| ..|  .|...|..  |  ..       | ..|..|.. .  |.. ..
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

RRKR-LTELEVQCYVVQIVNALKYLHSHKVIHRDLKLGNLFLNEKMEIKLGDFGLATKLEFD-------GEKKH--TICGTP----NYIAPEILDGKTG-
.... |.  .   . .|| .   ||||...|||||   |  ..|.  .| .||||. ... |         ...  . .|         ||| .  ..| 
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI--NYGK

HSYQVDIWSLGVI---IYTLLIGKPPFET-----PDVKTTYKKIRNI-SYGFPEN--------VPISDQARGLITRILNIDPQRRPTLDEIMSSSFL
 . . |.|| ||    |.|.  |..| .       . .  ......      |.|         |       ....  . ||  |||  ||   ...
FTTKSDVWSFGVCMWEIFTY--GQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ--IMKQCWHEDPEDRPTFSEI--HECF
POLO_box 8829.AA POLO_box 466-534 35 1.4e-25 96.12 Pfam 1-74 (74) Show / Hide 
Range on Protein: 466-534
Range on HMM: 1-74/74
Sequence Identity: 35% (26 aa)

YSAKYGLGYLLSNGCSGVF-FNDSTKVILDPTTN-NIEYIE--RLGNERQDFVQQFTLK-DYPPEMKKKVTLLS
|. |||..|.||||. .|. |||.||.||.|..  ...||.  . ......  .. .   .||....||.|.|.
YRTKYGIMYQLSNGTVQVNFFNDHTKIILCPNMKYAVTYIDHDPNWQRQTYPLSTILEHGCYPEDLQKKLTYLK
POLO_box 8829.AA POLO_box 570-637 43 6.4e-26 97.23 Pfam 1-74 (74) Show / Hide 
Range on Protein: 570-637
Range on HMM: 1-74/74
Sequence Identity: 43% (32 aa)

MKTKHAIMFRLSNKIVQVS-FQDKTEILLSSENK-MVTYVD--RKGTRTDYPLSTALES--SNTEMSKRLKYTK
..||..||..|||..|||  | |.|.|.|... |  ||| |  ....|. |||||.||.   . .. |.|.|.|
YRTKYGIMYQLSNGTVQVNFFNDHTKIILCPNMKYAVTYIDHDPNWQRQTYPLSTILEHGCYPEDLQKKLTYLK